The Evolving Landscape in Multiple Myeloma: From Risk Stratification to T Cell-Directed Advanced Therapies.

Authors: Besliu, Carmen, Tanase, Alina Daniela, Rotaru, Ionela, Espinoza, Jose, Vidal, Laura, Poelman, Martine, Juan, Manel, de Larrea, Carlos Fernández, Saini, Kamal S.

Source: Cancers; Feb2025, Vol. 17 Issue 3, p525, 19p

Subject Terms: MULTIPLE myeloma, RISK assessment, T cells, CANCER relapse, IMMUNOTHERAPY, CELLULAR therapy, DISEASE risk factors

Clinical significance of complete remission and measurable residual disease in relapsed/refractory multiple myeloma patients treated with T‐cell redirecting immunotherapy.

Authors: Zabaleta, Aintzane, Puig, Noemi, Cedena, Maria‐Teresa, Oliver‐Caldes, Aina, Perez, José J., Moreno, Cristina, Tamariz‐Amador, Luis‐Esteban, Rodriguez‐Otero, Paula, Prosper, Felipe, Gonzalez‐Calle, Veronica, López‐Corral, Lucía, Rey‐Búa, Beatriz, Puertas, Borja, Mirás, Fátima, Sánchez‐Pina, José María, López‐Muñoz, Nieves, Juan, Manel, González‐Navarro, E. Azucena, Urbano, Álvaro, de Larrea, Carlos Fernández

Source: American Journal of Hematology; Jan2025, Vol. 100 Issue 1, p93-102, 10p

MM-374 Efficacy and Safety of Elranatamab in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) and Prior B-Cell Maturation Antigen (BCMA)-Directed Therapies: Pooled Analysis From MagnetisMM Studies

Authors: Nooka, Ajay K., Lesokhin, Alexander M., Mohty, Mohamad, Niesvizky, Ruben, Maisel, Christopher, Arnulf, Bertrand, Larson, Sarah M., Varshavsky-Yanovsky, Asya Nina, Leleu, Xavier, Karlin, Lionel, Vesole, David H., Bahlis, Nizar J., de Larrea, Carlos Fernández, Raje, Noopur, Leip, Eric, Conte, Umberto, Elmeliegy, Mohamed, Viqueira, Andrea, Manier, Salomon

Source: Clinical lymphoma, myeloma & leukemia. 23(S1):S496-S497

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196309882.0x000001&indx=1&recIds=ETOCvdc_100196309882.0x000001

Ibrutinib for patients with rituximab-refractory Waldenström's macroglobulinaemia (iNNOVATE): an open-label substudy of an international, multicentre, phase 3 trial

Authors: Dimopoulos, Meletios A, Trotman, Judith, Tedeschi, Alessandra, Matous, Jeffrey V, Macdonald, David, Tam, Constantine, Tournilhac, Olivier, Ma, Shuo, Oriol, Albert, Heffner, Leonard T, Shustik, Chaim, García-Sanz, Ramón, Cornell, Robert F, de Larrea, Carlos Fernández, Castillo, Jorge J, Granell, Miquel, Kyrtsonis, Marie-Christine, Leblond, Veronique, Symeonidis, Argiris, Kastritis, Efstathios, Singh, Priyanka, Li, Jianling, Graef, Thorsten, Bilotti, Elizabeth, Treon, Steven, Buske, Christian

Source: In The Lancet Oncology February 2017 18(2):241-250

Enzymatic activities of circulating plasma proteasomes in newly diagnosed multiple myeloma patients treated with carfilzomib, lenalidomide and dexamethasone

Authors: Manasanch, Elisabet E., de Larrea, Carlos Fernández, Zingone, Adriana, Steinberg, Seth M., Kwok, Mary, Tageja, Nishant, Bhutani, Manisha, Kazandjian, Dickran, Roschewski, Mark, Wu, Peter, Carter, George, Zuchlinski, Diamond, Mulquin, Marcia, Lamping, Liz, Costello, Rene, Burton, Deborah, Gil, Lindsay A., Figg, William D., Maric, Irina, Calvo, Katherine R., Yuan, Constance, Stetler-Stevenson, Maryalice, Korde, Neha, Landgren, Ola

Source: Leukemia & lymphoma. 58(3):639-645

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100049435949.0x000001&indx=1&recIds=ETOCvdc_100049435949.0x000001

P-154: Incidence and prognosis of renal failure in multiple myeloma: 50-years experience from an academic institution

Authors: Rosiñol, Laura, Concu, Claudia, Cibeira, M Teresa, de Larrea, Carlos Fernández, Quintana, Luix, Tovar, Natalia, Jiménez-Segura, Raquel, Rodríguez-Lobato, Luis Gerardo, Moreno, David F, Oliver-Caldés, Aina, Blade, Joan

Source: Clinical lymphoma, myeloma & leukemia. 22(S):S119-S120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170830621.0x000001&indx=1&recIds=ETOCvdc_100170830621.0x000001

POSTER: MM-374 Efficacy and Safety of Elranatamab in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) and Prior B-Cell Maturation Antigen (BCMA)- Directed Therapies: Pooled Analysis From MagnetisMM Studies

Authors: Nooka, Ajay K., Lesokhin, Alexander M., Mohty, Mohamad, Niesvizky, Ruben, Maisel, Christopher, Arnulf, Bertrand, Larson, Sarah M., Varshavsky-Yanovsky, Asya Nina, Leleu, Xavier, Karlin, Lionel, Vesole, David H., Bahlis, Nizar J., de Larrea, Carlos Fernández, Raje, Noopur, Leip, Eric, Conte, Umberto, Elmeliegy, Mohamed, Viqueira, Andrea, Manier, Salomon

Source: Clinical lymphoma, myeloma & leukemia. 23(S1):S219-S219

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196317837.0x000001&indx=1&recIds=ETOCvdc_100196317837.0x000001

The Changing Landscape of Smoldering Multiple Myeloma: A European Perspective

Authors: Caers, Jo, de Larrea, Carlos Fernández, Leleu, Xavier, Heusschen, Roy, Zojer, Niklas, Decaux, Olivier, Kastritis, Efstathios, Minnema, Monique, Jurczyszyn, Artur, Beguin, Yves

Source: Oncologist. 21(3):333-342

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605505129&indx=1&recIds=ETOCRN605505129

International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)

Authors: Mateos, María-Victoria, Kumar, Shaji, Dimopoulos, Meletios A., González-Calle, Verónica, Kastritis, Efstathios, Hajek, Roman, De Larrea, Carlos Fernández, Morgan, Gareth J., Merlini, Giampaolo, Goldschmidt, Hartmut, Geraldes, Catarina, Gozzetti, Alessandro, Kyriakou, Charalampia, Garderet, Laurent, Hansson, Markus, Zamagni, Elena, Fantl, Dorotea, Leleu, Xavier, Kim, Byung-Su, Esteves, Graça, Ludwig, Heinz, Usmani, Saad, Min, Chang-Ki, Qi, Ming, Ukropec, Jon, Weiss, Brendan M., Rajkumar, S. Vincent, Durie, Brian G. M., San-Miguel, Jesús

Source: Blood cancer journal. 10(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100175963982.0x000001&indx=1&recIds=ETOCvdc_100175963982.0x000001

A practical approach to the diagnosis of systemic amyloidoses

Authors: de Larrea, Carlos Fernández, Verga, Laura, Morbini, Patrizia, Klersy, Catherine, Lavatelli, Francesca, Foli, Andrea, Obici, Laura, Milani, Paolo, Capello, Gian Luca, Paulli, Marco

Source: Blood. 125(14):2239-2244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601729671&indx=1&recIds=ETOCRN601729671

How I treat relapsed myeloma

Authors: Bladé, Joan, Rosiñol, Laura, de Larrea, Carlos Fernández

Source: Blood. 125(10):1532-1540

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600221642&indx=1&recIds=ETOCRN600221642

P-155: Paraskeletal and extramedullary plasmacytomas in multiple myeloma at diagnosis and at first relapse: 49-years experience from an academic institution

Authors: Rosiñol, Laura, Jiménez-Segura, Raquel, Cibeira, M Teresa, de Larrea, Carlos Fernández, Tovar, Natalia, Rodríguez-Lobato, Luis Gerardo, Bladé, Esther, Moreno, David F, Oliver-Caldés, Aina, Blade, Joan

Source: Clinical lymphoma, myeloma & leukemia. 22(S):S120-S120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169001211.0x000001&indx=1&recIds=ETOCvdc_100169001211.0x000001

The effect of Bacille Calmette-Guérin vaccine on tuberculin reactivity in indigenous children from communities with high prevalence of tuberculosis

Authors: Araujo, Zaida, de Waard, Jacobus Henri, de Larrea, Carlos Fernández, Borges, Rafael, Convit, Jacinto

Source: In Vaccine 2008 26(44):5575-5581

P-311 Survival of patients with relapsed/refractory multiple myeloma receiving palliative therapy with cyclophosphamide/ prednisone: results in 346 patients from a single institution over the last 50 years

Authors: Rosinol, Laura, de Larrea, Carlos Fernández, Cibeira, Maria Teresa, Rodriguez-Lobato, Luis Gerardo, Tovar, Natalia, Moreno, David, Bladé, Joan

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S209-S210

P-120 Impact of exclusion from clinical trials in non-candidate transplant patients with newly diagnosed multiple myeloma

Authors: Rodriguez-Lobato, Luis Gerardo, de Daniel i Bisbe, Anna, Tovar, Natalia, de Larrea, Carlos Fernández, Cibeira, Maria Teresa, Jimenez-Segura, Raquel, Moreno, David, Oliver-Caldes, Aina, Bladé, Joan, Rosinol, Laura

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S101-S102

OA-45 Pharmacokinetic and correlative analysis of ciltacabtagene autoleucel in patients with lenalidomide-refractory multiple myeloma in the CARTITUDE-4 trial

Authors: de Larrea, Carlos Fernández, Harrison, Simon, Martinez-Lopez, Joaquín, Mateos, Maria-Victoria, Oriol, Albert, van de Donk, Niels, Purtill, Duncan, Benjamin, Reuben, Cavo, Michele, Corradini, Paolo, Dytfeld, Dominik, Li, Katherine, Banerjee, Arnob, Chang, Shirley Shih-Yu, Jaiprasart, Pharavee, Slaughter, Ana, Lonardi, Carolina, Schecter, Jordan, Deraedt, William, Chen, Diana, Yeh, Tzu-min, Patel, Nitin, Geng, Dong, Min, Chang-Ki, Strouse, Christopher

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S28-S28

Diagnostic Potential of the Serological Response to Synthetic Peptides from Mycobacterium tuberculosis Antigens for Discrimination Between Active and Latent Tuberculosis Infections.

Authors: Araujo, Zaida, de Waard, Jacobus H., Camargo, Milena, Lopez-Ramos, Juan Ernesto, de Larrea, Carlos Fernández, Vanegas, Magnolia, Patarroyo, Manuel A.

Source: International Journal of Peptide Research & Therapeutics; May2022, Vol. 28 Issue 3, p1-12, 12p

15 - Toxicidad hematológica

Authors: Cibeira López, M.ª Teresa, de Larrea, Carlos Fernández

Source: In Toxicología clínica 2019:89-94

Extensive soft-tissue involvement by plasmablastic myeloma arising from displaced humeral fractures de Larrea et al. Bilateral plasmablastic myeloma arising from humeral fractures.

Authors: De Larrea, Carlos Fernández¹, Rosiñol, Laura¹, Cibeira, María Teresa¹, Rozman, María², Rovira, Montserrat¹, Bladé, Joan¹ jblade@clinic.ub.es

Source: European Journal of Haematology. Nov2010, Vol. 85 Issue 5, p448-451. 4p. 2 Color Photographs, 2 Black and White Photographs.

Subject Terms: *CASE studies, *PLASMACYTOMA, *MULTIPLE myeloma treatment, *STEM cell transplantation, *CYCLOPHOSPHAMIDE, *DEXAMETHASONE, *THERAPEUTICS

Generalized cutis laxa and fibrillar glomerulopathy resulting from IgG Deposition in IgG-lambda Monoclonal Gammopathy: pulmonary hemorrhage during stem cell mobilization and complete hematological response with bortezomib and dexamethasone therapy.

Authors: de Larrea, Carlos Fernández¹, Rovira, Montserrat¹, Mascaró Jr., José M.², Torras, Albert³, Sol, Manel⁴, Lloreta, Josep⁵, Serra, Núria³, Cibeira, Maria Teresa¹, Bladé, Joan¹ jblade@clinic.ub.es

Source: European Journal of Haematology. Feb2009, Vol. 82 Issue 2, p154-158. 5p. 3 Color Photographs.

Subject Terms: *CASE studies, *NEPHROTIC syndrome diagnosis, *IMMUNOGLOBULIN G, *MONOCLONAL gammopathies, *STEM cell transplantation, *COLONY-stimulating factors (Physiology), *BONE marrow transplantation