Comprehensive invitro evaluation of the inhibitory effects of relatively high molecular weight peptides on drug-drug interaction-associated four liver transporters and its association with physicochemical properties

Authors: Ishikawa, Rika ^a, Misawa, Takashi ^b, Demizu, Yosuke ^b, Saito, Yoshiro ^c, Kikura-Hanajiri, Ruri ^a, Saito, Kosuke ^{a, ⁎}

Source: In Drug Metabolism and Pharmacokinetics April 2025 61

Nitrosamine contamination of pharmaceuticals: Cases in Japan, formation mechanisms, detection methods, regulatory perspectives, and insights

Authors: Tsuji, Genichiro, Yokoo, Hidetomo, Demizu, Yosuke, Abe, Yasuhiro, Masada, Sayaka, Uchiyama, Nahoko, Tsutsumi, Tomoaki, Yamamoto, Eiichi

Source: In Journal of Pharmaceutical and Biomedical Analysis Open December 2024 4

Dual-modified penetratin peptides: Enhancing nucleic acid delivery through stapling and endosomal escape domain

Authors: Horikoshi, Kanako, Miyamoto, Maho, Tsuchiya, Keisuke, Yokoo, Hidetomo, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 1 September 2024 111

Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins

Authors: Yokoo, Hidetomo, Tsuji, Genichiro, Inoue, Takao, Naito, Mikihiko, Demizu, Yosuke, Ohoka, Nobumichi

Source: In Bioorganic Chemistry April 2024 145

Design of antimicrobial peptides containing non-proteinogenic amino acids using multi-objective Bayesian optimisationElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3dd00090g

Authors: Murakami, Yuki, Ishida, Shoichi, Demizu, Yosuke, Terayama, Kei

Source: Digital discovery. 2(5):1347-1353

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195209489.0x000001&indx=1&recIds=ETOCvdc_100195209489.0x000001

Magainin 2-derived stapled peptides derived with the ability to deliver pDNA, mRNA, and siRNA into cellsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3sc04124g

Authors: Hirano, Motoharu, Yokoo, Hidetomo, Goto, Chihiro, Oba, Makoto, Misawa, Takashi, Demizu, Yosuke

Source: Chemical science. 14(38):10403-10410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194732358.0x000001&indx=1&recIds=ETOCvdc_100194732358.0x000001

Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)

Authors: Yokoo, Hidetomo, Naito, Mikihiko, Demizu, Yosuke

Source: Expert opinion on drug discovery. 18(4):357-361

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179821138.0x000001&indx=1&recIds=ETOCvdc_100179821138.0x000001

Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3

Authors: Shih, Po-Chang, Naganuma, Miyako, Tsuji, Genichiro, Demizu, Yosuke, Naito, Mikihiko

Source: In Bioorganic & Medicinal Chemistry 15 November 2023 95

Development of versatile solid-phase methods for syntheses of PROTACs with diverse E3 ligands

Authors: Xu, Hanqiao, Kurohara, Takashi, Ohoka, Nobumichi, Tsuji, Genichiro, Inoue, Takao, Naito, Mikihiko, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 15 May 2023 86

In silico optimization of peptides that inhibit Wnt/β-catenin signaling

Authors: Fujita, Minami, Tsuchiya, Keisuke, Kurohara, Takashi, Fukuhara, Kiyoshi, Misawa, Takashi, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 15 April 2023 84

CRBN ligand expansion for hematopoietic prostaglandin D2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles

Authors: Osawa, Hinata, Kurohara, Takashi, Ito, Takahito, Shibata, Norihito, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 15 April 2023 84

Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors

Authors: Irie, Tomohiko, Yanase, Yuta, Demizu, Yosuke, Usami, Makoto, Kikura-Hanajiri, Ruri

Source: In Journal of Pharmacological Sciences December 2022 150(4):233-243

Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling

Authors: Tsuchiya, Keisuke, Kiyoshi, Masato, Hashii, Noritaka, Fujita, Minami, Kurohara, Takashi, Ishii-Watabe, Akiko, Fukuhara, Kiyoshi, Misawa, Takashi, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 1 November 2022 73

Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine

Authors: Yokoo, Hidetomo, Misawa, Takashi, Kato, Takuma, Tanaka, Masakazu, Demizu, Yosuke, Oba, Makoto

Source: In Bioorganic & Medicinal Chemistry 15 October 2022 72

Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity

Authors: Takada, Hiroyuki, Tsuchiya, Keisuke, Demizu, Yosuke

Source: Bioconjugate chemistry. 33(7):1311-1318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631460962&indx=1&recIds=ETOCRN631460962

Structure–activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthaseElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00284a

Authors: Murakami, Yuki, Osawa, Hinata, Kurohara, Takashi, Yanase, Yuta, Ito, Takahito, Yokoo, Hidetomo, Shibata, Norihito, Naito, Mikihiko, Aritake, Kosuke, Demizu, Yosuke

Source: RSC medicinal chemistry. 13(12):1495-1503

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168310515.0x000001&indx=1&recIds=ETOCvdc_100168310515.0x000001

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) that Induces Targeted Protein Degradation of ERα

Authors: Ohoka, Nobumichi, Yokoo, Hidetomo, Okuhira, Keiichiro, Demizu, Yosuke, Naito, Mikihiko

Source: Methods in molecular biology. 2418:363-382

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628860281&indx=1&recIds=ETOCRN628860281

Advances in the development of Wnt/β-catenin signaling inhibitors.

Authors: Fujita, Minami, Demizu, Yosuke

Source: RSC Medicinal Chemistry; Mar2025, Vol. 16 Issue 3, p984-999, 16p

Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor

Authors: Kurohara, Takashi, Ito, Takahito, Tsuji, Genichiro, Misawa, Takashi, Yokoo, Hidetomo, Yanase, Yuta, Shoda, Takuji, Sakai, Takatoshi, Hosoe, Junko, Uchiyama, Nahoko, Akiyama, Hiroshi, Demizu, Yosuke

Source: In Bioorganic & Medicinal Chemistry 1 November 2021 49

TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

Authors: Kaiho-Soma, Ai, Akizuki, Yoshino, Igarashi, Katsuhide, Endo, Akinori, Shoda, Takuji, Kawase, Yasuko, Demizu, Yosuke, Naito, Mikihiko, Saeki, Yasushi, Tanaka, Keiji, Ohtake, Fumiaki

Source: In Molecular Cell 1 April 2021 81(7):1411-1424