Targeting cancer-associated fibroblasts/tumor cells cross-talk inhibits intrahepatic cholangiocarcinoma progression via cell-cycle arrest

Authors: Serena Mancarella, Isabella Gigante, Elena Pizzuto, Grazia Serino, Alberta Terzi, Francesco Dituri, Eugenio Maiorano, Leonardo Vincenti, Mario De Bellis, Francesco Ardito, Diego F. Calvisi, Gianluigi Giannelli

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Subject Terms: Cholangiocarcinoma progression, Tumor microenvironment, Gamma secretase inhibitor, Tumor stroma, Liver cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/f7201f2a93ed4fb2bd5f4cc907746a8b

HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma

Authors: Antonio Cigliano, Isabella Gigante, Marina Serra, Gianpaolo Vidili, Maria M. Simile, Sara Steinmann, Francesco Urigo, Eleonora Cossu, Giovanni M. Pes, Maria P. Dore, Silvia Ribback, Egle P. Milia, Elena Pizzuto, Serena Mancarella, Li Che, Rosa M. Pascale, Gianluigi Giannelli, Matthias Evert, Xin Chen, Diego F. Calvisi

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)

Subject Terms: Intrahepatic cholangiocarcinoma, HSF1, Mouse models, KRIBB-11, Navitoclax, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/4358a36380b8455e977ec4053d406fe2

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma

Authors: Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F. Calvisi, Benjamin L. Green, Xin Chen

Source: Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/904e8d75b78a4941a72af5c5e04ec7b8

Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis

Authors: Sophie Klemm, Katja Evert, Kirsten Utpatel, Alexandra Muggli, Maria M. Simile, Xin Chen, Matthias Evert, Diego F. Calvisi, Alexander Scheiter

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)

Subject Terms: Hepatocellular carcinoma, Cholangiocarcinoma, NRAS, DUSP4, CD133, MAPK pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/de2d353499314a8ba83c34a067ed7892

Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F. Calvisi, Shumei Lin, Xin Chen, Haichuan Wang

Source: Cell Death and Disease, Vol 14, Iss 7, Pp 1-9 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/50c8d9e46b1e429bb2b167e784a197cc

Preclinical Models of Hepatocellular Carcinoma: Current Utility, Limitations, and Challenges

Authors: Antonio Cigliano, Weiting Liao, Giovanni A. Deiana, Davide Rizzo, Xin Chen, Diego F. Calvisi

Source: Biomedicines, Vol 12, Iss 7, p 1624 (2024)

Subject Terms: liver cancer, genetically engineered mice, hydrodynamic gene delivery, organoids, signaling pathways, precision medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/7/1624; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b14a71e1dcc342b2839dfb7a55032f4d

Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation

Authors: Antonio Cigliano, Maria M. Simile, Gianpaolo Vidili, Giovanni M. Pes, Maria P. Dore, Francesco Urigo, Eleonora Cossu, Li Che, Claudio Feo, Sara M. Steinmann, Silvia Ribback, Rosa M. Pascale, Matthias Evert, Xin Chen, Diego F. Calvisi

Source: Medicina, Vol 60, Iss 7, p 1160 (2024)

Subject Terms: hepatocellular carcinoma, lipogenesis, FASN, SKP2, p27KIP1, mouse models, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/1648-9144/60/7/1160; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144

Access URL: https://doaj.org/article/9b831399f08b4b718d5859120af5fc63

A new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors

Authors: Weiting Liao, Diego F. Calvisi, Xin Chen

Source: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/ec33d20b9f984bc9a9d8e380ecb54579

Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition

Authors: Serena Mancarella, Isabella Gigante, Grazia Serino, Elena Pizzuto, Francesco Dituri, Maria F. Valentini, Jingxiao Wang, Xin Chen, Raffaele Armentano, Diego F. Calvisi, Gianluigi Giannelli

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-14 (2022)

Subject Terms: Tissue microenvironment, Liver fibrosis, Tumor stroma crosstalk, Crenigacestat, Smad2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/04d9818126634bcbb9a920a39c75e01a

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Authors: Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-22 (2022)

Subject Terms: Intrahepatic cholangiocarcinoma, Hippo pathway, TAZ, AKT, Notch, TEAD transcription factors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/24475e56d1704391a7f9f3b92ecffe6a

Combination of AFP vaccine and immune checkpoint inhibitors slows hepatocellular carcinoma progression in preclinical models

Authors: Xinjun Lu, Shanshan Deng, Jiejie Xu, Benjamin L. Green, Honghua Zhang, Guofei Cui, Yi Zhou, Yi Zhang, Hongwei Xu, Fapeng Zhang, Rui Mao, Sheng Zhong, Thorsten Cramer, Matthias Evert, Diego F. Calvisi, Yukai He, Chao Liu, Xin Chen

Source: The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)

Subject Terms: Hepatology, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/0120b966f8424bdb9d9719e9d5c72fb1

RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues

Authors: Alexander Scheiter, Katja Evert, Lucas Reibenspies, Antonio Cigliano, Katharina Annweiler, Karolina Müller, Laura‐Maria‐Giovanna Pöhmerer, Hongwei Xu, Guofei Cui, Timo Itzel, Silvia Materna‐Reichelt, Andrea Coluccio, Kamran Honarnejad, Andreas Teufel, Christoph Brochhausen, Frank Dombrowski, Xin Chen, Matthias Evert, Diego F. Calvisi, Kirsten Utpatel

Source: Molecular Oncology, Vol 16, Iss 5, Pp 1091-1118 (2022)

Subject Terms: alpelisib, galectin‐1, hepatocellular carcinoma, OTX008, SCD1, ZIP4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/db2315a1864e41beaeb3a952e323cea0

CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype

Authors: Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi, Gianluigi Giannelli

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)

Subject Terms: Intrahepatic Cholangiocarcinoma, THY1/CD90, NOTCH pathway inhibition, Xenograft models, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/b6b55b840ca44c9c9951bdeb98bc1f08

Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage

Authors: Weiting Liao, Diego F. Calvisi, Xin Chen

Source: Hepatology Communications, Vol 7, Iss 3, Pp e0074-e0074 (2023)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HC9.0000000000000074; https://doaj.org/toc/2471-254X

Access URL: https://doaj.org/article/0c84098cde3d4b1e8ecfc92eecbeda3a

Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma

Authors: Hongwei Xu, Kefei Chen, Runze Shang, Xinyan Chen, Yi Zhang, Xinhua Song, Matthias Evert, Sheng Zhong, Bo Li, Diego F. Calvisi, Xin Chen

Source: Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/26ba8f3f76ef4440b6b6c410f6f316c5

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Authors: Arianna Pocaterra, Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen, Matthias Evert, Diego F. Calvisi, Sirio Dupont

Source: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/b7806795bac144798bc500c28e43add1

Identification and In-Depth Analysis of the Novel FGFR2-NDC80 Fusion in a Cholangiocarcinoma Patient: Implication for Therapy

Authors: Alexander Scheiter, Felix Keil, Florian Lüke, Jirka Grosse, Niklas Verloh, Sabine Opitz, Sophie Schlosser, Arne Kandulski, Tobias Pukrop, Wolfgang Dietmaier, Matthias Evert, Diego F. Calvisi, Kirsten Utpatel

Source: Current Oncology, Vol 28, Iss 2, Pp 1161-1169 (2021)

Subject Terms: cholangiocarcinoma, FGFR fusion, NDC80, FRS2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/28/2/112; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/f2ad679a909f4daf81e62e6f9b6cc0ab

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression

Authors: Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen

Source: Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/abe6dba9aa36446c801ce9127474ec64

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse HepatocarcinogenesisSummary

Authors: Haichuan Wang, Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang, Pan Wang, Xinhua Song, Li Che, Ke Liu, Silvia Ribback, Antonio Cigliano, Matthias Evert, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)

Subject Terms: YAP, TAZ, Hepatocellular Carcinoma, Cell Cycle, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X20301879; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/3e2b66d39a0349fc8c74647e42182481

Corrigendum: Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

Authors: Li Che, Panagiotis Paliogiannis, Antonio Cigliano, Maria G. Pilo, Xin Chen, Diego F. Calvisi

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: hepatocellular carcinoma, de novo lipogenesis, FASN, tumor metabolism, precision medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.874053/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ee6de553599e42e8baf48d3e03ee714a