Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut

Authors: Urtecho, Guillaume ¹, Moody, Thomas ^{1, 2}, Huang, Yiming ^{1, 2}, Sheth, Ravi U. ^{1, 2, 15}, Richardson, Miles ^{1, 2}, Descamps, Hélène C. ^{3, 4, 5}, Kaufman, Andrew ¹, Lekan, Opeyemi ^{1, 6}, Zhang, Zetian ^{1, 7}, Velez-Cortes, Florencia ^{1, 2}, Qu, Yiming ¹, Cohen, Lucas ¹, Ricaurte, Deirdre ^{1, 2}, Gibson, Travis E. ^{8, 9, 10, 11}, Gerber, Georg K. ^{8, 9, 12}, Thaiss, Christoph A. ^{3, 4, 5}, Wang, Harris H. ^{1, 13, 14, 16, ∗}

Source: In Cell Systems 20 November 2024 15(11):1002-1017

Astrocyte TrkB promotes brain injury and edema formation in ischemic stroke

Authors: Colombo, Emanuela, Bacigaluppi, Marco, Bartoccetti, Michela, Triolo, Daniela, Bassani, Claudia, Bergamaschi, Andrea, Descamps, Hélène C., Gullotta, Giorgia Serena, Henley, Maria, Piccoli, Marco, Anastasia, Luigi, Pitt, David, Newcombe, Jia, Martino, Gianvito, Farina, Cinthia

Source: In Neurobiology of Disease 15 October 2024 201

Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets

Authors: Patil, Abhijeet R., Schug, Jonathan, Liu, Chengyang, Lahori, Deeksha, Descamps, Hélène C., Naji, Ali, Kaestner, Klaus H., Faryabi, Robert B., Vahedi, Golnaz

Source: In Cell Reports Medicine 21 May 2024 5(5)

Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke

Authors: Nong, Jia, Glassman, Patrick M., Shuvaev, Vladimir V., Reyes-Esteves, Sahily, Descamps, Helene C., Kiseleva, Raisa Y., Papp, Tyler E., Alameh, Mohamad-Gabriel, Tam, Ying K., Mui, Barbara L., Omo-Lamai, Serena, Zamora, Marco E., Shuvaeva, Tea, Arguiri, Evguenia, Gong, Xijing, Brysgel, Taylor V., Tan, Ai Wen, Woolfork, Ashley G., Weljie, Aalim, Thaiss, Christoph A., Myerson, Jacob W., Weissman, Drew, Kasner, Scott E., Parhiz, Hamideh, Muzykantov, Vladimir R., Brenner, Jacob S., Marcos-Contreras, Oscar A.

Source: In Molecular Therapy 1 May 2024 32(5):1344-1358

Serotonin reduction in post-acute sequelae of viral infection

Authors: Wong, Andrea C., Devason, Ashwarya S., Umana, Iboro C., Cox, Timothy O., Dohnalová, Lenka, Litichevskiy, Lev, Perla, Jonathan, Lundgren, Patrick, Etwebi, Zienab, Izzo, Luke T., Kim, Jihee, Tetlak, Monika, Descamps, Hélène C., Park, Simone L., Wisser, Stephen, McKnight, Aaron D., Pardy, Ryan D., Kim, Junwon, Blank, Niklas, Patel, Shaan, Thum, Katharina, Mason, Sydney, Beltra, Jean-Christophe, Michieletto, Michaël F., Ngiow, Shin Foong, Miller, Brittany M., Liou, Megan J., Madhu, Bhoomi, Dmitrieva-Posocco, Oxana, Huber, Alex S., Hewins, Peter, Petucci, Christopher, Chu, Candice P., Baraniecki-Zwil, Gwen, Giron, Leila B., Baxter, Amy E., Greenplate, Allison R., Kearns, Charlotte, Montone, Kathleen, Litzky, Leslie A., Feldman, Michael, Henao-Mejia, Jorge, Striepen, Boris, Ramage, Holly, Jurado, Kellie A., Wellen, Kathryn E., O’Doherty, Una, Abdel-Mohsen, Mohamed, Landay, Alan L., Keshavarzian, Ali, Henrich, Timothy J., Deeks, Steven G., Peluso, Michael J., Meyer, Nuala J., Wherry, E. John, Abramoff, Benjamin A., Cherry, Sara, Thaiss, Christoph A., Levy, Maayan

Source: In Cell 26 October 2023 186(22):4851-4867

The enteric nervous system relays psychological stress to intestinal inflammation

Authors: Schneider, Kai Markus, Blank, Niklas, Alvarez, Yelina, Thum, Katharina, Lundgren, Patrick, Litichevskiy, Lev, Sleeman, Madeleine, Bahnsen, Klaas, Kim, Jihee, Kardo, Simon, Patel, Shaan, Dohnalová, Lenka, Uhr, Giulia T., Descamps, Hélène C., Kircher, Susanna, McSween, Alana M., Ardabili, Ashkan Rezazadeh, Nemec, Kelsey M., Jimenez, Monica T., Glotfelty, Lila G., Eisenberg, Joshua D., Furth, Emma E., Henao-Mejia, Jorge, Bennett, F. Chris, Pierik, Marie J., Romberg-Camps, Mariëlle, Mujagic, Zlatan, Prinz, Marco, Schneider, Carolin V., Wherry, E. John, Bewtra, Meenakshi, Heuckeroth, Robert O., Levy, Maayan, Thaiss, Christoph A.

Source: In Cell 22 June 2023 186(13):2823-2838

NAD precursors cycle between host tissues and the gut microbiome

Authors: Chellappa, Karthikeyani, McReynolds, Melanie R., Lu, Wenyun, Zeng, Xianfeng, Makarov, Mikhail, Hayat, Faisal, Mukherjee, Sarmistha, Bhat, Yashaswini R., Lingala, Siddharth R., Shima, Rafaella T., Descamps, Hélène C., Cox, Timothy, Ji, Lixin, Jankowski, Connor, Chu, Qingwei, Davidson, Shawn M., Thaiss, Christoph A., Migaud, Marie E., Rabinowitz, Joshua D., Baur, Joseph A.

Source: In Cell Metabolism 6 December 2022 34(12):1947-1959

NAD+ flux is maintained in aged mice despite lower tissue concentrations

Authors: McReynolds, Melanie R., Chellappa, Karthikeyani, Chiles, Eric, Jankowski, Connor, Shen, Yihui, Chen, Li, Descamps, Hélène C., Mukherjee, Sarmistha, Bhat, Yashaswini R., Lingala, Siddharth R., Chu, Qingwei, Botolin, Paul, Hayat, Faisal, Doke, Tomohito, Susztak, Katalin, Thaiss, Christoph A., Lu, Wenyun, Migaud, Marie E., Su, Xiaoyang, Rabinowitz, Joshua D., Baur, Joseph A.

Source: In Cell Systems 15 December 2021 12(12):1160-1172

No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data.

Authors: Manduchi, Elisabetta¹ (AUTHOR), Descamps, Hélène C.¹ (AUTHOR), Schug, Jonathan¹ (AUTHOR), Da, Tong¹ (AUTHOR), Lahori, Deeksha¹ (AUTHOR), El-Mekkoussi, Hilana¹ (AUTHOR), Betts, Michael R.² (AUTHOR), Kaestner, Klaus H.¹ (AUTHOR) kaestner@pennmedicine.upenn.edu

Source: Diabetes. Oct2024, Vol. 73 Issue 10, p1697-1704. 8p.

Subject Terms: *TYPE 1 diabetes, *ENTEROVIRUS diseases, *TYPE 2 diabetes, *HUMAN gene mapping, *RNA sequencing

The path toward using microbial metabolites as therapies

Authors: Descamps, Hélène C. ¹, Herrmann, Beatrice ¹, Wiredu, Daphne ¹, Thaiss, Christoph A. ^⁎

Source: In eBioMedicine June 2019 44:747-754

Response to Comment on Manduchi et al. No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data. Diabetes 2024;73:1697–1704.

Authors: Manduchi, Elisabetta¹ (AUTHOR), Descamps, Hélène C.¹ (AUTHOR), Schug, Jonathan¹ (AUTHOR), Da, Tong¹ (AUTHOR), Lahori, Deeksha¹ (AUTHOR), El-Mekkoussi, Hilana¹ (AUTHOR), Betts, Michael R.² (AUTHOR), Kaestner, Klaus H.¹ (AUTHOR) kaestner@pennmedicine.upenn.edu

Source: Diabetes. Mar2025, Vol. 74 Issue 3, pe5-e5. 1p.

Subject Terms: *ENTEROVIRUS diseases, *TYPE 1 diabetes, *DIGESTIVE system diseases, *MOLECULAR mimicry, *RNA sequencing

A microbiome-dependent gut–brain pathway regulates motivation for exercise.

Authors: Dohnalová, Lenka, Lundgren, Patrick, Carty, Jamie R. E., Goldstein, Nitsan, Wenski, Sebastian L., Nanudorn, Pakjira, Thiengmag, Sirinthra, Huang, Kuei-Pin, Litichevskiy, Lev, Descamps, Hélène C., Chellappa, Karthikeyani, Glassman, Ana, Kessler, Susanne, Kim, Jihee, Cox, Timothy O., Dmitrieva-Posocco, Oxana, Wong, Andrea C., Allman, Erik L., Ghosh, Soumita, Sharma, Nitika

Source: Nature; Dec2022, Vol. 612 Issue 7941, p739-747, 9p

β-Hydroxybutyrate suppresses colorectal cancer.

Authors: Dmitrieva-Posocco, Oxana, Wong, Andrea C., Lundgren, Patrick, Golos, Aleksandra M., Descamps, Hélène C., Dohnalová, Lenka, Cramer, Zvi, Tian, Yuhua, Yueh, Brian, Eskiocak, Onur, Egervari, Gabor, Lan, Yemin, Liu, Jinping, Fan, Jiaxin, Kim, Jihee, Madhu, Bhoomi, Schneider, Kai Markus, Khoziainova, Svetlana, Andreeva, Natalia, Wang, Qiaohong

Source: Nature; May2022, Vol. 605 Issue 7908, p160-165, 6p

Interferon-γ/Interleukin-27 Axis Induces Programmed Death Ligand 1 Expression in Monocyte-Derived Dendritic Cells and Restores Immune Tolerance in Central Nervous System Autoimmunity.

Authors: Casella, Giacomo, Rasouli, Javad, Thome, Rodolfo, Descamps, Hélène C., Vattikonda, Asrita, Ishikawa, Larissa, Boehm, Alexandra, Hwang, Daniel, Zhang, Weifeng, Xiao, Dan, Park, Jeongho, Zhang, Guang-Xian, Alvarez, Jorge I., Rostami, Abdolmohamad, Ciric, Bogoljub

Source: Frontiers in Immunology; 10/26/2020, Vol. 11, pN.PAG-N.PAG, 15p

Subject Terms: CENTRAL nervous system, DENDRITIC cells, IMMUNOLOGICAL tolerance, APOPTOSIS, AUTOIMMUNITY

NAD+flux is maintained in aged mice despite lower tissue concentrations

Authors: McReynolds, Melanie R., Chellappa, Karthikeyani, Chiles, Eric, Jankowski, Connor, Shen, Yihui, Chen, Li, Descamps, Hélène C., Mukherjee, Sarmistha, Bhat, Yashaswini R., Lingala, Siddharth R., Chu, Qingwei, Botolin, Paul, Hayat, Faisal, Doke, Tomohito, Susztak, Katalin, Thaiss, Christoph A., Lu, Wenyun, Migaud, Marie E., Su, Xiaoyang, Rabinowitz, Joshua D., Baur, Joseph A.

Source: Cell Systems; December 2021, Vol. 12 Issue: 12 p1160-1172.e4