sdRNA-D43 derived from small nucleolar RNA snoRD43 improves chondrocyte senescence and osteoarthritis progression by negatively regulating PINK1/Parkin-mediated mitophagy pathway via dual-targeting NRF1 and WIPI2.

Authors: Deng, Zengfa^1,2,3,4 (AUTHOR), Li, Changzhao^2,5,6 (AUTHOR), Hu, Shu^3,4 (AUTHOR), Zhong, Yanlin^1,2 (AUTHOR), Li, Wei^1,2 (AUTHOR), Lin, Zhencan^1,2 (AUTHOR), Mo, Xiaolin^1,2 (AUTHOR), Li, Ming^1,2 (AUTHOR), Xu, Dongliang^2,5 (AUTHOR), Long, Dianbo^1,2 (AUTHOR) longdb@mail2.sysu.edu.cn, Mao, Guping^1,2 (AUTHOR) maogp@mail2.sysu.edu.cn, Kang, Yan^1,2 (AUTHOR) kangyan2@mail.sysu.edu.cn

Source: Cell Communication & Signaling. 2/11/2025, Vol. 23 Issue 1, p1-21. 21p.

Subject Terms: *KNEE joint, *GENE expression, *LABORATORY rats, *MEDICAL sciences, *GENETIC regulation

m7G-modified mt-tRF3b-LeuTAA regulates mitophagy and metabolic reprogramming via SUMOylation of SIRT3 in chondrocytes

Authors: Long, Dianbo, Deng, Zengfa, Zhao, Xiaoyi, Xu, Yiyang, Li, Wei, Mo, Xiaolin, Zhong, Yanlin, Li, Ming, He, Aishan, Zhang, Ziji, Kang, Yan, Mao, Guping

Source: In Biomaterials March 2025 314

tRNA-derived fragment 3031B regulates human anterior cruciate ligament cell proliferation and survival by targeting RELA

Authors: Long, Dianbo, Deng, Zengfa, Li, Ming, Li, Wei, Zhong, Yanlin, Lin, Zhencan, He, Aishan, Kang, Yan, Mao, Guping

Source: In Gene 15 January 2025 933

The Optimal Variation Range of Posterior Condylar Offset Associated with Positive Clinical Outcomes of Primary Total Knee Arthroplasty: A Retrospective Analysis.

Authors: Zhong, Yanlin¹ (AUTHOR), Deng, Zengfa¹ (AUTHOR), Gu, Cheng¹ (AUTHOR), Li, Ming¹ (AUTHOR), Kang, Yan¹ (AUTHOR), Liao, Weiming¹ (AUTHOR), Zhang, Zhiqi¹ (AUTHOR) zhzhiqi@mail.sysu.edu.cn

Source: Orthopaedic Surgery. Nov2024, Vol. 16 Issue 11, p2708-2713. 6p.

Subject Terms: *TOTAL knee replacement, *KNEE osteoarthritis, *RECEIVER operating characteristic curves, *PATIENT satisfaction, *UNIVARIATE analysis

Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway

Authors: Li, Wei, Zhong, Yanlin, Lin, Zhencan, Deng, Zengfa, Long, Dianbo, Li, Ming, Li, Changzhao, Mao, Guping, Kang, Yan

Source: In Phytomedicine December 2024 135

IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2.

Authors: Deng, Zengfa, Long, Dianbo, Li, Changzhao, Liu, Hailong, Li, Wei, Zhong, Yanlin, Mo, Xiaolin, Li, Ruiyun, Yang, Zibo, Kang, Yan, Mao, Guping

Source: Bone Research; 10/28/2024, Vol. 12 Issue 1, p1-19, 19p

Subject Terms: INTERFERON regulatory factors, MITOFUSIN 2, LABORATORY rats, GENETIC translation, JOINT diseases, POLY ADP ribose

Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.

Authors: Liu, Hailong^1,2 (AUTHOR), Deng, Zengfa^1,2 (AUTHOR), Yu, Baoxi^1,2 (AUTHOR), Liu, Hui³ (AUTHOR), Yang, Zhijian^1,2 (AUTHOR), Zeng, Anyu^1,2 (AUTHOR), Fu, Ming^1,2 (AUTHOR) fuming@mail.sysu.edu.cn

Source: Cells (2073-4409). Nov2022, Vol. 11 Issue 21, p3430. 17p.

Subject Terms: *JOINT pain, *OSTEOARTHRITIS, *GENE expression, *DATA libraries, *STAINS & staining (Microscopy), *CHARGE carrier mobility, *BIOINFORMATICS software, *RANK correlation (Statistics)

tRNA-Derived Fragment tRF-5009A Regulates Autophagy and Degeneration of Cartilage in Osteoarthritis via Targeting mTOR.

Authors: Deng, Zengfa, Long, Dianbo, Liu, Hailong, Xu, Yiyang, Xin, Ruobing, Liao, Hongyi, Li, Zhiwen, Li, Ruiyun, Mao, Guping, Zhang, Ziji, Kang, Yan

Source: Oxidative Medicine & Cellular Longevity; 8/5/2022, p1-26, 26p

tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.

Authors: Long, Dianbo, Xu, Yiyang, Mao, Guping, Xin, Ruobing, Deng, Zengfa, Liao, Hongyi, Li, Zhiwen, Yang, Zhi, Yu, Baoxi, Yang, Zhijian, He, Aishan, Zhang, Ziji, Kang, Yan

Source: Cell Death Discovery; 1/10/2022, Vol. 8 Issue 1, p1-11, 11p

Author Correction: Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis.

Authors: Xu, Yiyang, Mao, Guping, Long, Dianbo, Deng, Zengfa, Xin, Ruobin, Zhang, Ziji, Xue, Ting, Liao, Weiming, Xu, Jie, Kang, Yan

Source: Experimental & Molecular Medicine EMM; Jun2023, Vol. 55 Issue 6, p1276-1276, 1p