Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee

Authors: Chhabra, Arpit M. ^{a, ⁎}, Amos, Richard A. ^b, Simone, Charles B., II ^a, Kaiser, Adeel ^c, Perles, Luis A. ^d, Giap, Huan ^e, Hallemeier, Christopher L. ^f, Johnson, Jedediah E. ^f, Lin, Haibo ^a, Wroe, Andrew J. ^c, Diffenderfer, Eric S. ^g, Wolfgang, John A. ^h, Sakurai, Hideyuki ⁱ, Lu, Hsiao-Ming ^j, Hong, Theodore S. ^h, Koay, Eugene J. ^k, Terashima, Kazuki ^l, Vitek, Pavel ^m, Rule, William G. ⁿ, Apisarnthanarax, Smith Jim ^o, Badiyan, Shahed N. ^p, Molitoris, Jason K. ^q, Chuong, Michael ^c, Nichols, Romaine C., Jr ^r

Source: In International Journal of Radiation Oncology, Biology, Physics December 2024

FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone

Authors: Verginadis, Ioannis I. ^{a, 1}, Velalopoulou, Anastasia ^{a, 1}, Kim, Michele M. ^a, Kim, Kyle ^a, Paraskevaidis, Ioannis ^a, Bell, Brett ^b, Oliaei Motlagh, Seyyedeh Azar ^a, Karaj, Antoneta ^c, Banerjee, Esha ^d, Finesso, Giovanni ^d, Assenmacher, Charles-Antoine ^d, Radaelli, Enrico ^d, Lu, Jiawei ^e, Lin, Yuewei ^e, Putt, Mary E. ^c, Diffenderfer, Eric S. ^a, Guha, Chandan ^b, Qin, Ling ^e, Metz, James M. ^a, Maity, Amit ^{a, 2}, Cengel, Keith A. ^{a, 2}, Koumenis, Constantinos ^{a, 2}, Busch, Theresa M. ^{a, ⁎, 2}

Source: In Radiotherapy and Oncology April 2025 205

FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease

Authors: Kim, Kyle ^⁎, Kim, Michele M. ^⁎, Skoufos, Giorgos ^{†, ‡}, Diffenderfer, Eric S. ^*, Motlagh, Seyyedeh Azar Oliaei ^*, Kokkorakis, Michail ^{⁎, §}, Koliaki, Ilektra ^{⁎, §}, Morcos, George ^*, Shoniyozov, Khayrullo ^*, Griffin, Joanna ^║, Hatzigeorgiou, Artemis G. ^{†, ‡, ¶}, Metz, James M. ^*, Lin, Alexander ^*, Feigenberg, Steven J. ^*, Cengel, Keith A. ^*, Ky, Bonnie ^#, Koumenis, Constantinos ^{*, 2}, Verginadis, Ioannis I. ^{*, 2}

Source: In International Journal of Radiation Oncology, Biology, Physics 15 July 2024 119(4):1234-1247

FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma?

Authors: Cengel, Keith A., Kim, Michele M., Diffenderfer, Eric S., Busch, Theresa M.

Source: In Seminars in Radiation Oncology April 2024 34(2):218-228

Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps

Authors: Zou, Wei, Zhang, Rongxiao, Schüler, Emil, Taylor, Paige A., Mascia, Anthony E., Diffenderfer, Eric S., Zhao, Tianyu, Ayan, Ahmet S., Sharma, Manju, Yu, Shu-Jung, Lu, Weiguo, Bosch, Walter R., Tsien, Christina, Surucu, Murat, Pollard-Larkin, Julianne M., Schuemann, Jan, Moros, Eduardo G., Bazalova-Carter, Magdalena, Gladstone, David J., Li, Heng, Simone, Charles B., Petersson, Kristoffer, Kry, Stephen F., Maity, Amit, Loo, Billy W., Dong, Lei, Maxim, Peter G., Xiao, Ying, Buchsbaum, Jeffrey C.

Source: International journal of radiation oncology, biology, physics. 116(5):1202-1217

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194267022.0x000001&indx=1&recIds=ETOCvdc_100194267022.0x000001

Ultrafast Tracking of Oxygen Dynamics During Proton FLASH

Authors: El Khatib, Mirna, Van Slyke, Alexander L., Velalopoulou, Anastasia, Kim, Michele M., Shoniyozov, Khayrullo, Allu, Srinivasa Rao, Diffenderfer, Eric S., Busch, Theresa M., Wiersma, Rodney D., Koch, Cameron J., Vinogradov, Sergei A.

Source: International journal of radiation oncology, biology, physics. 113(3):624-634

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166770415.0x000001&indx=1&recIds=ETOCvdc_100166770415.0x000001

The current status of preclinical proton FLASH radiation and future directions

Authors: Diffenderfer, Eric S., Sørensen, Brita S., Mazal, Alejandro, Carlson, David J.

Source: Medical physics. 49(3):2039-2054

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163880173.0x000001&indx=1&recIds=ETOCvdc_100163880173.0x000001

Evaluation of Two-Voltage and Three-Voltage Linear Methods for Deriving Ion Recombination Correction Factors in Proton FLASH Irradiation

Authors: Yin, Lingshu, Zou, Wei, Kim, Michele M., Avery, Stephen M., Wiersma, Rodney D., Teo, Boon-Keng K., Dong, Lei, Diffenderfer, Eric S.

Source: IEEE transactions on radiation and plasma medical sciences. 6(3):263-270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100143612996.0x000001&indx=1&recIds=ETOCvdc_100143612996.0x000001

REPLY TO NOCK AND NIELSEN : Onthe work of Nock and Nielsen and its relationship to the additive tree

Authors: Valdes, Gilmer, Luna, José Marcio, Gennatas, Efstathios D., Ungar, Lyle H., Eaton, Eric, Diffenderfer, Eric S., Jensen, Shane T., Simone, Charles B., Friedman, Jerome H., Solberg, Timothy D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Apr . 117(16), 8694-8695.

Access URL: https://www.jstor.org/stable/26929631

Current delivery limitations of proton PBS for FLASH

Authors: Zou, Wei, Diffenderfer, Eric S., Cengel, Keith A., Kim, Michele M., Avery, Steve, Konzer, Joshua, Cai, Yongliang, Boisseu, Paul, Ota, Kan, Yin, Lingshu, Wiersma, Rodney, Carlson, David J., Fan, Yi, Busch, Theresa M., Koumenis, Costas, Lin, Alexander, Metz, James M., Teo, BoonKeng K., Dong, Lei

Source: In Radiotherapy and Oncology February 2021 155:212-218

Characterization of a high‐resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery

Authors: Zou, Wei, Diffenderfer, Eric S., Ota, Kan, Boisseau, Paul, Kim, Michele M., Cai, Yongliang, Avery, Stephen M., Carlson, David J., Wiersma, Rodney D., Lin, Alexander, Koumenis, Constantinos, Cengel, Keith A., Metz, James M., Dong, Lei, Teo, Boonkeng K.

Source: Medical physics. 48(7):3948-3957

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125715070.0x000001&indx=1&recIds=ETOCvdc_100125715070.0x000001

Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation

Authors: Luna, José Marcio, Chao, Hann-Hsiang, Shinohara, Russel T., Ungar, Lyle H., Cengel, Keith A., Pryma, Daniel A., Chinniah, Chidambaram, Berman, Abigail T., Katz, Sharyn I., Kontos, Despina, Simone, Charles B., II, Diffenderfer, Eric S.

Source: In Clinical and Translational Radiation Oncology May 2020 22:69-75

Building more accurate decision trees with the additive tree

Authors: Luna, José Marcio, Gennatas, Efstathios D., Ungar, Lyle H., Eaton, Eric, Diffenderfer, Eric S., Jensen, Shane T., Simone, Charles B., Friedman, Jerome H., Solberg, Timothy D., Valdes, Gilmer

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Oct 01. 116(40), 19887-19893.

Access URL: https://www.jstor.org/stable/26857065

Predicting radiation pneumonitis in locally advanced stage II–III non-small cell lung cancer using machine learning

Authors: Luna, José Marcio, Chao, Hann-Hsiang, Diffenderfer, Eric S., Valdes, Gilmer, Chinniah, Chidambaram, Ma, Grace, Cengel, Keith A., Solberg, Timothy D., Berman, Abigail T., Simone, Charles B., II

Source: In Radiotherapy and Oncology April 2019 133:106-112

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

Authors: Diffenderfer, Eric S., Verginadis, Ioannis I., Kim, Michele M., Shoniyozov, Khayrullo, Velalopoulou, Anastasia, Goia, Denisa, Putt, Mary, Hagan, Sarah, Avery, Stephen, Teo, Kevin, Zou, Wei, Lin, Alexander, Swisher-McClure, Samuel, Koch, Cameron, Kennedy, Ann R., Minn, Andy, Maity, Amit, Busch, Theresa M., Dong, Lei, Koumenis, Costas, Metz, James, Cengel, Keith A.

Source: International journal of radiation oncology, biology, physics. 106(2):440-448

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096462995.0x000001&indx=1&recIds=ETOCvdc_100096462995.0x000001

Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.

Authors: Amit, Uri, Uslu, Ugur, Verginadis, Ioannis I., Kim, Michele M., Oliaei Motlagh, Seyyedeh Azar, Diffenderfer, Eric S., Assenmacher, Charles-Antoine, Bicher, Sandra, Atoche, Sebastian J., Ben-Josef, Edgar, Young, Regina M., June, Carl H., Koumenis, Constantinos

Source: Proceedings of the National Academy of Sciences of the United States of America; 7/30/2024, Vol. 121 Issue 31, p1-11, 22p

Subject Terms: MYELOID-derived suppressor cells, CHIMERIC antigen receptors, T cells, PANCREATIC duct, RADIOTHERAPY

Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model

Authors: Sanzari, Jenine K., Diffenderfer, Eric S., Hagan, Sarah, Billings, Paul C., Gridley, Daila S., Seykora, John T., Kennedy, Ann R., Cengel, Keith A.

Source: In Life Sciences in Space Research July 2015 6:21-28

Effect of electron radiation on vasomotor function of the left anterior descending coronary artery

Authors: Sanzari, Jenine K., Billings, Paul C., Wilson, Jolaine M., Diffenderfer, Eric S., Arce-Esquivel, Arturo A., Thorne, Pamela K., Laughlin, Maurice H., Kennedy, Ann R.

Source: In Life Sciences in Space Research January 2015 4:6-10

Acute Biological Effects of Simulating the Whole-Body Radiation Dose Distribution from a Solar Particle Event Using a Porcine Model

Authors: Wilson, Jolaine M., Sanzari, Jenine K., Diffenderfer, Eric S., Yee, Stephanie S., Seykora, John T., Maks, Casey, Ware, Jeffrey H., Litt, Harold I., Reetz, Jennifer A., McDonough, James, Weissman, Drew, Kennedy, Ann R., Cengel, Keith A.

Source: Radiation Research, 2011 Nov 01. 176(5), 649-659.

Access URL: http://dx.doi.org/10.1667/RR2541.1

A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply.

Authors: Wei Zou, Kim, Haram, Diffenderfer, Eric S., Carlson, David J., Koch, Cameron J., Ying Xiao, Teo, BoonKeng K., Kim, Michele M., Metz, James M., Yi Fan, Maity, Amit, Koumenis, Costas, Busch, Theresa M., Wiersma, Rodney, Cengel, Keith A., Lei Dong

Source: Frontiers in Oncology; 11/28/2022, Vol. 12, p1-15, 15p

Subject Terms: PARABOLIC differential equations, LINEAR energy transfer, BLOOD vessels, MONTE Carlo method, PROTONS