Effect of Clonally Expanded PD‐1highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis

Authors: Fischer, Jonas, Dirks, Johannes, Klaussner, Julia, Haase, Gabriele, Holl‐Wieden, Annette, Hofmann, Christine, Hackenberg, Stephan, Girschick, Hermann, Morbach, Henner

Source: Arthritis & rheumatology. 74(1):150-162

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100143352173.0x000001&indx=1&recIds=ETOCvdc_100143352173.0x000001

CD94-driven in vitro expansion of highly functional adaptive NKG2C⁺ NKG2A^- CD57⁺ NK cells from CMV⁺ healthy donors.

Authors: Giordano, Chiara, Carlomagno, Simona, Falco, Michela, Cantoni, Claudia, Vitale, Massimo, Caruana, Ignazio, Dirks, Johannes, Serio, Alberto, Muccio, Letizia, Bartalucci, Giulia, Bo, Alessandra, Locatelli, Franco, Bottino, Cristina, Sivori, Simona, Della Chiesa, Mariella

Source: Frontiers in Immunology; 2025, p1-12, 12p

Subject Terms: KILLER cells, IMMUNE response, IMMUNE checkpoint proteins, PROGRAMMED cell death 1 receptors, MONOCLONAL antibodies

Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations

Authors: Boztug, Kaan, Brunner, Juergen, Demel, Ulrike F., Förster-Waldl, Elisabeth, Gasteiger, Lukas M., Göschl, Lisa, Kojić, Marina, Schroll, Andrea, Seidel, Markus G., Wintergerst, Uwe, Wisgrill, Lukas, Sharapova, Svetlana O., Goffard, Jean-Christophe, Kerre, Tessa, Meyts, Isabelle, Roosens, Fine, Smet, Julie, Haerynck, Filomeen, Eric, Zelimir Pavle, Milenova, Veneta, Gagro, Alenka, Richter, Darko, Chovancova, Zita, Hlavackova, Eva, Litzman, Jiri, Milota, Tomas, Sediva, Anna, Elaziz, Dalia Abd, Alkady, Radwa Salaheldin, El Sayed El Hawary, Rabab, Eldash, Alia S., Galal, Nermeen, Lotfy, Sohilla, Meshaal, Safa S., Reda, Shereen M., Sobh, Ali, Elmarsafy, Aisha, Seppänen, Mikko R.J., Brosselin, Pauline, Courteille, Virginie, De Vergnes, Nathalie, Kracker, Sven, Pergent, Martine, Randrianomenjanahary, Philippe, Ahrenstorf, Gerrit, Albert, Michael H., Ankermann, Tobias, Atschekzei, Faranaz, Baumann, Ulrich, Becker, Benjamin C., Behrends, Uta, Belohradsky, Bernd H., Biegner, Anika-Kerstin, Binder, Nadine, Bode, Sebastian F.N., Boesecke, Christoph, Boetticher, Benedikt, Borte, Michael, Borte, Stephan, Classen, Carl Friedrich, Dirks, Johannes, Dückers, Gregor, El-Helou, Sabine, Ernst, Diana, Fasshauer, Maria, Fecker, Gisela, Felgentreff, Kerstin, Foell, Dirk, Ghosh, Sujal, Girschick, Hermann J., Goldacker, Sigune, Graf, Norbert, Graf, Dagmar, Greil, Johann, Hanitsch, Leif Gunnar, Hauck, Fabian, Heeg, Maximilian, Heine, Sabine I., Henes, Joerg C., Hoenig, Manfred, Holzer, Ursula, Holzinger, Dirk, Horneff, Gerd, Hundsdoerfer, Patrick, Jablonka, Alexandra, Jakoby, Donate, Joean, Oana, Kaiser-Labusch, Petra, Klemann, Christian, Kobbe, Robin, Körholz, Julia, Kramm, Christof M., Krüger, Renate, Landwehr-Kenzel, Sybille, Lehmberg, Kai, Liese, Johannes G., Lippert, Conrad Ferdinand, Maccari, Maria Elena, Masjosthusmann, Katja, Meinhardt, Andrea, Metzler, Markus, Morbach, Henner, Müller, Ingo, Naumann-Bartsch, Nora, Neubert, Jennifer, Niehues, Tim, Peter, Hans-Hartmut, Rieber, Nikolaus, Ritterbusch, Henrike, Rockstroh, Jürgen Kurt, Roesler, Joachim, Schauer, Uwe, Scheible, Raphael, Schmalzing, Marc, Schmidt, Reinhold Ernst, Schneider, Dominik T., Schreiber, Stefan, Schuetz, Catharina, Schulz, Ansgar, Schulze-Koops, Hendrik, Schulze-Sturm, Ulf, Schuster, Volker, Schwaneck, Eva C., Schwarz, Klaus, Schwarze-Zander, Carolynne, Sirin, Mehtap, Skapenko, Alla, Sogkas, Georgios, Sparber-Sauer, Monika, Speckmann, Carsten, Steinmann, Sandra, Stiehler, Sophie, Tenbrock, Klaus, von Bernuth, Horst, Warnatz, Klaus, Wasmuth, Jan-Christian, Weiss, Michael, Witte, Torsten, Wittke, Kirsten, Wittkowski, Helmut, Zeuner, Rainald A., Farmaki, Evangelia, Hatzistilianou, Maria N., Kakkas, Ioannis, Kanariou, Maria G., Kapousouzi, Androniki, Liatsis, Emmanouil, Maggina, Paraskevi, Papadopoulou-Alataki, Efimia, Raptaki, Maria, Speletas, Matthaios, Tantou, Sofia, Goda, Vera, Kriván, Gergely, Marodi, Laszlo, Abolhassani, Hassan, Aghamohammadi, Asghar, Rezaei, Nima, Feighery, Conleth, Leahy, Timothy Ronan, Ryan, Paul, Batzir, Nurit Assia, Garty, Ben Zion, Tamary, Hannah, Aiuti, Alessandro, Amodio, Donato, Azzari, Chiara, Barzaghi, Federica, Baselli, Lucia A., Cancrini, Caterina, Carrabba, Maria, Cazzaniga, Marco, Cesaro, Simone, Chinello, Matteo, Danieli, Maria Giovanna, Dellepiane, Rosa Maria, Fabio, Giovanna, Gambineri, Eleonora, Lodi, Lorenzo, Lougaris, Vassilios, Marasco, Carolina, Martire, Baldassarre, Marzollo, Antonio, Milito, Cinzia, Moschese, Viviana, Pignata, Claudio, Plebani, Alessandro, Porta, Fulvio, Quinti, Isabella, Ricci, Silvia, Soresina, Annarosa, Tommasini, Alberto, Vacca, Angelo, Vanessa, Clementina, Blažienė, Audra, Sitkauskiene, Brigita, Gowin, Ewelina, Heropolitańska-Pliszka, Edyta, Pietrucha, Barbara, Szaflarska, Anna, Więsik-Szewczyk, Ewa, Wolska-Kuśnierz, Beata, Esteves, Isabel, Faria, Emilia, Marques, Laura Hora, Neves, João Farela, Silva, Susana L., Teixeira, Carla, Pereira da Silva, Sara, Capilna, Brindusa Ruxandra, Guseva, Marina N., Shcherbina, Anna, Bobcakova, Anna, Ciznar, Peter, Gabzdilova, Juliana, Jesenak, Milos, Kapustova, Lenka, Orosova, Jaroslava, Petrovicova, Otilia, Raffac, Stefan, Kopač, Peter, Allende, Luis M., Antolí, Arnau, Blanch, Gemma Rocamora, Carbone, Javier, Dieli-Crimi, Romina, Garcia-Prat, Marina, Gil-Herrera, Juana, Gonzalez-Granado, Luis Ignacio, Agulló, Pilar Llobet, Olbrich, Peter, Parra-Martínez, Alba, Paz-Artal, Estela, Pleguezuelo, Daniel E., Rodríguez, Nerea Salmón, Sánchez-Ramón, Silvia, Santos-Pérez, Juan Luis, Solanich, Xavier, Soler-Palacin, Pere, González-Amores, Miriam, Ekwall, Olov, Fasth, Anders, Bitzenhofer-Grüber, Michaela, Candotti, Fabio, Dimitriou, Florentia, Heininger, Ulrich, Holbro, Andreas, Jandus, Peter, Kolios, Antonios G.A., Marschall, Karin, Schmid, Jana Pachlopnik, Posfay-Barbe, Klara M., Prader, Seraina, Reichenbach, Janine, Steiner, Urs C., Trück, Johannes, Bredius, Robbert G., de Kruijf- Bazen, Suzanne, de Vries, Esther, Henriet, Stefanie S.V., Kuijpers, Taco W., Potjewijd, Judith, Rutgers, Abraham, Stol, Kim, van Aerde, Koen J., Van den Berg, J. Merlijn, van de Ven, Annick A.J.M., Montfrans, Jorisvan, Aydemir, Sezin, Baris, Safa, Dogu, Figen, Ikinciogullari, Aydan, Karakoc-Aydiner, Elif, Kilic, Sara S., Kiykim, Ayca, Kökçü Karadağ, Şefika İlknur, Kutukculer, Necil, Ocak, Suheyla, UNAL, Ekrem, Boyarchuk, Oksana, Hilfanova, Anna, Kostyuchenko, Larysa V., Alachkar, Hana, Arkwright, Peter D., Baxendale, Helen E., Bernatoniene, Jolanta, Coulter, Tanya I., Garcez, Tomaz, Goddard, Sarah, Gompels, Mark M., Grigoriadou, Sofia, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Ibberson, Lisa, Nademi, Zoreh, Noorani, Sadia, Parvin, Shahnaz, Steele, Cathal Laurence, Thomas, Moira, Waruiru, Catherine, Yong, Patrick F.K., Bourne, Helen, Thalhammer, Julian, Kindle, Gerhard, Nieters, Alexandra, Rusch, Stephan, Fischer, Alain, Grimbacher, Bodo, Edgar, David, Buckland, Matthew, Mahlaoui, Nizar, Ehl, Stephan

Source: In The Journal of Allergy and Clinical Immunology November 2021 148(5):1332-1341

A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI).

Authors: Hartmann, Carina R., Khan, Robin, Schöning, Jennifer, Richter, Maximilian, Willers, Maike, Pirr, Sabine, Heckmann, Julia, Dirks, Johannes, Morbach, Henner, Konrad, Monika, Fries, Elena, Winkler, Magdalene, Büchel, Johanna, Seidenspinner, Silvia, Fischer, Jonas, Vollmuth, Claudia, Meinhardt, Martin, Marissen, Janina, Schmolke, Mirco, Haid, Sibylle

Source: Frontiers in Immunology; 10/1/2024, p01-14, 14p

Subject Terms: SARS-CoV-2, RESPIRATORY syncytial virus, VIRUS diseases, COHORT analysis, RESPIRATORY infections, HUMORAL immunity

IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis

Authors: Fischer, Jonas, Dirks, Johannes, Haase, Gabriele, Holl-Wieden, Annette, Hofmann, Christine, Girschick, Hermann, Morbach, Henner

Source: In Clinical Immunology August 2020 217

Insights into B‐cell ontogeny inferred from human immunology

Authors: Dirks, Johannes, Viemann, Dorothee, Beyersdorf, Niklas, Härtel, Christoph, Morbach, Henner

Source: European journal of immunology. 53(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184656162.0x000001&indx=1&recIds=ETOCvdc_100184656162.0x000001

Disease-specific T cell receptors maintain pathogenic T helper cell responses in postinfectious Lyme arthritis.

Authors: Dirks, Johannes^1,2, Fischer, Jonas¹, Klaussner, Julia¹, Hofmann, Christine¹, Holl-Wieden, Annette¹, Buck, Viktoria³, Klemann, Christian⁴, Girschick, Hermann J.⁵, Caruana, Ignazio⁶, Erhard, Florian^7,8, Morbach, Henner¹ Morbach_H@ukw.de

Source: Journal of Clinical Investigation. 9/3/2024, Vol. 134 Issue 17, p1-15. 15p.

Subject Terms: *T helper cells, *T cell receptors, *LYME disease, *BIOMARKERS, *JOINT pain, *T cells

Geographic Terms: NORTH America

Inborn Errors of Immunity in Early Childhood: Essential Insights for the Neonatologist.

Authors: Dirks, Johannes^1,2 (AUTHOR), Wölfl, Matthias¹ (AUTHOR), Speer, Christian P.¹ (AUTHOR), Härtel, Christoph^1,2 (AUTHOR), Morbach, Henner^1,3 (AUTHOR)

Source: Neonatology (16617800). 2024, Vol. 121 Issue 5, p646-655. 10p.

Subject Terms: *EARLY medical intervention, *PRIMARY immunodeficiency diseases, *EXANTHEMA, *NEWBORN screening, *HEMOPHAGOCYTIC lymphohistiocytosis

Immunization of preterm infants: current evidence and future strategies to individualized approaches.

Authors: Fortmann, Mats Ingmar¹ (AUTHOR), Dirks, Johannes² (AUTHOR), Goedicke-Fritz, Sybelle³ (AUTHOR), Liese, Johannes² (AUTHOR), Zemlin, Michael³ (AUTHOR), Morbach, Henner³ (AUTHOR), Härtel, Christoph² (AUTHOR) haertel_c1@ukw.de

Source: Seminars in Immunopathology. Nov2022, Vol. 44 Issue 6, p767-784. 18p.

Subject Terms: *B cells, *PREMATURE infants, *MEDICAL personnel, *B cell receptors, *IMMUNIZATION, *PREMATURE labor, *T cell receptors, *FETUS

IgD shapes the pre-immune naïve B cell compartment in humans.

Authors: Dirks, Johannes, Andres, Oliver, Paul, Luisa, Manukjan, Georgi, Schulze, Harald, Morbach, Henner

Source: Frontiers in Immunology; 1/26/2023, Vol. 13, p1-13, 13p

Subject Terms: B cells, B cell receptors, CELL populations, GENETIC variation

A Novel AICDA Splice-Site Mutation in Two Siblings with HIGM2 Permits Somatic Hypermutation but Abrogates Mutational Targeting.

Authors: Dirks, Johannes¹ (AUTHOR), Haase, Gabriele¹ (AUTHOR), Cantaert, Tineke² (AUTHOR), Frey, Lea³ (AUTHOR), Klaas, Moritz⁴ (AUTHOR), Rickert, Christian H.⁵ (AUTHOR), Girschick, Hermann^4,6 (AUTHOR), Meffre, Eric⁷ (AUTHOR), Morbach, Henner^1,8 (AUTHOR) Morbach_H@ukw.de

Source: Journal of Clinical Immunology. May2022, Vol. 42 Issue 4, p771-782. 12p.

Subject Terms: *AGAMMAGLOBULINEMIA, *IMMUNOGLOBULIN class switching, *CYTIDINE deaminase, *GENETIC variation, *PRIMARY immunodeficiency diseases, *AUTOIMMUNE diseases

Effect of Clonally Expanded PD‐1^highCXCR5–CD4+ Peripheral T Helper Cells on B Cell Differentiation in the Joints of Patients With Antinuclear Antibody–Positive Juvenile Idiopathic Arthritis.

Authors: Fischer, Jonas¹, Dirks, Johannes¹, Klaussner, Julia¹, Haase, Gabriele¹, Holl‐Wieden, Annette¹, Hofmann, Christine¹, Hackenberg, Stephan¹, Girschick, Hermann², Morbach, Henner¹ morbach_h@ukw.de

Source: Arthritis & Rheumatology. Jan2022, Vol. 74 Issue 1, p150-162. 13p.

Subject Terms: *CELL differentiation, *AUTOANTIBODIES, *FLOW cytometry, *INTERLEUKINS, *CYTOKINES, *B cells, *SEQUENCE analysis, *JUVENILE idiopathic arthritis, *GENE expression, *T cells, *CHEMOKINES, *PHENOTYPES, *SYNOVIAL fluid

Lyme-Arthritis

Authors: Morbach, Henner, Holl-Wieden, Annette, Dirks, Johannes, Forster, Johannes, Liese, Johannes

Source: Arthritis + Rheuma; May 2022, Vol. 42 Issue: 3 p185-192, 8p

Use of Macrogol to Accelerate Feeding Advancement in Extremely Preterm Infants.

Authors: Faust, Kirstin Barbara^1,2,3 (AUTHOR) kirstin.faust@uksh.de, Lupatsii, Mariia⁴ (AUTHOR), Römer, Frederike¹ (AUTHOR), Graspeuntner, Simon^2,4 (AUTHOR), Waschina, Silvio⁵ (AUTHOR), Zimmermann, Sina⁵ (AUTHOR), Humberg, Alexander^2,3,6 (AUTHOR), Fortmann, Mats Ingmar^1,2,3 (AUTHOR), Hanke, Kathrin¹ (AUTHOR), Böckenholt, Kai^3,7 (AUTHOR), Dirks, Johannes^2,8 (AUTHOR), Silwedel, Christine⁸ (AUTHOR), Rupp, Jan^2,4 (AUTHOR), Herting, Egbert^1,2,3 (AUTHOR), Göpel, Wolfgang^1,3 (AUTHOR), Härtel, Christoph^2,3,8,9 (AUTHOR)

Source: Neonatology (16617800). Feb2025, p1-10. 10p. 3 Illustrations, 2 Charts.