Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications

Authors: Gomez, Ivana M., Uriarte, Maia, Fernandez, Gimena, Barrile, Franco, Castrogiovanni, Daniel, Cantel, Sonia, Fehrentz, Jean-Alain, De Francesco, Pablo N., Perello, Mario

Source: In Molecular Metabolism December 2024 90

Ghrelin’s orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation

Authors: Barrile, Franco, Cassano, Daniela, Fernandez, Gimena, De Francesco, Pablo N., Reynaldo, Mirta, Cantel, Sonia, Fehrentz, Jean-Alain, Donato, José, Jr, Schiöth, Helgi B., Zigman, Jeffrey M., Perello, Mario

Source: In Psychoneuroendocrinology October 2023 156

Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Authors: Fittipaldi, Antonela S., Castrogiovanni, Daniel, Lufrano, Daniela, Saenz, Camila, De Francesco, Pablo N., Lalonde, Tyler, Luyt, Leonard G., Cantel, Sonia, Fehrentz, Jean-Alain, Andreoli, María F., Perello, Mario

Source: In Life Sciences 15 January 2023 313

The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond

Authors: Perelló, Mario, Cornejo, María P., De Francesco, Pablo N., Fernandez, Gimena, Gautron, Laurent, Valdivia, Lesly S.

Source: In IBRO Neuroscience Reports June 2022 12:228-239

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice

Authors: Aguggia, Julieta P., Cornejo, María P., Fernandez, Gimena, De Francesco, Pablo N., Mani, Bharath K., Cassano, Daniela, Cabral, Agustina, Valdivia, Spring, García Romero, Guadalupe, Reynaldo, Mirta, Fehrentz, Jean-Alain, Zigman, Jeffrey M., Perello, Mario

Source: In Psychoneuroendocrinology May 2022 139

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Authors: Uriarte, Maia, De Francesco, Pablo N., Fernández, Gimena, Castrogiovanni, Daniel, D'Arcangelo, Micaela, Imbernon, Mónica, Cantel, Sonia, Denoyelle, Severine, Fehrentz, Jean-Alain, Praetorius, Jeppe, Prevot, Vincent, Perello, Mario

Source: In Molecular and Cellular Endocrinology 1 December 2021 538

THE INTRIGUING LIGAND-DEPENDENT AND LIGAND-INDEPENDENT ACTIONS OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR ON REWARD-RELATED BEHAVIORS

Authors: Cornejo, María P., Mustafá, Emilio R., Barrile, Franco, Cassano, Daniela, De Francesco, Pablo N., Raingo, Jesica, Perello, Mario ^*

Source: In Neuroscience and Biobehavioral Reviews January 2021 120:401-416

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain.

Authors: Saenz, Camila, Fernandez, Gimena, Llovera, Ramiro, Tolosa, María J., Cantel, Sonia, Fehrentz, Jean-Alain, Mackie, Kenneth, Leggio, Lorenzo, Zigman, Jeffrey, De Francesco, Pablo N., Perello, Mario

Source: Brain Structure & Function; Jan2025, Vol. 230 Issue 1, p1-25, 25p

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor–dependent manner

Authors: Cabral, Agustina, Fernandez, Gimena, Tolosa, María J., Rey Moggia, Ángeles, Calfa, Gastón, De Francesco, Pablo N., Perello, Mario

Source: In Molecular Metabolism February 2020 32:69-84

Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region

Authors: Barrile, Franco, M'Kadmi, Céline, De Francesco, Pablo N., Cabral, Agustina, García Romero, Guadalupe, Mustafá, Emilio R., Cantel, Sonia, Damian, Marjorie, Mary, Sophie, Denoyelle, Séverine, Banères, Jean-Louis, Marie, Jacky, Raingo, Jesica, Fehrentz, Jean-Alain, Perelló, Mario

Source: In Molecular and Cellular Endocrinology 1 December 2019 498

LEAP2 is associated with impulsivity and reward sensitivity depending on the nutritional status and decreases with protein intake in humans.

Authors: Andreoli, María F., Kruger, Ana Luz, Sokolov, Aleksandr V., Rukh, Gull, De Francesco, Pablo N., Perello, Mario, Schiöth, Helgi B.

Source: Diabetes, Obesity & Metabolism; Oct2024, Vol. 26 Issue 10, p4734-4743, 10p

Subject Terms: REWARD (Psychology), ANTIMICROBIAL peptides, SINGLE nucleotide polymorphisms, FOOD consumption, BODY mass index

Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner.

Authors: Andreoli, María F., Fittipaldi, Antonela S., Castrogiovanni, Daniel, De Francesco, Pablo N., Valdivia, Spring, Heredia, Florencia, Ribet-Travers, Carole, Mendez, Ignacio, Fasano, María V., Schioth, Helgi B., Doi, Suhail A., Habib, Abdella M., Perello, Mario

Source: European Journal of Nutrition; Apr2024, Vol. 63 Issue 3, p751-762, 12p

Subject Terms: GLUCOSE metabolism, STATISTICAL correlation, FOOD consumption, RESEARCH funding, SEX distribution, ANTIMICROBIAL peptides, HUNGER, APPETITE, PEPTIDE hormones, DESCRIPTIVE statistics, GENE expression, PRE-tests & post-tests, GHRELIN, BLOOD plasma, RESEARCH, FOOD habits, LIVER, CONFIDENCE intervals, FASTING, BREAKFASTS, OBESITY

Escalation in high fat intake in a binge eating model differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling

Authors: Valdivia, Spring, Cornejo, María P., Reynaldo, Mirta, De Francesco, Pablo N., Perello, Mario

Source: In Psychoneuroendocrinology October 2015 60:206-216

Fabry disease peripheral blood immune cells release inflammatory cytokines: Role of globotriaosylceramide

Authors: De Francesco, Pablo N., Mucci, Juan M., Ceci, Romina, Fossati, Carlos A., Rozenfeld, Paula A.

Source: In Molecular Genetics and Metabolism May 2013 109(1):93-99

Higher apoptotic state in Fabry disease peripheral blood mononuclear cells.: Effect of globotriaosylceramide

Authors: De Francesco, Pablo N., Mucci, Juan M., Ceci, Romina, Fossati, Carlos A., Rozenfeld, Paula A.

Source: In Molecular Genetics and Metabolism November 2011 104(3):319-324

Brain accessibility delineates the central effects of circulating ghrelin

Authors: Perello, Mario, Cabral, Agustina, Cornejo, María P., De Francesco, Pablo N., Fernandez, Gimena, Uriarte, Maia

Source: Journal of neuroendocrinology. 31(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087302577.0x000001&indx=1&recIds=ETOCvdc_100087302577.0x000001

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.

Authors: Fernandez, Gimena, Cabral, Agustina, De Francesco, Pablo N., Uriarte, Maia, Reynaldo, Mirta, Castrogiovanni, Daniel, Zubiría, Guillermina, Giovambattista, Andrés, Cantel, Sonia, Denoyelle, Severine, Fehrentz, Jean-Alain, Tolle, Virginie, Schiöth, Helgi B., Perello, Mario

Source: Cellular & Molecular Life Sciences; May2022, Vol. 79 Issue 5, p1-17, 17p

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction

Authors: Aguggia, Julieta, Fernandez, Gimena, Cassano, Daniela, Mustafá, Emilio R, Rodríguez, Silvia S, Cantel, Sonia, Fehrentz, Jean-Alain, Raingo, Jesica, Schiöth, Helgi B, Habib, Abdella M, De Francesco, Pablo N, Perello, Mario

Source: Endocrinology; January 2025, Vol. 166 Issue: 1

Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance.

Authors: Fittipaldi, Antonela S., Hernández, Julieta, Castrogiovanni, Daniel, Lufrano, Daniela, De Francesco, Pablo N., Garrido, Verónica, Vitaux, Patrick, Fasano, María Victoria, Fehrentz, Jean-Alain, Fernández, Adriana, Andreoli, María F., Perello, Mario

Source: European Journal of Endocrinology; Feb2020, Vol. 182 Issue 2, p165-175, 11p

Subject Terms: GHRELIN, CHILDHOOD obesity, INSULIN resistance, GHRELIN receptors, CHILDREN, AGE

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