GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy

Authors: Shi, Yuzhe, Kotchetkov, Ivan S., Dobrin, Anton, Hanina, Sophie A., Rajasekhar, Vinagolu K., Healey, John H., Sadelain, Michel

Source: In Molecular Therapy 3 July 2024 32(7):2393-2405

The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Authors: Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

Source: In Immunity 10 January 2023 56(1):93-106

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Authors: Hamieh, Mohamad, Dobrin, Anton, Cabriolu, Annalisa, van der Stegen, Sjoukje, Giavridis, Theodoros, Mansilla-Soto, Jorge, Eyquem, Justin, Zhao, Zeguo, Whitlock, Benjamin, Miele, Matthew, Li, Zhuoning, Cunanan, Kristen, Huse, Morgan, Hendrickson, Ronald, Wang, Xiuyan, Rivière, Isabelle, Sadelain, Michel

Source: Nature. 568(7750):112-116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129219443.0x000001&indx=1&recIds=ETOCvdc_100129219443.0x000001

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Authors: Feucht, Judith, Sun, Jie, Eyquem, Justin, Ho, Yu-Jui, Zhao, Zeguo, Leibold, Josef, Dobrin, Anton, Cabriolu, Annalisa, Hamieh, Mohamad, Sadelain, Michel

Source: Nature medicine. 25(1):82-88

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102162117.0x000001&indx=1&recIds=ETOCvdc_100102162117.0x000001

A nonimmune function of T cells in promoting lung tumor progression

Authors: Green, Jesse A., Arpaia, Nicholas, Schizas, Michail, Dobrin, Anton, Rudensky, Alexander Y.

Source: Journal of experimental medicine. 214(12):3565-3576

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN613893087&indx=1&recIds=ETOCRN613893087

TET2 guards against unchecked BATF3-induced CAR T cell expansion.

Authors: Jain, Nayan, Zhao, Zeguo, Feucht, Judith, Koche, Richard, Iyer, Archana, Dobrin, Anton, Mansilla-Soto, Jorge, Yang, Julie, Zhan, Yingqian, Lopez, Michael, Gunset, Gertrude, Sadelain, Michel

Source: Nature; Mar2023, Vol. 615 Issue 7951, p315-322, 8p

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.

Authors: Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber

Source: Nature; 6/9/2022, Vol. 606 Issue 7913, p389-395, 7p

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Authors: Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.

Source: Nature; 20230101, Issue: Preprints p1-7, 7p

HLA-independent T cell receptors for targeting tumors with low antigen density

Authors: Mansilla-Soto, Jorge, Eyquem, Justin, Haubner, Sascha, Hamieh, Mohamad, Feucht, Judith, Paillon, Noémie, Zucchetti, Andrés Ernesto, Li, Zhuoning, Sjöstrand, Maria, Lindenbergh, Pieter L., Saetersmoen, Michelle, Dobrin, Anton, Maurin, Mathieu, Iyer, Archana, Garcia Angus, Andreina, Miele, Matthew M., Zhao, Zeguo, Giavridis, Theodoros, van der Stegen, Sjoukje J. C., Tamzalit, Fella, Rivière, Isabelle, Huse, Morgan, Hendrickson, Ronald C., Hivroz, Claire, Sadelain, Michel

Source: Nature Medicine; February 2022, Vol. 28 Issue: 2 p345-352, 8p

Publisher Correction: Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Authors: Feucht, Judith, Sun, Jie, Eyquem, Justin, Ho, Yu-Jui, Zhao, Zeguo, Leibold, Josef, Dobrin, Anton, Cabriolu, Annalisa, Hamieh, Mohamad, Sadelain, Michel

Source: Nature medicine. 25(3):530-530

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127961199.0x000001&indx=1&recIds=ETOCvdc_100127961199.0x000001

Calibrated CAR Activation Potential Directs Alternative T Cell Fates and Therapeutic Potency

Authors: Feucht, Judith ^*, Sun, Jie ^*, Eyquem, Justin ^*, Ho, Yu-Jui ^*, Zhao, Zeguo ^*, Leibold, Josef ^*, Dobrin, Anton ^*, Cabriolu, Annalisa ^*, Hamieh, Mohamad ^*, Sadelain, Michel

Source: In Blood 29 November 2018 132 Supplement 1:1412-1412

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