A GLB1 transgene with enhanced therapeutic potential for the preclinical development of ex-vivo gene therapy to treat mucopolysaccharidosis type IVB

Authors: Crippa, Stefania, Alberti, Gaia, Passerini, Laura, Savoia, Evelyn Oliva, Mancino, Marilena, De Ponti, Giada, Santi, Ludovica, Berti, Margherita, Testa, Marialuisa, Hernandez, Raisa Jofra, Quaranta, Pamela, Ceriotti, Selene, Visigalli, Ilaria, Morrone, Amelia, Paoli, Antonella, Forni, Claudia, Scala, Serena, Degano, Massimo, Staiano, Leopoldo, Gregori, Silvia, Aiuti, Alessandro, Bernardo, Maria Ester

Source: In Molecular Therapy - Methods & Clinical Development 12 September 2024 32(3)

A riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis

Authors: Patrone, Marco, Galasyn, Gregory S., Kerin, Fiona, Nyitray, Mattias M., Parkin, David W., Stockman, Brian J., Degano, Massimo

Source: In Journal of Biological Chemistry September 2023 299(9)

How J-chain ensures the assembly of immunoglobulin IgM pentamers.

Authors: Giannone, Chiara, Mess, Xenia, He, Ruiming, Chelazzi, Maria Rita, Mayer, Annika, Bakunts, Anush, Nguyen, Tuan, Bushman, Yevheniia, Orsi, Andrea, Gansen, Benedikt, Degano, Massimo, Buchner, Johannes, Sitia, Roberto

Source: EMBO Journal; Jan2025, Vol. 44 Issue 2, p505-533, 29p

Subject Terms: LIFE sciences, CYTOLOGY, ANTIBODY formation, QUALITY control, COVALENT bonds, IMMUNOGLOBULIN receptors

Higher-order immunoglobulin repertoire restrictions in CLL: the illustrative case of stereotyped subsets 2 and 169

Authors: Gemenetzi, Katerina, Psomopoulos, Fotis, Carriles, Alejandra A., Gounari, Maria, Minici, Claudia, Plevova, Karla, Sutton, Lesley-Ann, Tsagiopoulou, Maria, Baliakas, Panagiotis, Pasentsis, Kostas, Anagnostopoulos, Achilles, Sandaltzopoulos, Raphael, Rosenquist, Richard, Davi, Frederic, Pospisilova, Sarka, Ghia, Paolo, Stamatopoulos, Kostas, Degano, Massimo ^*, Chatzidimitriou, Anastasia ^{*, *}

Source: In Blood 8 April 2021 137(14):1895-1904

Structures of catalytic cycle intermediates of the Pyrococcus furiosus methionine adenosyltransferase demonstrate negative cooperativity in the archaeal orthologues

Authors: Minici, Claudia, Mosca, Laura, Ilisso, Concetta Paola, Cacciapuoti, Giovanna, Porcelli, Marina, Degano, Massimo

Source: In Journal of Structural Biology 1 April 2020 210(1)

IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Authors: Maity, Palash C., Bilal, Mayas, Koning, Marvyn T., Young, Marc, van Bergen, Cornelis A. M., Renna, Valerio, Nicolò, Antonella, Datta, Moumita, Gentner-Göbel, Eva, Barendse, Rob S., Somers, Sebastiaan F., de Groen, Ruben A. L., Vermaat, Joost S. P., Steinbrecher, Daniela, Schneider, Christof, Tausch, Eugen, Bittolo, Tamara, Bomben, Riccardo, Mazzarello, Andrea Nicola, del Poeta, Giovanni, Kroes, Wilma G. M., van Wezel, J. Tom, Imkeller, Katharina, Busse, Christian E., Degano, Massimo, Bakchoul, Tamam, Schulz, Axel Ronald, Mei, Henrik, Ghia, Paolo, Kotta, Konstantia, Stamatopoulos, Kostas, Wardemann, Hedda, Zucchetto, Antonella, Chiorazzi, Nicholas, Gattei, Valter, Stilgenbauer, Stephan, Veelken, Hendrik, Jumaa, Hassan

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Feb . 117(8), 4320-4327.

Access URL: https://www.jstor.org/stable/26929087

T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency

Authors: Brigida, Immacolata, Zoccolillo, Matteo, Cicalese, Maria Pia, Pfajfer, Laurène, Barzaghi, Federica, Scala, Serena, Oleaga-Quintas, Carmen, Álvarez-Álvarez, Jesus A., Sereni, Lucia, Giannelli, Stefania, Sartirana, Claudia, Dionisio, Francesca, Pavesi, Luca, Benavides-Nieto, Marta, Basso-Ricci, Luca, Capasso, Paola, Mazzi, Benedetta, Rosain, Jeremie, Marcus, Nufar, Lee, Yu Nee, Somech, Raz, Degano, Massimo, Raiola, Giuseppe, Caorsi, Roberta, Picco, Paolo, Moncada Velez, Marcela, Khourieh, Joelle, Arias, Andrés Augusto, Bousfiha, Aziz, Issekutz, Thomas, Issekutz, Andrew, Boisson, Bertrand, Dobbs, Kerry, Villa, Anna, Lombardo, Angelo, Neven, Benedicte, Moshous, Despina, Casanova, Jean-Laurent, Franco, José Luis, Notarangelo, Luigi D., Scielzo, Cristina, Volpi, Stefano, Dupré, Loïc, Bustamante, Jacinta, Gattorno, Marco ^*, Aiuti, Alessandro ^*

Source: In Blood 29 November 2018 132(22):2362-2374

The N-Terminal Domain of NPHP1 Folds into a Monomeric Left-Handed Antiparallel Three-Stranded Coiled Coil with Anti-apoptotic Function

Authors: Mannella, Valeria, Quilici, Giacomo, Nigro, Elisa Agnese, Lampis, Matteo, Minici, Claudia, Degano, Massimo, Boletta, Alessandra, Musco, Giovanna

Source: ACS chemical biology. 14(8):1845-1854

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621343543&indx=1&recIds=ETOCRN621343543

Crystal Structure of γδ T Cell Receptor Ligand T22: A Truncated MHC-like Fold

Authors: Wingren, Christer, Crowley, Michael P., Degano, Massimo, Chien, Yueh-hsiu, Wilson, Ian A.

Source: Science, 2000 Jan . 287(5451), 310-314.

Access URL: https://www.jstor.org/stable/3074493

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

Authors: Garia, K. Christopher, Degano, Massimo, Pease, Larry R., Huang, Mingdong, Peterson, Per A., Teyton, Luc, Wilson, Ian A.

Source: Science, 1998 Feb . 279(5354), 1166-1172.

Access URL: https://www.jstor.org/stable/2894806

α β T Cell Receptor Interactions with Syngeneic and Allogeneic Ligands: Affinity Measurements and Crystallization

Authors: Garcia, K. Christopher, Tallquist, Michelle D., Pease, Larry R., Brunmark, Anders, Scott, Christopher A., Degano, Massimo, Stura, Enrico A., Peterson, Per A., Wilson, Ian A., Teyton, Luc

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Dec 01. 94(25), 13838-13843.

Access URL: https://www.jstor.org/stable/43821

Anαβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

Authors: Garcia, K. Christopher, Degano, Massimo, Stanfield, Robyn L., Brunmark, Anders, Jackson, Michael R., Peterson, Per A., Teyton, Luc, Wilson, Ian A.

Source: Science, 1996 Oct 01. 274(5285), 209-219.

Access URL: https://www.jstor.org/stable/2892161

Characterization of inosine–uridine nucleoside hydrolase (RihC) from Escherichia coli

Authors: Arivett, Brock, Farone, Mary, Masiragani, Ranjith, Burden, Andrew, Judge, Shelby, Osinloye, Adedoyin, Minici, Claudia, Degano, Massimo, Robinson, Matthew, Kline, Paul

Source: In BBA - Proteins and Proteomics March 2014 1844(3):656-662

A pH-Regulated Quality Control Cycle for Surveillance of Secretory Protein Assembly

Authors: Vavassori, Stefano, Cortini, Margherita, Masui, Shoji, Sannino, Sara, Anelli, Tiziana, Caserta, Imma R., Fagioli, Claudio, Mossuto, Maria F., Fornili, Arianna, van Anken, Eelco, Degano, Massimo, Inaba, Kenji, Sitia, Roberto

Source: In Molecular Cell 27 June 2013 50(6):783-792

Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor

Authors: Patrone, Marco, Cammarota, Eugenia, Berno, Valeria, Tornaghi, Paola, Mazza, Davide, Degano, Massimo

Source: Communications biology. 3(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130041751.0x000001&indx=1&recIds=ETOCvdc_100130041751.0x000001

Disease-associated mutations in the coil 2B domain of human lamin A/C affect structural properties that mediate dimerization and intermediate filament formation

Authors: Gangemi, Fabrizio, Degano, Massimo

Source: In Journal of Structural Biology January 2013 181(1):17-28

The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase

Authors: Sala, Kristyna, Corbetta, Agnese, Minici, Claudia, Tonoli, Diletta, Murray, David H., Cammarota, Eugenia, Ribolla, Lucrezia, Ramella, Martina, Fesce, Riccardo, Mazza, Davide, Degano, Massimo, de Curtis, Ivan

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132542597.0x000001&indx=1&recIds=ETOCvdc_100132542597.0x000001

Evidence of Defective Cell-Autonomous Signalling By B Cell Receptors in CLL Stereotyped Subset #1

Authors: Minici, Claudia, Cocomazzi, Paolo G., Akpınaroğlu, Can, Iatrou, Anastasia, Gounari, Maria, Frenquelli, Michela, Scarfo, Lydia, Buske, Christian, Agathangelidis, Andreas, Jumaa, Hassan, Maity, Palash, Ghia, Paolo, Stamatopoulos, Kostas, Degano, Massimo

Source: In Blood 2 November 2023 142 Supplement 1:3255-3255

A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer.

Authors: Zuppone, Stefania, Assalini, Chiara, Minici, Claudia, Botrugno, Oronza A., Curnis, Flavio, Degano, Massimo, Corti, Angelo, Montorsi, Francesco, Salonia, Andrea, Vago, Riccardo

Source: Frontiers in Oncology; 4/11/2022, Vol. 12, p1-11, 11p

Subject Terms: BLADDER cancer, MITOMYCINS, TUMOR growth, LABORATORY mice, PEPTIDES, MITOMYCIN C, ANTINEOPLASTIC agents

Structural requirements for antigen presentation by mouse CD1.

Authors: Burdin, Nicolas, Brossay, Laurent, Degano, Massimo

Source: Proceedings of the National Academy of Sciences of the United States of America; August 29 2000, Vol. 97 Issue 18, p10156-10161, 6p