A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells

Authors: Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun, Sadaf Amin, Su-Yi Tsai, Mona Khalaj, Ting Zhou, Ryan M. Samuel, Tuo Zhang, Francis A. Ortega, Miriam Gordillo, Dorota Moroziewicz, Daniel Paull, Scott A. Noggle, Jenny Zhaoying Xiang, Lorenz Studer, David J. Christini, Geoffrey S. Pitt, Todd Evans, Shuibing Chen

Source: iScience, Vol 25, Iss 4, Pp 104153- (2022)

Subject Terms: Biological sciences, Stem cells research, Methodology in biological sciences, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222004230; https://doaj.org/toc/2589-0042

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Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

Authors: Francis A. Ortega, Eleonora Grandi, Trine Krogh-Madsen, David J. Christini

Source: Frontiers in Physiology, Vol 8 (2018)

Subject Terms: dynamic clamp, cardiac electrophysiology, cardiac modeling, arrhythmia mechanisms, antiarrhythmic drugs, pharmacology & drug discovery, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphys.2017.01099/full; https://doaj.org/toc/1664-042X

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Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes

Authors: Trine Krogh-Madsen, Anna F. Jacobson, Francis A. Ortega, David J. Christini

Source: Frontiers in Physiology, Vol 8 (2017)

Subject Terms: cardiac modeling, model optimization, safety pharmacology, long QT, in silico drug trial, cardiotoxicity, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphys.2017.01059/full; https://doaj.org/toc/1664-042X

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Rapid genetic algorithm optimization of a mouse computational model: Benefits for anthropomorphization of neonatal mouse cardiomyocytes

Authors: Corina Teodora Bot, Armen R. Kherlopian, Francis A. Ortega, David J. Christini, Trine eKrogh-Madsen

Source: Frontiers in Physiology, Vol 3 (2012)

Subject Terms: action potential, dynamic clamp, Genetic Algorithm, cell-specific model, neonatal mouse cardiomyocyte, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00421/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/48f6783b47f24ceeacebeaf853a9be37

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MinK-dependent internalization of the IKs potassium channel.

Authors: Xianghua Xu, Vikram A. Kanda, Eun Choi, Gianina Panaghie, Torsten K. Roepke, Stephen A. Gaeta, David J. Christini, Daniel J. Lerner, Geoffrey W. Abbott

Source: Cardiovascular Research; Jun2009, Vol. 82 Issue 3, p430-430, 1p

Subject Terms: POTASSIUM channels, HEART ventricles, ELECTROPHYSIOLOGY, ELECTRIC properties of heart cells, GENE silencing, BIOLOGICAL rhythms

Re-evaluating the efficacy of {beta}-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.

Authors: Rebecca C. Ahrens-Nicklas, Colleen E. Clancy, David J. Christini

Source: Cardiovascular Research; Jun2009, Vol. 82 Issue 3, p439-439, 1p

Subject Terms: ADRENERGIC beta agonists, PHARMACODYNAMICS, LONG QT syndrome, MATHEMATICAL models, ION channels, ELECTROCARDIOGRAPHY, CARDIAC arrest

Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI).

Authors: Yogi A Patel, Ansel George, Alan D Dorval, John A White, David J Christini, Robert J Butera

Source: PLoS Computational Biology, Vol 13, Iss 5, p e1005430 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5469488?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/ef075f59f68e49a7900846b09a88d561

Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes.

Authors: Kemar Brown, Stephanie Legros, Francis A Ortega, Yunkai Dai, Michael Xavier Doss, David J Christini, Richard B Robinson, Ann C Foley

Source: PLoS ONE, Vol 12, Iss 12, p e0189818 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5744947?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b5f7aed9224a42478ecb7be635eb5f22

Cell-specific cardiac electrophysiology models.

Authors: Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini

Source: PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4415772?pdf=render; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/955d66251d1f439a96259fddd41f95af

NHE isoform switching and KChIP2 upregulation in aging porcine atria.

Authors: Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott

Source: PLoS ONE, Vol 8, Iss 12, p e82951 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3871617?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f402597591de49fbb3bba7b484b83cbb

Nonlinear dynamics of cardiac alternans: subcellular to tissue level mechanisms of arrhythmia

Authors: Stephen eGaeta, David J Christini

Source: Frontiers in Physiology, Vol 3 (2012)

Subject Terms: cardiac alternans, calcium handling, subcellular alternans, repolarization alternans, T-wave alternans, pattern formation, Physiology, QP1-981

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00157/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/c4265849a7234fd8a9a5d48e2747d096

Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study.

Authors: Trine Krogh-Madsen, Geoffrey W Abbott, David J Christini

Source: PLoS Computational Biology, Vol 8, Iss 2, p e1002390 (2012)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22383869/?tool=EBI; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/d5e1779b4ad148299a55120c630d9782

The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study.

Authors: Byron N Roberts, David J Christini

Source: PLoS ONE, Vol 7, Iss 11, p e47117 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3492384?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/aa11d8d8781a471486983fee70573309

NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure.

Authors: Byron N Roberts, David J Christini

Source: PLoS Computational Biology, Vol 7, Iss 10, p e1002241 (2011)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22028644/?tool=EBI; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

Access URL: https://doaj.org/article/e2210c65c06548518518355f66deefc4