Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Authors: Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin L. Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1cbfc186befb4c289f8694e2f8ebe72c

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

Authors: Dominik Trzupek, Melanie Dunstan, Antony J. Cutler, Mercede Lee, Leila Godfrey, Lorna Jarvis, Daniel B. Rainbow, Dominik Aschenbrenner, Joanne L. Jones, Holm H. Uhlig, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-22 (2020)

Subject Terms: Single-cell RNA sequencing (scRNA-seq), Multi-omics, CD4+ T cells, AbSeq, Immunophenotyping, CD80, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-020-00756-z; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/6eeadf402a094fd884bcd1203a87702a

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus [version 2; peer review: 2 approved, 1 approved with reservations]

Authors: Dominik Trzupek, Fiona Hamey, Mercede Lee, John A. Todd, Linda S. Wicker, Ricardo C. Ferreira

Source: Wellcome Open Research, Vol 6 (2022)

Subject Terms: Single-cell RNA-sequencing (scRNA-seq), multi-omics, BD Rhapsody, AbSeq, cytotoxic CD4+ T cells (CTLs), systemic lupus erythematosus (SLE), eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/6-149/v2; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/29511b154d4649cf9a3cca4542ee9c1f

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus [version 1; peer review: 1 approved, 2 approved with reservations]

Authors: Dominik Trzupek, Fiona Hamey, Mercede Lee, John A. Todd, Linda S. Wicker, Ricardo C. Ferreira

Source: Wellcome Open Research, Vol 6 (2021)

Subject Terms: Single-cell RNA-sequencing (scRNA-seq), multi-omics, BD Rhapsody, AbSeq, cytotoxic CD4+ T cells (CTLs), systemic lupus erythematosus (SLE), eng, Medicine, Science

File Description: electronic resource

Relation: https://wellcomeopenresearch.org/articles/6-149/v1; https://doaj.org/toc/2398-502X

Access URL: https://doaj.org/article/6f7b8027351748d68ec660fd13021b07

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

Authors: Ricardo C. Ferreira, Xaquin Castro Dopico, João J. Oliveira, Daniel B. Rainbow, Jennie H. Yang, Dominik Trzupek, Sarah A. Todd, Mhairi McNeill, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Daniel J. M. Crouch, Marcin L. Pekalski, Francesco Cucca, Tim I. Tree, Tim J. Vyse, Linda S. Wicker, John A. Todd

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: regulatory T cells (Tregs), systemic lupus erythematosus (SLE), autoimmunity, FOXP3, PTPN22 Arg620Trp, PD-1, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02606/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/491641df1e794e1fa267f30eab0edc3f