Pharmacologic inhibition of dipeptidyl peptidase 1 (cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Authors: Vivien R. Sutton, Sally V. Watt, Hedieh Akhlaghi, David C. Cipolla, Kuan-Ju Chen, Daniel LaSala, Patrick P. McDonald, Paul A. Beavis, Isabelle Munoz, Adrian W. Hodel, Tahereh Noori, Ilia Voskoboinik, Joseph A. Trapani

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: DPP1, granzyme, apoptosis, serine protease, T cell, lysosome, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1396710/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/637ceae3f9ef4a27add5a0ac7f8e1bc1

Dipeptidyl peptidase-1 inhibition with brensocatib reduces the activity of all major neutrophil serine proteases in patients with bronchiectasis: results from the WILLOW trial

Authors: David Cipolla, Jimin Zhang, Brice Korkmaz, James D. Chalmers, Jessica Basso, Daniel Lasala, Carlos Fernandez, Ariel Teper, Kevin C. Mange, Walter R. Perkins, Eugene J. Sullivan

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)

Subject Terms: Non-cystic fibrosis bronchiectasis, Brensocatib, Dipeptidyl peptidase-1 inhibitor, Neutrophil serine protease, Sputum biomarkers, Neutrophil elastase, Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/85f654da54af4f9a8406df384ca1cca2

The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species

Authors: Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala, Arielle Dorfman, Mary Atalla, Donald Chun, Veronica Viramontes, Christina Chang, Franziska Leifer, Patrick P. McDonald, David C. Cipolla

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: neutrophil elastase (NE), proteinase 3 (PR3), cathepsin G (CatG), cathepsin C (CatC), dipeptidyl peptidase 1 (DPP1), brensocatib, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1208780/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/a26331d5dd3f4103b5293969b4ae00de

Brensocatib, an oral, reversible inhibitor of dipeptidyl peptidase 1, mitigates interferon-α-accelerated lupus nephritis in mice

Authors: Kuan-Ju Chen, Jimin Zhang, Daniel LaSala, Jessica Basso, Donald Chun, Yuchen Zhou, Patrick P. McDonald, Walter R. Perkins, David C. Cipolla

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: brensocatib, neutrophil serine proteases (NSP), lupus nephritis (LN), interferon-alpha (IFNα), systemic lupus erythematosus (SLE), DPP1 inhibitor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185727/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/39068ea155094654afda96d63a8b6583

An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells.

Authors: Jessica Basso, Jimin Zhang, Daniel Lasala, Sasha J Rose, Kuan-Ju Chen, David Cipolla

Source: PLoS ONE, Vol 17, Iss 8, p e0272575 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0272575&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2a93b283d3564f1a9866e8426a8f046d

When Less is More: Enhanced Baculovirus Production of Recombinant Proteins at Very Low Multiplicities of Infection

Authors: Jeffrey M. Liebman, Daniel LaSala, Weigwang Wang, Paul M. Steed

Source: BioTechniques, Vol 26, Iss 1, Pp 36-42 (1999)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/f4a174056878437ca77fb98aac5ec53d

Structure–ActivityRelationships, Pharmacokinetics,and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.

Authors: Julien P. N. Papillon, ChristopherM. Adams, Qi-Ying Hu, Changgang Lou, Alok K. Singh, Chun Zhang, Jose Carvalho, Srinivan Rajan, Adam Amaral, Michael E. Beil, Fumin Fu, Eric Gangl, Chii-Whei Hu, Arco Y. Jeng, Daniel LaSala, Guiqing Liang, Michael Logman, WieslawaM. Maniara, Dean F. Rigel, SherriA. Smith

Source: Journal of Medicinal Chemistry; Jun2015, Vol. 58 Issue 11, p4749-4770, 22p