Getting to YES: The Evolution of the University of Pittsburgh Medical Center Hillman Cancer Center Youth Enjoy Science (YES) Academy

Authors: Ayoob, Joseph C., Boyce, Richard D., Livshits, Solomon, Bruno, Tullia C., Delgoffe, Greg M., Galson, Deborah L., Duncan, Andrew W., Atkinson, Jennifer M., Oesterreich, Steffi, Evans, Steve, Alikhani, Malihe, Baker, Tobias A., Pratt, Sheila, DeHaan, Kenneth J., Chen, Yuanyuan, Boone, David N.

Source: Journal of STEM Outreach. Aug 2022 5(2).

Peer Reviewed: Y

Page Count: 15

Sponsoring Agency: National Cancer Institute (NCI) (DHHS/NIH)

Descriptors: Program Development, Cancer, High School Students, STEM Education, Scientific Research, Internship Programs, Disproportionate Representation, Mentors, Deafness, Hearing Impairments

Geographic Terms: Pennsylvania (Pittsburgh)

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

Authors: Frisch, Andrew T. ^{1, 2}, Wang, Yiyang ^{1, 3}, Xie, Bingxian ^{1, 2}, Yang, Aaron ^{1, 4}, Ford, B. Rhodes ^{1, 4}, Joshi, Supriya ^{1, 2}, Kedziora, Katarzyna M. ⁵, Peralta, Ronal ^{1, 2}, Wilfahrt, Drew ^{1, 2}, Mullett, Steven J. ^{6, 7}, Spahr, Kellie ^{1, 2}, Lontos, Konstantinos ^{1, 2}, Jana, Jessica A. ^{1, 2}, Dean, Victoria G. ^{1, 2}, Gunn, William G. ^{1, 2}, Gelhaus, Stacy ^{6, 7}, Poholek, Amanda C. ^{1, 4}, Rivadeneira, Dayana B. ^{1, 2}, Delgoffe, Greg M. ^{1, 2, 6, 8, ∗}

Source: In Cell Metabolism 1 April 2025 37(4):870-885

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

Authors: Andrews, Lawrence P., Butler, Samuel C., Cui, Jian, Cillo, Anthony R., Cardello, Carly, Liu, Chang, Brunazzi, Erin A., Baessler, Andrew, Xie, Bingxian, Kunning, Sheryl R., Ngiow, Shin Foong, Huang, Yinghui Jane, Manne, Sasikanth, Sharpe, Arlene H., Delgoffe, Greg M., Wherry, E. John, Kirkwood, John M., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.

Source: In Cell 8 August 2024 187(16):4355-4372

Integrating innate and adaptive immunity in oncolytic virus therapy

Authors: DePeaux, Kristin, Delgoffe, Greg M.

Source: In Trends in Cancer February 2024 10(2):135-146

The effect of opioids on the efficacy of immunotherapy in recurrent/metastatic squamous cell carcinoma of the head and neck

Authors: Scheff, Nicole N., Nilsen, Marci L., Li, Jinhong, Harris, Alexandria L., Acharya, Rajesh, Swartz, Andrew, Hsieh, Ronan W, Anderson, Jennifer L., Ferris, Robert L, Menk, Ashley V., Delgoffe, Greg M, Zandberg, Dan P.

Source: In Oral Oncology May 2023 140

Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage

Authors: Burr, Ansen H.P., Ji, Junyi, Ozler, Kadir, Mentrup, Heather L., Eskiocak, Onur, Yueh, Brian, Cumberland, Rachel, Menk, Ashley V., Rittenhouse, Natalie, Marshall, Chris W., Chiaranunt, Pailin, Zhang, Xiaoyi, Mullinax, Lauren, Overacre-Delgoffe, Abigail, Cooper, Vaughn S., Poholek, Amanda C., Delgoffe, Greg M., Mollen, Kevin P., Beyaz, Semir, Hand, Timothy W.

Source: In Cellular and Molecular Gastroenterology and Hepatology 2023 16(2):287-316

Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

Authors: Sugitani, Norie, Vendetti, Frank P., Cipriano, Andrew J., Pandya, Pinakin, Deppas, Joshua J., Moiseeva, Tatiana N., Schamus-Haynes, Sandra, Wang, Yiyang, Palmer, Drake, Osmanbeyoglu, Hatice U., Bostwick, Anna, Snyder, Nathaniel W., Gong, Yi-Nan, Aird, Katherine M., Delgoffe, Greg M., Beumer, Jan H., Bakkenist, Christopher J.

Source: In Cell Reports 20 September 2022 40(12)

Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity

Authors: Li, De-Dong, Jawale, Chetan V., Zhou, Chunsheng, Lin, Li, Trevejo-Nunez, Giraldina J., Rahman, Syed A., Mullet, Steven J., Das, Jishnu, Wendell, Stacy G., Delgoffe, Greg M., Lionakis, Michail S., Gaffen, Sarah L., Biswas, Partha S.

Source: In Cell Host & Microbe 13 April 2022 30(4):530-544

Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

Authors: Banerjee, Hridesh, Nieves-Rosado, Hector, Kulkarni, Aditi, Murter, Benjamin, McGrath, Kyle V., Chandran, Uma R., Chang, Alexander, Szymczak-Workman, Andrea L., Vujanovic, Lazar, Delgoffe, Greg M., Ferris, Robert L., Kane, Lawrence P.

Source: In Cell Reports 14 September 2021 36(11)

Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet

Authors: Zhao, Steven, Peralta, Ronal M., Avina-Ochoa, Natalia, Delgoffe, Greg M. ^*, Kaech, Susan M. ^*

Source: In Seminars in Immunology February 2021 52

Evaluation of radiomics as a predictor of efficacy and the tumor immune microenvironment in anti‐PD‐1 mAb treated recurrent/metastatic squamous cell carcinoma of the head and neck patients.

Authors: Zandberg, Dan P., Zenkin, Serafettin, Ak, Murat, Mamindla, Priyadarshini, Peddagangireddy, Vishal, Hsieh, Ronan, Anderson, Jennifer L., Delgoffe, Greg M., Menk, Ashely, Skinner, Heath D., Duvvuri, Umamaheswar, Ferris, Robert L., Colen, Rivka R.

Source: Head & Neck; Jan2025, Vol. 47 Issue 1, p129-138, 10p

Subject Terms: COMPUTED tomography, RADIOMICS, SQUAMOUS cell carcinoma, T cells, CELL imaging

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

Authors: Rivadeneira, Dayana B., DePeaux, Kristin, Wang, Yiyang, Kulkarni, Aditi, Tabib, Tracy, Menk, Ashley V., Sampath, Padmavathi, Lafyatis, Robert, Ferris, Robert L., Sarkar, Saumendra N., Thorne, Stephen H., Delgoffe, Greg M.

Source: In Immunity 17 September 2019 51(3):548-560

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

Authors: Liu, Chang, Chikina, Maria, Deshpande, Rahul, Menk, Ashley V., Wang, Ting, Tabib, Tracy, Brunazzi, Erin A., Vignali, Kate M., Sun, Ming, Stolz, Donna B., Lafyatis, Robert A., Chen, Wei, Delgoffe, Greg M., Workman, Creg J., Wendell, Stacy G., Vignali, Dario A.A.

Source: In Immunity 20 August 2019 51(2):381-397

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

Authors: Previte, Dana M., Martins, Christina P., O’Connor, Erin C., Marre, Meghan L., Coudriet, Gina M., Beck, Noah W., Menk, Ashley V., Wright, Rebecca H., Tse, Hubert M., Delgoffe, Greg M., Piganelli, Jon D.

Source: In Cell Reports 2 April 2019 27(1):129-141

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

Authors: Revu, Shankar, Wu, Jing, Henkel, Matthew, Rittenhouse, Natalie, Menk, Ashley, Delgoffe, Greg M., Poholek, Amanda C., McGeachy, Mandy J.

Source: In Cell Reports 6 March 2018 22(10):2642-2653

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

Authors: Menk, Ashley V., Scharping, Nicole E., Moreci, Rebecca S., Zeng, Xue, Guy, Cliff, Salvatore, Sonia, Bae, Heekyong, Xie, Jianxin, Young, Howard A., Wendell, Stacy Gelhaus, Delgoffe, Greg M.

Source: In Cell Reports 6 February 2018 22(6):1509-1521

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection.

Authors: Carreno-Florez, Grace P.^1,2, Kocak, Brian R.¹, Hendricks, Matthew R.¹, Melvin, Jeffrey A.¹, Mar, Katrina B.³, Kosanovich, Jessica⁴, Cumberland, Rachel L.⁵, Delgoffe, Greg M.⁵, Shiva, Sruti⁶, Empey, Kerry M.^4,5, Schoggins, John W.³, Bomberger, Jennifer M.², jbomb@dartmouth.edu

Source: PLoS Pathogens; 11/8/2023, Vol. 19 Issue 11, p1-18, 18p

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Authors: Overacre-Delgoffe, Abigail E., Chikina, Maria, Dadey, Rebekah E., Yano, Hiroshi, Brunazzi, Erin A., Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M., Kolls, Jay K., Sander, Cindy, Shuai, Yongli, Normolle, Daniel P., Kirkwood, John M., Ferris, Robert L., Delgoffe, Greg M., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.

Source: In Cell 1 June 2017 169(6):1130-1141

VHL Brings Warburg into the Memory Spotlight

Authors: Delgoffe, Greg M.

Source: In Immunity 15 November 2016 45(5):953-955

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Authors: Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.

Source: In Immunity 16 August 2016 45(2):374-388