Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress

Authors: Rabinovich-Nikitin, Inna, Rasouli, Mina, Reitz, Cristine J., Posen, Illana, Margulets, Victoria, Dhingra, Rimpy, Khatua, Tarak N., Thliveris, James A., Martino, Tami A., Kirshenbaum, Lorrie A.

Source: Autophagy. 17(11):3794-3812

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135223292.0x000001&indx=1&recIds=ETOCvdc_100135223292.0x000001

Unc51-like-kinase 1-mediated mitophagy prevents pathological cardiac remodelling and heart failure

Authors: Dhingra, Rimpy, Kirshenbaum, Lorrie A

Source: Cardiovascular research. 118(12):2561-2563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166558049.0x000001&indx=1&recIds=ETOCvdc_100166558049.0x000001

Ageing‐associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca2+ homeostasis and promotes cardiac dysfunction

Authors: Olgar, Yusuf, Tuncay, Erkan, Degirmenci, Sinan, Billur, Deniz, Dhingra, Rimpy, Kirshenbaum, Lorrie, Turan, Belma

Source: Journal of cellular and molecular medicine. 24(15):8567-8578

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119311396.0x000001&indx=1&recIds=ETOCvdc_100119311396.0x000001

Hypoxia‐induced downregulation of cyclooxygenase 2 leads to the loss of immunoprivilege of allogeneic mesenchymal stem cells

Authors: Sareen, Niketa, Abu‐El‐Rub, Ejlal, Ammar, Hania I., Yan, Weiang, Sequiera, Glen Lester, ShamsEldeen, Asmaa M., Moudgil, Meenal, Dhingra, Rimpy, Shokry, Heba S., Rashed, Laila A., Kirshenbaum, Lorrie A., Dhingra, Sanjiv

Source: FASEB journal. 34(11):15236-15251

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118311235.0x000001&indx=1&recIds=ETOCvdc_100118311235.0x000001

Response by Dhingra et al to Letter Regarding Article, 'Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy'

Authors: Dhingra, Rimpy, Javaheri, Ali, Diwan, Abhinav, Kirshenbaum, Lorrie A.

Source: Circulation. 147(13):1051-1052

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187540273.0x000001&indx=1&recIds=ETOCvdc_100187540273.0x000001

Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes

Authors: Dhingra, Abhinav, Jayas, Rahul, Afshar, Pegah, Guberman, Matthew, Maddaford, Graham, Gerstein, Johnathan, Lieberman, Brooke, Nepon, Hilary, Margulets, Victoria, Dhingra, Rimpy, Kirshenbaum, Lorrie A.

Source: In Free Radical Biology and Medicine November 2017 112:411-422

IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy.

Authors: Guberman, Matthew^1,2 (AUTHOR), Dhingra, Rimpy^1,2 (AUTHOR), Cross, Jenna^1,2 (AUTHOR), Margulets, Victoria^1,2 (AUTHOR), Gang, Hongying^1,2 (AUTHOR), Rabinovich-Nikitin, Inna^1,2 (AUTHOR), Kirshenbaum, Lorrie A^1,2,3 (AUTHOR) lkirshenbaum@sbrc.ca

Source: Cardiovascular Research. Jan2024, Vol. 120 Issue 2, p164-173. 10p.

Subject Terms: *MITOFUSIN 2, *CELL death, *DOXORUBICIN, *CARDIOMYOPATHIES, *MITOCHONDRIAL proteins, *PROTEIN stability

Mitochondrial dynamics: Orchestrating the journey to advanced age

Authors: Biala, Agnieszka K., Dhingra, Rimpy, Kirshenbaum, Lorrie A.

Source: In Journal of Molecular and Cellular Cardiology June 2015 83:37-43

Activation of Mitophagy in High-Fat Diet–Induced Diabetic Cardiomyopathy

Authors: Rabinovich-Nikitin, Inna, Dhingra, Rimpy, Kirshenbaum, Lorrie A.

Source: Circulation research. 124(9):1288-1290

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100080136099.0x000001&indx=1&recIds=ETOCvdc_100080136099.0x000001

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling

Authors: Dhingra, Rimpy, Margulets, Victoria, Chowdhury, Subir Roy, Thliveris, James, Jassal, Davinder, Fernyhough, Paul, Dorn, Gerald W., Kirshenbaum, Lorrie A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Dec . 111(51), 18110-18111.

Access URL: https://www.jstor.org/stable/43279099

Epigenetic regulation of cardiac cell cycle Re-entry and proliferation

Authors: Rabinovich-Nikitin, Inna, Dhingra, Rimpy, Kirshenbaum, Lorrie A.

Source: Journal of molecular and cellular cardiology. 121:297-299

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069951265.0x000001&indx=1&recIds=ETOCvdc_100069951265.0x000001

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

Authors: Gang, Hongying, Dhingra, Rimpy, Lin, Junjun, Hai, Yan, Aviv, Yaron, Margulets, Victoria, Hamedani, Mohammad, Thanasupawat, Thatchawan, Leygue, Etienne, Klonisch, Thomas

Source: Journal of cell biology. 210(7):1101-1116

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603081089&indx=1&recIds=ETOCRN603081089

Ellagic acid inhibits mitochondrial fission protein Drp-1 and cell proliferation in cancer.

Authors: Yakobov, Shay, Dhingra, Rimpy, Margulets, Victoria, Dhingra, Abhinav, Crandall, Molly, Kirshenbaum, Lorrie A.

Source: Molecular & Cellular Biochemistry; Sep2023, Vol. 478 Issue 9, p2029-2040, 12p

Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.

Authors: Dhingra, Rimpy¹ (AUTHOR) sdhingra@sbrc.ca, Rabinovich-Nikitin, Inna¹ (AUTHOR) IRabinovich-Nikitin@sbrc.ca, Rothman, Sonny¹ (AUTHOR) sonnymikarothman@gmail.com, Guberman, Matthew¹ (AUTHOR) MGuberman@sbrc.ca, Gang, Hongying¹ (AUTHOR) hgang@sbrc.ca, Margulets, Victoria¹ (AUTHOR) vmargulets@sbrc.ca, Jassal, Davinder S.¹ (AUTHOR) djassal@sbgh.mb.ca, Alagarsamy, Keshav N.^1,2 (AUTHOR) KAlagarsamy@sbrc.ca, Dhingra, Sanjiv^1,2 (AUTHOR) sdhingra@sbrc.ca, Valenzuela Ripoll, Carla³ (AUTHOR) carlav@wustl.edu, Billia, Filio⁴ (AUTHOR) Phyllis.Billia@uhn.ca, Diwan, Abhinav⁵ (AUTHOR) adiwan@dom.wustl.edu, Javaheri, Ali^3,5 (AUTHOR) ali.javaheri@wustl.edu, Kirshenbaum, Lorrie A.^1,6 (AUTHOR) lkirshenbaum@sbrc.ca, Alagarsamy, Keshav Narayan^7,8 (AUTHOR)

Source: Circulation. 9/20/2022, Vol. 146 Issue 12, p934-954. 21p.

Subject Terms: *DEUBIQUITINATING enzymes, *HEART cells, *CARDIOTOXICITY, *CELL death, *MITOCHONDRIA

NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia.

Authors: Rabinovich-Nikitin, Inna, Blant, Alexandra, Dhingra, Rimpy, Kirshenbaum, Lorrie A., Czubryt, Michael P.

Source: Cells (2073-4409); Jul2022, Vol. 11 Issue 14, pN.PAG-N.PAG, 14p

Subject Terms: PGC-1 protein, CELL death, HYPOXIA-inducible factor 1, PEROXISOME proliferator-activated receptors, HYPOXEMIA

Erratum to 'Epigenetic regulation of cardiac cell cycle Re-entry and proliferation' [Journal of Molecular and Cellular Cardiology 121C (2018) 297–299]

Authors: Rabinovich-Nikitin, Inna, Dhingra, Rimpy, Kirshenbaum, Lorrie A.

Source: Journal of molecular and cellular cardiology. 133:75-75

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084585094.0x000001&indx=1&recIds=ETOCvdc_100084585094.0x000001

Ulk1/Rab9-mediated alternative mitophagy confers cardioprotection during energy stress

Authors: Dhingra, Rimpy, Rabinovich-Nikitin, Inna, Kirshenbaum, Lorrie A.

Source: Journal of clinical investigation. 129(2):509-509

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618959970&indx=1&recIds=ETOCRN618959970

Mitochondrial autophagy and cell survival is regulated by the circadian Clockgene in cardiac myocytes during ischemic stress

Authors: Rabinovich-Nikitin, Inna, Rasouli, Mina, Reitz, Cristine J., Posen, Illana, Margulets, Victoria, Dhingra, Rimpy, Khatua, Tarak N., Thliveris, James A., Martino, Tami A., Kirshenbaum, Lorrie A.

Source: Autophagy; November 2021, Vol. 17 Issue: 11 p3794-3812, 19p

Ageing‐associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca²⁺ homeostasis and promotes cardiac dysfunction.

Authors: Olgar, Yusuf, Tuncay, Erkan, Degirmenci, Sinan, Billur, Deniz, Dhingra, Rimpy, Kirshenbaum, Lorrie, Turan, Belma

Source: Journal of Cellular & Molecular Medicine; Aug2020, Vol. 24 Issue 15, p8567-8578, 12p

Subject Terms: HEART diseases, SARCOPLASMIC reticulum, REACTIVE oxygen species, BRUGADA syndrome, HOMEOSTASIS, BLOOD sugar

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy.

Authors: Dhingra, Rimpy¹ (AUTHOR), Guberman, Matthew¹ (AUTHOR), Rabinovich-Nikitin, Inna¹ (AUTHOR), Gerstein, Jonathon¹ (AUTHOR), Margulets, Victoria¹ (AUTHOR), Gang, Hongying¹ (AUTHOR), Madden, Nicholas¹ (AUTHOR), Thliveris, James² (AUTHOR), Kirshenbaum, Lorrie A¹ (AUTHOR) Lorrie@sbrc.ca

Source: Cardiovascular Research. May2020, Vol. 116 Issue 6, p1161-1174. 14p.

Subject Terms: *HIGH mobility group proteins, *PERMEABILITY, *CELL death, *MITOCHONDRIAL proteins, *GENETIC regulation