A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

Authors: Roya Yousefi, Luis Daniel Cruz-Zaragoza, Anusha Valpadashi, Carina Hansohn, Drishan Dahal, Ricarda Richter-Dennerlein, Silvio Rizzoli, Henning Urlaub, Peter Rehling, David Pacheu-Grau

Source: Cell Reports, Vol 44, Iss 1, Pp 115143- (2025)

Subject Terms: CP: Metabolism, CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724014943; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/599ecb1a27b44baab950134a6a13524d

Identification and characterization of a new pathologic mutation in a large Leber hereditary optic neuropathy pedigree

Authors: Sonia Emperador, Mouna Habbane, Ester López-Gallardo, Alejandro del Rio, Laura Llobet, Javier Mateo, Ana María Sanz-López, María José Fernández-García, Hortensia Sánchez-Tocino, Sol Benbunan-Ferreiro, María Calabuig-Goena, Carlos Narvaez-Palazón, Beatriz Fernández-Vega, Hector González-Iglesias, Roser Urreizti, Rafael Artuch, David Pacheu-Grau, Pilar Bayona-Bafaluy, Julio Montoya, Eduardo Ruiz-Pesini

Source: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-10 (2024)

Subject Terms: Leber hereditary optic neuropathy, Mitochondrial DNA, Pathologic mutation, Large pedigree, Incomplete penetrance, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/6e3b9de78c4e4071ad94d231642e4ed6

Is population frequency a useful criterion to assign pathogenicity to newly described mitochondrial DNA variants?

Authors: M. Pilar Bayona-Bafaluy, Ester López-Gallardo, Sonia Emperador, David Pacheu-Grau, Julio Montoya, Eduardo Ruiz-Pesini

Source: Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-4 (2022)

Subject Terms: Mitochondrial DNA, Pathological variants, Population frequency, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/70a53b9337a44c7882f306eb3cf15732

Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy

Authors: Marie-Christine Reinert, David Pacheu-Grau, Claudia B. Catarino, Thomas Klopstock, Andreas Ohlenbusch, Michael Schittkowski, Ekkehard Wilichowski, Peter Rehling, Knut Brockmann

Source: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-8 (2021)

Subject Terms: Sulthiame, Carbonic anhydrase inhibitor, Adverse effects, Leber hereditary optic neuropathy, LHON, Oxygen consumption rate, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/f2ed60a7286945d8b7912beced21838e

Editorial: Mitochondrial OXPHOS System: Emerging Concepts and Technologies and Role in Disease

Authors: Erika Fernández-Vizarra, Sylvie Callegari, Glòria Garrabou, David Pacheu-Grau

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: mitochondria, OXPHOS, mtDNA, mitochondrial proteome, mitochondrial dysfunction, mitochondrial quality control, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.924272/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/80ac3cfc268a44c79aa1251f7a360bb9

Mitochondrial dysfunction and its role in tissue-specific cellular stress

Authors: David Pacheu-Grau, Robert Rucktäschel, Markus Deckers

Source: Cell Stress, Vol 2, Iss 8, Pp 184-199 (2018)

Subject Terms: mitochondrial dysfunction, cellular stress, mitochondrial pathology, therapy, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.cell-stress.com/researcharticles/mitochondrial-dysfunction-and-its-role-in-tissue-specific-cellular-stress/; https://doaj.org/toc/2523-0204

Access URL: https://doaj.org/article/7c50b05ecbdc4268b99398193fb9a78a

Pharmacologic concentrations of linezolid modify oxidative phosphorylation function and adipocyte secretome

Authors: Laura Llobet, M. Pilar Bayona-Bafaluy, David Pacheu-Grau, Elena Torres-Pérez, José M. Arbones-Mainar, M. Ángeles Navarro, Covadonga Gómez-Díaz, Julio Montoya, Ester López-Gallardo, Eduardo Ruiz-Pesini

Source: Redox Biology, Vol 13, Iss C, Pp 244-254 (2017)

Subject Terms: Linezolid, Oxidative phosphorylation, Adipocyte, Secretome, Apolipoprotein E, Adipokine, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221323171730366X; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/d23601e1230a488e95ba31fbe2b17f7e

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Authors: King Faisal Yambire, Christine Rostosky, Takashi Watanabe, David Pacheu-Grau, Sylvia Torres-Odio, Angela Sanchez-Guerrero, Ola Senderovich, Esther G Meyron-Holtz, Ira Milosevic, Jens Frahm, A Phillip West, Nuno Raimundo

Source: eLife, Vol 8 (2019)

Subject Terms: iron, lysosome, acidification, inflammation, mitochondria, brain, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/51031; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/fd107a889da64064b712d694b9b3d129

Influence of Subcellular Localization and Functional State on Protein Turnover

Authors: Roya Yousefi, Kristina Jevdokimenko, Verena Kluever, David Pacheu-Grau, Eugenio F. Fornasiero

Source: Cells, Vol 10, Iss 7, p 1747 (2021)

Subject Terms: protein stability, optical analysis of protein turnover, SNAP-tag, pulse-chase, Rab5a, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/7/1747; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/07b9ebb2b70141b09dd11adeaab3ddec

COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis

Authors: Abhishek Aich, Cong Wang, Arpita Chowdhury, Christin Ronsör, David Pacheu-Grau, Ricarda Richter-Dennerlein, Sven Dennerlein, Peter Rehling

Source: eLife, Vol 7 (2018)

Subject Terms: mitochondria, Cytochrome c oxidase, protein assembly, mitochondrial diseases, Copper chaperone, Mitochondrial oxidative phosphorylation, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/32572; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/56ef4f043956409097d51c5990eae926