Dual ASXL1 and CSF3R mutations drive myeloid-biased stem cell expansion and enhance neutrophil differentiation

Authors: Darmusey, Lucie ¹, Bagley, Anna J. ¹, Nguyen, Thai T. ¹, Carlson, Hanqian L. ¹, Blaylock, Hunter ¹, Shrestha, Shawn B. ¹, Pang, Amara ¹, Tauchmann, Samantha ¹, Taylor, Sarah C. ¹, Foley, Amy C. ¹, Niño, Katia E. ², Pietras, Eric M. ², Braun, Theodore P. ¹, Maxson, Julia E. ^{1, ∗}

Source: In Blood Advances 8 April 2025 9(7):1593-1607

3047 – ROLE OF EPIGENETIC DYSFUNCTION IN CHRONIC NEUTROPHILIC LEUKEMIA

Authors: Darmusey, Lucie, Bagley, Anna, Blaylock, Hunter, Foley, Amy, Nguyen, Thai, Nino, Katia, Kong, Garth, Pietras, Eric, Braun, Ted, Maxson, Julia

Source: Experimental hematology. 124(S):S73-S73

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195477346.0x000001&indx=1&recIds=ETOCvdc_100195477346.0x000001

Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas.

Authors: Darbo, Elodie, Pérot, Gaëlle, Darmusey, Lucie, Le Guellec, Sophie, Leroy, Laura, Gaston, Laëtitia, Desplat, Nelly, Thébault, Noémie, Merle, Candice, Rochaix, Philippe, Valentin, Thibaud, Ferron, Gwenaël, Chevreau, Christine, Bui, Binh, Stoeckle, Eberhard, Ranchere-Vince, Dominique, Méeus, Pierre, Terrier, Philippe, Piperno-Neumann, Sophie, Collin, Françoise

Source: Cancers; Jan2023, Vol. 15 Issue 2, p534, 24p

Subject Terms: LEIOMYOSARCOMA, CELL differentiation, DISEASE progression, CELL cycle, RESEARCH funding, GENE amplification, PHENOTYPES

Dual ASXL1and CSF3Rmutations drive myeloid biased stem cell expansion and enhance neutrophil differentiation

Authors: Darmusey, Lucie, Bagley, Anna J, Nguyen, Thai T, Carlson, Hanqian L, Blaylock, Hunter, Shrestha, Shawn B, Pang, Amara, Tauchmann, Samantha, Taylor, Sarah C, Foley, Amy C, Niño, Katia E, Pietras, Eric M, Braun, Theodore P, Maxson, Julia E

Source: Blood Advances; 20250101, Issue: Preprints

Asxl1deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors

Authors: Braun, Theodore P., Estabrook, Joseph, Schonrock, Zachary, Curtiss, Brittany M., Darmusey, Lucie, Macaraeg, Jommel, Enright, Trevor, Coblentz, Cody, Callahan, Rowan, Yashar, William, Taherinasab, Akram, Mohammed, Hisham, Coleman, Daniel J., Druker, Brian J., Demir, Emek, Lusardi, Theresa A., Maxson, Julia E.

Source: Leukemia; February 2023, Vol. 37 Issue: 2 p478-487, 10p

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas.

Authors: Darmusey, Lucie^1,2,3 (AUTHOR) lucie.darmusey@inserm.fr, Pérot, Gaëlle^1,4 (AUTHOR) gaelle.perot@inserm.fr, Thébault, Noémie^1,2 (AUTHOR) noemie.thebault@inserm.fr, Le Guellec, Sophie^1,2 (AUTHOR) LeGuellec.Sophie@iuct-oncopole.fr, Desplat, Nelly⁵ (AUTHOR) N.Desplat@bordeaux.unicancer.fr, Gaston, Laëtitia⁶ (AUTHOR) laetitia.gaston@chu-bordeaux.fr, Delespaul, Lucile^1,7 (AUTHOR) lucile.delespaul@icr.ac.uk, Lesluyes, Tom^1,7 (AUTHOR) tom.lesluyes@crick.ac.uk, Darbo, Elodie^5,7,8 (AUTHOR) elodie.darbo@u-bordeaux.fr, Gomez-Brouchet, Anne^1,2,4 (AUTHOR) brouchet.anne@chu-toulouse.fr, Richard, Elodie⁵ (AUTHOR) E.Richard@bordeaux.unicancer.fr, Baud, Jessica⁵ (AUTHOR) j.massiere@bordeaux.unicancer.fr, Leroy, Laura^1,2 (AUTHOR) laura.leroy@inserm.fr, Coindre, Jean-Michel^5,9 (AUTHOR) j.coindre@bordeaux.unicancer.fr, Blay, Jean-Yves^10,11 (AUTHOR) Jean-yves.blay@lyon.unicancer.fr, Chibon, Frédéric^1,2,5 (AUTHOR) frederic.chibon@inserm.fr, Richter, Günther H. S. (AUTHOR)

Source: Cancers. May2021, Vol. 13 Issue 9, p2151-2151. 1p.

Subject Terms: *DISEASE progression, *LEIOMYOSARCOMA, *TELOMERES, *CELL differentiation, *GENETIC mutation, *SOFT tissue tumors, *IMMUNITY, *MAST cells, *GENE expression profiling