A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity

Authors: Anirban Ghoshal, Edwin G. Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M. Merten, John D. Sears, Stefanie Howell, Sumera Perveen, Jane Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Bennett J. Davenport, Thomas E. Morrison, Zachary J. Streblow, Daniel N. Streblow, Angie L. Mordant, Thomas S. Webb, Aurora Cabrera, Laura E. Herring, Cheryl H. Arrowsmith, Kenneth H. Pearce, Nathaniel J. Moorman, Mark T. Heise, Rafael M. Couñago, Peter J. Brown, Timothy M. Willson

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-14 (2025)

Subject Terms: Covalent inhibitor, Cysteine protease, Chemical probe, Antiviral, Alphavirus, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8aca8b6ee16a4bd28a2ac2f20004c49b

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

Authors: Daniel N. Streblow, Alec J. Hirsch, Jeffrey J. Stanton, Anne D. Lewis, Lois Colgin, Ann J. Hessell, Craig N. Kreklywich, Jessica L. Smith, William F. Sutton, David Chauvin, Jennifer Woo, Benjamin N. Bimber, Cierra N. LeBlanc, Sonia N. Acharya, Brian J. O’Roak, Harjinder Sardar, Mohammad M. Sajadi, Zahra R. Tehrani, Mark R. Walter, Luis Martinez-Sobrido, James J. Kobie, Rachel J. Reader, Katherine J. Olstad, Theodore R. Hobbs, Erica Ollmann Saphire, Sharon L. Schendel, Robert H. Carnahan, Jonas Knoch, Luis M. Branco, James E. Crowe, Koen K. A. Van Rompay, Phillip Lovalenti, Vu Truong, Donald N. Forthal, Nancy L. Haigwood

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8766bd1dd34746b3b375ff5406037cd7

The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ®) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection

Authors: Whitney C. Weber, Zachary J. Streblow, Craig N. Kreklywich, Michael Denton, Gauthami Sulgey, Magdalene M. Streblow, Dorca Marcano, Paola N. Flores, Rachel M. Rodriguez-Santiago, Luisa I. Alvarado, Vanessa Rivera-Amill, William B. Messer, Romana Hochreiter, Karin Kosulin, Katrin Dubischar, Vera Buerger, Daniel N. Streblow

Source: Vaccines, Vol 12, Iss 8, p 893 (2024)

Subject Terms: chikungunya virus (CHIKV), alphaviruses, IXCHIQ, vaccine, cross-neutralization, antibody, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/8/893; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/bffc37a281b04519b216184bce06b458

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Authors: Whitney C. Weber, Takeshi F. Andoh, Craig N. Kreklywich, Zachary J. Streblow, Michael Denton, Magdalene M. Streblow, John M. Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T. Curiel, Nicole N. Haese, Daniel N. Streblow

Source: Vaccines, Vol 12, Iss 9, p 970 (2024)

Subject Terms: Chikungunya virus (CHIKV), Mayaro virus (MAYV), alphaviruses, vaccine, cross-neutralization, antibody, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/9/970; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/a5c3ecbf3e444fc38d200d6716b2545d

Differential Type 1 IFN Gene Expression in CD14+ Placenta Cells Elicited by Zika Virus Infection During Pregnancy

Authors: Nicole N. Haese, Hannah Smith, Kosiso Onwuzu, Craig N. Kreklywich, Jessica L. Smith, Michael Denton, Nicholas Kreklywich, Aaron D. Streblow, Antonio E. Frias, Terry K. Morgan, Alec J. Hirsch, Benjamin N. Bimber, Victoria H. J. Roberts, Daniel N. Streblow

Source: Frontiers in Virology, Vol 1 (2021)

Subject Terms: Zika virus, pregnancy, monocyte, macrophage, interferon, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fviro.2021.783407/full; https://doaj.org/toc/2673-818X

Access URL: https://doaj.org/article/0b1682a400b24b2bbf2004af064df1b4

Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury

Authors: Laura Goetzl, Angela J. Stephens, Yechiel Schlesinger, Nune Darbinian, Nana Merabova, Miriam Hillel, Alec J. Hirsch, Daniel N. Streblow, Antonio E. Frias, Victoria H. J. Roberts, Nicole N. Haese, Arunmani Mani, Yifat Eldar-Yedidia

Source: Frontiers in Virology, Vol 1 (2021)

Subject Terms: exosomes/extracellular vesicles (EVs/ECVs), cytomegalovirus (CMV), Zika (ZIKV), Contactin-2, prenatal diagnosis, microcephaly, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fviro.2021.782863/full; https://doaj.org/toc/2673-818X

Access URL: https://doaj.org/article/311dd73ce289441aa9742497f6f4b333

Comparison of SARS-CoV-2 PCR-Based Detection Using Saliva or Nasopharyngeal Swab Specimens in Asymptomatic Populations

Authors: Guang Fan, Xuan Qin, Daniel N. Streblow, Cristina Magallanes Hoyos, Donna E. Hansel

Source: Microbiology Spectrum, Vol 9, Iss 1 (2021)

Subject Terms: SARS-CoV-2, saliva, asymptomatic, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/781889c83ed74c058ae5794e42d38f69

Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells

Authors: Byeong-Jae Lee, Chan-Ki Min, Meaghan Hancock, Daniel N. Streblow, Patrizia Caposio, Felicia D. Goodrum, Andrew D. Yurochko

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: human cytomegalovirus (HCMV), monocytes, progenitor cells, epidermal growth factor receptor (EGFR), glycoproteins, cell signaling, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.660901/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/5c4294f8eb494330a7d035bdf35bd0b7

The Differentiation of Human Cytomegalovirus Infected-Monocytes Is Required for Viral Replication

Authors: Chan-Ki Min, Akhalesh K. Shakya, Byeong-Jae Lee, Daniel N. Streblow, Patrizia Caposio, Andrew D. Yurochko

Source: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Subject Terms: HCMV, monocyte, macrophage, EGFR, integrin, signaling, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2020.00368/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/f0f19a05541441f78a83141f40b1e6a3

Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology

Authors: Alec J. Hirsch, Victoria H. J. Roberts, Peta L. Grigsby, Nicole Haese, Matthias C. Schabel, Xiaojie Wang, Jamie O. Lo, Zheng Liu, Christopher D. Kroenke, Jessica L. Smith, Meredith Kelleher, Rebecca Broeckel, Craig N. Kreklywich, Christopher J. Parkins, Michael Denton, Patricia Smith, Victor DeFilippis, William Messer, Jay A. Nelson, Jon D. Hennebold, Marjorie Grafe, Lois Colgin, Anne Lewis, Rebecca Ducore, Tonya Swanson, Alfred W. Legasse, Michael K. Axthelm, Rhonda MacAllister, Ashlee V. Moses, Terry K. Morgan, Antonio E. Frias, Daniel N. Streblow

Source: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b27991f416df40acb0fbda1482c193c4

Nonhuman Primate Models of Zika Virus Infection and Disease during Pregnancy

Authors: Nicole N. Haese, Victoria H. J. Roberts, Athena Chen, Daniel N. Streblow, Terry K. Morgan, Alec J. Hirsch

Source: Viruses, Vol 13, Iss 10, p 2088 (2021)

Subject Terms: nonhuman primate, zika virus, pregnancy, placenta, immune response, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/10/2088; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/db8a427c2db24cb497bed5efce8be377

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice

Authors: Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Craig Kreklywich, Patricia Smith, Louis J. Picker, Jay A. Nelson, Patrizia Caposio

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/63f137c8af204eeab7c5949faeb8e663

Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease

Authors: Rebecca M. Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N. Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E. Morrison, Mark Heise, Victor DeFilippis, Ilhem Messaoudi, David T. Curiel, Daniel N. Streblow

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: Chikungunya virus (CHIKV), vaccine, T cell, pathogenesis, cytokine, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02563/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e0f6d6c3c6d84f9c8c83a6a0453541c9

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34+ Hematopoietic Progenitor Cells and Humanized NSG Mice

Authors: Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow

Source: mBio, Vol 10, Iss 4 (2019)

Subject Terms: US28, hematopoiesis, human cytomegalovirus, latency, reactivation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/2213cd7c92b0456f946b96b2a577e848

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Authors: Maria Pelliccia, Patrizia Andreozzi, Jayson Paulose, Marco D’Alicarnasso, Valeria Cagno, Manuela Donalisio, Andrea Civra, Rebecca M. Broeckel, Nicole Haese, Paulo Jacob Silva, Randy P. Carney, Varpu Marjomäki, Daniel N. Streblow, David Lembo, Francesco Stellacci, Vincenzo Vitelli, Silke Krol

Source: Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6897222ac66a4957bef12c2b0a62fd79

Rat Cytomegalovirus Virion-Associated Proteins R131 and R129 Are Necessary for Infection of Macrophages and Dendritic Cells

Authors: Iris K. A. Jones, Nicole N. Haese, Philippe Gatault, Zachary J. Streblow, Takeshi F. Andoh, Michael Denton, Cassilyn E. Streblow, Kiley Bonin, Craig N. Kreklywich, Jennifer M. Burg, Susan L. Orloff, Daniel N. Streblow

Source: Pathogens, Vol 9, Iss 11, p 963 (2020)

Subject Terms: cytomegalovirus, viral entry, dissemination, dendritic cells, chemokines, chemokine receptors, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/9/11/963; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/303e2efdd53f48689f0b149d8424a7d6

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Authors: Sara Botto, Jinu Abraham, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Igor Landais, Daniel N. Streblow, Klaus J. Fruh, Victor R. DeFilippis

Source: mBio, Vol 10, Iss 1 (2019)

Subject Terms: AIM2, DNA sensor, HCMV, IE2, IE86, STING, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/a95aa84d8b4242769d2b7f127e460ec9

Human Cytomegalovirus Infection Suppresses CD34+ Progenitor Cell Engraftment in Humanized Mice

Authors: Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Andrew D. Yurochko, Felicia D. Goodrum, Jay A. Nelson, Patrizia Caposio

Source: Microorganisms, Vol 8, Iss 4, p 525 (2020)

Subject Terms: human cytomegalovirus, progenitor cell, hematopoietic stem cell transplant, myelosuppression, hematopoiesis, humanized mice, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2076-2607/8/4/525; https://doaj.org/toc/2076-2607

Access URL: https://doaj.org/article/fd04cf77fd6d44d2a57c0f8ec7654d01

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model)

Authors: Rebecca Broeckel, Nicole Haese, Ilhem Messaoudi, Daniel N. Streblow

Source: Pathogens, Vol 4, Iss 3, Pp 662-681 (2015)

Subject Terms: chikungunya virus, nonhuman primate, polyarthritis, pathogenesis, immunity, Medicine

File Description: electronic resource

Relation: http://www.mdpi.com/2076-0817/4/3/662; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/0244a1483cd94aeb89e527d928a8e1d5

In Utero Administration of Drugs Targeting Microglia Improves the Neurodevelopmental Outcome Following Cytomegalovirus Infection of the Rat Fetal Brain

Authors: Robin Cloarec, Sylvian Bauer, Natacha Teissier, Fabienne Schaller, Hervé Luche, Sandra Courtens, Manal Salmi, Vanessa Pauly, Emilie Bois, Emilie Pallesi-Pocachard, Emmanuelle Buhler, François J. Michel, Pierre Gressens, Marie Malissen, Thomas Stamminger, Daniel N. Streblow, Nadine Bruneau, Pierre Szepetowski

Source: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Subject Terms: cytomegalovirus, microglia, rat model, fetal brain, neurological outcome, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fncel.2018.00055/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/63b2d4afd38e434c9e4dd67eb610625a