Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

Authors: Huygens, Caroline, Liénart, Stéphanie, Dedobbeleer, Olivier, Stockis, Julie, Gauthy, Emilie, Coulie, Pierre G., Lucas, Sophie

Source: In Journal of Biological Chemistry 14 August 2015 290(33):20105-20116

Cutting Edge: Active TGF-β1 Released from GARP/TGF-β1 Complexes on the Surface of Stimulated Human B Lymphocytes Increases Class-Switch Recombination and Production of IgA

Authors: Dedobbeleer, Olivier, Stockis, Julie, van der Woning, Bas, Coulie, Pierre G., Lucas, Sophie

Source: Journal of immunology. 199(2):391-396

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612179565&indx=1&recIds=ETOCRN612179565

Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice.

Authors: Gaignage, Mélanie, Zhang, Xuhao, Stockis, Julie, Dedobbeleer, Olivier, Michiels, Camille, Cochez, Perrine, Dumoutier, Laure, Coulie, Pierre G., Lucas, Sophie

Source: Cancer Immunology, Immunotherapy; Aug2022, Vol. 71 Issue 8, p1851-1862, 12p

Subject Terms: BACTERIAL proteins, IMMUNE response, BACTERIAL diseases, MEMBRANE proteins, IMMUNIZATION

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

Authors: Liénart, Stéphanie, Stockis, Julie, Dedobbeleer, Olivier, Lucas, Sophie

Source: Oncoimmunology. 5(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042793700.0x000001&indx=1&recIds=ETOCvdc_100042793700.0x000001

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Role of GARP in the activation of latent TGF-β1.

Authors: Stockis, Julie, Dedobbeleer, Olivier, Lucas, Sophie

Source: Molecular BioSystems; Oct2017, Vol. 13 Issue 10, p1925-1935, 11p

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.

Authors: Cuende, Julia, Liénart, Stéphanie, Dedobbeleer, Olivier, van der Woning, Bas, De Boeck, Gitte, Stockis, Julie, Huygens, Caroline, Colau, Didier, Somja, Joan, Delvenne, Philippe, Hannon, Muriel, Baron, Frédéric, Dumoutier, Laure, Renauld, Jean-Christophe, De Haard, Hans, Saunders, Michael, Coulie, Pierre G., Lucas, Sophie

Source: Science Translational Medicine; 4/22/2015, Vol. 7 Issue 284, p1-12, 12p, 1 Diagram, 1 Chart, 4 Graphs

Subject Terms: MONOCLONAL antibodies, TRANSFORMING growth factors-beta, IMMUNOSUPPRESSION, T cells, IMMUNOGLOBULINS, EPITOPES, CANCER immunotherapy, PHYSIOLOGY