Clinical activity and safety of the anti-PD-1 monoclonal antibody dostarlimab for patients with recurrent or advanced dMMR endometrial cancer

Authors: Oaknin, Ana, Tinker, Anna V, Gilbert, Lucy, Samouëlian, Vanessa, Mathews, Cara, Brown, Jubilee, Barretina-Ginesta, Maria-Pilar, Moreno, Victor, Gravina, Adriano, Abdeddaim, Cyril, Banerjee, Susana, Guo, Wei, Danaee, Hadi, Im, Ellie, Sabatier, Renaud

Source: Future oncology. 17(29):3781-3785

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187739307.0x000001&indx=1&recIds=ETOCvdc_100187739307.0x000001

TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study

Authors: Bang, Yung-Jue, Takano, Toshimi, Lin, Chia-Chi, Fasanmade, Adedigbo, Yang, Huyuan, Danaee, Hadi, Asato, Takayuki, Kalebic, Thea, Wang, Hui, Doi, Toshihiko

Source: Cancer research and treatment. 50(2):398-404

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615409933&indx=1&recIds=ETOCRN615409933

Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models

Authors: Kumar, Sujatha, Ghosh, Srimoyee, Sharma, Geeta, Wang, Zebin, Kehry, Marilyn R., Marino, Margaret H., Neben, Tamlyn Y., Lu, Sharon, Luo, Shouqi, Roberts, Simon, Ramaswamy, Sridhar, Danaee, Hadi, Jenkins, David

Source: MAbs. 13(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137172342.0x000001&indx=1&recIds=ETOCvdc_100137172342.0x000001

Development and Validation of an ERCC1 Immunohistochemistry Assay for Solid Tumors

Authors: Bahamon, Brittany N., Gao, Feng, Danaee, Hadi

Source: Archives of pathology & laboratory medicine. 140(12):1397-1403

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631215930&indx=1&recIds=ETOCRN631215930

Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma

Authors: Matulonis, Ursula A., Sharma, Sudarshan, Ghamande, Sharad, Gordon, Michael S., Del Prete, Salvatore A., Ray-Coquard, Isabelle, Kutarska, Elzbieta, Liu, Hua, Fingert, Howard, Zhou, Xiaofei, Danaee, Hadi, Schilder, Russell J.

Source: In Gynecologic Oncology October 2012 127(1):63-69

Validation of a flow cytometry based G 2M delay cell cycle assay for use in evaluating the pharmacodynamic response to Aurora A inhibition

Authors: Estevam, Jose, Danaee, Hadi, Liu, Ray, Ecsedy, Jeffrey, Trepicchio, William L., Wyant, Timothy

Source: In Journal of Immunological Methods 2011 363(2):135-142

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.

Authors: Danaee, Hadi¹, Kalebic, Thea¹ Thea.Kalebic@takeda.com, Wyant, Timothy¹, Fassan, Matteo², Mescoli, Claudia², Gao, Feng¹, Trepicchio, William L.¹, Rugge, Massimo²

Source: PLoS ONE. 12/19/2017, Vol. 12 Issue 12, p1-10. 10p.

Subject Terms: *GUANYLATE cyclase, *COLON cancer, *GASTROINTESTINAL agents, *METASTASIS, *PROTEIN expression

Assessment of chromosomal alterations to predict clinical outcome of bortezomib treatment

Allelic Loss at Drosophila Patched Gene Is Highly Prevalent in Basal and Squamous Cell Carcinomas of the Skin

Authors: Danaee, Hadi, Karagas, Margaret R., Kelsey, Karl T., Perry, Ann E., Nelson, Heather H ^*

Source: In Journal of Investigative Dermatology May 2006 126(5):1152-1158

Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose–escalation phase 1 trial.

Authors: Patnaik, Amita, Weiss, Glen J., Rasco, Drew W., Blaydorn, Lisa, Mirabella, Amy, Beeram, Murali, Guo, Wei, Lu, Sharon, Danaee, Hadi, McEachern, Kristen, Im, Ellie, Sachdev, Jasgit C.

Source: Cancer Chemotherapy & Pharmacology; Jan2022, Vol. 89 Issue 1, p93-103, 11p

Subject Terms: PROGRAMMED cell death 1 receptors, ANTINEOPLASTIC agents, PHARMACOKINETICS

Clinical Activity and Safety of the Anti–Programmed Death 1 Monoclonal Antibody Dostarlimab for Patients With Recurrent or Advanced Mismatch Repair–Deficient Endometrial Cancer: A Nonrandomized Phase 1 Clinical Trial.

Authors: Oaknin, Ana, Tinker, Anna V., Gilbert, Lucy, Samouëlian, Vanessa, Mathews, Cara, Brown, Jubilee, Barretina-Ginesta, Maria-Pilar, Moreno, Victor, Gravina, Adriano, Abdeddaim, Cyril, Banerjee, Susana, Guo, Wei, Danaee, Hadi, Im, Ellie, Sabatier, Renaud

Source: JAMA Oncology; Nov2020, Vol. 6 Issue 11, p1766-1772, 7p

Microsatellite instability at tetranucleotide repeats in skin and bladder cancer.

Authors: Danaee, Hadi, Nelson, Heather H., Karagas, Margaret R., Schned, Alan R., Ashok, Tara Devi S., Hirao, Tomoko, Perry, Ann E., Kelsey, Karl T.

Source: Oncogene. 7/25/2002, Vol. 21 Issue 32, p4894. 6p. 4 Charts, 1 Graph.

Subject Terms: *BLADDER cancer, *MICROSATELLITE repeats, *P53 antioncogene

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Sequence analysis of β-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone

Authors: Lichter, David I. ^*, Danaee, Hadi ^*, Pickard, Michael D., Tayber, Olga, Sintchak, Michael, Shi, Hongliang, Richardson, Paul G., Cavenagh, Jamie, Bladé, Joan, Façon, Thierry, Niesvizky, Ruben, Alsina, Melissa, Dalton, William, Sonneveld, Pieter, Lonial, Sagar, van de Velde, Helgi, Ricci, Deborah, Esseltine, Dixie-Lee, Trepicchio, William L., Mulligan, George ^†, Anderson, Kenneth C. ^†

Source: In Blood 29 November 2012 120(23):4513-4516