Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 2a study

Authors: Yu, Hui Jing, Dickson, Samuel P., Wang, Pei-Ning, Chiu, Ming-Jang, Huang, Chin-Chang, Chang, Chiung-Chih, Liu, Hope, Hendrix, Suzanne B., Dodart, Jean-Cosme, Verma, Ajay, Wang, Chang Yi, Cummings, Jeffrey

Source: In eBioMedicine August 2023 94

Survival analyses from the CENTAUR trial in amyotrophic lateral sclerosis: Evaluating the impact of treatment crossover on outcomes

Authors: Paganoni, Sabrina, Watkins, Claire, Cawson, Matthew, Hendrix, Suzanne, Dickson, Samuel P., Knowlton, Newman, Timmons, Jamie, Manuel, Machelle, Cudkowicz, Merit

Source: Muscle & nerve. 66(2):136-141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157126593.0x000001&indx=1&recIds=ETOCvdc_100157126593.0x000001

Long‐term survival of participants in the CENTAUR trial of sodium phenylbutyrate‐taurursodiol in amyotrophic lateral sclerosis

Authors: Paganoni, Sabrina, Hendrix, Suzanne, Dickson, Samuel P., Knowlton, Newman, Macklin, Eric A., Berry, James D., Elliott, Michael A., Maiser, Samuel, Karam, Chafic, Caress, James B., Owegi, Margaret Ayo, Quick, Adam, Wymer, James, Goutman, Stephen A., Heitzman, Daragh, Heiman‐Patterson, Terry D., Jackson, Carlayne E., Quinn, Colin, Rothstein, Jeffrey D., Kasarskis, Edward J., Katz, Jonathan, Jenkins, Liberty, Ladha, Shafeeq, Miller, Timothy M., Scelsa, Stephen N., Vu, Tuan H., Fournier, Christina N., Glass, Jonathan D., Johnson, Kristin M., Swenson, Andrea, Goyal, Namita A., Pattee, Gary L., Andres, Patricia L., Babu, Suma, Chase, Marianne, Dagostino, Derek, Hall, Meghan, Kittle, Gale, Eydinov, Matthew, McGovern, Michelle, Ostrow, Joseph, Pothier, Lindsay, Randall, Rebecca, Shefner, Jeremy M., Sherman, Alexander V., St Pierre, Maria E., Tustison, Eric, Vigneswaran, Prasha, Walker, Jason, Yu, Hong, Chan, James, Wittes, Janet, Yu, Zi‐Fan, Cohen, Joshua, Klee, Justin, Leslie, Kent, Tanzi, Rudolph E., Gilbert, Walter, Yeramian, Patrick D., Schoenfeld, David, Cudkowicz, Merit E.

Source: Muscle & nerve. 63(1):31-39

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114183429.0x000001&indx=1&recIds=ETOCvdc_100114183429.0x000001

Perspectives on statistical strategies for the regulatory biomarker qualification process

Authors: Hendrix, Suzanne B, Mogg, Robin, Wang, Sue Jane, Chakravarty, Aloka, Romero, Klaus, Dickson, Samuel P, Sauer, John-Michael, McShane, Lisa M

Source: Biomarkers in medicine. 15(9):669-684

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186728477.0x000001&indx=1&recIds=ETOCvdc_100186728477.0x000001

Development of a General Composite Scale (GENCOMS) for Progressive Neurodegenerative Diseases and Implications for the Assessment of Disease-Modifying Therapies.

Authors: Dickson, Samuel P.¹ (AUTHOR) sdickson@pentaracorp.com, Mallinckrodt, Craig H.¹ (AUTHOR), Rogula, Basia² (AUTHOR), Powell, Lauren C.² (AUTHOR), Potashman, Michele H.³ (AUTHOR), Coric, Vladimir³ (AUTHOR), L'Italien, Gilbert J.³ (AUTHOR), Hendrix, Suzanne B.¹ (AUTHOR)

Source: Neurology & Therapy. Dec2024, Vol. 13 Issue 6, p1627-1639. 13p.

Subject Terms: *PARTIAL least squares regression, *DISEASE progression, *NEURODEGENERATION, *LEAST squares, *REGRESSION analysis

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Avoiding future controversies in the Alzheimer's disease space through understanding the aducanumab data and FDA review.

Authors: Dickson, Samuel P.¹ (AUTHOR) sdickson@pentara.com, Hennessey, Sean¹ (AUTHOR), Nicodemus Johnson, Jessie¹ (AUTHOR), Knowlton, Newman¹ (AUTHOR), Hendrix, Suzanne B.¹ (AUTHOR)

Source: Alzheimer's Research & Therapy. 5/24/2023, Vol. 15 Issue 1, p1-13. 13p.

Subject Terms: *ADUCANUMAB, *ALZHEIMER'S disease, *BUSINESS enterprises

Individualized clinical management of patients at risk for Alzheimer's dementia

Authors: Isaacson, Richard S., Hristov, Hollie, Saif, Nabeel, Hackett, Katherine, Hendrix, Suzanne, Melendez, Juan, Safdieh, Joseph, Fink, Matthew, Thambisetty, Madhav, Sadek, George, Bellara, Sonia, Lee, Paige, Berkowitz, Cara, Rahman, Aneela, Meléndez-Cabrero, Josefina, Caesar, Emily, Cohen, Randy, Lu, Pei-lin, Dickson, Samuel P., Hwang, Mu Ji, Scheyer, Olivia, Mureb, Monica, Schelke, Matthew W., Niotis, Kellyann, Greer, Christine E., Attia, Peter, Mosconi, Lisa, Krikorian, Robert

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association December 2019 15(12):1588-1602

Evaluation of Clinical Meaningfulness of Fortasyn Connect in Terms of "Time Saved".

Authors: Dickson, Samuel P., Solomon, A., Kivipelto, M., Hartmann, T., van Hees, A. M. J., Brownlee, A., Haaland, B., Mallinckrodt, C. H., Hendrix, S. B.

Source: Journal of Prevention of Alzheimer's Disease; Aug2024, Vol. 11 Issue 4, p992-997, 6p

Not sexy enough: the uphill battle faced by non‐traditional treatments in the U.S. despite having the most compelling AD results to date

Authors: Hendrix, Suzanne B., Nicodemus‐Johnson, Jessie, Hogan, Nathaniel J., Knowlton, Newman, Hennessey, Sean, Dickson, Samuel P.

Source: Alzheimer's & dementia. 18(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176993413.0x000001&indx=1&recIds=ETOCvdc_100176993413.0x000001

Efficacy and safety of pimavanserin in patients with Alzheimer's dementia psychosis in the HARMONY phase 3, randomized discontinuation study: a post hoc subgroup analysis

Authors: Cummings, Jeffrey, Devanand, Davangere P, Ballard, Clive G, Tariot, Pierre N., Hendrix, Suzanne B., Dickson, Samuel P., Li, Caiyan, Abler, Victor, Pathak, Sanjeev, Stankovic, Srdjan

Source: Alzheimer's & dementia. 18(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177004161.0x000001&indx=1&recIds=ETOCvdc_100177004161.0x000001

ACT‐AD: Fosgonimeton in mild‐to‐moderate Alzheimer's disease – first results of a randomized, placebo‐controlled, 26‐week Phase 2 proof‐of‐concept trial

Authors: Moebius, Hans J., Bernick, Charles B., Winner, Paul, Maalouf, Joyce, Ooi, Kai‐Bin, Dickson, Samuel P., Hendrix, Suzanne B., Church, Kevin, Olichney, John M.

Source: Alzheimer's & dementia. 18(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177003969.0x000001&indx=1&recIds=ETOCvdc_100177003969.0x000001

The CDR‐SB and other clinical trial mistakes made due to regulatory momentum

Authors: Dickson, Samuel P., Hogan, Nathaniel J., Nicodemus‐Johnson, Jessie, Knowlton, Newman, Hennessey, Sean, Hendrix, Suzanne B.

Source: Alzheimer's & dementia. 18(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176997957.0x000001&indx=1&recIds=ETOCvdc_100176997957.0x000001

GenoRisk: A polygenic risk score for Alzheimer's disease

Authors: Dickson, Samuel P., Hendrix, Suzanne B., Brown, Bruce L., Ridge, Perry G., Nicodemus‐Johnson, Jessie, Hardy, Marci L., McKeany, Allison M., Booth, Steven B., Fortna, Ryan R., Kauwe, John S.K.

Source: Alzheimer's & dementia.Translational research & clinical interventions. 7(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140148260.0x000001&indx=1&recIds=ETOCvdc_100140148260.0x000001

Using Bayesian hierarchical analysis to combine evidence across outcomes and trials

Authors: Dickson, Samuel P, Nicodemus‐Johnson, Jessie, Knowlton, Newman, Syndergaard, Tess, Neff, Jacob, Earnshaw, Madison, Hennessey, Sean, Hendrix, Suzanne B.

Source: Alzheimer's & dementia. 17(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139016144.0x000001&indx=1&recIds=ETOCvdc_100139016144.0x000001

Viscous Aqueous Gel Illustrating Natural Anatomy: The VAGINA method in gynaecological MRI simulation

Authors: Skehan, Kate, Richardson, Matthew, O'Connor, Laura M, Dickson, Samuel, Martin, Kate, Govindarajulu, Geetha, Sridharan, Swetha

Source: Journal of Medical Radiation Sciences; March 2024, Vol. 71 Issue: 1 p150-155, 6p

Prioritizing Genetic Variants for Causality on the Basis of Preferential Linkage Disequilibrium

Authors: Zhu, Qianqian, Ge, Dongliang, Heinzen, Erin L., Dickson, Samuel P., Urban, Thomas J., Zhu, Mingfu, Maia, Jessica M., He, Min, Zhao, Qian, Shianna, Kevin V., Goldstein, David B.

Source: In The American Journal of Human Genetics 7 September 2012 91(3):422-434

A Genome-wide Comparison of the Functional Properties of Rare and Common Genetic Variants in Humans

Authors: Zhu, Qianqian, Ge, Dongliang, Maia, Jessica M., Zhu, Mingfu, Petrovski, Slave, Dickson, Samuel P., Heinzen, Erin L., Shianna, Kevin V., Goldstein, David B.

Source: In The American Journal of Human Genetics 8 April 2011 88(4):458-468

Whole-Genome Sequencing to Predict Antimicrobial Susceptibility Profiles in Neisseria gonorrhoeae.

Authors: Bristow, Claire C, Mortimer, Tatum D, Morris, Sheldon, Grad, Yonatan H, Soge, Olusegun O, Wakatake, Erika, Pascual, Rushlenne, Murphy, Sara McCurdy, Fryling, Kyra E, Adamson, Paul C, Dillon, Jo-Anne, Parmar, Nidhi R, Le, Hai Ha Long, Le, Hung Van, Ureña, Reyna Margarita Ovalles, Mitchev, Nireshni, Mlisana, Koleka, Wi, Teodora, Dickson, Samuel P, Klausner, Jeffrey D

Source: Journal of Infectious Diseases; Apr2023, Vol. 227 Issue 7, p917-925, 9p

Subject Terms: NEISSERIA gonorrhoeae, NUCLEOTIDE sequencing, DRUG resistance in microorganisms, DISC diffusion tests (Microbiology), GENETIC markers

Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association Studies

Authors: Wang, Kai, Dickson, Samuel P., Stolle, Catherine A., Krantz, Ian D., Goldstein, David B., Hakonarson, Hakon

Source: In The American Journal of Human Genetics 14 May 2010 86(5):730-742