Surgical Outcomes Following Neoadjuvant Treatment for Locally Advanced and Borderline Resectable Pancreatic Ductal Adenocarcinoma

Authors: Kai Tai Derek Yeung, PhD, FRCS, Sacheen Kumar, PhD, FRCS, David Cunningham, MD, FRCP, FMedSci, OBE, Long R. Jiao, MD, FRCS, Ricky Harminder Bhogal, PhD, FRCS

Source: Annals of Surgery Open, Vol 5, Iss 3, p e486 (2024)

Subject Terms: Surgery, RD1-811

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/AS9.0000000000000486; https://doaj.org/toc/2691-3593

Access URL: https://doaj.org/article/19a4b1a5853d4dc497b7d645dd301528

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

Authors: James L. Alexander, Joram M. Posma, Alasdair Scott, Liam Poynter, Sam E. Mason, M. Luisa Doria, Lili Herendi, Lauren Roberts, Julie A. K. McDonald, Simon Cameron, David J. Hughes, Vaclav Liska, Simona Susova, Pavel Soucek, Verena Horneffer-van der Sluis, Maria Gomez-Romero, Matthew R. Lewis, Lesley Hoyles, Andrew Woolston, David Cunningham, Ara Darzi, Marco Gerlinger, Robert Goldin, Zoltan Takats, Julian R. Marchesi, Julian Teare, James Kinross

Source: Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)

Subject Terms: Colorectal cancer, Gut microbiota, Metabolome, Metataxonomics, Microbial ecology, QR100-130

File Description: electronic resource

Relation: https://doaj.org/toc/2049-2618

Access URL: https://doaj.org/article/12e07005f08c4eff961ce1c2bc1eb63e

A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications

Authors: Dima El-Sharkawi, Amit Sud, Catherine Prodger, Jahanzaib Khwaja, Rohan Shotton, Brian Hanley, Victoria Peacock, Ying Ying Peng, Anita Arasaretnam, Sarkhara Sharma, Frances Aldridge, Bhupinder Sharma, Andrew Wotherspoon, Betty Cheung, Corinne De Lord, Rosalynd Johnston, Shireen Kassam, Ruth Pettengel, Kim Linton, Paul Greaves, Lucy Cook, Kikkeri N. Naresh, Kate Cwynarski, Toby A. Eyre, Ian Chau, David Cunningham, Sunil Iyengar

Source: Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/f34c82b257694a09bb76d27d1f3ce733

Impact of pharmacogenomic DPYD variant guided dosing on toxicity in patients receiving fluoropyrimidines for gastrointestinal cancers in a high-volume tertiary centre

Authors: David K. Lau, Caroline Fong, Faten Arouri, Lillian Cortez, Hannah Katifi, Reyes Gonzalez-Exposito, Muhammad Bilal Razzaq, Su Li, Aislinn Macklin-Doherty, Monica Arenas Hernandez, Michael Hubank, Charlotte Fribbens, David Watkins, Sheela Rao, Ian Chau, David Cunningham, Naureen Starling

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-8 (2023)

Subject Terms: DPYD, Dihydropyrimidine dehydrogenase, Capecitabine, 5-fluorouracil, Pharmacogenomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/8c4c528d564e402aa51ff80d19849ea5

ctDNA guided adjuvant chemotherapy versus standard of care adjuvant chemotherapy after curative surgery in patients with high risk stage II or stage III colorectal cancer: a multi-centre, prospective, randomised control trial (TRACC Part C)

Authors: Susanna Slater, Annette Bryant, Hsiang-Chi Chen, Ruwaida Begum, Isma Rana, Maria Aresu, Clare Peckitt, Oleg Zhitkov, Retchel Lazaro-Alcausi, Victoria Borja, Rachel Powell, David Lowery, Michael Hubank, Thereasa Rich, Gayathri Anandappa, Ian Chau, Naureen Starling, David Cunningham

Source: BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)

Subject Terms: Colorectal cancer, ctDNA, Adjuvant chemotherapy, Randomised, Disease free survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/fd82327f73c3444fa40eeb618feddeee

Providing paediatric surgery in low-resource countries

Authors: David Cunningham, Emma Bryce, Maíra Fedatto

Source: BMJ Paediatrics Open, Vol 7, Iss 1 (2023)

Subject Terms: Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://bmjpaedsopen.bmj.com/content/7/1/e001603.full; https://doaj.org/toc/2399-9772

Access URL: https://doaj.org/article/5245b9cc84fb4fe586e2b5d49064e217

MicroRNAs as biomarkers for trastuzumab-based therapy in HER2-positive advanced oesophago-gastric cancer patients

Authors: Hazel Lote, Florentia Mousoullou, George Vlachogiannis, Andrea Lampis, Laura Satchwell, Clare Peckitt, Caroline Fong, Ruwaida Begum, Shannon Kidd, Susan Cromarty, Anderley Gordon, Charlotte Fribbens, Sheela Rao, Naureen Starling, Ian Chau, David Cunningham, Nicola Valeri

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: oesophageal adenocarcinoma, gastric cancer, microRNA, HER2, biomarkers, trastuzumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1258365/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ce00e101c55741ff998c109728418068

Characterization of an induced pluripotent stem cell line NCHi011-A from a 23-year-old female with Alagille Syndrome harboring a heterozygous JAG1 pathogenic variant

Authors: Isaac Stanberry, David Cunningham, Shiqiao Ye, Matthew Alonzo, Ming-Tao Zhao, Vidu Garg, Brenda Lilly

Source: Stem Cell Research, Vol 72, Iss , Pp 103213- (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S187350612300199X; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/76446d6f621a40738f84a8d0537f9766

Parsaclisib, a PI3Kδ inhibitor, in relapsed and refractory follicular lymphoma (CITADEL-203): a phase 2 studyResearch in context

Authors: Marek Trněný, Abraham Avigdor, Matthew S. McKinney, Shankara Paneesha, Björn E. Wahlin, John S. Hrom, David Cunningham, Nicholas Morley, Miguel Canales, Mariana Bastos-Oreiro, David Belada, Liliana Devizzi, Fred Zheng, Douglas J. DeMarini, Wei Jiang, Ping Jiang, Ryan C. Lynch

Source: EClinicalMedicine, Vol 63, Iss , Pp 102130- (2023)

Subject Terms: Follicular lymphoma, Parsaclisib, PI3K inhibitor, Non-Hodgkin lymphoma, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537023003073; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/c66821b07c654aec8c095879560486da

Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene

Authors: David Cunningham, Isaac Stanberry, Shiqiao Ye, Matthew Alonzo, Ming-Tao Zhao, Vidu Garg, Brenda Lilly

Source: Stem Cell Research, Vol 71, Iss , Pp 103177- (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506123001630; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/e6ae087feb1f4ef8823214d3d75727ed

P1118: LONGER FOLLOW-UP FROM THE PIVOTAL EPCORE NHL-1 TRIAL REAFFIRMS SUBCUTANEOUS EPCORITAMAB INDUCES DEEP, DURABLE COMPLETE REMISSIONS IN PATIENTS WITH RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA

Authors: Wojciech Jurczak, Herve Ghesquieres, Yasmin Karimi, Chan Cheah, Michael Roost Clausen, David Cunningham, Young Rok Do, David Lewis, Robin Gasiorowski, Tae Min Kim, Marjolein Van Der Poel, Michelle Limei Poon, Tatyana Feldman, Kim Linton, Anna Sureda, Martin Hutchings, Salim Kanoun, Laetitia Vercellino, Mariana Cota Stirner, Stephanie Mcgoldrick, Yan Liu, Mariana Sacchi, Pieternella Lugtenburg, Catherine Thieblemont

Source: HemaSphere, Vol 7, p e081065c (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971368.08106.5c; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/e0f9fede8f014c7495ab4f4759ea8757

Obinutuzumab Versus Rituximab Immunochemotherapy in Previously Untreated iNHL: Final Results From the GALLIUM Study

Authors: William Townsend, Wolfgang Hiddemann, Christian Buske, Guillaume Cartron, David Cunningham, Martin J.S. Dyer, John G. Gribben, Elizabeth H. Phillips, Martin Dreyling, John F. Seymour, Andrew Grigg, Judith Trotman, Tong-Yu Lin, Xiao-Nan Hong, Dirk Kingbiel, Tina G. Nielsen, Andrea Knapp, Michael Herold, Robert Marcus

Source: HemaSphere, Vol 7, Iss 7, p e919 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000919; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/54ee041689654f5486a8b741a193c36c

Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma: Results of the Proof-of-Concept iMYC Study

Authors: Fiona Turkes, Annette Bryant, Ruwaida Begum, Michael Davidson, Eleftheria Kalaitzaki, Maria Aresu, Retchel Lazaro-Alcausi, Jane Bryant, Isma Rana, Sue Chua, Lauren Aronson, Sanna Hulkki-Wilson, Charlotte Fribbens, David Watkins, Sheela Rao, Naureen Starling, David Cunningham, Irene Y. Chong, Ian Chau

Source: Current Oncology, Vol 29, Iss 4, Pp 2174-2184 (2022)

Subject Terms: oesophagogastric cancer, HER2, c-MYC, ibrutinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.mdpi.com/1718-7729/29/4/176; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729

Access URL: https://doaj.org/article/5d5338a80b2f46c49f2a37fe4ad17d3e

The iR2 regimen (ibrutinib plus lenalidomide and rituximab) for relapsed/refractory DLBCL: a multicentre, non-randomised, open-label phase 2 studyResearch in context

Authors: Radhakrishnan Ramchandren, Peter Johnson, Nilanjan Ghosh, Jia Ruan, Kirit M. Ardeshna, Roderick Johnson, Gregor Verhoef, David Cunningham, Sven de Vos, Shireen Kassam, Luis Fayad, John Radford, Sarah Bailly, Fritz Offner, David Morgan, Javier Munoz, Jerry Ping, Edith Szafer-Glusman, Karl Eckert, Jutta K. Neuenburg, Andre Goy

Source: EClinicalMedicine, Vol 56, Iss , Pp 101779- (2023)

Subject Terms: Diffuse large B-cell lymphoma, Ibrutinib, Lenalidomide, Rituximab, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537022005089; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/dfd82da8bbb84527a2f321cc93dfec23

PARP inhibition utilized in combination therapy with Olaparib‐Temozolomide to achieve disease stabilization in a rare case of BRCA1‐mutant, metastatic myxopapillary ependymoma

Authors: Preethika Mahalingam, Sam Smith, Juanita Lopez, Rajaei K Sharma, Thomas Millard, Khin Thway, Cyril Fisher, David A Reardon, Robin Jones, Andrew G Nicholson, David Cunningham, Liam Welsh, Bhupinder Sharma

Source: Rare Tumors, Vol 15 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2036-3613

Access URL: https://doaj.org/article/83463f5c2d154c77a10b96c61be09d20

Automated detection and delineation of lymph nodes in haematoxylin & eosin stained digitised slides

Authors: Manon Beuque, Derek R. Magee, Avishek Chatterjee, Henry C. Woodruff, Ruth E. Langley, William Allum, Matthew G. Nankivell, David Cunningham, Philippe Lambin, Heike I. Grabsch

Source: Journal of Pathology Informatics, Vol 14, Iss , Pp 100192- (2023)

Subject Terms: Oesophageal cancer, Deep learning, Autodelineation, Explainability, Digital pathology, Lymph nodes, Computer applications to medicine. Medical informatics, R858-859.7, Pathology, RB1-214

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2153353923000068; https://doaj.org/toc/2153-3539

Access URL: https://doaj.org/article/647692b79c974cfabcef5c60744e7a9c

Steps toward a digital twin for functional food production with increased health benefits

Authors: Helena Mylise Sørensen, David Cunningham, Rengesh Balakrishnan, Susan Maye, George MacLeod, Dermot Brabazon, Christine Loscher, Brian Freeland

Source: Current Research in Food Science, Vol 7, Iss , Pp 100593- (2023)

Subject Terms: Digital twin, Bioprocessing, Process control, Process modelling, Artificial neural network, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2665927123001612; https://doaj.org/toc/2665-9271

Access URL: https://doaj.org/article/4e169f6a660448959557ff8c6681faac

DCE-MRI is more sensitive than IVIM-DWI for assessing anti-angiogenic treatment-induced changes in colorectal liver metastases

Authors: Mihaela Rata, Khurum Khan, David J Collins, Dow-Mu Koh, Nina Tunariu, Maria Antonietta Bali, James d’Arcy, Jessica M Winfield, Simona Picchia, Nicola Valeri, Ian Chau, David Cunningham, Matteo Fassan, Martin O Leach, Matthew R Orton

Source: Cancer Imaging, Vol 21, Iss 1, Pp 1-12 (2021)

Subject Terms: Dynamic contrast enhanced MRI (DCE-MRI), Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI), Perfusion, Colorectal liver metastasis, Clinical trial., Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1470-7330

Access URL: https://doaj.org/article/54d6e0e5e80f43fc874ccfe2a6ae6ee5

Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage

Authors: Pietro Carotenuto, Francesco Amato, Andrea Lampis, Colin Rae, Somaieh Hedayat, Maria C. Previdi, Domenico Zito, Maya Raj, Vincenza Guzzardo, Francesco Sclafani, Andrea Lanese, Claudia Parisi, Caterina Vicentini, Ian Said-Huntingford, Jens C. Hahne, Albert Hallsworth, Vladimir Kirkin, Kate Young, Ruwaida Begum, Andrew Wotherspoon, Kyriakos Kouvelakis, Sergio Xavier Azevedo, Vasiliki Michalarea, Rosie Upstill-Goddard, Sheela Rao, David Watkins, Naureen Starling, Anguraj Sadanandam, David K. Chang, Andrew V. Biankin, Nigel B. Jamieson, Aldo Scarpa, David Cunningham, Ian Chau, Paul Workman, Matteo Fassan, Nicola Valeri, Chiara Braconi

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a029501cd4ea4989bf6d137ae286835e

Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery.

Authors: David M Gordon, David Cunningham, Gloria Zender, Patrick J Lawrence, Jacqueline S Penaloza, Hui Lin, Sara M Fitzgerald-Butt, Katherine Myers, Tiffany Duong, Donald J Corsmeier, Jeffrey B Gaither, Harkness C Kuck, Saranga Wijeratne, Blythe Moreland, Benjamin J Kelly, Baylor-Johns Hopkins Center for Mendelian Genomics, Vidu Garg, Peter White, Kim L McBride

Source: PLoS Genetics, Vol 18, Iss 6, p e1010236 (2022)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/6e68cf7a081a4dec8fa9470de632ba33