A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response.

Authors: Richter, Clémentine^1,2, Latta, Lorenz¹, Harig, Daria^1,2, Carius, Patrick^1,2, Stucki, Janick D.^3,4, Hobi, Nina^3,4, Hugi, Andreas³, Schumacher, Paul⁵, Krebs, Tobias⁵, Gamrekeli, Alexander⁶, Stöckle, Felix⁶, Urbschat, Klaus⁷, Montalvo, Galia^8,9, Lautenschläger, Franziska^8,10, Loretz, Brigitta¹, Hidalgo, Alberto¹, Schneider‐Daum, Nicole¹, nicole.schneider-daum@helmholtz-hips.de, Lehr, Claus‐Michael^1,2

Source: Bioengineering & Translational Medicine; Jan2025, Vol. 10 Issue 1, p1-17, 17p

A New Class of Polyion Complex Vesicles (PIC‐somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms.

Authors: Yildirim, Turgay, Bali, Aghiad, Koch, Marcus, Paul, Pascal, Latta, Lorenz, Schneider‐Daum, Nicole, Gallei, Markus, Lehr, Claus‐Michael

Source: Small; 10/3/2024, Vol. 20 Issue 40, p1-10, 10p

A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria

Authors: Richter, Robert, Kamal, Mohamed.A.M., García-Rivera, Mariel A., Kaspar, Jerome, Junk, Maximilian, Elgaher, Walid A.M., Srikakulam, Sanjay Kumar, Gress, Alexander, Beckmann, Anja, Grißmer, Alexander, Meier, Carola, Vielhaber, Michael, Kalinina, Olga, Hirsch, Anna K.H., Hartmann, Rolf W., Brönstrup, Mark, Schneider-Daum, Nicole, Lehr, Claus-Michael

Source: In Materials Today Bio September 2020 8

A Monoclonal Human Alveolar Epithelial Cell Line ('Arlo') with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections

Authors: Carius, Patrick, Jungmann, Annemarie, Bechtel, Marco, Grißmer, Alexander, Boese, Annette, Gasparoni, Gilles, Salhab, Abdulrahman, Seipelt, Ralf, Urbschat, Klaus, Richter, Clémentine, Meier, Carola, Bojkova, Denisa, Cinatl, Jindrich, Walter, Jörn, Schneider‐Daum, Nicole, Lehr, Claus‐Michael

Source: Advanced science. 10(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181443672.0x000001&indx=1&recIds=ETOCvdc_100181443672.0x000001

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

Authors: Artzy-Schnirman, Arbel, Hobi, Nina, Schneider-Daum, Nicole, Guenat, Olivier T., Lehr, Claus-Michael, Sznitman, Josué

Source: In European Journal of Pharmaceutics and Biopharmaceutics November 2019 144:11-17

An Outer Membrane Vesicle‐Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Authors: Richter, Robert, Kamal, Mohamed A. M., Koch, Marcus, Niebuur, Bart‐Jan, Huber, Anna‐Lena, Goes, Adriely, Volz, Carsten, Vergalli, Julia, Kraus, Tobias, Müller, Rolf, Schneider‐Daum, Nicole, Fuhrmann, Gregor, Pagès, Jean‐Marie, Lehr, Claus‐Michael

Source: Advanced healthcare materials. 11(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100143379703.0x000001&indx=1&recIds=ETOCvdc_100143379703.0x000001

Nanoencapsulation of a glucocorticoid improves barrier function and anti-inflammatory effect on monolayers of pulmonary epithelial cell lines

Authors: Rigo, Lucas A., Carvalho-Wodarz, Cristiane S., Pohlmann, Adriana R., Guterres, Silvia S., Schneider-Daum, Nicole, Lehr, Claus-Michael, Beck, Ruy C.R.

Source: In European Journal of Pharmaceutics and Biopharmaceutics October 2017 119:1-10

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

Authors: Hittinger, Marius, Schneider-Daum, Nicole, Lehr, Claus-Michael

Source: In European Journal of Pharmaceutics and Biopharmaceutics September 2017 118:73-78

Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections

Authors: Castoldi, Arianna, Herr, Christian, Niederstraßer, Julia, Labouta, Hagar Ibrahim, Melero, Ana, Gordon, Sarah, Schneider-Daum, Nicole, Bals, Robert, Lehr, Claus-Michael

Source: In European Journal of Pharmaceutics and Biopharmaceutics September 2017 118:62-67

Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections

Authors: Günday Türeli, Nazende, Torge, Afra, Juntke, Jenny, Schwarz, Bianca C., Schneider-Daum, Nicole, Türeli, Akif Emre, Lehr, Claus-Michael, Schneider, Marc

Source: In European Journal of Pharmaceutics and Biopharmaceutics August 2017 117:363-371

Chapter 3.5 - Cell-based in vitro models for pulmonary permeability studies

Authors: Richter, Clémentine, Neu, Tobias, Latta, Lorenz, Schneider-Daum, Nicole, Lehr, Claus-Michael

Source: In Concepts and Models for Drug Permeability Studies Edition: Second Edition. 2024:137-168

Medium throughput breathing human primary cell alveolus-on-chip model

Authors: Stucki, Janick, Hobi, Nina, Galimov, Artur, Stucki, Andreas, Schneider-Daum, Nicole, Lehr, Claus-Michael, Huwer, Hanno, Frick, Manfred, Funke-Chambour, Manuela, Geiser, Thomas, Guenat, Olivier

Source: Scientific reports. 8(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183822297.0x000001&indx=1&recIds=ETOCvdc_100183822297.0x000001

Surface-modified yeast cells: A novel eukaryotic carrier for oral application

Authors: Kenngott, Elisabeth E., Kiefer, Ruth, Schneider-Daum, Nicole, Hamann, Alf, Schneider, Marc, Schmitt, Manfred J., Breinig, Frank

Source: In Journal of Controlled Release 28 February 2016 224:1-7

Mutual Regulation of Transcriptomes between Murine Pneumocytes and Fibroblasts Mediates Alveolar Regeneration in Air-Liquid Interface Cultures.

Authors: Yao, Yiwen, Miethe, Sarah, Kattler, Kathrin, Colakoglu, Betül, Walter, Jörn, Schneider-Daum, Nicole, Herr, Christian, Garn, Holger, Ritzmann, Felix, Bals, Robert, Beisswenger, Christoph

Source: American Journal of Respiratory Cell & Molecular Biology; Mar2024, Vol. 70 Issue 3, p203-214, 12p

Subject Terms: LUNGS, STEM cell niches, FIBROBLAST growth factors, FIBROBLASTS, EPITHELIAL cells, TRANSCRIPTOMES, REGENERATION (Biology)

Macrophage uptake of cylindrical microparticles investigated with correlative microscopy

Authors: Tscheka, Clemens, Hittinger, Marius, Lehr, Claus-Michael, Schneider-Daum, Nicole, Schneider, Marc

Source: In European Journal of Pharmaceutics and Biopharmaceutics September 2015 95 Part A:151-155

Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models

Authors: Hittinger, Marius, Juntke, Jenny, Kletting, Stephanie, Schneider-Daum, Nicole, de Souza Carvalho, Cristiane, Lehr, Claus-Michael

Source: In Advanced Drug Delivery Reviews May 2015 85:44-56

P-glycoprotein interactions of novel psychoactive substances – Stimulation of ATP consumption and transport across Caco-2 monolayers

Authors: Meyer, Markus R., Wagmann, Lea, Schneider-Daum, Nicole, Loretz, Brigitta, de Souza Carvalho, Cristiane, Lehr, Claus-Michael, Maurer, Hans H.

Source: In Biochemical Pharmacology 1 April 2015 94(3):220-226

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

Authors: Zamprogno, Pauline, Wüthrich, Simon, Achenbach, Sven, Thoma, Giuditta, Stucki, Janick D., Hobi, Nina, Schneider-Daum, Nicole, Lehr, Claus-Michael, Huwer, Hanno, Geiser, Thomas, Schmid, Ralph A., Guenat, Olivier T.

Source: Communications biology. 4(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194166517.0x000001&indx=1&recIds=ETOCvdc_100194166517.0x000001

Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery

Authors: de Souza Carvalho, Cristiane, Daum, Nicole, Lehr, Claus-Michael

Source: In Advanced Drug Delivery Reviews 30 August 2014 75:129-140

A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials

Authors: Susewind, Julia, de Souza Carvalho-Wodarz, Cristiane, Repnik, Urska, Collnot, Eva-Maria, Schneider-Daum, Nicole, Griffiths, Gareth Wyn, Lehr, Claus-Michael

Source: Nanotoxicology. 10(1):53-62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105935575.0x000001&indx=1&recIds=ETOCvdc_100105935575.0x000001