Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Authors: Carrie Corkish, Cristhiane Favero Aguiar, David K. Finlay

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f1a2f171b3bd45a1b681a80d072d847b

Fatty acids are crucial to fuel NK cells upon acute retrovirus infection

Authors: Simone Schimmer, Daniela Mittermüller, Tanja Werner, Paul E. Görs, Sven W. Meckelmann, David K. Finlay, Ulf Dittmer, Elisabeth Littwitz-Salomon

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: NK cells, lipid metabolism, retrovirus, beta-oxidation, migration, fatty acids, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1296355/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/da17f99fb71643ae8dbf695a93a6124d

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

Authors: Mariana P. Cervantes-Silva, Richard G. Carroll, Mieszko M. Wilk, Diana Moreira, Cloe A. Payet, James R. O’Siorain, Shannon L. Cox, Lauren E. Fagan, Paula A. Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M. Buel, George A. Timmons, James O. Early, Roger J. S. Preston, Jennifer M. Hurley, David K. Finlay, Ingmar Schoen, F. Javier Sánchez-García, Kingston H. G. Mills, Annie M. Curtis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4caf147bafa74b10bfcfd8fe7b6234a5

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

Authors: Leonard R. Pelgrom, Gavin M. Davis, Simon O’Shaughnessy, Emilie J.M. Wezenberg, Sander I. Van Kasteren, David K. Finlay, Linda V. Sinclair

Source: Cell Reports, Vol 42, Iss 8, Pp 112828- (2023)

Subject Terms: CP: Metabolism, CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723008392; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/f8ed02eb6f6c4fc3b2176333693c7e6f

Metabolic requirements of NK cells during the acute response against retroviral infection

Authors: Elisabeth Littwitz-Salomon, Diana Moreira, Joe N. Frost, Chloe Choi, Kevin T. Liou, David K. Ahern, Simon O’Shaughnessy, Bernd Wagner, Christine A. Biron, Hal Drakesmith, Ulf Dittmer, David K. Finlay

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb6d712437cd41c090de8bf024bdfc27

Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination

Authors: Elena Woods, Vanessa Zaiatz-Bittencourt, Ciaran Bannan, Colm Bergin, David K. Finlay, Matthias Hoffmann, Anthony Brown, Bethany Turner, Shokouh Makvandi-Nejad, Ventzi Vassilev, Stefania Capone, Antonella Folgori, Tomáš Hanke, Eleanor Barnes, Lucy Dorrell, Clair M. Gardiner, PEACHI Consortium

Source: npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/74d0067fe0754a63bf1b9631ac60ca73

Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy

Authors: Chloe Choi, David K. Finlay

Source: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2021)

Subject Terms: Natural Killer cells, Tumour microenvironment, Cancer immunotherapy, Metabolism, Nutrients, Mitochondria, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/30096456eceb4901b64f12a70d7635e4

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Authors: Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny I. Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

Authors: Nicholas Jones, Julianna Blagih, Fabio Zani, April Rees, David G. Hill, Benjamin J. Jenkins, Caroline J. Bull, Diana Moreira, Azari I. M. Bantan, James G. Cronin, Daniele Avancini, Gareth W. Jones, David K. Finlay, Karen H. Vousden, Emma E. Vincent, Catherine A. Thornton

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e704cf7cb7a0484a9ad0d96a44d08b6a

The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1β

Authors: George A. Timmons, Richard G. Carroll, James R. O’Siorain, Mariana P. Cervantes-Silva, Lauren E. Fagan, Shannon L. Cox, Eva Palsson-McDermott, David K. Finlay, Emma E. Vincent, Nicholas Jones, Annie M. Curtis

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: macrophage inflammation, metabolism, molecular clock, IL-1β, pSTAT3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.700431/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8e053272114849dda92fb87d549b098f

Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

Authors: Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8

Competition for nutrients and its role in controlling immune responses

Authors: Nidhi Kedia-Mehta, David K. Finlay

Source: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e2bb47ec5ad24dfab6567dcad10db195

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Authors: Róisín M. Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L. O’Brien, Arianne Garcia, Conor Gillespie, Jens L. Hukelmann, Peter J. Oefner, Angus I. Lamond, Clair M. Gardiner, Katja Dettmer, Doreen A. Cantrell, Linda V. Sinclair, David K. Finlay

Source: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/428103db6a8c40348a0ae092d9d2a982

Glucose represses dendritic cell-induced T cell responses

Authors: Simon J. Lawless, Nidhi Kedia-Mehta, Jessica F. Walls, Ryan McGarrigle, Orla Convery, Linda V. Sinclair, Maria N. Navarro, James Murray, David K. Finlay

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8b6f6381f79247dc8ef24920ae6d6002

Diverse Immunoregulatory Roles of Oxysterols—The Oxidized Cholesterol Metabolites

Authors: Chloe Choi, David K. Finlay

Source: Metabolites, Vol 10, Iss 10, p 384 (2020)

Subject Terms: oxysterols, cholesterol, SREBP, LXR, GPR183, ROR, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/10/10/384; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/925e037c40cd415f979a2c08ef59f87b

Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

Authors: Hesham M. Shehata, Andrew J. Murphy, Man kit Sam Lee, Clair M. Gardiner, Suzanne M. Crowe, Shomyseh Sanjabi, David K. Finlay, Clovis Steve Palmer

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: immunometabolism, glycolysis, mTOR, HIV, T cells, viral infection, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01311/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/422cda86895e40e39ae714dcace1ba39

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Authors: Michael Conroy, John Kennedy, Karen Slattery, Elena Woods, Vanessa Zaiatz-Bittencourt, Sam Marks, Sonya Chew, Caitriona Goggin, Colm MacEochagain, Sophie Lucas, David K Finlay, Clair M Gardiner

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/2/e002044.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b8a8d841ff7e409c8d04b1a423e2c8fe

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Authors: Jessica F Walls, Jeff J Subleski, Erika M Palmieri, Marieli Gonzalez-Cotto, Clair M Gardiner, Daniel W McVicar, David K Finlay

Source: eLife, Vol 9 (2020)

Subject Terms: metabolism, immunology, nk cells, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/59166; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/1481e7d755214c67a942f1f77128d836

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.

Authors: Marouan Zarrouk, David K Finlay, Marc Foretz, Benoit Viollet, Doreen A Cantrell

Source: PLoS ONE, Vol 9, Iss 9, p e106710 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4152329?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bb3fdc28cc38417b9055a44bcd4b5cbe

Regulation of glucose metabolism in T cells; new insight into the role of Phosphoinositide 3-kinases

Authors: David K Finlay

Source: Frontiers in Immunology, Vol 3 (2012)

Subject Terms: Glycolysis, Migration, T cell, Cell signaling, PI3K, Homing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00247/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/78c1fe29f9d84e1c881a22d12d9b96fd