Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia

Authors: Mathieu Quesnel-Vallières, David C. Schultz, Alena Orlenko, Yancy Lo, Jason Moore, Marylyn Ritchie, David Roth, Martin Carroll, Yoseph Barash, Kristen W. Lynch, Sara Cherry

Source: Drugs in R&D, Vol 24, Iss 3, Pp 489-499 (2024)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1174-5886; https://doaj.org/toc/1179-6901

Access URL: https://doaj.org/article/78f8c8838ccd45aa82c602b01e1016de

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Authors: Nian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, James C. Sacchettini

Source: Cell Reports, Vol 43, Iss 11, Pp 114929- (2024)

Subject Terms: CP: Microbiology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724012804; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/fee5e4e3bedd475abadbb75db127898b

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Authors: Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W. Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, David C. Schultz, P. Toby Coates, Elisha D. O. Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ca3eac3b209b443bb4c3882b9c20a335

SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection

Authors: Minghua Li, Kasirajan Ayyanathan, Mark Dittmar, Jesse Miller, Iulia Tapescu, Jae Seung Lee, Marisa E. McGrath, Yong Xue, Sanjay Vashee, David C. Schultz, Matthew B. Frieman, Sara Cherry

Source: mBio, Vol 14, Iss 4 (2023)

Subject Terms: SARS-CoV-2, ORF6, interferon, antagonism, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/5a2277c98fd74afdb069e8e30a0a024a

TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model

Authors: Nunziata Maio, Sara Cherry, David C. Schultz, Brett L. Hurst, W. Marston Linehan, Tracey A. Rouault

Source: iScience, Vol 25, Iss 10, Pp 105074- (2022)

Subject Terms: Health sciences, pharmacology, virology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222013463; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/43d4c990e034466291b40eae203536e4

Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

Authors: Deepti Abbey, Donna Conlon, Christopher Rainville, Susannah Elwyn, Katherine Quiroz‐Figueroa, Jeffrey Billheimer, David C. Schultz, Nicholas J. Hand, Sara Cherry, Daniel J. Rader

Source: Clinical and Translational Science, Vol 14, Iss 4, Pp 1369-1379 (2021)

Subject Terms: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

Access URL: https://doaj.org/article/b112e81aa3844aa0a2a202a30036c4e6

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

Authors: Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas-Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C. Schultz, Sara Cherry

Source: Cell Reports, Vol 35, Iss 1, Pp 108959- (2021)

Subject Terms: antiviral, entry, coronavirus, TMPRSS2, cyclosporin, cyclophilin, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721002734; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/8f60a618f20a43da8cfde02376a0da5e

Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses

Authors: Brent A. Hackett, Mark Dittmar, Elisha Segrist, Nathan Pittenger, Julie To, Trevor Griesman, Beth Gordesky-Gold, David C. Schultz, Sara Cherry

Source: mBio, Vol 10, Iss 4 (2019)

Subject Terms: alphavirus, arbovirus, bunyavirus, flavivirus, sirtinol, sirtuin, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/443ecdb4a429445e8eefee560540f5c9

Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche

Authors: Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson

Source: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/84db73bd9d44488982b5724af9d64be0

Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

Authors: Keiko Rausch, Brent A. Hackett, Nathan L. Weinbren, Sophia M. Reeder, Yoel Sadovsky, Christopher A. Hunter, David C. Schultz, Carolyn B. Coyne, Sara Cherry

Source: Cell Reports, Vol 18, Iss 3, Pp 804-815 (2017)

Subject Terms: antivirals, flavivirus, arbovirus, therapeutics, repurposing, drugs, entry, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716317752; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/f105e08ebf28469199a0037fe022385f

Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma

Authors: Jessie Villanueva, Jeffrey R. Infante, Clemens Krepler, Patricia Reyes-Uribe, Minu Samanta, Hsin-Yi Chen, Bin Li, Rolf K. Swoboda, Melissa Wilson, Adina Vultur, Mizuho Fukunaba-Kalabis, Bradley Wubbenhorst, Thomas Y. Chen, Qin Liu, Katrin Sproesser, Douglas J. DeMarini, Tona M. Gilmer, Anne-Marie Martin, Ronen Marmorstein, David C. Schultz, David W. Speicher, Giorgos C. Karakousis, Wei Xu, Ravi K. Amaravadi, Xiaowei Xu, Lynn M. Schuchter, Meenhard Herlyn, Katherine L. Nathanson

Source: Cell Reports, Vol 4, Iss 6, Pp 1090-1099 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124713004646; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/def1fcb2813549cea0a237cf8e63bb48

Assessment of sera for chromatin-immunoprecipitation

Authors: Juliette Nguyen, Daisuke Yamada, David C. Schultz, Pierre-Antoine Defossez

Source: BioTechniques, Vol 44, Iss 1, Pp 66-68 (2008)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/9a7456be9d904611a951fddccaf2fcf8

The lipopeptide Pam3CSK4 inhibits Rift Valley fever virus infection and protects from encephalitis.

Authors: Trevor Griesman, Cynthia M McMillen, Seble Getenet Negatu, Jesse J Hulahan, Kanupriya Whig, Lenka Dohnalová, Mark Dittmar, Christoph A Thaiss, Kellie A Jurado, David C Schultz, Amy L Hartman, Sara Cherry

Source: PLoS Pathogens, Vol 20, Iss 6, p e1012343 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/d221228f379b45f0b4778a0afb0e3282

A High Polarization and High Quantum Efficiency Photocathode Using a GaAs-AlGaAs Superlattice

Authors: Yoshimasa Kurihara, Yoshimasa Kurihara, Tsunehiko Omori, Tsunehiko Omori, Yasunori Takeuchi, Yasunori Takeuchi, Masakazu Yoshioka, Masakazu Yoshioka, Tsutomu Nakanishi, Tsutomu Nakanishi, Syooji Okumi, Syooji Okumi, Mmasabumi Tawada, Mmasabumi Tawada, Kazuaki Togawa, Kazuaki Togawa, Mitsuru Tsubata, Mitsuru Tsubata, Toshio Baba, Toshio Baba, Masashi Mizuta, Masashi Mizuta, Raymond K. Alley, Raymond K. Alley, Hideki Aoyagi, Hideki Aoyagi, James E. Clendenin, James E. Clendenin, Josef C. Frisch, Josef C. Frisch, Gregory A. Mulhollan, Gregory A. Mulhollan, Pablo J. Sáez, Pablo J. Sáez, David C. Schultz, David C. Schultz, Huan Tang, Huan Tang, Klaus H. Witte, Klaus H. Witte

Source: Japanese Journal of Applied Physics; January 1995, Vol. 34 Issue: 1 p355-355, 1p

Structure of the human telomeric Stn1-Ten1 capping complex.

Authors: Christopher Bryan, Cory Rice, Michael Harkisheimer, David C Schultz, Emmanuel Skordalakes

Source: PLoS ONE, Vol 8, Iss 6, p e66756 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3691326?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f9d5fa09cfa648c8b8a2fc4fa917f649

Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.

Authors: Ning Li, Scott Thompson, David C Schultz, Weiliang Zhu, Hualiang Jiang, Cheng Luo, Paul M Lieberman

Source: PLoS ONE, Vol 5, Iss 4, p e10126 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2853575?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5f2cb7035d4342c2aaf8f1fdc7dda8fa