CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer

Authors: Darja Marolt Presen, Duško Lainšček, Jane Kinghorn, Zsolt Sebestyen, Jurgen Kuball, Leila Amini, Petra Reinke, Anke Fuchs, Roman Jerala, Mojca Benčina

Source: Computational and Structural Biotechnology Journal, Vol 27, Iss , Pp 10-16 (2025)

Subject Terms: Gene therapy, Cell therapy, Neurological diseases, Cancer immunotherapy, Synthetic biology, Translational medicine, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037024004227; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/e0e2f9fb97a74787b4a70fbb52df83d0

Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium

Authors: Darja Marolt Presen, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra-Larissa Stetco, Anja Tansek, Laura Pozenel, Bella Bruszel, Goran Mitulovic, Johannes Oesterreicher, Johannes Zipperle, Barbara Schaedl, Wolfgang Holnthoner, Johannes Grillari, Heinz Redl

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)

Subject Terms: Conditioned medium, Secretome, Human iPSCs, Human bone marrow mesenchymal stromal cells, Mesenchymal progenitors, Osteogenic differentiation, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/5f30f58b46244a1a9d29c678452bb930

Osteosarcoma Cells and Undifferentiated Human Mesenchymal Stromal Cells Are More Susceptible to Ferroptosis than Differentiated Human Mesenchymal Stromal Cells

Authors: Yuliya D. Smirnova, Dominik Hanetseder, Lukas Derigo, Andreas Sebastian Gasser, Annette Vaglio-Garro, Simon Sperger, Regina Brunauer, Olga S. Korneeva, Johanna Catharina Duvigneau, Darja Marolt Presen, Andrey V. Kozlov

Source: Antioxidants, Vol 14, Iss 2, p 189 (2025)

Subject Terms: ferroptosis, osteosarcoma, Erastin, RSL3, Ferrostatin-1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/14/2/189; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/4bb266ea617f4cb59c288faf51eb7216

Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age

Authors: Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen

Source: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Subject Terms: extracellular matrix, iPSCs, bone marrow stromal cells, aging, osteogenic differentiation, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2023.1214019/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/fb56295a26444d579a2054b950b5c795

Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem/stromal cells in patients with osteoarthritis and femoral neck fracture

Authors: Klemen Čamernik, Anže Mihelič, Rene Mihalič, Gregor Haring, Simon Herman, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc, Janja Zupan

Source: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Mesenchymal stem/stromal cells, Skeletal muscle, Trabecular bone, Osteoarthritis, Osteoporosis, Controls, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13287-020-01657-z; https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/9a92aba986d1416cbe19d0cb2b29ab51

Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered Grafts

Authors: Jonathan C. Bernhard, Darja Marolt Presen, Ming Li, Xavier Monforte, James Ferguson, Gabriele Leinfellner, Patrick Heimel, Susanna L. Betti, Sharon Shu, Andreas H. Teuschl-Woller, Stefan Tangl, Heinz Redl, Gordana Vunjak-Novakovic

Source: Cells, Vol 11, Iss 19, p 3070 (2022)

Subject Terms: endochondral, intramembranous, ossification, bone tissue engineering, mesenchymal stromal cells, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/19/3070; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/65e645ec185f4babb0df61d06c613b36

Engineered extracellular matrix enhances the bone regeneration potential of aged human bone marrow stromal cells

Authors: Dominik Hanetseder, Tina Levstek, Heinz Redl, Darja Marolt Presen

Source: Bone Reports, Vol 13, Iss , Pp 100382- (2020)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235218722030142X; https://doaj.org/toc/2352-1872

Access URL: https://doaj.org/article/331ad6d5249347d8aeb12115ce796175

Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles

Authors: Darja Marolt Presen, Andreas Traweger, Mario Gimona, Heinz Redl

Source: Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)

Subject Terms: mesenchymal stromal cells, stem cells, MSCs, secretome, extracellular vesicles, cell therapy, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fbioe.2019.00352/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/0f694a6e5a0a4dde8ad5f253f5e82b2f

Skeletal-muscle-derived mesenchymal stem/stromal cells from patients with osteoarthritis show superior biological properties compared to bone-derived cells

Authors: Klemen Čamernik, Anže Mihelič, Rene Mihalič, Darja Marolt Presen, Andrej Janež, Rihard Trebše, Janja Marc, Janja Zupan

Source: Stem Cell Research, Vol 38, Iss , Pp - (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506119300959; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/fdf7bb658ea546988173439e8047168d

Effect of Diphenyleneiodonium Chloride on Intracellular Reactive Oxygen Species Metabolism with Emphasis on NADPH Oxidase and Mitochondria in Two Therapeutically Relevant Human Cell Types

Authors: Sergejs Zavadskis, Adelheid Weidinger, Dominik Hanetseder, Asmita Banerjee, Cornelia Schneider, Susanne Wolbank, Darja Marolt Presen, Andrey V. Kozlov

Source: Pharmaceutics, Vol 13, Iss 1, p 10 (2020)

Subject Terms: diphenyleneiodonium, reactive oxygen species, mitochondria, NADPH-oxidase, differentiation, proliferation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/1/10; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/7dc927379ad247d9ba04fd76eba0ca1e