Targeting shared molecular etiologies to accelerate drug development for rare diseases

Authors: Galliano Zanello, Macarena Garrido‐Estepa, Ana Crespo, Daniel O'Connor, Rima Nabbout, Christina Waters, Anthony Hall, Maurizio Taglialatela, Chun‐Hung Chan, David A Pearce, Marc Dooms, Philip John Brooks

Source: EMBO Molecular Medicine, Vol 15, Iss 7, Pp 1-10 (2023)

Subject Terms: basket clinical trials, IRDiRC, rare diseases, shared molecular etiologies, therapeutic development, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/6fff0fada4b5495890eea6b6f2758b6c

Searching for novel biomarkers using a mouse model of CLN3-Batten disease.

Authors: Derek Timm, Jacob T Cain, Ryan D Geraets, Katherine A White, Seung Yon Koh, Tammy Kielian, David A Pearce, Michelle L Hastings, Jill M Weimer

Source: PLoS ONE, Vol 13, Iss 8, p e0201470 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6080763?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1d107ecde9b04446bdecf6b33b0ce7da

Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

Authors: Benedikt Grünewald, Maren D Lange, Christian Werner, Aet O'Leary, Andreas Weishaupt, Sandy Popp, David A Pearce, Heinz Wiendl, Andreas Reif, Hans C Pape, Klaus V Toyka, Claudia Sommer, Christian Geis

Source: eLife, Vol 6 (2017)

Subject Terms: Batten disease, cln3, synaptic dysfunction, GABA, Hippocampus, Amygdala, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/28685; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/73ff6f4c6ad249a0ae51af6071b9bb4c

A tailored mouse model of CLN2 disease: A nonsense mutant for testing personalized therapies.

Authors: Ryan D Geraets, Logan M Langin, Jacob T Cain, Camille M Parker, Rosanna Beraldi, Attila D Kovacs, Jill M Weimer, David A Pearce

Source: PLoS ONE, Vol 12, Iss 5, p e0176526 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5413059?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f34a5113df834253a0b39fab17e9eda5

Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils.

Authors: Gregory C A Amos, Chiara Borsetto, Paris Laskaris, Martin Krsek, Andrew E Berry, Kevin K Newsham, Leo Calvo-Bado, David A Pearce, Carlos Vallin, Elizabeth M H Wellington

Source: PLoS ONE, Vol 10, Iss 9, p e0138327 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4580463?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/85caf57d066f41ff98169158feb6886d

Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.

Authors: Amanda Getty, Attila D Kovács, Tímea Lengyel-Nelson, Andrew Cardillo, Caitlin Hof, Chun-Hung Chan, David A Pearce

Source: PLoS ONE, Vol 8, Iss 6, p e66203 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3688782?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/11408540151d44bb9ab889b54de72bf1

The discovery of new deep-sea hydrothermal vent communities in the southern ocean and implications for biogeography.

Authors: Alex D Rogers, Paul A Tyler, Douglas P Connelly, Jon T Copley, Rachael James, Robert D Larter, Katrin Linse, Rachel A Mills, Alfredo Naveira Garabato, Richard D Pancost, David A Pearce, Nicholas V C Polunin, Christopher R German, Timothy Shank, Philipp H Boersch-Supan, Belinda J Alker, Alfred Aquilina, Sarah A Bennett, Andrew Clarke, Robert J J Dinley, Alastair G C Graham, Darryl R H Green, Jeffrey A Hawkes, Laura Hepburn, Ana Hilario, Veerle A I Huvenne, Leigh Marsh, Eva Ramirez-Llodra, William D K Reid, Christopher N Roterman, Christopher J Sweeting, Sven Thatje, Katrin Zwirglmaier

Source: PLoS Biology, Vol 10, Iss 1, p e1001234 (2012)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22235194/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/8d518801d5b145eeb9e0d1c56b6397f1

Phytohormones and shoot growth in a three-generation hybrid poplar family.

Authors: David W. Pearce¹

Source: Tree Physiology. Feb2004, Vol. 24 Issue 2, p217-224. 8p.

This result is not displayed to guests.
Login for full access.

The biodiversity and ecology of Antarctic lakes: models for evolution.

Authors: Johanna Laybourn-Parry¹, David A. Pearce²

Source: Philosophical Transactions of the Royal Society B: Biological Sciences. Dec2007, Vol. 362 Issue 1488, p2273-2289. 17p.

Subject Terms: *RADIOACTIVE pollution of water, *RADIOACTIVE substances in rivers, lakes, etc., *PROTEINS, *ENVIRONMENTAL sciences

Interplanetary Transfer of Photosynthesis An Experimental Demonstration of A Selective Dispersal Filter in Planetary Island Biogeography.

Authors: Charles S. Cockell, André Brack, David D. Wynn-Williams, Pietro Baglioni, Franz Brandstätter, René Demets, Howell G.M. Edwards, Aaron L. Gronstal, Gero Kurat, Pascal Lee, Gordon R. Osinski, David A. Pearce, Judith M. Pillinger, Claude-Alain Roten, Suzy Sancisi-Frey

Source: Astrobiology; Mar2007, Vol. 7 Issue 1, p1-9, 9p

Standardized assessment of behavior and adaptive living skills in juvenile neuronal ceroid lipofuscinosis.

Authors: Heather Adams, Elisabeth A de Blieck, Jonathan W Mink, Frederick J Marshall, Jennifer Kwon, Leon Dure, Paul G Rothberg, Denia Ramirez-Montealegre, David A Pearce

Source: Developmental Medicine & Child Neurology; Apr2006, Vol. 48 Issue 4, p259-264, 6p

Subject Terms: NEURONAL ceroid-lipofuscinosis, CHILDREN'S health, MENTAL health, CHILD psychology, BEHAVIORAL assessment of children, CHILDREN with disabilities

Growth of riparian cottonwoods: a developmental pattern and the influence of geomorphic context.

Authors: Chad R. Willms, David W. Pearce, Stewart B. Rood

Source: Trees: Structure & Function; Mar2006, Vol. 20 Issue 2, p210-218, 9p

Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.

Authors: Steve K. Cho, Ningguo Gao, David A. Pearce, Mark A. Lehrman, Sandra L. Hofmann

Source: Glycobiology; Jun2005, Vol. 15 Issue 6, p637-648, 12p

Subject Terms: TISSUE banks, HEALTH care rationing, TISSUES, HISTOLOGY

CLN3, the protein associated with batten disease: Structure, function and localization.

Authors: Seasson N. Phillips, Jared W. Benedict, Jill M. Weimer, David A. Pearce

Source: Journal of Neuroscience Research; Mar2005, Vol. 79 Issue 5, p573-583, 11p

Online Cycle Detection and Difference Propagation: Applications to Pointer Analysis.

Authors: David J. Pearce, Paul H.J. Kelly, Chris Hankin

Source: Software Quality Journal; Dec2004, Vol. 12 Issue 4, p311-337, 27p

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.

This result is not displayed to guests.
Login for full access.