A molecular picture of the problems in ensuring structural purity of tazofelone

Authors: Price, Louise S., McMahon, Jennifer A., Lingireddy, Sreenivas R., Lau, Suk-Fai, Diseroad, Benjamin A., Price, Sarah L., Reutzel-Edens, Susan M.

Source: In Journal of Molecular Structure 25 December 2014 1078:26-42

Salt Disproportionation in the Solid State: Role of Solubility and Counterion Volatility

Authors: Thakral, Naveen K., Behme, Robert J., Aburub, Aktham, Peterson, Jeffrey A., Woods, Timothy A., Diseroad, Benjamin A., Suryanarayanan, Raj, Stephenson, Gregory A.

Source: Molecular pharmaceutics. 13(12):4141-4151

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609177042&indx=1&recIds=ETOCRN609177042

Isolation, Identification, and Synthesis of Two Oxidative Degradation Products of Olanzapine (LY170053) in Solid Oral Formulations

Authors: Baertschi, Steven W., Brunner, Heiko, Bunnell, Charles A., Cooke, Gary G., Diseroad, Benjamin, Dorman, Douglas E., Jansen, Patrick J. ^*, Kemp, Craig A.J., Maple, Steven R., McCune, Karen A., Speakman, Jeffrey L.

Source: In Journal of Pharmaceutical Sciences February 2008 97(2):883-892

Crystalline (R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol

CRYSTALLINE (R)-(E)-2-(4-(2-(5-(1-(3,5-DICHLOROPYRIDIN-4-YL)ETHOXY)-1H-INDAZOL-3-YL)VINYL)-1H-PYRAZOL-1-YL)ETHANOL

Lactam compound

Lactam compound

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Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Authors: Hao, Junliang, Beck, James P., Schaus, John M., Krushinski, Joseph H., Chen, Qi, Beadle, Christopher D., Vidal, Paloma, Reinhard, Matthew R., Dressman, Bruce A., Massey, Steven M., Boulet, Serge L., Cohen, Michael P., Watson, Brian M., Tupper, David, Gardinier, Kevin M., Myers, Jason, Johansson, Anette M., Richardson, Jeffery, Richards, Daniel S., Hembre, Erik J., Remick, David M., Coates, David A., Bhardwaj, Rajni M., Diseroad, Benjamin A., Bender, David, Stephenson, Greg, Wolfangel, Craig D., Diaz, Nuria, Getman, Brian G., Wang, Xu-shan, Heinz, Beverly A., Cramer, Jeff W., Zhou, Xin, Maren, Deanna L., Falcone, Julie F., Wright, Rebecca A., Mitchell, Stephen N., Carter, Guy, Yang, Charles R., Bruns, Robert F., Svensson, Kjell A.

Source: Journal of Medicinal Chemistry; October 2019, Vol. 62 Issue: 19 p8711-8732, 22p

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus

Authors: Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M., DeBaillie, Amy C., Otto, Keith A., Wilbur, Kelly L., Kahl, Steven D., Patel Lewis, Anjana, Cardona, Guemalli R., Zink, Richard W., Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P., Neathery, Grace L., Bouaichi, Cecilia, Diseroad, Benjamin A., Campbell, Alison N., Sweetana, Stephanie A., Adams, Lisa A., Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P., Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel

Source: Journal of Medicinal Chemistry; 20240101, Issue: Preprints