Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted

Authors: Acar, Delphine Diana, Witkowski, Wojciech, Wejda, Magdalena, Wei, Ruifang, Desmet, Tim, Schepens, Bert, De Cae, Sieglinde, Sedeyn, Koen, Eeckhaut, Hannah, Fijalkowska, Daria, Roose, Kenny, Vanmarcke, Sandrine, Poupon, Anne, Jochmans, Dirk, Zhang, Xin, Abdelnabi, Rana, Foo, Caroline S., Weynand, Birgit, Reiter, Dirk, Callewaert, Nico, Remaut, Han, Neyts, Johan, Saelens, Xavier, Gerlo, Sarah, Vandekerckhove, Linos

Source: In eBioMedicine February 2024 100

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models.

Authors: Schepens, Bert, van Schie, Loes, Nerinckx, Wim, Roose, Kenny, Van Breedam, Wander, Fijalkowska, Daria, Devos, Simon, Weyts, Wannes, De Cae, Sieglinde, Vanmarcke, Sandrine, Lonigro, Chiara, Eeckhaut, Hannah, Van Herpe, Dries, Borloo, Jimmy, Oliveira, Ana Filipa, Catani, João Paulo Portela, Creytens, Sarah, De Vlieger, Dorien, Michielsen, Gitte, Marchan, Jackeline Cecilia Zavala

Source: Science Translational Medicine; 11/24/2021, Vol. 13 Issue 621, p1-17, 17p

Subject Terms: MONOCLONAL antibodies, COVID-19, ANGIOTENSIN converting enzyme, SARS-CoV-2, CORONAVIRUS disease treatment, CHO cell, VIRAL antibodies, IMMUNOGLOBULINS