Identification of potential therapeutic targets in prostate cancer through a cross‐species approach

Authors: Sarah Jurmeister, Antonio Ramos‐Montoya, Chiranjeevi Sandi, Nelma Pértega‐Gomes, Karan Wadhwa, Alastair D Lamb, Mark J Dunning, Jan Attig, Jason S Carroll, Lee GD Fryer, Sérgio L Felisbino, David E Neal

Source: EMBO Molecular Medicine, Vol 10, Iss 3, Pp 1-18 (2018)

Subject Terms: cross‐species analysis, MELK, mouse models, new cancer targets, prostate cancer, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/f4f3abda48f3447a8e0ee97abf3bc7cf

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.

Authors: Niedzica Camacho, Peter Van Loo, Sandra Edwards, Jonathan D Kay, Lucy Matthews, Kerstin Haase, Jeremy Clark, Nening Dennis, Sarah Thomas, Barbara Kremeyer, Jorge Zamora, Adam P Butler, Gunes Gundem, Sue Merson, Hayley Luxton, Steve Hawkins, Mohammed Ghori, Luke Marsden, Adam Lambert, Katalin Karaszi, Gill Pelvender, Charlie E Massie, Zsofia Kote-Jarai, Keiran Raine, David Jones, William J Howat, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, David Nicol, Erik Mayer, Tim Dudderidge, Yongwei Yu, Hongwei Zhang, Nimish C Shah, Vincent J Gnanapragasam, CRUK-ICGC Prostate Group, William Isaacs, Tapio Visakorpi, Freddie Hamdy, Dan Berney, Clare Verrill, Anne Y Warren, David C Wedge, Andrew G Lynch, Christopher S Foster, Yong Jie Lu, G Steven Bova, Hayley C Whitaker, Ultan McDermott, David E Neal, Rosalind Eeles, Colin S Cooper, Daniel S Brewer

Source: PLoS Genetics, Vol 13, Iss 9, p e1007001 (2017)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5628936?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/923e8bd162014727a66863bedfb19b8d

HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E2F1‐mediated cell cycle network

Authors: Antonio Ramos‐Montoya, Alastair D Lamb, Roslin Russell, Thomas Carroll, Sarah Jurmeister, Nuria Galeano‐Dalmau, Charlie E Massie, Joan Boren, Helene Bon, Vasiliki Theodorou, Maria Vias, Greg L Shaw, Naomi L Sharma, Helen Ross‐Adams, Helen E Scott, Sarah L Vowler, William J Howat, Anne Y Warren, Richard F Wooster, Ian G Mills, David E Neal

Source: EMBO Molecular Medicine, Vol 6, Iss 5, Pp 651-661 (2014)

Subject Terms: androgen receptor, castrate‐resistant prostate cancer, gene expression signature, HES6, PLK1, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/a381e788e932488b8fe13b0d3eb31910

Validating the use of Hospital Episode Statistics data and comparison of costing methodologies for economic evaluation: an end-of-life case study from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)

Authors: Richard M Martin, Jenny L Donovan, Luke Hounsome, Julia Verne, Joanna C Thorn, Emma L Turner, Eleanor Walsh, Liz Down, David E Neal, Freddie C Hamdy, Sian M Noble

Source: BMJ Open, Vol 6, Iss 4 (2016)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/6/4/e011063.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/fd1206a7e74b46f49ba81a914864c96a

Development, validation and evaluation of an instrument for active monitoring of men with clinically localised prostate cancer: systematic review, cohort studies and qualitative study

Authors: Andrew J Simpkin, Leila Rooshenas, Julia Wade, Jenny L Donovan, J Athene Lane, Richard M Martin, Chris Metcalfe, Peter C Albertsen, Freddie C Hamdy, Lars Holmberg, David E Neal, Kate Tilling

Source: Health Services and Delivery Research, Vol 3, Iss 30 (2015)

Subject Terms: systematic review, prostate cancer, active surveillance, active monitoring, prostate-specific antigen, Public aspects of medicine, RA1-1270, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2050-4349; https://doaj.org/toc/2050-4357

Access URL: https://doaj.org/article/9297775ec62e46c4a3b863f0bb8df261

Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy.

Authors: Rebecca Gilbert, Richard M Martin, David M Evans, Kate Tilling, George Davey Smith, John P Kemp, J Athene Lane, Freddie C Hamdy, David E Neal, Jenny L Donovan, Chris Metcalfe

Source: PLoS ONE, Vol 10, Iss 10, p e0136735 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4592274?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a832a8046efc4f98a30eac5419da371b

Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.

Authors: Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Sarah Jugurnauth-Little, Malgorzata Tymrakiewicz, Fredrik Wiklund, Ali Amin Al Olama, Sara Benlloch, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Gianluca Severi, Henrik Gronberg, Markus Aly, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Børge G Nordestgaard, Federico Canzian, Daniele Campa, Elio Riboli, Tim J Key, Ruth C Travis, Sue A Ingles, Esther M John, Richard B Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Daniel Schaid, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Judith A Clements, Manuel R Teixeira, Jianfeng Xu, Christos Mikropoulos, Chee Goh, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, UK Genetic Prostate Cancer Study Collaborators, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F Easton, Ken Muir, Rosalind A Eeles, Zsofia Kote-Jarai

Source: PLoS Genetics, Vol 10, Iss 2, p e1004129 (2014)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24550738/?tool=EBI; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/ef4e48a676e14b05b1bb979807ceb684

Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.

Authors: Pei-Hsuan Weng, Yi-Ling Huang, John H Page, Jen-Hau Chen, Jianfeng Xu, Stella Koutros, Sonja Berndt, Stephen Chanock, Meredith Yeager, John S Witte, Rosalind A Eeles, Douglas F Easton, David E Neal, Jenny Donovan, Freddie C Hamdy, Kenneth R Muir, Graham Giles, Gianluca Severi, Jeffrey R Smith, Carmela R Balistreri, Irene M Shui, Yen-Ching Chen

Source: PLoS ONE, Vol 9, Iss 10, p e110569 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4215920?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ba2843a06c55451ab954b258992258ee

No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses.

Authors: Harriet C T Groom, Anne Y Warren, David E Neal, Kate N Bishop

Source: PLoS ONE, Vol 7, Iss 3, p e34221 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3314598?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/58d598ba54644b0a97f857d5b2ffc165

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.

Authors: Jyotsna Batra, Felicity Lose, Tracy O'Mara, Louise Marquart, Carson Stephens, Kimberly Alexander, Srilakshmi Srinivasan, Rosalind A Eeles, Douglas F Easton, Ali Amin Al Olama, Zsofia Kote-Jarai, Michelle Guy, Kenneth Muir, Artitaya Lophatananon, Aneela A Rahman, David E Neal, Freddie C Hamdy, Jenny L Donovan, Suzanne Chambers, Robert A Gardiner, Joanne Aitken, John Yaxley, Mary-Anne Kedda, Judith A Clements, Amanda B Spurdle

Source: PLoS ONE, Vol 6, Iss 11, p e26527 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132073/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e5eabb200e4343a1a2ae91e654fe29f2

The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.

Authors: Hayley C Whitaker, Zsofia Kote-Jarai, Helen Ross-Adams, Anne Y Warren, Johanna Burge, Anne George, Elizabeth Bancroft, Sameer Jhavar, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Edward Saunders, Elizabeth Page, Anita Mitra, Gillian Mitchell, Geoffrey J Lindeman, D Gareth Evans, Ignacio Blanco, Catherine Mercer, Wendy S Rubinstein, Virginia Clowes, Fiona Douglas, Shirley Hodgson, Lisa Walker, Alan Donaldson, Louise Izatt, Huw Dorkins, Alison Male, Kathy Tucker, Alan Stapleton, Jimmy Lam, Judy Kirk, Hans Lilja, Douglas Easton, IMPACT Study Steering Committee, IMPACT Study Collaborators, UK GPCS Collaborators, Colin Cooper, Rosalind Eeles, David E Neal

Source: PLoS ONE, Vol 5, Iss 10, p e13363 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2954177?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4071d7f5c507467a8717560736280a71

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

Authors: Katherine S Elliott, Eleftheria Zeggini, Mark I McCarthy, Julius Gudmundsson, Patrick Sulem, Simon N Stacey, Steinunn Thorlacius, Laufey Amundadottir, Henrik Grönberg, Jianfeng Xu, Valerie Gaborieau, Rosalind A Eeles, David E Neal, Jenny L Donovan, Freddie C Hamdy, Kenneth Muir, Shih-Jen Hwang, Margaret R Spitz, Brent Zanke, Luis Carvajal-Carmona, Kevin M Brown, Australian Melanoma Family Study Investigators, Nicholas K Hayward, Stuart Macgregor, Ian P M Tomlinson, Mathieu Lemire, Christopher I Amos, Joanne M Murabito, William B Isaacs, Douglas F Easton, Paul Brennan, PanScan Consortium, Rosa B Barkardottir, Daniel F Gudbjartsson, Thorunn Rafnar, David J Hunter, Stephen J Chanock, Kari Stefansson, John P A Ioannidis

Source: PLoS ONE, Vol 5, Iss 5, p e10858 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20526366/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ed86bff323304eb0bb405d306b665368

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Thiol isomerases negatively regulate the cellular shedding activity of ADAM17.

Authors: Sofie H. Willems, Christopher J. Tape, Peter L. Stanley, Neil A. Taylor, Ian G. Mills, David E. Neal, John McCafferty, Gillian Murphy

Source: Biochemical Journal; May2010, Vol. 428 Issue 3, p439-450, 12p

Subject Terms: ISOMERASES, CELLULAR signal transduction, THIOLS, METALLOPROTEINASES, CELL membranes, PROTEIN disulfide isomerase, REACTIVE oxygen species

A role for neurotensin in bicalutamide resistant prostate cancer cells.

Authors: Maria Vias, Glyn Burtt, Zoran Culig, Abhi Veerakumarasivam, David E. Neal, Ian G. Mills

Source: Prostate; Feb2007, Vol. 67 Issue 2, p190-202, 13p

Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer.

Authors: Kalipso Halkidou, Luke Gaughan, Susan Cook, Hing Y. Leung, David E. Neal, Craig N. Robson

Source: Prostate; May2004, Vol. 59 Issue 2, p177-189, 13p

Screen-detected prostate cancer and the insulin-like growth factor axis: Results of a population-based case-control study.

Authors: Steven E. Oliver, David Gunnell, Jenny Donovan, Tim J. Peters, Raj Persad, David Gillatt, Anya Pearce, David E. Neal, Freddie C. Hamdy, Jeff Holly

Source: International Journal of Cancer; 3/1/2004, Vol. 108 Issue 6, p887-892, 6p

Subject Terms: PROSTATE cancer, INSULIN, INSULIN-like growth factor-binding proteins

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