The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis

Authors: Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

Source: Nature Communications, Vol 16, Iss 1, Pp 1-15 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/711ad436a22e4af4a30f74d92daa1049

Glycerophospholipid remodeling is critical for orthoflavivirus infection

Authors: Julia Hehner, Laura Schneider, Anna Woitalla, Benjamin Ott, Kim Chi Thi Vu, Anja Schöbel, Torsten Hain, Dominik Schwudke, Eva Herker

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b982738030eb4a9ea28c81f6c95003d9

The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data

Authors: Dominik Kopczynski, Christer S. Ejsing, Jeffrey G. McDonald, Takeshi Bamba, Erin S. Baker, Justine Bertrand-Michel, Britta Brügger, Cristina Coman, Shane R. Ellis, Timothy J. Garrett, William J. Griffiths, Xue Li Guan, Xianlin Han, Marcus Höring, Michal Holčapek, Nils Hoffmann, Kevin Huynh, Rainer Lehmann, Jace W. Jones, Rima Kaddurah-Daouk, Harald C. Köfeler, Peter J. Meikle, Thomas O. Metz, Valerie B. O’Donnell, Daisuke Saigusa, Dominik Schwudke, Andrej Shevchenko, Federico Torta, Juan Antonio Vizcaíno, Ruth Welti, Markus R. Wenk, Denise Wolrab, Yu Xia, Kim Ekroos, Robert Ahrends, Gerhard Liebisch

Source: Journal of Lipid Research, Vol 65, Iss 9, Pp 100621- (2024)

Subject Terms: checklist, lipid metabolism, lipidomics, mass spectrometry, metabolomics, reference standards, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227524001263; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/3fdedc2e62704f2cb1a553af8d558f83

Lipidation of pneumococcal proteins enables activation of human antigen-presenting cells and initiation of an adaptive immune response

Authors: Antje D. Paulikat, Dominik Schwudke, Sven Hammerschmidt, Franziska Voß

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: Streptococcus pneumoniae, lipoproteins, lipidation, immune response, vaccine, antigen presenting cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1392316/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c85ee291149641538c48408d52ca3cd9

Resolving colistin resistance and heteroresistance in Enterobacter species

Authors: Swapnil Prakash Doijad, Nicolas Gisch, Renate Frantz, Bajarang Vasant Kumbhar, Jane Falgenhauer, Can Imirzalioglu, Linda Falgenhauer, Alexander Mischnik, Jan Rupp, Michael Behnke, Michael Buhl, Simone Eisenbeis, Petra Gastmeier, Hanna Gölz, Georg Alexander Häcker, Nadja Käding, Winfried V. Kern, Axel Kola, Evelyn Kramme, Silke Peter, Anna M. Rohde, Harald Seifert, Evelina Tacconelli, Maria J. G. T. Vehreschild, Sarah V. Walker, Janine Zweigner, Dominik Schwudke, DZIF R-Net Study Group, Trinad Chakraborty

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8f1968e0788d4d10b57c9ebfdab99a01

Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation

Authors: Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M. Collinson, Dominik Schwudke, Michael J. Blackman, Tim-Wolf Gilberger

Source: mBio, Vol 14, Iss 4 (2023)

Subject Terms: malaria, blood stage, phospholipase, phosphoinositides, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/c204e2746b334bc1a200c8924a7767df

A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience

Authors: Renate Frantz, Konrad Gwozdzinski, Nicolas Gisch, Swapnil Prakash Doijad, Martina Hudel, Maria Wille, Mobarak Abu Mraheil, Dominik Schwudke, Can Imirzalioglu, Linda Falgenhauer, Michael Ehrmann, Trinad Chakraborty

Source: Microbiology Spectrum, Vol 11, Iss 3 (2023)

Subject Terms: E. coli, MCR-1, envelope stress response (ESR), pH-enhanced resistance, plasmid elimination, lipid A, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/2d2db4a596354834aa96a8c1a3bfb711

Quality control requirements for the correct annotation of lipidomics data

Authors: Harald C. Köfeler, Thomas O. Eichmann, Robert Ahrends, John A. Bowden, Niklas Danne-Rasche, Edward A. Dennis, Maria Fedorova, William J. Griffiths, Xianlin Han, Jürgen Hartler, Michal Holčapek, Robert Jirásko, Jeremy P. Koelmel, Christer S. Ejsing, Gerhard Liebisch, Zhixu Ni, Valerie B. O’Donnell, Oswald Quehenberger, Dominik Schwudke, Andrej Shevchenko, Michael J. O. Wakelam, Markus R. Wenk, Denise Wolrab, Kim Ekroos

Source: Nature Communications, Vol 12, Iss 1, Pp 1-4 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/83316378728a498088000222c0fb33af

LipidCreator workbench to probe the lipidomic landscape

Authors: Bing Peng, Dominik Kopczynski, Brian S. Pratt, Christer S. Ejsing, Bo Burla, Martin Hermansson, Peter Imre Benke, Sock Hwee Tan, Mark Y. Chan, Federico Torta, Dominik Schwudke, Sven W. Meckelmann, Cristina Coman, Oliver J. Schmitz, Brendan MacLean, Mailin-Christin Manke, Oliver Borst, Markus R. Wenk, Nils Hoffmann, Robert Ahrends

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cf125a979bd74b198ac9797a20846f29

Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1

Authors: Nicolas Gisch, Christian Utpatel, Lisa M. Gronbach, Thomas A. Kohl, Ursula Schombel, Sven Malm, Karen M. Dobos, Danny C. Hesser, Roland Diel, Udo Götsch, Silke Gerdes, Yassir A. Shuaib, Nyanda E. Ntinginya, Celso Khosa, Sofia Viegas, Glennah Kerubo, Solomon Ali, Sahal A. Al-Hajoj, Perpetual W. Ndung’u, Andrea Rachow, Michael Hoelscher, Florian P. Maurer, Dominik Schwudke, Stefan Niemann, Norbert Reiling, Susanne Homolka

Source: Frontiers in Microbiology, Vol 13 (2022)

Subject Terms: Mycobacterium tuberculosis complex, single nucleotide polymorphism (SNPs), NMR, phenolic glycolipids, genetic diversity, phylogeny, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.832054/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/d89af2c5cf0e449ba33491933f596aaf

Systematic Analysis of Composition, Interfacial Performance and Effects of Pulmonary Surfactant Preparations on Cellular Uptake and Cytotoxicity of Aerosolized Nanomaterials

Authors: Benedikt Huck, Alberto Hidalgo, Franziska Waldow, Dominik Schwudke, Karoline I. Gaede, Claus Feldmann, Patrick Carius, Chiara Autilio, Jesus Pérez-Gil, Konrad Schwarzkopf, Xabier Murgia, Brigitta Loretz, Claus-Michael Lehr

Source: Small Science, Vol 1, Iss 12, Pp n/a-n/a (2021)

Subject Terms: air–blood barrier, air–liquid interfaces, cellular lung models, drug delivery, lipidomics, nanotoxicities, Materials of engineering and construction. Mechanics of materials, TA401-492

File Description: electronic resource

Relation: https://doaj.org/toc/2688-4046

Access URL: https://doaj.org/article/9bbd7c9cd0c448ae95b5eb07a31d19ef

LAMP3 deficiency affects surfactant homeostasis in mice.

Authors: Lars P Lunding, Daniel Krause, Guido Stichtenoth, Cordula Stamme, Niklas Lauterbach, Jan Hegermann, Matthias Ochs, Björn Schuster, Radislav Sedlacek, Paul Saftig, Dominik Schwudke, Michael Wegmann, Markus Damme

Source: PLoS Genetics, Vol 17, Iss 6, p e1009619 (2021)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/530766cbc3c546f5bac9311145dd3f03

Intranasal Administration of Bedaquiline-Loaded Fucosylated Liposomes Provides Anti-Tubercular Activity while Reducing the Potential for Systemic Side Effects

Authors: Franziska Marwitz (Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center), Gabriela Hädrich (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Natalja Redinger (Cellular Microbiology, Research Center Borstel, Leibniz Lung Center), Karen F. W. Besecke (Rodos Biotarget GmbH), Feng Li (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna), Nadine Aboutara (Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center), Simone Thomsen (Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center), Michaela Cohrs (Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg), Paul Robert Neumann (Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg), Henrike Lucas (Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg), Julia Kollan (Institute of Pharmacy, Martin-Luther-Universität Halle-Wittenberg), Constantin Hozsa (Rodos Biotarget GmbH), Robert K. Gieseler (Rodos Biotarget GmbH), Dominik Schwudke (Bioanalytical Chemistry, Research Center Borstel, Leibniz Lung Center), Marcus Furch (Rodos Biotarget GmbH), Ulrich Schaible (German Center for Infection Research, Thematic Translational Unit Tuberculosis), Lea Ann Dailey (Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna)

Availability: http://data.europeana.eu/aggregation/europeana/1300/https___phaidra_univie_ac_at_o_2114568

Perspective for Precision Medicine for Tuberculosis

Authors: Christoph Lange, Rob Aarnoutse, Dumitru Chesov, Reinout van Crevel, Stephen H. Gillespie, Hans-Peter Grobbel, Barbara Kalsdorf, Irina Kontsevaya, Arjan van Laarhoven, Tomoki Nishiguchi, Anna Mandalakas, Matthias Merker, Stefan Niemann, Niklas Köhler, Jan Heyckendorf, Maja Reimann, Morten Ruhwald, Patricia Sanchez-Carballo, Dominik Schwudke, Franziska Waldow, Andrew R. DiNardo

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: precision medicine, tuberculosis, tailor-made regimen, mycobacterial genotypes, endotypes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.566608/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a9519587606f40858abc88bdda14edc9

A Current Encyclopedia of Bioinformatics Tools, Data Formats and Resources for Mass Spectrometry Lipidomics

Authors: Nils Hoffmann, Gerhard Mayer, Canan Has, Dominik Kopczynski, Fadi Al Machot, Dominik Schwudke, Robert Ahrends, Katrin Marcus, Martin Eisenacher, Michael Turewicz

Source: Metabolites, Vol 12, Iss 7, p 584 (2022)

Subject Terms: lipidomics, bioinformatics, data format, database, mass spectrometry, standardization, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/7/584; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/81652065a880448c99c73caa105c473a

Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

Authors: Nathalie Heß, Franziska Waldow, Thomas P. Kohler, Manfred Rohde, Bernd Kreikemeyer, Alejandro Gómez-Mejia, Torsten Hain, Dominik Schwudke, Waldemar Vollmer, Sven Hammerschmidt, Nicolas Gisch

Source: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/981ad421dad041efb626412019f1aa32

A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline

Authors: Samantha J. Hindle, Sarita Hebbar, Dominik Schwudke, Christopher J.H. Elliott, Sean T. Sweeney

Source: Neurobiology of Disease, Vol 98, Iss , Pp 77-87 (2017)

Subject Terms: Prosaposin deficiency, Saposin, Lysosomal storage disease, Drosophila, Neurodegeneration, Sphingolipids, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996116302807; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/07e2643c00114f30b27667dc7e19b429

Lipidation of Pneumococcal Antigens Leads to Improved Immunogenicity and Protection

Authors: Franziska Voß, Lucille F. van Beek, Dominik Schwudke, Thomas H. A. Ederveen, Fred J. van Opzeeland, Daniela Thalheim, Sidney Werner, Marien I. de Jonge, Sven Hammerschmidt

Source: Vaccines, Vol 8, Iss 2, p 310 (2020)

Subject Terms: Streptococcus pneumoniae, lipoproteins, lipidation, pneumococcal colonization, vaccine, protection, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/8/2/310; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/d7bc99e9b9c94b5bb3271c7795d820da

Structural Studies of the Lipopolysaccharide from the Fish Pathogen Aeromonas veronii Strain Bs19, Serotype O16

Authors: Anna Turska-Szewczuk, Katarzyna A. Duda, Dominik Schwudke, Agnieszka Pekala, Alicja Kozinska, Otto Holst

Source: Marine Drugs, Vol 12, Iss 3, Pp 1298-1316 (2014)

Subject Terms: lipopolysaccharide, O-specific polysaccharide, Aeromonas veronii, fish pathogen, ESI MS, NMR, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.mdpi.com/1660-3397/12/3/1298; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/445cbe5ecda5472ea9353fba79d85833

Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia

Authors: Manivannan Subramanian, Suman Kumar Metya, Sufia Sadaf, Satish Kumar, Dominik Schwudke, Gaiti Hasan

Source: Disease Models & Mechanisms, Vol 6, Iss 3, Pp 734-744 (2013)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/6/3/734; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/f2073e88e47944819f8e907a94ae107c