Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies

Authors: Frigault, Matthew J., Graham, Charlotte E., Berger, Trisha R., Ritchey, Julie, Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Schmidts, Andrea, Haradhvala, Nicholas J., Wehrli, Marc, Lee, Won-Ho, Parker, Aiyana L., Wiggin, Hadley R., Bouffard, Amanda, Dey, Aonkon, Leick, Mark B., Katsis, Katelin, Elder, Eva L., Dolaher, Maria A., Cook, Daniella T., Chekmasova, Alena A., Huang, Lu, Nikiforow, Sarah, Daley, Heather, Ritz, Jerome, Armant, Myriam, Preffer, Fred, DiPersio, John F., Nardi, Valentina, Chen, Yi-Bin, Gallagher, Kathleen M. E., Maus, Marcela V.

Source: In Blood 12 September 2024 144(11):1153-1167

Phase 1 study of CART-ddBCMA for the treatment of subjects with relapsed and refractory multiple myeloma

Authors: Frigault, Matthew J., Bishop, Michael R., Rosenblatt, Jacalyn, O’Donnell, Elizabeth K., Raje, Noopur, Cook, Daniella, Yee, Andrew J., Logan, Emma, Avigan, David E., Jakubowiak, Andrzej, Shaw, Kit, Daley, Heather, Nikiforow, Sarah, Griffin, Faith, Cornwell, Christine, Shen, Angela, Heery, Christopher, Maus, Marcela V.

Source: In Blood Advances 14 March 2023 7(5):768-777

GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized, double-blinded, phase 2 trial

Authors: Ho, Vincent T. ^*, Kim, Haesook T., Brock, Jennifer, Galinsky, Ilene, Daley, Heather, Reynolds, Carol, Weber, Augustine, Pozdnyakova, Olga, Severgnini, Mariano, Nikiforow, Sarah, Cutler, Corey, Koreth, John, Alyea, Edwin P., III, Antin, Joseph H., Gooptu, Mahasweta, Romee, Rizwan, Shapiro, Roman, Chen, Yi-Bin, Rosenblatt, Jacalyn, Avigan, David, Hodi, F. Stephen, Dranoff, Glenn, Wu, Catherine J., Ritz, Jerome, Soiffer, Robert J.

Source: In Blood Advances 12 April 2022 6(7):2183-2194

Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.

Authors: Sîrbulescu, Ruxandra F., Nicholson, Katharine, Kawai, Kento, Hilton, Orla M., Sobell, Don, Jin, Gina, Verrill, David E., Dwyer, Liam J., Xiong, Yueyue, Bachanová, Petra, Kim, Spencer E., Gallup, Shannon, Gelevski, Dario, Daley, Heather, Hernandez Rodriguez, Diego E., Negre, Hélène, Sturtevant, Olive, Nikiforow, Sarah, Ritz, Jerome, Chen, Yi‐Bin

Source: FASEB Journal; 7/15/2024, Vol. 38 Issue 13, p1-15, 15p

Novel Autologous Dendritic Cell Therapy AVT001 for Type 1 Diabetes.

Authors: Gaglia, Jason L., Daley, Heather L., Bryant, Nora K., Ritz, Jerome, Dong, Tuochuan, Skyler, Jay S., Hong Jiang

Source: NEJM Evidence; Jul2024, Vol. 3 Issue 7, p1-10, 10p

Subject Terms: TYPE 1 diabetes, T cells, PLACEBOS, GLYCOSYLATED hemoglobin, STATISTICAL sampling, BLIND experiment, CELLULAR therapy, TREATMENT effectiveness, RANDOMIZED controlled trials, SEVERITY of illness index, DESCRIPTIVE statistics, INTRAVENOUS therapy, C-peptide, CONFIDENCE intervals, DENDRITIC cells, DISEASE progression

Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients

Authors: Esrick, Erica B. ^*, Manis, John P. ^*, Daley, Heather, Baricordi, Cristina, Trébéden-Negre, Hélène, Pierciey, Francis J., Armant, Myriam, Nikiforow, Sarah, Heeney, Matthew M., London, Wendy B., Biasco, Luca, Asmal, Mohammed, Williams, David A., Biffi, Alessandra

Source: In Blood Advances 9 October 2018 2(19):2505-2512

Manufacturing development and clinical production of NKG2D chimeric antigen receptor–expressing T cells for autologous adoptive cell therapy

Authors: Murad, Joana M. ^*, Baumeister, Susanne H. ^*, Werner, Lillian, Daley, Heather, Trébéden-Negre, Hélène, Reder, Jake, Sentman, Charles L., Gilham, David, Lehmann, Frederic, Snykers, Sarah, Sentman, Marie-Louise, Wade, Terri, Schmucker, Adam, Fanger, Michael W., Dranoff, Glenn, Ritz, Jerome, Nikiforow, Sarah ^*

Source: In Cytotherapy July 2018 20(7):952-963

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Authors: Keskin, Derin, Anandappa, Annabelle, Sun, Jing, Tirosh, Itay, Mathewson, Nathan, Li, Shuqiang, Oliveira, Giacomo, Giobbie-Hurder, Anita, Felt, Kristen, Gjini, Evisa, Shukla, Sachet, Hu, Zhuting, Li, Letitia, Le, Phuong, Allesøe, Rosa, Richman, Alyssa, Kowalczyk, Monika, Abdelrahman, Sara, Geduldig, Jack, Charbonneau, Sarah, Pelton, Kristine, Iorgulescu, J., Elagina, Liudmila, Zhang, Wandi, Olive, Oriol, McCluskey, Christine, Olsen, Lars, Stevens, Jonathan, Lane, William, Salazar, Andres, Daley, Heather, Wen, Patrick, Chiocca, E., Harden, Maegan, Lennon, Niall, Gabriel, Stacey, Getz, Gad, Lander, Eric, Regev, Aviv, Ritz, Jerome, Neuberg, Donna, Rodig, Scott, Ligon, Keith, Suvà, Mario, Wucherpfennig, Kai, Hacohen, Nir, Fritsch, Edward, Livak, Kenneth, Ott, Patrick, Wu, Catherine, Reardon, David

Source: Nature. 565(7738):234-239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103845853.0x000001&indx=1&recIds=ETOCvdc_100103845853.0x000001

Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+lymphoid malignancies

Authors: Frigault, Matthew J., Graham, Charlotte E., Berger, Trisha R., Ritchey, Julie, Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Schmidts, Andrea, Haradhvala, Nicholas J., Wehrli, Marc, Lee, Won-Ho, Parker, Aiyana L., Wiggin, Hadley R., Bouffard, Amanda, Dey, Aonkon, Leick, Mark B., Katsis, Katelin, Elder, Eva L., Dolaher, Maria A., Cook, Daniella T., Chekmasova, Alena A., Huang, Lu, Nikiforow, Sarah, Daley, Heather, Ritz, Jerome, Armant, Myriam, Preffer, Fred, DiPersio, John F., Nardi, Valentina, Chen, Yi-Bin, Gallagher, Kathleen M. E., Maus, Marcela V.

Source: Blood; September 2024, Vol. 144 Issue: 11 p1153-1167, 15p

Vaccination with autologous myeloblasts admixed with GM-K562 cells in patients with advanced MDS or AML after allogeneic HSCT

Authors: Ho, Vincent T. ^{1, 2, *}, Kim, Haesook T. ³, Bavli, Natalie ^{1, 2}, Mihm, Martin ^{4, 5}, Pozdnyakova, Olga ⁶, Piesche, Matthias ^{1, 2, 7}, Daley, Heather ^{1, 2}, Reynolds, Carol ^{1, 2}, Souders, Nicholas C. ^{1, 2}, Cutler, Corey ^{1, 2}, Koreth, John ^{1, 2}, Alyea, Edwin P. ^{1, 2}, Antin, Joseph H. ^{1, 2}, Ritz, Jerome ^{1, 2}, Dranoff, Glenn ^{1, 2}, Soiffer, Robert J. ^{1, 2}

Source: In Blood Advances 14 November 2017 1(24):2269-2279

Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocytemacrophage colony stimulating factor in patients with stage III and IV melanoma.

Authors: Sussman, Tamara A., Severgnini, Mariano, Giobbie-Hurder, Anita, Friedlander, Philip, Swanson, Scott J., Jaklitsch, Michael, Clancy, Thomas, Goguen, Laura A., Lautz, David, Swanson, Richard, Daley, Heather, Ritz, Jerome, Dranoff, Glenn, Hodi, F. Stephen

Source: Frontiers in Oncology; 2024, p1-11, 11p

Subject Terms: GENETIC transformation, IMMUNE checkpoint inhibitors, PULMONARY alveolar proteinosis, TUMOR antigens, IMMUNE checkpoint proteins, CANCER vaccines, MELANOMA

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome.

Authors: Hammond, Terese C., Purbhoo, Marco A., Kadel, Sapana, Ritz, Jerome, Nikiforow, Sarah, Daley, Heather, Shaw, Kit, van Besien, Koen, Gomez-Arteaga, Alexandra, Stevens, Don, Ortuzar, Waldo, Michelet, Xavier, Smith, Rachel, Moskowitz, Darrian, Masakayan, Reed, Yigit, Burcu, Boi, Shannon, Soh, Kah Teong, Chamberland, John, Song, Xin

Source: Nature Communications; 2/6/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: ADULT respiratory distress syndrome, CYTOTOXIC T cells, KILLER cells, T cells, T cell receptors, CELLULAR therapy, CLINICAL trials, EXTRACORPOREAL membrane oxygenation

Induction of Fetal Hemoglobin and Reduction of Clinical Manifestations in Patients with Severe Sickle Cell Disease Treated with Shmir-Based Lentiviral Gene Therapy for Post-Transcriptional Gene Editing of BCL11A: Updated Results from Pilot and Feasibility Trial

Authors: Esrick, Erica B., Federico, Amy ^*, Abriss, Daniela ^*, Armant, Myriam ^*, Boardman, Kari ^*, Brendel, Christian ^*, Ciuculescu, Marioara-Felicia ^*, Daley, Heather ^*, Dansereau, Colleen ^*, Fernandes, Augustine ^*, Heeney, Matthew M., Justus, David G. ^*, Kao, Pei-Chi ^*, Kim, Annette S., Kohn, Donald B., Lehmann, Leslie E., Liu, Donghui ^*, London, Wendy B., Manis, John P, Moore, Theodore B., Morris, Emily ^*, Pellin, Danilo ^*, Proeung, Ellen ^*, Richard, Shanna ^*, Roach, Gavin D., Shaw, Kit L. ^*, Terrazas, Dayna ^*, White, Shanna L ^*, Williams, David A.

Source: In Blood 15 November 2022 140 Supplement 1:10665-10667

High density electromyography data of normally limbed and transradial amputee subjects for multifunction prosthetic control

Authors: Daley, Heather, Englehart, Kevin, Hargrove, Levi, Kuruganti, Usha

Source: In Journal of Electromyography and Kinesiology June 2012 22(3):478-484

Expansion, Persistence, and Characteristics of Autologous, Bhv-1100 Armored Memory-like NK Cells Infused Prior to Autologous Stem Cell Transplant in MRD+ Multiple Myeloma Patients: A First-in-Human Trial

Authors: Birch, Grace Caroline, Vergara-Cadavid, Juliana, Maqbool, Mohsin, Martini, Alba, Dinh, Khanlinh, Shapiro, Roman M., Ansuinelli, Michela, Nguyen, Tuyet, Reynolds, Carol, Soo Y, Im, Wei, Hope, Hogan, Sarah, Kendricken, Elizabeth, Sperling, Adam S., Nadeem, Omar, Laubach, Jacob, Rybicki, Alissa, Schnittman, Steven, Stock, Elyse, Hernandez Rodriguez, Diego, Daley, Heather, Nikiforow, Sarah, Ritz, Jerome, Soiffer, Robert J., Bianchi, Giada, Romee, Rizwan

Source: In Blood 2 November 2023 142 Supplement 1:2105-2105

CTLA-4 Blockade Results in the Enrichment of Proliferative CD56 dimCD16 + NK Cells Following Infusion of Haploidentical Donor Memory-like Natural Killer Cells Plus IL-15 Superagonist in a Phase 1 Trial

Authors: Shapiro, Roman M., Sheffer, Michal, Booker, Matthew Aaron, Tolstorukov, Michael Yevgeniy, Ansuinelli, Michela, Sade-Feldman, Moshe, Fang, Jacy, Birch, Grace Caroline, Vergara-Cadavid, Juliana, Abdulhamid, Yasmin Z, Kaplan, Isabel E, Khanhlinh, Dinh, Redd, Robert A., Alonso, Alejandro, Bat-Erdene, Denbaa, Uppaluri, Ravindra, Daley, Heather, Hernandez Rodriguez, Diego, Koreth, John, Ritz, Jerome, Nikiforow, Sarah, Soiffer, Robert J., Hanna, Glenn J, Romee, Rizwan

Source: In Blood 2 November 2023 142 Supplement 1:6850-6850

Phase 1 Study of CART-ddBCMA, a CAR-T therapy utilizing a novel synthetic binding domain, for the treatment of subjects with relapsed and refractory multiple myeloma.

Authors: Frigault, Matthew J., O'Donnell, Elizabeth, Raje, Noopur S., Cook, Daniella, Yee, Andrew, Rosenblatt, Jacalyn, Gibson, Chelsey, Logan, Emma, Avigan, David, Bishop, Michael Russell, Eckert, Katherine, Daley, Heather, Rodriguez, Diego Hernandez, Mason, Andrew, Nikiforow, Sarah, Mangus, Carissa, Gil-Krzewska, Aleksandra, Currence, Scott, Shen, Angela, Maus, Marcela Valderrama

Source: Journal of clinical oncology. 39(15 suppl):8015-8015

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173216855.0x000001&indx=1&recIds=ETOCvdc_100173216855.0x000001

The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II–III and metastatic breast cancers.

Authors: Anderson, Karen S., Erick, Timothy K., Chen, Meixuan, Daley, Heather, Campbell, Margaret, Colson, Yolonda, Mihm, Martin, Zakka, Labib R., Hopper, Marika, Barry, William, Winer, Eric P., Dranoff, Glenn, Overmoyer, Beth

Source: Breast Cancer Research & Treatment; Jul2022, Vol. 194 Issue 1, p65-78, 14p

Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in

Authors: Sperling, Adam S., Nikiforow, Sarah, Nadeem, Omar, Mo, Clifton C, Laubach, Jacob P., Anderson, Kenneth C., Alonso, Alejandro, Ikegawa, Shuntaro, Prabhala, Rao, Hernandez Rodriguez, Diego, Daley, Heather, Shaw, Kit L., Arihara, Yohei, Ansari, Soudeh, Quinn, David S, Pearson, David, Hack, Anniesha, Treanor, Louise M, Bu, Dexiu, Mataraza, Jennifer, Rispoli, Lawrence, Credi, Marc, Ritz, Jerome, De Vita, Serena, Munshi, Nikhil C.

Source: In Blood 23 November 2021 138 Supplement 1:3864-3864

Phase 1 Study of CD37-Directed CAR T Cells in Patients with Relapsed or Refractory CD37+ Hematologic Malignancies

Authors: Frigault, Matthew J., Chen, Yi-Bin, Gallagher, Kathleen M.E., Horick, Nora K., El-Jawahri, Areej, Scarfò, Irene, Wehrli, Marc, Huang, Lu, Casey, Keagan, Cook, Daniella, Spitzer, Thomas, McAfee, Steven, Preffer, Frederic I., Armant, Myriam, Shaw, Kit L., Daley, Heather, Nikiforow, Sarah, Ritz, Jerome, Maus, Marcela V.

Source: In Blood 23 November 2021 138 Supplement 1:653-653