Auricular acupuncture plays a neuroprotective role in 6-hydroxydopamine-induced Parkinson's disease in rats

Authors: Huong Thi-Mai Nguyen, Der-Yen Lee, Ching-Liang Hsieh

Source: Journal of Traditional and Complementary Medicine, Vol 15, Iss 2, Pp 128-139 (2025)

Subject Terms: Parkinson's disease, Auricular acupuncture, 6-Hydroxydopamine, Tyrosine hydroxylase, α-synuclein, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2225411024000646; https://doaj.org/toc/2225-4110

Access URL: https://doaj.org/article/5c745f6f82f74e3c9c24684e8f9a598f

Effect of electrode configuration in electroacupuncture on ischemic stroke treatment in rats

Authors: Chung-Hsiang Liu, Huong Thi Mai Nguyen, Der-Yen Lee, Ching-Liang Hsieh

Source: Journal of Traditional and Complementary Medicine, Vol 13, Iss 6, Pp 588-599 (2023)

Subject Terms: Electroacupuncture, Ischemic stroke, Electrode configuration, Neuroprotection, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2225411023001001; https://doaj.org/toc/2225-4110

Access URL: https://doaj.org/article/cdaa81c0c8574b54a7813050a57fd6f1

Corrigendum: A novel Chinese herbal and corresponding chemical formula for cancer treatment by targeting tumor maintenance, progression, and metastasis

Authors: Ying-Chyi Song, Der-Yen Lee, Pei-Yen Yeh

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: cancer, botanical drug, Huang-Lian (Coptis chinensis Franch.), Huang-Qin (Scutellaria baicalensis Georgi), Bai-Wei (Vincetoxicum atratum (Bunge), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1312683/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/a152d21f204f40899f2b3e57f8262961

METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

Authors: Kai-Wen Hsu, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Pei-Hua Peng, Ching-Hui Huang, Der-Yen Lee, Yu-Cheng Tsai, Chi-Jung Chung, Han Chang, Chao-Hsiang Chang, Ji-Lin Chen, See-Tong Pang, Ziyang Hao, Xiao-Long Cui, Chuan He, Kou-Juey Wu

Source: Genome Biology, Vol 23, Iss 1, Pp 1-37 (2022)

Subject Terms: METTL4, 6mA, Hypoxia, lncRNA, ZMIZ1, Metastasis, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/6c0fad365ca1454eb69e277ce3013571

Metabolism modulation in rat tissues in response to point specificity of electroacupuncture

Authors: Der-Yen Lee, Yu-Rung Jiu, Ching-Liang Hsieh

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b77e7a1be96f4996b5ddf214adfb14d3

White Spot Syndrome Virus Triggers a Glycolytic Pathway in Shrimp Immune Cells (Hemocytes) to Benefit Its Replication

Authors: Yen Siong Ng, Der-Yen Lee, Chun-Hung Liu, Cheng-Yi Tung, Shu-Ting He, Han-Ching Wang

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: white spot syndrome virus, white shrimp, glycolysis, stable isotope tracing, hexokinase, phosphofructokinase, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.901111/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e4923b735c58459783a6a88f9f62739f

A Novel Chinese Herbal and Corresponding Chemical Formula for Cancer Treatment by Targeting Tumor Maintenance, Progression, and Metastasis

Authors: Ying-Chyi Song, Der-Yen Lee, Pei-Yen Yeh

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: cancer, botanical drug, Huang-Lian (Coptis chinensis Franch.), Huang-Qin (Scutellaria baicalensis Georgi), Bai-Wei (Vincetoxicum atratum (Bunge)), Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.907826/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/bb813357d3c74ab391ed826f05ccacee

Evaluations and Mechanistic Interrogation of Natural Products Isolated From Paeonia suffruticosa for the Treatment of Inflammatory Bowel Disease

Authors: Kun-Chang Wu, Der-Yen Lee, Jeh-Ting Hsu, Chi-Fang Cheng, Joung-Liang Lan, Shao-Chih Chiu, Der-Yang Cho, Jye-Lin Hsu

Source: Frontiers in Pharmacology, Vol 12 (2021)

Subject Terms: anti-inflammation, traditional Chinese medicine, moutan radicis cortex, inflammatory bowel disease, mu dan pi, Paeonia suffruticosa, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.696158/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/caaa4f02d0794d51aa2a4836948a0c49

Synthesis and Characterization of the Ethylene-Carbonate-Linked L-Valine Derivatives of 4,4-Dimethylcurcumin with Potential Anticancer Activities

Authors: Der-Yen Lee, Hui-Yi Lin, Manickavasakam Ramasamy, Sheng-Chu Kuo, Pei-Chih Lee, Min-Tsang Hsieh

Source: Molecules, Vol 26, Iss 22, p 7050 (2021)

Subject Terms: cellular uptake, 4,4-dimethylcurcumin, LC-MS spectroscopy, lung cancer, water solubility, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/22/7050; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/ca82165300ea4a049a17af6cc97b4170

Docosahexaenoic acid inhibits the proliferation of Kras/TP53 double mutant pancreatic ductal adenocarcinoma cells through modulation of glutathione level and suppression of nucleotide synthesis.

Authors: Wei-Chia Hung, Der-Yen Lee, En-Pei Isabel Chiang, Jia-Ning Syu, Che-Yi Chao, Mei-Due Yang, Shu-Yao Tsai, Feng-Yao Tang

Source: PLoS ONE, Vol 15, Iss 11, p e0241186 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8caba8e3c77f4fed8a8fafcb1ee23def

Glutamine Metabolism in Both the Oxidative and Reductive Directions Is Triggered in Shrimp Immune Cells (Hemocytes) at the WSSV Genome Replication Stage to Benefit Virus Replication

Authors: Shu-Ting He, Der-Yen Lee, Cheng-Yi Tung, Chun-Yuan Li, Han-Ching Wang

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: white spot syndrome virus, IDHs, oxidative glutaminolysis, reductive carboxylation, hemocytes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02102/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3a4fca2e6269461794de49fe1d2572bc

Docosahexaenoic Acid Inhibits Cell Proliferation through a Suppression of c-Myc Protein in Pancreatic Ductal Adenocarcinoma Cells

Authors: Jia-Ning Syu, Der-Yen Lee, Hung-Chang Hung, Chia-Ying Li, Hung-Yu Lin, En-Pei Isabel Chiang, Yi-Heng Chen, Shu-Ming Huang, Feng-Yao Tang

Source: Antioxidants, Vol 10, Iss 11, p 1721 (2021)

Subject Terms: DHA, STAT3, CAMKII, c-Myc, oxidative stress, cell apoptosis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/10/11/1721; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/cf07a4e0e35f4892a9ffdf7f2b386aac

Biochemical Regulation of the Glyoxalase System in Response to Insulin Signaling

Authors: Der-Yen Lee, Yu-Chin Lin, Geen-Dong Chang

Source: Antioxidants, Vol 10, Iss 2, p 326 (2021)

Subject Terms: glyoxalase, methylglyoxal, glycation, insulin, metformin, metabolism, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/10/2/326; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/8c838e8eb07c492f8ed4aece7511b689

Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives

Authors: Der-Yen Lee, Yu-Chi Hou, Jai-Sing Yang, Hui-Yi Lin, Tsu-Yuan Chang, Kuo-Hsiung Lee, Sheng-Chu Kuo, Min-Tsang Hsieh

Source: Molecules, Vol 25, Iss 3, p 479 (2020)

Subject Terms: curcuminoid derivatives, prodrug, colon cancer, breast cancer, active metabolites, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/25/3/479; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/fe2a24688e6b4f0b8dee0f3739064ea8

Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1

Authors: Der-Yen Lee, Geen-Dong Chang

Source: Redox Biology, Vol 2, Iss C, Pp 196-205 (2014)

Subject Terms: Transglutaminase 2, Glyoxalase 1, Methylglyoxal, Oxidative stress, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221323171400007X; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/d2eccfa116674dcb961bad3112190eb6

An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.

Authors: Mei-An Su, Yun-Tzu Huang, I-Tung Chen, Der-Yen Lee, Yun-Chieh Hsieh, Chun-Yuan Li, Tze Hann Ng, Suh-Yuen Liang, Shu-Yu Lin, Shiao-Wei Huang, Yi-An Chiang, Hon-Tsen Yu, Kay-Hooi Khoo, Geen-Dong Chang, Chu-Fang Lo, Han-Ching Wang

Source: PLoS Pathogens, Vol 10, Iss 6, p e1004196 (2014)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24945378/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/bc700c6a000f4d76beffb3323cb67691

The genome and occlusion bodies of marine Penaeus monodon nudivirus (PmNV, also known as MBV and PemoNPV) suggest that it should be assigned to a new nudivirus genus that is distinct from the terrestrial nudiviruses

Authors: Yi-Ting Yang^1,2 (AUTHOR), Der-Yen Lee³ (AUTHOR), Yongjie Wang^4,5 (AUTHOR), Jer-Ming Hu⁶ (AUTHOR), Wen-Hsiung Li^7,8 (AUTHOR), Jiann-Horng Leu^9,10 (AUTHOR), Geen-Dong Chang¹¹ (AUTHOR), Huei-Mien Ke^7,12 (AUTHOR), Shin-Ting Kang^1,2 (AUTHOR), Shih-Shun Lin¹³ (AUTHOR), Guang-Hsiung Kou² (AUTHOR) ghkou@ntu.edu.tw, Chu-Fang Lo^1,2,14 (AUTHOR) gracelow@mail.ncku.edu.tw

Source: BMC Genomics. 2014, Vol. 15 Issue 1, p628-651. 24p. 2 Black and White Photographs, 4 Diagrams, 4 Charts, 3 Graphs.

Enrichment of Metabolite-Binding Proteins by Affinity Elution in Tandem Hydrophobic Interaction Chromatography (AETHIC) Reveals RKIP Regulating ERK Signaling in an ATP-Dependent Manner.

Authors: Wei-Chieh Huang, Der-Yen Lee, Geen-Dong Chang

Source: Journal of Proteome Research; Oct2016, Vol. 15 Issue 10, p3574-3584, 11p

White Spot Syndrome Virus Protein Kinase 1 Defeats the Host Cell's Iron-Withholding Defense Mechanism by Interacting with Host Ferritin.

Authors: Shin-Jen Lin^1,2, Der-Yen Lee³, Hao-Ching Wang⁴, Shih-Ting Kang^1,2, Pung-Pung Hwang⁵, Guang-Hsiung Kou², Ming-Fen Huang⁴, Geen-Dong Chang⁶ gdchang@ntu.edu.tw, Chu-Fang Lo^1,2 gracelow@mail.ncku.edu.tw

Source: Journal of Virology. Jan2015, Vol. 89 Issue 2, p1083-1093. 11p.

Subject Terms: *WHITE spot syndrome virus, *PROTEIN kinases, *PROTEIN kinase regulation, *SHRIMP diseases, *DNA viruses

Electrolytic Reduction: Modification of Proteins Occurring in Isoelectric Focusing Electrophoresis and in Electrolytic Reactions in the Presence of High Salts.

Authors: Der-Yen Lee¹, Geen-Dong Chang¹ gdchang@ntu.edu.tw

Source: Analytical Chemistry. 5/15/2009, Vol. 81 Issue 10, p3957-3964. 8p. 2 Diagrams, 6 Graphs.

Subject Terms: *PROTEINS, *ELECTROLYSIS, *ELECTROLYTIC reduction, *ELECTROPHORESIS, *ISOELECTRIC focusing, *SALTS