Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci

Authors: Chenfu Shi, Danyun Zhao, Jake Butler, Antonios Frantzeskos, Stefano Rossi, James Ding, Carlo Ferrazzano, Charlotte Wynn, Ryan Malcolm Hum, Ellie Richards, Muskan Gupta, Khadijah Patel, Chuan Fu Yap, Darren Plant, Richard Grencis, Paul Martin, Antony Adamson, Stephen Eyre, John Bowes, Anne Barton, Pauline Ho, Magnus Rattray, Gisela Orozco

Source: Genome Biology, Vol 26, Iss 1, Pp 1-29 (2025)

Subject Terms: Chromatin conformation, Hi-C, Inflammatory diseases, Gene regulation, GWAS, QTLs, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/c8cda9e5afd34a53b53b17cddf2a630f

O46 Distinct modular transcriptomic signatures associate with symptomatic fatigue and pain in ANA+ subjects both with and without clinically evolving SLE

Authors: Edward M Vital, Darren Plant, Md Yuzaiful Md Yusof, Zoe Wigston, Antonios Psarras, Adewonuola Alase, Lucy Marie Carter, Julien Bauer, Stephanie Wenlock

Source: Lupus Science and Medicine, Vol 11, Iss Suppl 1 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2053-8790

Access URL: https://doaj.org/article/279d1ef1cc534650b8bc1950a30850ba

High throughput screening of 0.5 million compounds against CRAF using Alpha CETSAⓇ

Authors: Hannah Rowlands, Kirsten Tschapalda, Carolyn Blackett, Delyan Ivanov, Darren Plant, Joseph Shaw, Andrew Thomas, Martin Packer, Laurence Arnold, Geoffrey A. Holdgate

Source: SLAS Discovery, Vol 28, Iss 3, Pp 102-110 (2023)

Subject Terms: CETSA, High-throughput screening, Automation, Cell-based assay, CRAF, Kinase, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555223000126; https://doaj.org/toc/2472-5552

Access URL: https://doaj.org/article/ad58a2ad53e14749991c8324b2b3f6b8

Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Authors: Stephanie F. Ling, Kayode Ogungbenro, Adam S. Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant

Source: Pharmaceutics, Vol 16, Iss 6, p 702 (2024)

Subject Terms: rheumatoid arthritis, pharmacokinetics, population pharmacokinetics, simulation, biologics, biosimilars, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/6/702; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/a8cfb2e5d9654bdba668ec4bfe031ac5

HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

Authors: Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton, Sebastien Viatte

Source: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-8 (2022)

Subject Terms: Cardiovascular mortality, Genetic biomarkers, HLA-DRB1, Rheumatoid arthritis, Anti-citrullinated protein antibodies, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/e750aa2d2f6a4498b1bd540f0004738b

Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunityResearch in context

Authors: James I. Robinson, Md Yuzaiful Md Yusof, Vinny Davies, Dawn Wild, Michael Morgan, John C. Taylor, Yasser El-Sherbiny, David L. Morris, Lu Liu, Andy C. Rawstron, Maya H. Buch, Darren Plant, Heather J. Cordell, John D. Isaacs, Ian N. Bruce, Paul Emery, Anne Barton, Timothy J. Vyse, Jennifer H. Barrett, Edward M. Vital, Ann W. Morgan

Source: EBioMedicine, Vol 86, Iss , Pp 104343- (2022)

Subject Terms: Autoimmune diseases, B-lymphocytes, Genetics, Rheumatoid arthritis, Rituximab, Systemic lupus erythematosus, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422005254; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/737647859b7c4fa4b27b129f6871d9c8

Prediction of response of methotrexate in patients with rheumatoid arthritis using serum lipidomics

Authors: Mateusz Maciejewski, Caroline Sands, Nisha Nair, Stephanie Ling, Suzanne Verstappen, Kimme Hyrich, Anne Barton, Daniel Ziemek, Matthew R. Lewis, Darren Plant

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/15aaa01033fa4c62b85b8be3ce377903

Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Authors: James OIiver, Nisha Nair, Gisela Orozco, Samantha Smith, Kimme L. Hyrich, Ann Morgan, John Isaacs, Anthony G. Wilson, BRAGGSS, Anne Barton, Darren Plant

Source: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-9 (2021)

Subject Terms: TNF-inhibitor, Adalimumab, Biomarkers, Gene expression, Longitudinal studies, Rheumatoid arthritis, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/bbb58074afc94d84ac2543b97fb97e06

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

Authors: Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward

Source: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Authors: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington

Source: Genome Medicine, Vol 10, Iss 1, Pp 1-12 (2018)

Subject Terms: Autoimmune disease, Rheumatoid arthritis, Epigenetics, DNA methylation, Twins, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-018-0575-9; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/32c0c5c3851c446a9a59cd9cd1a9608c

Correction to: Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Authors: James Oliver, Nisha Nair, Gisela Orozco, Samantha Smith, Kimme L. Hyrich, Ann Morgan, John Isaacs, Anthony G. Wilson, BRAGGSS, Anne Barton, Darren Plant

Source: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-1 (2021)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/f2efa8ebdc5a4f27a1c4c2f062fb77b2

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis

Authors: Srikant Ambatipudi, Gemma C. Sharp, Sarah L. N. Clarke, Darren Plant, Jonathan H. Tobias, David M. Evans, Anne Barton, Caroline L. Relton

Source: Journal of Immunology Research, Vol 2018 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156

Access URL: https://doaj.org/article/9e9e4ceedac74d9fa37d26986699aa3b

Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

Authors: Maria I Zervou, Efsevia Myrthianou, Irene Flouri, Darren Plant, Gregory Chlouverakis, Francesc Castro-Giner, Panayiota Rapsomaniki, Anne Barton, Dimitrios T Boumpas, Prodromos Sidiropoulos, George N Goulielmos

Source: PLoS ONE, Vol 8, Iss 9, p e74375 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040234/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/d815bff146db47889e607f6a9e99c7ec

Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.

Authors: Joanna E Cobb, Darren Plant, Edward Flynn, Meriem Tadjeddine, Philippe Dieudé, François Cornélis, Lisbeth Ärlestig, Solbritt Rantapää Dahlqvist, George Goulielmos, Dimitrios T Boumpas, Prodromos Sidiropoulos, Sophine B Krintel, Lykke M Ørnbjerg, Merete L Hetland, Lars Klareskog, Thomas Haeupl, Andrew Filer, Christopher D Buckley, Karim Raza, Torsten Witte, Reinhold E Schmidt, Oliver FitzGerald, Douglas Veale, Stephen Eyre, Jane Worthington

Source: PLoS ONE, Vol 8, Iss 6, p e66456 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840476/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/628ccdef86944f8a88af42fb2ef3e519

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.

Authors: Marcus Ronninger, Maria Seddighzadeh, Morten Christoph Eike, Darren Plant, Nina A Daha, Beate Skinningsrud, Jane Worthington, Tore K Kvien, Rene E M Toes, Benedicte A Lie, Lars Alfredsson, Leonid Padyukov

Source: PLoS ONE, Vol 7, Iss 3, p e32861 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3312880?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8a36cd766198420392d7d345949bfe68