Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

Authors: Marron, Thomas U ^*, Fiel, Maria Isabel, Hamon, Pauline, Fiaschi, Nathalie, Kim, Edward, Ward, Stephen C, Zhao, Zhen, Kim, Joel, Kennedy, Paul, Gunasekaran, Ganesh, Tabrizian, Parissa, Doroshow, Deborah, Legg, Meredith, Hammad, Ashley, Magen, Assaf, Kamphorst, Alice O, Shareef, Muhammed, Gupta, Namita T, Deering, Raquel, Wang, Wei, Wang, Fang, Thanigaimani, Pradeep, Mani, Jayakumar, Troncoso, Leanna, Tabachnikova, Alexandra, Chang, Christie, Akturk, Guray, Buckup, Mark, Hamel, Steven, Ioannou, Giorgio, Hennequin, Clotilde, Jamal, Hajra, Brown, Haley, Bonaccorso, Antoinette, Labow, Daniel, Sarpel, Umut, Rosenbloom, Talia, Sung, Max W, Kou, Baijun, Li, Siyu, Jankovic, Vladimir, James, Nicola, Hamon, Sara C, Cheung, Hung Kam, Sims, Jennifer S, Miller, Elizabeth, Bhardwaj, Nina, Thurston, Gavin, Lowy, Israel, Gnjatic, Sacha, Taouli, Bachir, Schwartz, Myron E, Merad, Miriam

Source: In The Lancet Gastroenterology & Hepatology March 2022 7(3):219-229

Complete responses to odronextamab in two patients with diffuse large B‐cell lymphoma refractory to chimeric antigen receptor T‐cell therapy

Authors: Weinstock, Matt, Elavalakanar, Pavania, Bright, Susan, Ambati, Srikanth R., Brouwer‐Visser, Jurriaan, Pourpe, Stephane, Fiaschi, Nathalie, Jankovic, Vladimir, Thurston, Gavin, Deering, Raquel P., Chaudhry, Aafia, Joyce, Robin, Arnason, Jon

Source: British journal of haematology. 199(3):366-370

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Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.

Authors: Deering, Raquel P.¹ (AUTHOR) raquel.deering@regeneron.com, Blumenberg, Lili¹ (AUTHOR), Li, Lianjie¹ (AUTHOR), Dhanik, Ankur¹ (AUTHOR), Jeong, Se¹ (AUTHOR), Pourpe, Stephane¹ (AUTHOR), Song, Hang¹ (AUTHOR), Boucher, Lauren¹ (AUTHOR), Ragunathan, Shoba¹ (AUTHOR), Li, Yanxia¹ (AUTHOR), Zhong, Maggie¹ (AUTHOR), Kuhnert, Jessica¹ (AUTHOR), Adler, Christina¹ (AUTHOR), Hawkins, Peter¹ (AUTHOR), Gupta, Namita T.¹ (AUTHOR), Moore, Michael¹ (AUTHOR), Ni, Min¹ (AUTHOR), Hansen, Johanna¹ (AUTHOR), Wei, Yi¹ (AUTHOR), Thurston, Gavin¹ (AUTHOR)

Source: Scientific Reports. 5/25/2023, Vol. 13 Issue 1, p1-16. 16p.

Subject Terms: *T cells, *ANTIGEN presenting cells, *T cell receptors, *TUMOR antigens, *BLOOD volume, *VIRAL antigens, *CELLULAR immunity

Genome-wide analyses and functional profiling of human NK cell lines

Authors: Gunesch, Justin T., Angelo, Laura S., Mahapatra, Sanjana, Deering, Raquel P., Kowalko, Johanna E., Sleiman, Patrick, Tobias, John W., Monaco-Shawver, Linda, Orange, Jordan S., Mace, Emily M. ^*

Source: In Molecular Immunology November 2019 115:64-75

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins

Authors: Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Li, Fan, Vandivier, Lee, Parada, Kimberly, Woo, Dong-Hun, Wang, Shan, Naqvi, Ammar S., Rao, Shilpa, Tobias, John, Cedeno, Ryan J., Minuesa, Gerard, Y, Katz, Barlowe, Trevor S., Valvezan, Alexander, Shankar, Sheila, Deering, Raquel P., Klein, Peter S., Jensen, Shane T., Kharas, Michael G., Gregory, Brian D., Yu, Zhengquan, Lengner, Christopher J.

Source: In Cell Reports 22 December 2015 13(11):2440-2455

Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

Authors: Amit, Ido, Garber, Manuel, Chevrier, Nicolas, Leite, Ana Paula, Donner, Yoni, Eisenhaure, Thomas, Guttman, Mitchell, Grenier, Jennifer K., Li, Weibo, Zuk, Or, Schubert, Lisa A., Birditt, Brian, Shay, Tal, Goren, Alon, Zhang, Xiaolan, Smith, Zachary, Deering, Raquel, McDonald, Rebecca C., Cabili, Moran, Bernstein, Bradley E., Rinn, John L., Meissner, Alex, Root, David E., Hacohen, Nir, Regev, Aviv

Source: Science, 2009 Oct 01. 326(5950), 257-263.

Access URL: https://www.jstor.org/stable/40328840

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

Authors: Deering, Raquel P, Kommareddy, Sushma, Ulmer, Jeffrey B, Brito, Luis A, Geall, Andrew J

Source: Expert opinion on drug delivery. 11(6):885-899

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102975786.0x000001&indx=1&recIds=ETOCvdc_100102975786.0x000001

IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function

Authors: Salt, Bryn H., Niemela, Julie E., Pandey, Rahul, Hanson, Eric P., Deering, Raquel P., Quinones, Ralph, Jain, Ashish, Orange, Jordan S., Gelfand, Erwin W.

Source: In The Journal of Allergy and Clinical Immunology 2008 121(4):976-982

Intratumoral dendritic cell–CD4+T helper cell niches enable CD8+T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Authors: Magen, Assaf, Hamon, Pauline, Fiaschi, Nathalie, Soong, Brian Y., Park, Matthew D., Mattiuz, Raphaël, Humblin, Etienne, Troncoso, Leanna, D’souza, Darwin, Dawson, Travis, Kim, Joel, Hamel, Steven, Buckup, Mark, Chang, Christie, Tabachnikova, Alexandra, Schwartz, Hara, Malissen, Nausicaa, Lavin, Yonit, Soares-Schanoski, Alessandra, Giotti, Bruno, Hegde, Samarth, Ioannou, Giorgio, Gonzalez-Kozlova, Edgar, Hennequin, Clotilde, Le Berichel, Jessica, Zhao, Zhen, Ward, Stephen C., Fiel, Isabel, Kou, Baijun, Dobosz, Michael, Li, Lianjie, Adler, Christina, Ni, Min, Wei, Yi, Wang, Wei, Atwal, Gurinder S., Kundu, Kunal, Cygan, Kamil J., Tsankov, Alexander M., Rahman, Adeeb, Price, Colles, Fernandez, Nicolas, He, Jiang, Gupta, Namita T., Kim-Schulze, Seunghee, Gnjatic, Sacha, Kenigsberg, Ephraim, Deering, Raquel P., Schwartz, Myron, Marron, Thomas U., Thurston, Gavin, Kamphorst, Alice O., Merad, Miriam

Source: Nature Medicine; 20230101, Issue: Preprints p1-11, 11p

Common and rare variant associations with clonal haematopoiesis phenotypes

Authors: Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., Jorgenson, Eric

Source: Nature; December 2022, Vol. 612 Issue: 7939 p301-309, 9p

Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes

Authors: Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., Jorgenson, Eric

Source: Nature; 20250101, Issue: Preprints p1-1, 1p

Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance

Authors: Brouwer-Visser, Jurriaan ^*, Fiaschi, Nathalie ^*, Deering, Raquel P. ^*, Dhanik, Ankur ^*, Cygan, Kamil J. ^*, Zhang, Wen ^*, Jeong, Se ^*, Pourpe, Stephane ^*, Boucher, Lauren ^*, Hamon, Sara ^*, Topp, Max S., Bannerji, Rajat, Duell, Johannes ^*, Advani, Ranjana, Flink, Dina M. ^*, Chaudhry, Aafia ^*, Sirulnik, Andres, Murphy, Andrew J. ^*, Weinreich, David M. ^*, Yancopoulos, George D. ^*, Thurston, Gavin ^*, Ambati, Srikanth R. ^*, Jankovic, Vladimir

Source: In Blood 5 November 2020 136 Supplement 1:10-11

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Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL)

Authors: Bannerji, Rajat, Allan, John N., Arnason, Jon E., Brown, Jennifer R. ^*, Advani, Ranjana H, Barnes, Jeffrey A., Ansell, Stephen M, O'Brien, Susan M., Chavez, Julio ^*, Duell, Johannes ^*, David, Kevin A., Martin, Peter, Joyce, Robin M., Charnas, Robert ^*, Ambati, Srikanth R. ^*, Adriaens, Lieve ^*, Ufkin, Melanie, Zhu, Min ^*, Li, Jingjin ^*, Gasparini, Peter ^*, Ibrahim, Anfal ^*, Jankovic, Vladimir, Fiaschi, Nathalie ^*, Aina, Olulanu ^*, Zhang, Wen ^*, Deering, Raquel P. ^*, Hamon, Sara ^*, Thurston, Gavin ^*, Murphy, Andrew J. ^*, Weinreich, David M. ^*, Yancopoulos, George D. ^*, Lowy, Israel, Sternberg, David, Topp, Max S.

Source: In Blood 13 November 2019 134 Supplement 1:762-762

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Musashi2 sustains the mixed-lineage leukemia—driven stem cell regulatory program

Authors: Park, Sun-Mi, Gönen, Mithat, Vu, Ly, Minuesa, Gerard, Tivnan, Patrick, Barlowe, Trevor S., Taggart, James, Lu, Yuheng, Deering, Raquel P., Hacohen, Nir

Source: Journal of clinical investigation. 125(3):1286-1286

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600415175&indx=1&recIds=ETOCRN600415175

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Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program

Authors: Park, Sun Mi, Gönen, Mithat ^*, Vu, Ly P. ^*, Minuesa, Gerard ^*, Tivnan, Patrick ^*, Barlowe, Trevor ^*, Taggart, James ^*, Lu, Yuheng ^*, Deering, Raquel P ^*, Hacohen, Nir ^*, Figueroa, Maria ^*, Paietta, Elisabeth M., Tallman, Martin S., Melnick, Ari M., Levine, Ross L., Leslie, Christina ^*, Lengner, Christopher J ^*, Kharas, Michael G

Source: In Blood 6 December 2014 124(21):836-836

Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells

Authors: Park, Sun-Mi, Deering, Raquel P, Lu, Yuheng, Patrick, Tivnan, Shenoy, Varun, Lianoglou, Steve, Al-Shahrour, Fatima, Leslie, Christina, Ebert, Benjamin L., Lengner, Christopher, Daley, George Q, Kharas, Michael G

Source: In Blood 15 November 2013 122(21):468-468