Optimizing CAR-T treatment: A T2EVOLVE guide to raw and starting material selection

Authors: Navarro, Sergio ^{1, 14, ∗}, Moukheiber, Carole ^{2, 14, ∗∗}, Inogés Sancho, Susana ^{3, 14, ∗∗∗}, Ruiz Guillén, Marta ³, López-Díaz de Cerio, Ascensión ³, Sanges, Carmen ⁴, Tanaka, Toshimitsu ⁵, Arnould, Sylvain ², Briones, Javier ⁶, Dolstra, Harry ⁷, Hudecek, Michael ^{4, 8}, Choudhary, Rashmi ⁹, Schapitz, Inga ¹⁰, Juan, Manel ¹, Worel, Nina ¹¹, Ammar, Delphine ¹², Luu, Maik ⁴, Müller, Mirko ⁸, Schroeder, Bernd ¹³, Negre, Hélène ², Franz, Paul ^{8, ∗∗∗∗}

Source: In Molecular Therapy 5 March 2025 33(3):847-865

Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells

Authors: Weiss, Lea, Schluck, Marjolein, Classens, René, de Jonge, Paul K.J.D., van der Waart, Anniek, Nguyen, Khue G., Nguyen, Tam T., Zaharoff, David A., Malmberg, Karl-Johan, Dolstra, Harry, Figdor, Carl G., Sohlberg, Ebba, Hammink, Roel

Source: In Acta Biomaterialia 1 January 2025 191:386-397

Current challenges in cell and gene therapy: a joint view from the European Committee of the International Society for Cell & Gene Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT)

Authors: Sanchez-Guijo, Fermin, Vives, Joaquim, Ruggeri, Annalisa, Chabannon, Christian, Corbacioglu, Selim, Dolstra, Harry, Farge, Dominique, Gagelmann, Nico, Horgan, Claire, Kuball, Jurgen, Neven, Benedicte, Rintala, Tuula, Rocha, Vanderson, Sanchez-Ortega, Isabel, Snowden, John A., Zwaginga, Jaap Jan, Gnecchi, Massimiliano, Sureda, Anna

Source: In Cytotherapy July 2024 26(7):681-685

Generation of human ILC3 from allogeneic and autologous CD34+ hematopoietic progenitors toward adoptive transfer

Authors: Van der Meer, Jolien M.R., Bulder, Ingrid, Kuijk, Carlijn, Kleijer, Marion, Verheij, Myrddin W., Omar, Said Z., Haverkate, Nienke J.E., Dolstra, Harry, Blom, Bianca, Hazenberg, Mette D., Voermans, Carlijn

Source: In Cytotherapy February 2024 26(2):136-144

A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells

Authors: Arvindam, Upasana Sunil, van Hauten, Paulien M. M., Schirm, Dawn, Schaap, Nicolaas, Hobo, Willemijn, Blazar, Bruce R., Vallera, Daniel A., Dolstra, Harry, Felices, Martin, Miller, Jeffrey S.

Source: Leukemia. 35(6):1586-1596

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192937807.0x000001&indx=1&recIds=ETOCvdc_100192937807.0x000001

What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings

Authors: ten Ham, Renske M.T., Hövels, Anke M., Hoekman, Jarno, Frederix, Geert W.J., Leufkens, Hubert G.M., Klungel, Olaf H., Jedema, Inge, Veld, Sabrina A.J., Nikolic, Tatjana, Van Pel, Melissa, Zwaginga, Jaap J., Lin, Fong, de Goede, Anna L., Schreibelt, Gerty, Budde, Sandy, de Vries, I. Jolanda M., Wilkie, Gwen M., Dolstra, Harry, Ovelgönne, Hans, Meij, Pauline, Mountford, Joanne C., Turner, Marc L., Hoefnagel, Marcel H.N.

Source: In Cytotherapy July 2020 22(7):388-397

Harnessing natural killer cells for the treatment of ovarian cancer

Authors: Hoogstad-van Evert, Janneke S., Bekkers, Ruud, Ottevanger, Nelleke, Jansen, Joop H., Massuger, Leon, Dolstra, Harry

Source: In Gynecologic Oncology June 2020 157(3):810-816

Single‐Cell Profiling Reveals Functional Heterogeneity and Serial Killing in Human Peripheral and Ex Vivo‐Generated CD34+ Progenitor‐Derived Natural Killer Cells

Authors: Subedi, Nikita, Verhagen, Liesbeth Petronella, Jonge, Paul, Van Eyndhoven, Laura C., Turnhout, Mark C., Koomen, Vera, Baudry, Jean, Eyer, Klaus, Dolstra, Harry, Tel, Jurjen

Source: Advanced biology. 7(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181411058.0x000001&indx=1&recIds=ETOCvdc_100181411058.0x000001

Peptide-mediated delivery of therapeutic mRNA in ovarian cancer

Authors: van den Brand, Dirk, Gorris, Mark A.J., van Asbeck, Alexander H., Palmen, Emma, Ebisch, Inge, Dolstra, Harry, Hällbrink, Mattias, Massuger, Leon F.A.G., Brock, Roland

Source: In European Journal of Pharmaceutics and Biopharmaceutics August 2019 141:180-190

Phase I/II Trial of a Combination of Anti-CD3/CD7 Immunotoxins for Steroid-Refractory Acute Graft-versus-Host Disease

Authors: Groth, Christoph, van Groningen, Lenneke F.J., Matos, Tiago R., Bremmers, Manita E., Preijers, Frank W.M.B., Dolstra, Harry, Reicherts, Christian, Schaap, Nicolaas P.M., van Hooren, Eric H.G., IntHout, Joanna, Masereeuw, Rosalinde, Netea, Mihai G., Levine, John E., Morales, George, Ferrara, James L., Blijlevens, Nicole M.A., van Oosterhout, Ypke V.J.M., Stelljes, Matthias, van der Velden, Walter J.F.M.

Source: In Biology of Blood and Marrow Transplantation April 2019 25(4):712-719

Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8+ T cells

Authors: Mousset, Charlotte M., Hobo, Willemijn, de Ligt, Aafke, Baardman, Sjoerd, Schaap, Nicolaas P. M., Jansen, Joop H., van der Waart, Anniek B., Dolstra, Harry

Source: Cancer immunology, immunotherapy. 69(11):2259-2273

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Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation

Authors: Hutten, Tim J.A., Norde, Wieger J., Woestenenk, Rob, Wang, Ruo Chen, Maas, Frans, Kester, Michel, Falkenburg, J.H. Frederik, Berglund, Sofia, Luznik, Leo, Jansen, Joop H., Schaap, Nicolaas, Dolstra, Harry, Hobo, Willemijn ^*

Source: In Biology of Blood and Marrow Transplantation April 2018 24(4):666-677

Decitabine enhances targeting of AML cells by CD34+ progenitor-derived NK cells in NOD/SCID/IL2Rgnull mice

Authors: Cany, Jeannette, Roeven, Mieke W.H., Hoogstad-van Evert, Janneke S., Hobo, Willemijn, Maas, Frans, Franco Fernandez, Rosalia, Blijlevens, Nicole M.A., van der Velden, Walter J., Huls, Gerwin, Jansen, Joop H., Schaap, Nicolaas P.M., Dolstra, Harry

Source: In Blood 11 January 2018 131(2):202-214

Comprehensive Phenotyping of T Cells Using Flow Cytometry

Authors: Mousset, Charlotte M., Hobo, Willemijn, Woestenenk, Rob, Preijers, Frank, Dolstra, Harry, van der Waart, Anniek B.

Source: Cytometry.Part A. 95(6):647-654

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103190603.0x000001&indx=1&recIds=ETOCvdc_100103190603.0x000001

MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis

Authors: van Loo, Pieter Fokko, Hangalapura, Basav N., Thordardottir, Soley, Gibbins, John D., Veninga, Henrike, Hendriks, Linda J. A., Kramer, Arjen, Roovers, Rob C., Leenders, Marij, de Kruif, John, Doornbos, Robert P., Sirulnik, Andres, Throsby, Mark, Logtenberg, Ton, Dolstra, Harry, Bakker, Alexander B. H.

Source: Expert opinion on biological therapy. 19(7):721-733

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098595803.0x000001&indx=1&recIds=ETOCvdc_100098595803.0x000001

CXCR4, but not CXCR3, drives CD8+ T‐cell entry into and migration through the murine bone marrow

Authors: Goedhart, Marieke, Gessel, Stephanie, der Voort, Robbert, Slot, Edith, Lucas, Beth, Gielen, Ellis, Hoogenboezem, Mark, Rademakers, Timo, Geerman, Sulima, Buul, Jaap D., Huveneers, Stephan, Dolstra, Harry, Anderson, Graham, Voermans, Carlijn, Nolte, Martijn A.

Source: European journal of immunology. 49(4):576-589

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087228342.0x000001&indx=1&recIds=ETOCvdc_100087228342.0x000001

Engineering of CD34+ progenitor-derived natural killer cells with higher-affinity CD16a for enhanced antibody-dependent cellular cytotoxicity

Authors: van Hauten, Paulien M.M., Hooijmaijers, Laura, Vidal-Manrique, Marcos, van der Waart, Anniek B., Hobo, Willemijn, Wu, Jianming, Blijlevens, Nicole M.A., Jansen, Joop H., Walcheck, Bruce, Schaap, Nicolaas P.M., de Jonge, Paul K.J.D. ^**, Dolstra, Harry

Source: In Cytotherapy March 2024 26(3):252-260

Immune checkpoint molecules in acute myeloid leukaemia: managing the double‐edged sword

Authors: Hobo, Willemijn, Hutten, Tim J. A., Schaap, Nicolaas P. M., Dolstra, Harry

Source: British journal of haematology. 181(1):38-53

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083091195.0x000001&indx=1&recIds=ETOCvdc_100083091195.0x000001

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Authors: Wimmers, Florian, Subedi, Nikita, Buuringen, Nicole, Heister, Daan, Vivié, Judith, Beeren-Reinieren, Inge, Woestenenk, Rob, Dolstra, Harry, Piruska, Aigars, Jacobs, Joannes, Oudenaarden, Alexander, Figdor, Carl, Huck, Wilhelm, Vries, I., Tel, Jurjen

Source: Nature communications. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179720689.0x000001&indx=1&recIds=ETOCvdc_100179720689.0x000001

Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses

Authors: Cruijsen, Marjan, Hobo, Willemijn, van der Velden, Walter J.F.M., Bremmers, Manita E.J., Woestenenk, Rob, Bär, Brigitte, Falkenburg, J.H. Frederik, Kester, Michel, Schaap, Nicolaas P.M., Jansen, Joop, Blijlevens, Nicole N.M., Dolstra, Harry, Huls, Gerwin

Source: In Biology of Blood and Marrow Transplantation June 2016 22(6):1000-1008