Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity

Authors: Dashwood, Amy ^{a, b, 1}, Makuyana, Ntombizodwa ^{a, b, 1}, van der Kant, Rob ^{c, d, 1}, Ghodsinia, Arman ^a, Hernandez, Alvaro R. ^{a, e}, Lienart, Stephanie ^b, Burton, Oliver ^{a, b}, Dooley, James ^{a, b}, Ali, Magda ^a, Kouser, Lubna ^b, Naranjo, Francisco ^b, Holt, Matthew G. ^{c, d, f}, Rousseau, Frederic ^{c, d, 2}, Schymkowitz, Joost ^{c, d, 2}, Liston, Adrian ^{a, b, ⁎, 2}

Source: In Computational and Structural Biotechnology Journal 2025 27:1112-1123

Highlight of 2023: Microglia biology.

Authors: Dashwood, Amy^1,2 (AUTHOR) ajd241@cam.ac.uk, Liston, Adrian¹ (AUTHOR)

Source: Immunology & Cell Biology. Jul2024, Vol. 102 Issue 6, p456-459. 4p.

Subject Terms: *MICROGLIA, *BIOLOGY, *CELL suspensions

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration.

Authors: Llorián-Salvador, María, de Fuente, Alerie G., McMurran, Christopher E., Dashwood, Amy, Dooley, James, Liston, Adrian, Penalva, Rosana, Dombrowski, Yvonne, Stitt, Alan W., Fitzgerald, Denise C.

Source: Molecular Neurodegeneration; 4/5/2024, Vol. 19 Issue 1, p1-17, 17p

Subject Terms: REGULATORY T cells, T cells, MACULAR degeneration, NEURODEGENERATION, IMMUNOSENESCENCE, RHODOPSIN, RETINAL diseases, AGE

Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination.

Authors: de la Fuente, Alerie Guzman, Dittmer, Marie, Heesbeen, Elise J., de la Vega Gallardo, Nira, White, Jessica A., Young, Andrew, McColgan, Tiree, Dashwood, Amy, Mayne, Katie, Cabeza-Fernández, Sonia, Falconer, John, Rodriguez-Baena, Francisco Javier, McMurran, Christopher E., Inayatullah, Mohammed, Rawji, Khalil S., Franklin, Robin J. M., Dooley, James, Liston, Adrian, Ingram, Rebecca J., Tiwari, Vijay K.

Source: Nature Communications; 3/11/2024, Vol. 15 Issue 1, p1-19, 19p

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Authors: Whyte, Carly E., Singh, Kailash, Burton, Oliver T., Aloulou, Meryem, Kouser, Lubna, Veiga, Rafael Valente, Dashwood, Amy, Okkenhaug, Hanneke, Benadda, Samira, Moudra, Alena

Source: Journal of experimental medicine. 219(7):e20212391-e20212391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629761937&indx=1&recIds=ETOCRN629761937

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Authors: Yshii, Lidia, Pasciuto, Emanuela, Bielefeld, Pascal, Mascali, Loriana, Lemaitre, Pierre, Marino, Marika, Dooley, James, Kouser, Lubna, Verschoren, Stijn, Lagou, Vasiliki, Kemps, Hannelore, Gervois, Pascal, de Boer, Antina, Burton, Oliver T., Wahis, Jérôme, Verhaert, Jens, Tareen, Samar H. K., Roca, Carlos P., Singh, Kailash, Whyte, Carly E., Kerstens, Axelle, Callaerts-Vegh, Zsuzsanna, Poovathingal, Suresh, Prezzemolo, Teresa, Wierda, Keimpe, Dashwood, Amy, Xie, Junhua, Van Wonterghem, Elien, Creemers, Eline, Aloulou, Meryem, Gsell, Willy, Abiega, Oihane, Munck, Sebastian, Vandenbroucke, Roosmarijn E., Bronckaers, Annelies, Lemmens, Robin, De Strooper, Bart, Van Den Bosch, Ludo, Himmelreich, Uwe, Fitzsimons, Carlos P., Holt, Matthew G., Liston, Adrian

Source: Nature Immunology; 20220101, Issue: Preprints p1-14, 14p