Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo

Authors: O'Brien, Robert, DeGiacomo, Francesco, Holcomb, Jennifer, Bonner, Akilah, Ring, Karen L., Zhang, Ningzhe, Zafar, Khan, Weiss, Andreas, Lager, Brenda, Schilling, Birgit, Gibson, Bradford W., Chen, Sylvia, Kwak, Seung, Ellerby, Lisa M.

Source: In Journal of Biological Chemistry 31 July 2015 290(31):19287-19306

Mass Spectrometric Identification of Novel Lysine Acetylation Sites in Huntingtin

Authors: Cong, Xin ^‡, Held, Jason M. ^‡, DeGiacomo, Francesco ^‡, Bonner, Akilah ^‡, Chen, Jan Marie ^‡, Schilling, Birgit ^‡, Czerwieniec, Gregg A. ^‡, Gibson, Bradford W. ^{‡, §}, Ellerby, Lisa M. ^{‡, §}

Source: In Molecular & Cellular Proteomics October 2011 10(10)

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

Authors: Leyva, Melissa J., DeGiacomo, Francesco, Kaltenbach, Linda S., Holcomb, Jennifer, Zhang, Ningzhe, Gafni, Juliette, Park, Hyunsun, Lo, Donald C., Salvesen, Guy S., Ellerby, Lisa M., Ellman, Jonathan A.

Source: In Chemistry & Biology 2010 17(11):1189-1200

A Genome-Scale RNA--Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease.

Authors: Miller, John P.¹, Yates, Bridget E.¹, Al-Ramahi, Ismael², Berman, Ari E.¹, Sanhueza, Mario², Kim, Eugene², de Haro, Maria², DeGiacomo, Francesco¹, Torcassi, Cameron¹, Holcomb, Jennifer¹, Gafni, Juliette¹, Mooney, Sean D.¹, Botas, Juan², Ellerby, Lisa M.¹, lellerby@buckinstitute.org, Hughes, Robert E.¹, rhughes@buckinstitute.org

Source: PLoS Genetics; Nov2012, Vol. 8 Issue 11, Special section p1-22, 22p, 1 Color Photograph, 1 Diagram, 2 Charts, 5 Graphs

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Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington’s Disease Models

Authors: Leyva, Melissa J., DeGiacomo, Francesco, Kaltenbach, Linda S., Holcomb, Jennifer, Zhang, Ningzhe, Gafni, Juliette, Park, Hyunsun, Lo, Donald C., Salvesen, Guy S., Ellerby, Lisa M., Ellman, Jonathan A.

Source: In Chemistry & Biology 23 May 2013 20(5):742-742

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