Dynamics of molecular heterogeneity in high-risk luminal breast cancer—From intrinsic to adaptive subtyping

Authors: Denkert, Carsten ^{1, ∗}, Rachakonda, Sivaramakrishna ², Karn, Thomas ³, Weber, Karsten ², Martin, Miguel ^{4, 5}, Marmé, Frederik ⁶, Untch, Michael ^{7, 8}, Bonnefoi, Hervé ⁹, Kim, Sung-Bae ¹⁰, Seiler, Sabine ², Bear, Harry D. ¹¹, Witkiewicz, Agnieszka K. ¹², Im, Seock-Ah ¹³, DeMichele, Angela ¹⁴, Pehl, Anika ¹, van't Veer, Laura ¹⁵, McCarthy, Nicole ¹⁶, Stiewe, Thorsten ¹⁷, Jank, Paul ¹, Gelmon, Karen A. ¹⁸, García-Sáenz, José A. ¹⁹, Westhoff, Christina C. ¹, Kelly, Catherine M. ²⁰, Reimer, Toralf ²¹, Felder, Bärbel ², Olivé, Mireia Melé ²², Knudsen, Erik S. ¹², Turner, Nicholas ²³, Rojo, Federico ^{5, 24}, Schmitt, Wolfgang D. ²⁵, Fasching, Peter A. ²⁶, Teply-Szymanski, Julia ¹, Zhang, Zhe ²⁷, Toi, Masakazu ^{28, 29}, Rugo, Hope S. ³⁰, Gnant, Michael ³¹, Makris, Andreas ³², Holtschmidt, Johannes ², Nekljudova, Valentina ², Loibl, Sibylle ^{2, 33, ∗∗}

Source: In Cancer Cell 10 February 2025 43(2):232-247

Multi-platform biomarkers of response to an immune checkpoint inhibitor in the neoadjuvant I-SPY 2 trial for early-stage breast cancer

Authors: Campbell, Michael J. ^{1, 18, ∗}, Wolf, Denise M. ², Yau, Christina ¹, Brown-Swigart, Lamorna ², Wulfkuhle, Julie ³, Gallagher, Isela R. ³, Zhu, Zelos ¹, Bolen, Jennifer ⁴, Vandenberg, Scott ⁵, Hoyt, Clifford ⁶, Mori, Hidetoshi ⁷, Borowsky, Alexander ^{7, 8}, Sit, Laura ¹, Perlmutter, Jane ⁹, Asare, Smita M. ¹⁰, Nanda, Rita ¹¹, Liu, Minetta C. ¹², Yee, Douglas ¹³, DeMichele, Angela M. ¹⁴, Hylton, Nola M. ¹⁵, Pusztai, Lajos ¹⁶, Berry, Donald A. ¹⁷, Hirst, Gillian L. ¹, Petricoin, Emanuel F. ³, Veer, Laura van’t ², Esserman, Laura ¹

Source: In Cell Reports Medicine 19 November 2024 5(11)

Prolonging the life of people with metastatic breast cancer in routine clinical practice by adding palbociclib to an aromatase inhibitor from a real-world database analysis: a plain language summary

Authors: Rugo, Hope S, Brufsky, Adam, Liu, Xianchen, Li, Benjamin, McRoy, Lynn, Chen, Connie, Layman, Rachel M, Cristofanilli, Massimo, Torres, Mylin A, Curigliano, Giuseppe, Finn, Richard S, DeMichele, Angela

Source: Future oncology. 19(7):489-498

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189950695.0x000001&indx=1&recIds=ETOCvdc_100189950695.0x000001

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients

Authors: Adamson, Kathi, Albain, Kathy S., Asare, Adam L., Asare, Smita M., Balassanian, Ron, Beckwith, Heather, Berry, Scott M., Berry, Donald A., Boughey, Judy C., Buxton, Meredith B., Chen, Yunn-Yi, Chen, Beiyun, Chien, A. Jo, Chui, Stephen Y., Clark, Amy S., Clennell, Julia L., Datnow, Brian, DeMichele, Angela M., Duan, Xiuzhen, Edmiston, Kirsten K., Elias, Anthony D., Ellis, Erin D., Esserman, Laura L., Euhus, David M., Fadare, Oluwole, Fan, Fang, Feldman, Michael D, Forero-Torres, Andres, Haley, Barbara B., Han, Hyo S., Harada, Shuko, Haugen, Patricia, Helsten, Teresa, Hirst, Gillian L., Hylton, Nola M., Isaacs, Claudine, Kemmer, Kathleen, Khan, Qamar J., Khazai, Laila, Klein, Molly E., Krings, Gregor, Lang, Julie E., LeBeau, Lauren G., Leyland-Jones, Brian, Liu, Minetta C., Lo, Shelly, Lu, Janice, Magliocco, Anthony, Matthews, Jeffrey B., Melisko, Michelle E., Mhawech-Fauceglia, Paulette, Moulder, Stacy L., Murthy, Rashmi K., Nanda, Rita, Northfelt, Donald W., Ocal, Idris T., Olopade, Olufunmilayo, Pambuccian, Stefan, Paoloni, Melissa, Park, John W., Parker, Barbara A., Perlmutter, Jane, Peterson, Garry, Pusztai, Lajos, Rendi, Mara, Rugo, Hope S., Sahoo, Sunati, Sams, Sharon, Sanil, Ashish, Sattar, Husain, Schwab, Richard B., Singhrao, Ruby, Steeg, Katherine, Stringer-Reasor, Erica, Symmans, W. Fraser, Tawfik, Ossama, Tripathy, Debasish, Troxell, Megan L., van't Veer, Laura J., Venters, Sara J., Vinh, Tuyethoa, Viscusi, Rebecca K., Wallace, Anne M., Wei, Shi, Wilson, Amy, Yau, Christina, Yee, Douglas, Zeck, Jay C., Osdoit, Marie ^*, van der Noordaa, Marieke, Shad, Sonal, Wei, Jane, de Croze, Diane, Hamy, Anne-Sophie, Laé, Marick, Reyal, Fabien, Sonke, Gabe S, Steenbruggen, Tessa G, van Seijen, Maartje, Wesseling, Jelle, Martín, Miguel, del Monte-Millán, Maria, López-Tarruella, Sara, Boughey, Judy C, Goetz, Matthew P, Hoskin, Tanya, Gould, Rebekah, Valero, Vicente, Edge, Stephen B, Abraham, Jean E, Bartlett, John M S, Caldas, Carlos, Dunn, Janet, Earl, Helena, Hayward, Larry, Hiller, Louise, Provenzano, Elena, Sammut, Stephen-John, Thomas, Jeremy S, Cameron, David, Graham, Ashley, Hall, Peter, Mackintosh, Lorna, Godwin, Andrew K, Schwensen, Kelsey, Sharma, Priyanka, DeMichele, Angela M, Cole, Kimberly, Kim, Mi-Ok, van 't Veer, Laura J, Esserman, Laura J, Symmans, W Fraser

Source: In The Lancet Oncology January 2022 23(1):149-160

Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy

Authors: Magbanua, Mark Jesus M., Brown Swigart, Lamorna, Ahmed, Ziad, Sayaman, Rosalyn W., Renner, Derrick, Kalashnikova, Ekaterina, Hirst, Gillian L., Yau, Christina, Wolf, Denise M., Li, Wen, Delson, Amy L., Asare, Smita, Liu, Minetta C., Albain, Kathy, Chien, A. Jo, Forero-Torres, Andres, Isaacs, Claudine, Nanda, Rita, Tripathy, Debu, Rodriguez, Angel, Sethi, Himanshu, Aleshin, Alexey, Rabinowitz, Matthew, Perlmutter, Jane, Symmans, W. Fraser, Yee, Douglas, Hylton, Nola M., Esserman, Laura J., DeMichele, Angela M., Rugo, Hope S., van ’t Veer, Laura J.

Source: In Cancer Cell 12 June 2023 41(6):1091-1102

Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

Authors: Strand, Siri H., Rivero-Gutiérrez, Belén, Houlahan, Kathleen E., Seoane, Jose A., King, Lorraine M., Risom, Tyler, Simpson, Lunden A., Vennam, Sujay, Khan, Aziz, Cisneros, Luis, Hardman, Timothy, Harmon, Bryan, Couch, Fergus, Gallagher, Kristalyn, Kilgore, Mark, Wei, Shi, DeMichele, Angela, King, Tari, McAuliffe, Priscilla F., Nangia, Julie, Lee, Joanna, Tseng, Jennifer, Storniolo, Anna Maria, Thompson, Alastair M., Gupta, Gaorav P., Burns, Robyn, Veis, Deborah J., DeSchryver, Katherine, Zhu, Chunfang, Matusiak, Magdalena, Wang, Jason, Zhu, Shirley X., Tappenden, Jen, Ding, Daisy Yi, Zhang, Dadong, Luo, Jingqin, Jiang, Shu, Varma, Sushama, Anderson, Lauren, Straub, Cody, Srivastava, Sucheta, Curtis, Christina, Tibshirani, Rob, Angelo, Robert Michael, Hall, Allison, Owzar, Kouros, Polyak, Kornelia, Maley, Carlo, Marks, Jeffrey R., Colditz, Graham A., Hwang, E. Shelley, West, Robert B.

Source: In Cancer Cell 12 December 2022 40(12):1521-1536

Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update

Authors: Henry, N. Lynn, Somerfield, Mark R., Dayao, Zoneddy, Elias, Anthony, Kalinsky, Kevin, McShane, Lisa M., Moy, Beverly, Park, Ben Ho, Shanahan, Kelly M., Sharma, Priyanka, Shatsky, Rebecca, Stringer-Reasor, Erica, Telli, Melinda, Turner, Nicholas C., DeMichele, Angela

Source: Journal of clinical oncology. 40(27):3205-3221

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171064974.0x000001&indx=1&recIds=ETOCvdc_100171064974.0x000001

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients

Authors: Yau, Christina, Osdoit, Marie, van der Noordaa, Marieke, Shad, Sonal, Wei, Jane, de Croze, Diane, Hamy, Anne-Sophie, Laé, Marick, Reyal, Fabien, Sonke, Gabe S, Steenbruggen, Tessa G, van Seijen, Maartje, Wesseling, Jelle, Martín, Miguel, del Monte-Millán, Maria, López-Tarruella, Sara, Boughey, Judy C, Goetz, Matthew P, Hoskin, Tanya, Gould, Rebekah, Valero, Vicente, Edge, Stephen B, Abraham, Jean E, Bartlett, John M S, Caldas, Carlos, Dunn, Janet, Earl, Helena, Hayward, Larry, Hiller, Louise, Provenzano, Elena, Sammut, Stephen-John, Thomas, Jeremy S, Cameron, David, Graham, Ashley, Hall, Peter, Mackintosh, Lorna, Fan, Fang, Godwin, Andrew K, Schwensen, Kelsey, Sharma, Priyanka, DeMichele, Angela M, Cole, Kimberly, Pusztai, Lajos, Kim, Mi-Ok, van 't Veer, Laura J, Esserman, Laura J, Symmans, W Fraser

Source: Lancet oncology. 23(1):149-160

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169136967.0x000001&indx=1&recIds=ETOCvdc_100169136967.0x000001

Therapeutische Behandlung der minimalen Resterkrankung zur Verhinderung von Spätrezidiven bei Hormonrezeptor-positivem Brustkrebs: Herausforderungen und neue Ansätze

Authors: Cescon, David W., Kalinsicy, Kevin, Parsons, Heather A., Smith, Karen Lisa, Spears, Patricia A., Thomas, Alexandra, Zhao, Fengmin, DeMichele, Angela

Source: Karger Kompass.Onkologie. 9(2):55-65

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152913919.0x000001&indx=1&recIds=ETOCvdc_100152913919.0x000001

A randomized study of genetic education versus usual care in tumor profiling for advanced cancer in the ECOG‐ACRIN Cancer Research Group (EAQ152)

Authors: Bradbury, Angela R., Lee, Ju‐Whei, Gaieski, Jill Bennett, Li, Shuli, Gareen, Ilana F., Flaherty, Keith T., Herman, Benjamin A., Domchek, Susan M., DeMichele, Angela M., Maxwell, Kara N., Onitilo, Adedayo A., Virani, Shamsuddin, Park, SuJung, Faller, Bryan A., Grant, Stefan C., Ramaekers, Ryan C., Behrens, Robert J., Nambudiri, Gopakumar S., Carlos, Ruth C., Wagner, Lynne I.

Source: Cancer. 128(7):1381-1391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144654284.0x000001&indx=1&recIds=ETOCvdc_100144654284.0x000001

Targeted Therapies, Sequencing Strategies, and Beyond in Metastatic Hormone Receptor–Positive Breast Cancer: ASCO Guideline Clinical Insights.

Authors: Makhlin, Igor, Fallowfield, Lesley, Henry, N. Lynn, Burstein, Harold J., Somerfield, Mark R., DeMichele, Angela

Source: JCO Oncology Practice; Feb2025, Vol. 21 Issue 2, p140-144, 5p

Subject Terms: MEDICAL protocols, PROTEINS, PREDIABETIC state, DIARRHEA, BREAST tumors, ANTINEOPLASTIC agents, CELLULAR signal transduction, TREATMENT effectiveness, METASTASIS, FULVESTRANT, HORMONE therapy, QUALITY of life, PROGRESSION-free survival, CELL receptors, COMORBIDITY, PATIENTS' attitudes, PHARMACODYNAMICS

Company/Entity: AMERICAN Society of Clinical Oncology

Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer.

Authors: Rugo, Hope S., Campbell, Mike, Yau, Christina, Jo Chien, A., Wallace, Anne M., Isaacs, Claudine, Boughey, Judy C., Han, Hyo S., Buxton, Meredith, Clennell, Julia L., Asare, Smita M., Steeg, Katherine, Wilson, Amy, Singhrao, Ruby, Matthews, Jeffrey B., Perlmutter, Jane, Fraser Symmans, W., Hylton, Nola M., DeMichele, Angela M., Yee, Douglas

Source: Breast Cancer Research & Treatment; Feb2025, Vol. 209 Issue 3, p487-492, 6p

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies

Authors: Wolf, Denise M., Yau, Christina, Wulfkuhle, Julia, Brown-Swigart, Lamorna, Gallagher, Rosa I., Lee, Pei Rong Evelyn, Zhu, Zelos, Magbanua, Mark J., Sayaman, Rosalyn, O’Grady, Nicholas, Basu, Amrita, Delson, Amy, Coppé, Jean Philippe, Lu, Ruixiao, Braun, Jerome, Asare, Smita M., Sit, Laura, Matthews, Jeffrey B., Perlmutter, Jane, Hylton, Nola, Liu, Minetta C., Pohlmann, Paula, Symmans, W. Fraser, Rugo, Hope S., Isaacs, Claudine, DeMichele, Angela M., Yee, Douglas, Berry, Donald A., Pusztai, Lajos, Petricoin, Emanuel F., Hirst, Gillian L., Esserman, Laura J., van 't Veer, Laura J.

Source: In Cancer Cell 13 June 2022 40(6):609-623

Impact of deformable registration methods for prediction of recurrence free survival response to neoadjuvant chemotherapy in breast cancer: Results from the ISPY 1/ACRIN 6657 trial

Authors: Thakran, Snekha, Cohen, Eric, Jahani, Nariman, Weinstein, Susan P., Pantalone, Lauren, Hylton, Nola, Newitt, David, DeMichele, Angela, Davatzikos, Christos, Kontos, Despina

Source: In Translational Oncology June 2022 20

Paraoxonase-1 Activity in Breast Cancer Patients Treated With Doxorubicin With or Without Trastuzumab

Authors: Thompson, Elizabeth W., Demissei, Biniyam G., Smith, Amanda M., Brahmbhatt, Priya, Wang, Jessica, Clark, Amy, DeMichele, Angela, Narayan, Vivek, Shah, Payal, Sun, Lova, Lefebvre, Benedicte, Fradley, Michael G., Carver, Joseph R., Tang, W.H. Wilson, Ky, Bonnie

Source: In JACC: Basic to Translational Science January 2022 7(1):1-10

Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial

Authors: Pusztai, Lajos, Yau, Christina, Wolf, Denise M., Han, Hyo S., Du, Lili, Wallace, Anne M., String-Reasor, Erica, Boughey, Judy C., Chien, A. Jo, Elias, Anthony D., Beckwith, Heather, Nanda, Rita, Albain, Kathy S., Clark, Amy S., Kemmer, Kathleen, Kalinsky, Kevin, Isaacs, Claudine, Thomas, Alexandra, Shatsky, Rebecca, Helsten, Theresa L., Forero-Torres, Andres, Liu, Minetta C., Brown-Swigart, Lamorna, Petricoin, Emmanuel F., Wulfkuhle, Julia D., Asare, Smita M., Wilson, Amy, Singhrao, Ruby, Sit, Laura, Hirst, Gillian L., Berry, Scott, Sanil, Ashish, Asare, Adam L., Matthews, Jeffrey B., Perlmutter, Jane, Melisko, Michelle, Rugo, Hope S., Schwab, Richard B., Symmans, W. Fraser, Yee, Doug, van’t Veer, Laura J., Hylton, Nola M., DeMichele, Angela M., Berry, Donald A., Esserman, Laura J.

Source: In Cancer Cell 12 July 2021 39(7):989-998

Palbociclib with adjuvant endocrine therapy in early breast cancer (PALLAS): interim analysis of a multicentre, open-label, randomised, phase 3 study

Authors: Mayer, Erica L ^*, Dueck, Amylou C, Martin, Miguel, Rubovszky, Gabor, Burstein, Harold J, Bellet-Ezquerra, Meritxell, Miller, Kathy D, Zdenkowski, Nicholas, Winer, Eric P, Pfeiler, Georg, Goetz, Matthew, Ruiz-Borrego, Manuel, Anderson, Daniel, Nowecki, Zbigniew, Loibl, Sibylle, Moulder, Stacy, Ring, Alistair, Fitzal, Florian, Traina, Tiffany, Chan, Arlene, Rugo, Hope S, Lemieux, Julie, Henao, Fernando, Lyss, Alan, Antolin Novoa, Silvia, Wolff, Antonio C, Vetter, Marcus, Egle, Daniel, Morris, Patrick G, Mamounas, Eleftherios P, Gil-Gil, Miguel J, Prat, Aleix, Fohler, Hannes, Metzger Filho, Otto, Schwarz, Magdalena, DuFrane, Carter, Fumagalli, Debora, Theall, Kathy Puyana, Lu, Dongrui Ray, Bartlett, Cynthia Huang, Koehler, Maria, Fesl, Christian, DeMichele, Angela, Gnant, Michael

Source: In The Lancet Oncology February 2021 22(2):212-222

A randomized trial of exercise and diet on health‐related quality of life in survivors of breast cancer with overweight or obesity

Authors: Brown, Justin C., Sarwer, David B., Troxel, Andrea B., Sturgeon, Kathleen, DeMichele, Angela M., Denlinger, Crystal S., Schmitz, Kathryn H.

Source: Cancer. 127(20):3856-3864

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132550538.0x000001&indx=1&recIds=ETOCvdc_100132550538.0x000001

Prognostic Factors for Overall Survival in Patients with Hormone Receptor‐Positive Advanced Breast Cancer: Analyses From PALOMA‐3

Authors: Rugo, Hope S., Cristofanilli, Massimo, Loibl, Sybille, Harbeck, Nadia, DeMichele, Angela, Iwata, Hiroji, Park, Yoon Hee, Brufsky, Adam, Theall, Kathy Puyana, Huang, Xin, McRoy, Lynn, Bananis, Eustratios, Turner, Nicholas C.

Source: Oncologist. 26(8):e1339-e1346

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100124811183.0x000001&indx=1&recIds=ETOCvdc_100124811183.0x000001

Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors

Authors: Charo, Lindsey M., Homer, Michael V., Natarajan, Loki, Haunschild, Carolyn, Chung, Karine, Mao, Jun J., DeMichele, Angela M., Su, H. Irene

Source: Journal of obstetrics and gynaecology. 41(3):447-452

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121164671.0x000001&indx=1&recIds=ETOCvdc_100121164671.0x000001