Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits

Authors: Dogra, Shalini, Aguayo, Caleb, Xiang, Zixiu, Putnam, Jason, Smith, Joshua, Johnston, Curran, Foster, Daniel J., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey

Source: In Biological Psychiatry 1 August 2024 96(3):230-242

GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders

Authors: Nicoletti, Ferdinando, Di Menna, Luisa, Iacovelli, Luisa, Orlando, Rosamaria, Zuena, Anna Rita, Conn, P. Jeffrey, Dogra, Shalini, Joffe, Max E.

Source: In Neuropharmacology 1 September 2023 235

Metabotropic glutamate receptor 3 as a potential therapeutic target for psychiatric and neurological disorders

Authors: Dogra, Shalini, Putnam, Jason, Conn, P. Jeffrey

Source: In Pharmacology, Biochemistry and Behavior November 2022 221

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Authors: Lin, Xin, Fisher, Nicole M., Dogra, Shalini, Senter, Rebecca K., Reed, Carson W., Kalbfleisch, Jacob J., Lindsley, Craig W., Asher, Wesley B., Xiang, Zixiu, Niswender, Colleen M., Javitch, Jonathan A.

Source: In Journal of Biological Chemistry October 2022 298(10)

Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia

Authors: Dogra, Shalini, Conn, P. Jeffrey ^*

Source: In Molecular Pharmacology May 2022 101(5):275-285

Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

Authors: Joffe, Max E., Maksymetz, James, Luschinger, Joseph R., Dogra, Shalini, Ferranti, Anthony S., Luessen, Deborah J., Gallinger, Isabel M., Xiang, Zixiu, Branthwaite, Hannah, Melugin, Patrick R., Williford, Kellie M., Centanni, Samuel W., Shields, Brenda C., Lindsley, Craig W., Calipari, Erin S., Siciliano, Cody A., Niswender, Colleen M., Tadross, Michael R., Winder, Danny G., Conn, P. Jeffrey

Source: In Neuron 16 March 2022 110(6):1068-1083

Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders

Authors: Dogra, Shalini, Conn, P. Jeffrey

Source: In Neuropharmacology 15 September 2021 196

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Authors: Dogra, Shalini, Stansley, Branden J., Xiang, Zixiu, Qian, Weilun, Gogliotti, Rocco G., Nicoletti, Ferdinando, Lindsley, Craig W., Niswender, Colleen M., Joffe, Max E., Conn, P. Jeffrey

Source: In Biological Psychiatry 15 September 2021 90(6):385-398

Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis

Authors: Kumar, Ajeet, Dogra, Shalini, Sona, Chandan, Umrao, Deepmala, Rashid, Mamunur, Singh, Sandeep K, Wahajuddin, Muhammad, Yadav, Prem N

Source: In Psychoneuroendocrinology March 2019 101:128-137

Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in Depression.

Authors: Yadav, Anubhav, Dogra, Shalini, Boda, Arun Kumar, Kumari, Poonam, Kumar, Ajeet, Dash, Manish K., Yadav, Prem N.

Source: ACS Chemical Neuroscience; 9/18/2024, Vol. 15 Issue 18, p3286-3297, 12p

Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice

Authors: Sona, Chandan, Kumar, Ajeet, Dogra, Shalini, Kumar, Boda Arun, Umrao, Deepmala, Yadav, Prem N.

Source: In Neurobiology of Disease October 2018 118:94-107

Discovery of an isocoumarin analogue that modulates neuronal functions via neurotrophin receptor TrkB

Authors: Sudarshan, Kasireddy, Boda, Arun kumar, Dogra, Shalini, Bose, Ishani, Yadav, Prem Narayan, Aidhen, Indrapal Singh

Source: Bioorganic & medicinal chemistry letters. 29(4):585-590

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100075574558.0x000001&indx=1&recIds=ETOCvdc_100075574558.0x000001

Activation of group II metabotropic glutamate (mGlu2/3) receptors regulates excitatory synaptic plasticity in the nucleus accumbens: Implications for the treatment of schizophrenia

Authors: Dogra, Shalini, Conn, P. Jeffrey

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196486333.0x000001&indx=1&recIds=ETOCvdc_100196486333.0x000001

Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors

Authors: Yadav, Manisha, Singh, Abhishek Kumar, Kumar, Harish, Rao, Geeta, Chakravarti, Bandana, Gurjar, Anagha, Dogra, Shalini, Kushwaha, Sapana, Vishwakarma, Achchhe Lal, Yadav, Prem Narayan, Datta, Dipak, Tripathi, Anil Kumar, Chattopadhyay, Naibedya, Trivedi, Arun Kumar, Sanyal, Sabyasachi

Source: In BBA - General Subjects October 2016 1860(10):2178-2190

Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders

Authors: Dogra, Shalini, Sona, Chandan, Kumar, Ajeet, Yadav, Prem N.

Source: In International Journal of Biochemistry and Cell Biology August 2016 77 Part B:226-239

Chapter 12 - Tango assay for ligand-induced GPCR–β-arrestin2 interaction: Application in drug discovery

Authors: Dogra, Shalini, Sona, Chandan, Kumar, Ajeet, Yadav, Prem N.

Source: In Methods in Cell Biology 2016 132:233-254

Biased agonism at kappa opioid receptors: Implication in pain and mood disorders

Authors: Dogra, Shalini, Yadav, Prem N.

Source: In European Journal of Pharmacology 15 September 2015 763 Part B:184-190

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Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity.

Authors: Kumar, Ajeet, Pasam, Venkata Reddy, Thakur, Ravi Kumar, Singh, Maninder, Singh, Kartikey, Shukla, Mahendra, Yadav, Anubhav, Dogra, Shalini, Sona, Chandan, Umrao, Deepmala, Jaiswal, Swati, Ahmad, Hafsa, Rashid, Mamunur, Singh, Sandeep K., Wahajuddin, Muhammad, Dwivedi, Anil Kumar, Siddiqi, Mohammad Imran, Lal, Jawahar, Tripathi, Rama Pati, Yadav, Prem N.

Source: Journal of Medicinal Chemistry; 5/9/2019, Vol. 62 Issue 9, p4638-4655, 18p