Galactose epimerase deficiency: lessons from the GalNet registry

Authors: Britt Derks, Didem Demirbas, Rodrigo R. Arantes, Samantha Banford, Alberto B. Burlina, Analía Cabrera, Ana Chiesa, M. Luz Couce, Carlo Dionisi-Vici, Matthias Gautschi, Stephanie Grünewald, Eva Morava, Dorothea Möslinger, Sabine Scholl-Bürgi, Anastasia Skouma, Karolina M. Stepien, David J. Timson, Gerard T. Berry, M. Estela Rubio-Gozalbo

Source: Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)

Subject Terms: Galactose epimerase deficiency, Galactosemia type III, Galactosemias Network, Galactose-restricted diet, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1172

Access URL: https://doaj.org/article/7b30d0500cf94f298bf161b0d11d2fb6

[13C]‐galactose breath test in a patient with galactokinase deficiency and spastic diparesis

Authors: Can Ficicioglu, Didem Demirbas, Britt Derks, G. Shashidhar Pai, David J. Timson, Maria Estela Rubio‐Gozalbo, Gerard T. Berry

Source: JIMD Reports, Vol 59, Iss 1, Pp 104-109 (2021)

Subject Terms: galactosemia, GALK1 deficiency, in vivo galactose oxidation, stable‐isotope labeled galactose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2192-8312

Access URL: https://doaj.org/article/b8646ce29b08414b95415f29487e97a8

RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development

Authors: Paul McCusker, Wasim Hussain, Paul McVeigh, Erin McCammick, Nathan G. Clarke, Emily Robb, Fiona M. McKay, Peter M. Brophy, David J. Timson, Angela Mousley, Nikki J. Marks, Aaron G. Maule

Source: International Journal for Parasitology: Drugs and Drug Resistance, Vol 14, Iss , Pp 46-55 (2020)

Subject Terms: Fasciola, Liver fluke, RNAi, Argonaute, Calmodulin, σGST, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211320720300245; https://doaj.org/toc/2211-3207

Access URL: https://doaj.org/article/6adc572dca29437098a0058fa1081fd4

Yeast Cellular Stress: Impacts on Bioethanol Production

Authors: Joshua Eardley, David J. Timson

Source: Fermentation, Vol 6, Iss 4, p 109 (2020)

Subject Terms: bioethanol, chaotropicity, fermentation, biofuel yield, compatible solute, cell stress, Fermentation industries. Beverages. Alcohol, TP500-660

File Description: electronic resource

Relation: https://www.mdpi.com/2311-5637/6/4/109; https://doaj.org/toc/2311-5637

Access URL: https://doaj.org/article/d6cb4d8dd32842c990b21d01a18656cc

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

Authors: Ernesto Anoz-Carbonell, David J. Timson, Angel L. Pey, Milagros Medina

Source: Antioxidants, Vol 9, Iss 9, p 772 (2020)

Subject Terms: antioxidant enzyme, antioxidant response, cancer, oxidoreductase, enzyme kinetic analysis, functional cooperativity, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/9/9/772; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/0a73d531608248d685995fee34ae3374

Four Challenges for Better Biocatalysts

Authors: David J. Timson

Source: Fermentation, Vol 5, Iss 2, p 39 (2019)

Subject Terms: protein folding, enzyme engineering, hydrophobic effect, chaotropicity, enzyme mechanism, water activity, green chemistry, enzyme specificity, biotechnology, protein structure, Fermentation industries. Beverages. Alcohol, TP500-660

File Description: electronic resource

Relation: https://www.mdpi.com/2311-5637/5/2/39; https://doaj.org/toc/2311-5637

Access URL: https://doaj.org/article/cda4eae09e8b42539a4bd344719f7545

Development of a novel mass spectrometric technique for studying DNA damage.

Authors: Tony L. Merrigan, C. Adam Hunniford, David J. Timson, Martin Catney, Robert W. McCullough

Source: Biochemical Society Transactions; 2009, Vol. 37 Issue 4, p905-909, 5p

Subject Terms: DNA damage, MATRIX-assisted laser desorption-ionization, MOLECULAR biology, GENE targeting, FLUORESCENCE

DNA damage by low-energy ions.

Authors: C. Adam Hunniford, Robert W. McCullough, R. Jeremy H. Davies, David J. Timson

Source: Biochemical Society Transactions; 2009, Vol. 37 Issue 4, p893-896, 4p

Subject Terms: DNA damage, CANCER radiotherapy complications, ELECTRONS, ELECTROTHERAPEUTICS, ION bombardment, PHYSIOLOGICAL effects of ionizing radiation

Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast.

Authors: Emma Barnard, Neil V. McFerran, Alan Trudgett, John Nelson, David J. Timson

Source: Biochemical Society Transactions; 2008, Vol. 36 Issue 3, p479-482, 4p

Subject Terms: BIOLOGICAL assay, FLUORESCENCE, PROTEIN-protein interactions, SACCHAROMYCES cerevisiae, PROTEIN analysis, GENE expression

Coumarin-Based Inhibitors of Human NAD(P)H:Quinone Oxidoreductase-1. Identification, Structure–Activity, Off-Target Effects and In Vitro Human Pancreatic Cancer Toxicity.

Authors: Karen A. Nolan¹, He Zhao¹, Paul F. Faulder¹, A. David Frenkel¹, David J. Timson¹, David Siegel¹, David Ross¹, Terrence R. Burke Jr.¹, Ian J. Stratford¹, Richard A. Bryce¹

Source: Journal of Medicinal Chemistry. Nov2007, Vol. 50 Issue 25, p6316-6325. 10p.