Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells

Authors: Karoline F. Troch, Manuel O. Jakob, Patrycja M. Forster, Katja J. Jarick, Jonathan Schreiber, Alexandra Preusser, Gabriela M. Guerra, Pawel Durek, Caroline Tizian, Nele Sterczyk, Sofia Helfrich, Claudia U. Duerr, David Voehringer, Mario Witkowski, David Artis, Tim Rollenske, Andrey A. Kruglov, Mir-Farzin Mashreghi, Christoph S. N. Klose

Source: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/dd935caff54143fd88f4d75ee1b90bea

Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis

Authors: Reyes Gámez-Belmonte, Yara Wagner, Mousumi Mahapatro, Ru Wang, Lena Erkert, Miguel González-Acera, Roodline Cineus, Saskia Hainbuch, Jay V. Patankar, David Voehringer, Ahmed N. Hegazy, Markus F. Neurath, Stefan Wirtz, Christoph Becker

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Intestinal homeostasis, Gut pathology, Gasdermin, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b1384b9584bd49dc96d572989f1a8151

Dominant immune tolerance in the intestinal tract imposed by RelB-dependent migratory dendritic cells regulates protective type 2 immunity

Authors: Anna-Lena Geiselhöringer, Daphne Kolland, Arisha Johanna Patt, Linda Hammann, Amelie Köhler, Luisa Kreft, Nina Wichmann, Miriam Hils, Christiane Ruedl, Marc Riemann, Tilo Biedermann, David Anz, Andreas Diefenbach, David Voehringer, Carsten B. Schmidt-Weber, Tobias Straub, Maria Pasztoi, Caspar Ohnmacht

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4cfef856783040f8968990d1cb8edde1

Signaling events driving Aspergillus fumigatus-induced eosinophil activation

Authors: Jasmin Adam, Lisa-Marie Graf, Stefanie Westermann, David Voehringer, Sven Krappmann

Source: International Journal of Medical Microbiology, Vol 318, Iss , Pp 151641- (2025)

Subject Terms: Allergic bronchopulmonary aspergillosis, Allergic lung inflammation, Granulocytes, Src, PI3K, Microbiology, QR1-502, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1438422124000456; https://doaj.org/toc/1438-4221

Access URL: https://doaj.org/article/1267c6bf979540a5b7ce4420310b96dd

Eosinophil extracellular vesicles and DNA traps in allergic inflammation

Authors: Tobias Weihrauch, Rossana C. N. Melo, Natalie Gray, David Voehringer, Peter F. Weller, Ulrike Raap

Source: Frontiers in Allergy, Vol 5 (2024)

Subject Terms: extracellular vesicles, eosinophil activation, sombrero vesicles, EETosis, inflammation, eosinophilic diseases, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/falgy.2024.1448007/full; https://doaj.org/toc/2673-6101

Access URL: https://doaj.org/article/e5c1d49cbf854c44bf03eea28a725a93

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Authors: Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett, Aline Bozec

Source: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5da2f219e2984371a8d14992bdd17d44

Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

Authors: Shun Li, Florian olde Heuvel, Rida Rehman, Oumayma Aousji, Albrecht Froehlich, Zhenghui Li, Rebecca Jark, Wanhong Zhang, Alison Conquest, Sarah Woelfle, Michael Schoen, Caitlin C. O´Meara, Richard Lee Reinhardt, David Voehringer, Jan Kassubek, Albert Ludolph, Markus Huber-Lang, Bernd Knöll, Maria Cristina Morganti-Kossmann, Marisa M. Brockmann, Tobias Boeckers, Francesco Roselli

Source: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a6966d3478aa47859f429edf593265f2

Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development

Authors: Acelya Yilmazer, Dimitra Maria Zevla, Rikke Malmkvist, Carlos Alejandro Bello Rodríguez, Pablo Undurraga, Emre Kirgin, Marie Boernert, David Voehringer, Olivia Kershaw, Susan Schlenner, Karsten Kretschmer

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: immune tolerance, autoimmunity, scurfy, diabetes, T cell development, pTreg, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298938/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8e7a3d9fd837449e8611dbef2c6c1dc5

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Authors: Régis Joulia, Idaira María Guerrero-Fonseca, Tamara Girbl, Jonathon A. Coates, Monja Stein, Laura Vázquez-Martínez, Eleanor Lynam, James Whiteford, Michael Schnoor, David Voehringer, Axel Roers, Sussan Nourshargh, Mathieu-Benoit Voisin

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/84b97690afca49fa86cbd85337ff0f72

Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection.

Authors: Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer

Source: PLoS Pathogens, Vol 19, Iss 4, p e1011296 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/3b4c9a548be54e7a81c549bf420874b9

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

Authors: Judith Schick, Meltem Altunay, Matthew Lacorcia, Nathalie Marschner, Stefanie Westermann, Julia Schluckebier, Christoph Schubart, Barbara Bodendorfer, Dennis Christensen, Christian Alexander, Stefan Wirtz, David Voehringer, Clarissa Prazeres da Costa, Roland Lang

Source: eLife, Vol 12 (2023)

Subject Terms: co-infection, Th cell differentiation, Nippostrongylus brasiliensis, Schistosoma mansoni, mycobacterial cord factor, C-type lectin receptors, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/72923; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/5ae7b59983a44ed9bd8dcf86dc279bbf

B cell fate mapping reveals their contribution to the memory immune response against helminths

Authors: Paul Haase, Simon Schäfer, Roman G. Gerlach, Thomas H. Winkler, David Voehringer

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: germinal center, plasma cells, fate mapping, helminths, memory responses, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016142/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d5baa4c8213a465abe0f3892b0e19eaf

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice

Authors: Daniel Radtke, Natalie Thuma, Christine Schülein, Philipp Kirchner, Arif B Ekici, Kilian Schober, David Voehringer

Source: eLife, Vol 11 (2022)

Subject Terms: Th2 cells, TCR repertoire, scRNAseq, gene expression, helminth infection, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/74183; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/37738b53d937450197cf738e8ff9bae9

A newly identified secreted larval antigen elicits basophil-dependent protective immunity against N. brasiliensis infection

Authors: Natalie Thuma, Daniela Döhler, Dirk Mielenz, Heinrich Sticht, Daniel Radtke, Lena Reimann, Bettina Warscheid, David Voehringer

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: hookworms, basophils, SCP/TAPS protein, CAP domain, immunization, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.979491/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/06fd5f6d76fa48ee81f6ad6763de2d1a

Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling

Authors: Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jürgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer

Source: mBio, Vol 13, Iss 4 (2022)

Subject Terms: eosinophils, Aspergillus fumigatus, phosphatidylinositol-3-kinase, Toll-like receptor, C-type lectin receptor, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/92daf7c4ba564f7e9c3b9b84d49251f7

Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes

Authors: Marie Wiedemann, David Voehringer

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: nematode, trematode, immunomodulation, type 2 immunity, parasites, schistosomes, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.572865/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/22cc24036b0a49f58e25806d0e1e1b68

The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment

Authors: Henrik Einwächter, Alexander Heiseke, Andreas Schlitzer, Georg Gasteiger, Heiko Adler, David Voehringer, Markus G. Manz, Zsolt Ruzsics, Lars Dölken, Ulrich H. Koszinowski, Tim Sparwasser, Wolfgang Reindl, Stefan Jordan

Source: Frontiers in Immunology, Vol 11 (2020)

Subject Terms: infection, inflammation, erythropoietin, dendritic cell, extramedullary hematopoiesis, TER119, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2020.01627/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/383234907d7a4f3ca0318070749c03a8

Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Authors: Kumi Izawa, Akie Maehara, Masamichi Isobe, Yuka Yasuda, Makoto Urai, Yasutaka Hoshino, Keigo Ueno, Toshihiro Matsukawa, Mariko Takahashi, Ayako Kaitani, Emiko Shiba, Ayako Takamori, Shino Uchida, Koichiro Uchida, Keiko Maeda, Nobuhiro Nakano, Yoshinori Yamanishi, Toshihiko Oki, David Voehringer, Axel Roers, Susumu Nakae, Junko Ishikawa, Yuki Kinjo, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Toshio Kitamura, Jiro Kitaura

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/aa59ba0107c3416ea07d058e0838adee

Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

Authors: Mark David Hayes, Sophie Ward, Greg Crawford, Rocio Castro Seoane, William David Jackson, David Kipling, David Voehringer, Deborah Dunn-Walters, Jessica Strid

Source: eLife, Vol 9 (2020)

Subject Terms: skin, IgE, epithelial cells, inflammation, cancer, basophils, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/51862; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/0b0bfa2ee5464967811018518a8262c3

Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains.

Authors: Alex Steimle, Sarah Menz, Annika Bender, Brianna Ball, Alexander N R Weber, Thomas Hagemann, Anna Lange, Jan K Maerz, Raphael Parusel, Lena Michaelis, Andrea Schäfer, Hans Yao, Hanna-Christine Löw, Sina Beier, Mehari Tesfazgi Mebrhatu, Kerstin Gronbach, Samuel Wagner, David Voehringer, Martin Schaller, Birgit Fehrenbacher, Ingo B Autenrieth, Tobias A Oelschlaeger, Julia-Stefanie Frick

Source: PLoS Biology, Vol 17, Iss 6, p e3000334 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/25a28d77ce84464a8ca7a455fcb19ac4