Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy

Authors: Wu, Kai Connie, Adedeji, Adeyemi O., Zabka, Tanja S., Hosseini, Iraj, Kenkre, Radhika, Getz, Jennifer A., Nguyen, Tien, Decalf, Jérémie, Bainbridge, Travis W., Chilton, Jennifer A., Moussion, Christine C., Rao, Gautham K.

Source: In Toxicology and Applied Pharmacology February 2024 483

A single point mutation on FLT3L-Fc protein increases the risk of immunogenicity.

Authors: Qin, Dan, Phung, Qui, Wu, Patrick, Yin, Zhaojun, Tam, Sien, Tran, Peter, ElSohly, Adel M., Gober, Joshua, Hu, Zicheng, Zhou, Zhenru, Cohen, Sivan, He, Dongping, Bainbridge, Travis W., Kemball, Christopher C., Zarzar, Jonathan, Sreedhara, Alavattam, Stephens, Nicole, Decalf, Jérémie, Moussion, Christine, Ye, Zhengmao

Source: Frontiers in Immunology; 2025, p1-16, 16p

Subject Terms: PROTEIN engineering, IMMUNE response, T cells, PEPTIDES, THERAPEUTIC use of proteins

A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants

Authors: Decalf, Jérémie, Tom, Jeffrey, Mai, Elaine, Hernandez-Barry, Hilda, Noland, Cameron L., Vollmar, Breanna S., Li, Alice, Li, Hong, Xie, Daniel, Zhu, Lunchao, Payandeh, Jian, Wu, Cong, Comps-Agrar, Laetitia, Moussion, Christine, Albert, Matthew L., Song, Aimin

Source: In Bioorganic Chemistry November 2021 116

Differential levels of IFNα subtypes in autoimmunity and viral infection

Authors: Bondet, Vincent, Rodero, Mathieu P., Posseme, Céline, Bost, Pierre, Decalf, Jérémie, Haljasmägi, Liis, Bekaddour, Nassima, Rice, Gillian I., Upasani, Vinit, Herbeuval, Jean-Philippe, Reynolds, John A., Briggs, Tracy A., Bruce, Ian N., Mauri, Claudia, Isenberg, David, Menon, Madhvi, Hunt, David, Schwikowski, Benno, Mariette, Xavier, Pol, Stanislas, Rozenberg, Flore, Cantaert, Tineke, Eric Gottenberg, J., Kisand, Kai, Duffy, Darragh

Source: In Cytokine August 2021 144

New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue

Authors: Decalf, Jérémie, Albert, Matthew L, Ziai, James

Source: Journal of pathology. 247(5):650-661

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090606820.0x000001&indx=1&recIds=ETOCvdc_100090606820.0x000001

Multimarker risk stratification approach at multiple sclerosis onset

Authors: Fernández-Paredes, Lidia, Casrouge, Armanda, Decalf, Jérémie, de Andrés, Clara, Villar, Luisa Maria, Pérez de Diego, Rebeca, Alonso, Bárbara, Álvarez Cermeño, José Carlos, Arroyo, Rafael, Tejera-Alhambra, Marta, Navarro, Joaquín, Oreja-Guevara, Celia, López Trascasa, Margarita, Seyfferth, Ansgar, García Martínez, Maria Angel, Álvarez Lafuente, Roberto, Albert, Matthew L., Sánchez-Ramón, Silvia

Source: In Clinical Immunology August 2017 181:43-50

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.

Authors: Hosseini, Iraj, Fleisher, Brett, Getz, Jennifer, Decalf, Jérémie, Kwong, Mandy, Ovacik, Meric, Bainbridge, Travis W., Moussion, Christine, Rao, Gautham K., Gadkar, Kapil, Kamath, Amrita V., Ramanujan, Saroja

Source: Pharmaceutics; May2024, Vol. 16 Issue 5, p660, 18p

Subject Terms: KRA, EXPERIMENTAL design, DRUG development, MOLECULES, DRUGS

Corrigendum to 'A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants' [Bioorg. Chem. 116 (2021) 105376]

Authors: Decalf, Jérémie, Tom, Jeffrey, Mai, Elaine, Hernandez-Barry, Hilda, Noland, Cameron L., Vollmar, Breanna S., Li, Alice, Li, Hong, Xie, Daniel, Zhu, Lunchao, Payandeh, Jian, Loyet, Kelly M., Wu, Cong, Comps-Agrar, Laetitia, Moussion, Christine, Albert, Matthew L., Song, Aimin

Source: Bioorganic chemistry. 120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164929481.0x000001&indx=1&recIds=ETOCvdc_100164929481.0x000001

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

Authors: Rodero, Mathieu P., Decalf, Jérémie, Bondet, Vincent, Hunt, David, Rice, Gillian I., Werneke, Scott, McGlasson, Sarah L., Alyanakian, Marie-Alexandra, Bader-Meunier, Brigitte, Barnerias, Christine

Source: Journal of experimental medicine. 214(5):1547-1556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612885471&indx=1&recIds=ETOCRN612885471

OatA, a Peptidoglycan O-Acetyltransferase Involved in Listeria monocytogenes Immune Escape, Is Critical for Virulence

Authors: Aubry, Camille, Goulard, Céline, Nahori, Marie-Anne, Cayet, Nadège, Decalf, Jérémie, Sachse, Martin, Boneca, Ivo G., Cossart, Pascale, Dussurget, Olivier

Source: The Journal of Infectious Diseases, 2011 Sep 01. 204(5), 731-740.

Access URL: http://dx.doi.org/10.1093/infdis/jir396

Circulating Plasmacytoid Dendritic Cells in Acutely Infected Patients with Hepatitis C Virus Genotype 4 Are Normal in Number and Phenotype

Authors: Mansour, Hala, Laird, Melissa E., Saleh, Rasha, Casrouge, Armanda, Eldin, Noha Sharaf, Kafrawy, Sherif El, Hamdy, Maha, Decalf, Jérémie, Rosenberg, Brad R., Fontanet, Arnaud, Abdel-Hamid, Mohammed, Mohamed, Mostafa K., Albert, Matthew L., Rafik, Mona

Source: The Journal of Infectious Diseases, 2010 Dec 01. 202(11), 1671-1675.

Access URL: https://www.jstor.org/stable/20799194

Immunosuppressive Signature of Cutaneous Mycobacterium ulcerans Infection in the Peripheral Blood of Patients with Buruli Ulcer Disease

Authors: Phillips, Richard, Sarfo, Fred S., Guenin-Macé, Laura, Decalf, Jérémie, Wansbrough-Jones, Mark, Albert, Matthew L., Demangel, Caroline

Source: The Journal of Infectious Diseases, 2009 Dec 01. 200(11), 1675-1684.

Access URL: https://www.jstor.org/stable/27794329

The sky is not the limit

Authors: Decalf, Jérémie

Responsibility: Jérémie Decalf

Plasmacytoid dendritic cells move down on the list of suspects: In search of the immune pathogenesis of chronic hepatitis C

Authors: Albert, Matthew L., Decalf, Jérémie, Pol, Stanislas

Source: In Journal of Hepatology 2008 49(6):1069-1078

Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy.

Authors: Meissner, Eric G.^1,2,3 meissner@musc.edu, Decalf, Jérémie^4,5, Casrouge, Armanda^4,5, Masur, Henry³, Kottilil, Shyam^2,6, Albert, Matthew L.^4,5,7, Duffy, Darragh^4,5,7 darragh.duffy@pasteur.fr

Source: PLoS ONE. 7/16/2015, Vol. 10 Issue 7, p1-9. 9p.

Subject Terms: *POST-translational modification, *CHEMOKINES, *HEPATITIS C treatment, *THERAPEUTIC use of interferons, *HEALTH outcome assessment, *VIRAL replication

Establishment of Murine Gammaherpesvirus Latency in B Cells Is Not a Stochastic Event.

Authors: Decalf, Jérémie¹, Godinho-Silva, Cristina¹, Fontinha, Diana¹, Marques, Sofia¹, Simas, J. Pedro¹ psimas@fm.ul.pt

Source: PLoS Pathogens. Jul2014, Vol. 10 Issue 7, p1-14. 14p.

Subject Terms: *MURINE gammaherpesviruses, *MURINE gammaherpesvirus diseases, *B cells, *LABORATORY mice, *PLASMA cells, *HERPESVIRUSES

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Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV.

Authors: Casrouge, Armanda^1,2, Decalf, Jérémie^1,2, Ahloulay, Mina^3,4,5, Lababidi, Cyril⁶, Mansour, Hala¹, Vallet-Pichard, Anaïs^3,4,5, Mallet, Vincent^3,4,5, Mottez, Estelle⁶, Mapes, James⁷, Fontanet, Arnaud⁸, Pol, Stanislas^3,4,5, Albert, Matthew L.^1,2 albertm@pasteur.fr, Decalf, Jérémie (AUTHOR), Vallet-Pichard, Anaïs (AUTHOR)

Source: Journal of Clinical Investigation. Jan2011, Vol. 121 Issue 1, p308-317. 10p. 6 Graphs.

Subject Terms: *HEPATITIS C virus, *PUBLIC health, *CHRONIC diseases, *RIBAVIRIN, *CHEMOKINES, *CD26 antigen, *PROGNOSIS, *BIOMARKERS, *THERAPEUTIC use of proteins, *ANTIVIRAL agents, *POLYETHYLENE glycol, *CELL receptors, *COMPARATIVE studies, *CYTOKINES, *RESEARCH methodology, *MEDICAL cooperation, *PEPTIDES, *PROTEOLYTIC enzymes, *RECOMBINANT proteins, *RESEARCH, *T cells, *EVALUATION research, *TREATMENT effectiveness, *PROTEIN microarrays, *BLOOD, *CHRONIC hepatitis C, *THERAPEUTICS