HBV serum RNA kinetics during nucleic acid polymers based therapy predict functional cure

Authors: Hershkovich, Leeor ^a, Cotler, Scott J. ^a, Shekhtman, Louis ^{a, b}, Bazinet, Michel ^c, Anderson, Mark ^d, Kuhns, Mary ^d, Cloherty, Gavin ^d, Vaillant, Andrew ^{c, ⁎⁎}, Dahari, Harel ^{a, ⁎}

Source: In Antiviral Research February 2025 234

Modeling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes

Authors: Shekhtman, Louis ^{1, 2, †}, Ishida, Yuji ^{3, †}, Tsuge, Masataka ^{4, 5}, Reinharz, Vladimir ⁶, Yamao, Mikaru ³, Takahashi, Masaki ³, Tateno, Chise ³, Uprichard, Susan L. ¹, Dahari, Harel ^{1, ⁎}, Chayama, Kazuaki ^{7, 8, ⁎}

Source: In JHEP Reports April 2025 7(4)

Multi-Objective Model Exploration of Hepatitis C Elimination in an Agent-Based Model of People who Inject Drugs

Authors: Tatara, Eric, Collier, Nicholson T., Ozik, Jonathan, Gutfraind, Alexander, Cotler, Scott J., Dahari, Harel, Major, Marian, Boodram, Basmattee

Source: 2019 Winter Simulation Conference (WSC) Winter Simulation Conference (WSC), 2019. :1008-1019 Dec, 2019

Relation: 2019 Winter Simulation Conference (WSC)

Modelling HDV kinetics under the entry inhibitor bulevirtide suggests the existence of two HDV-infected cell populations

Authors: Shekhtman, Louis, Cotler, Scott J., Degasperi, Elisabetta, Anolli, Maria Paola, Uceda Renteria, Sara Colonia, Sambarino, Dana, Borghi, Marta, Perbellini, Riccardo, Facchetti, Floriana, Ceriotti, Ferruccio, Lampertico, Pietro, Dahari, Harel

Source: In JHEP Reports February 2024 6(2)

Treatment of chronic hepatitis D with peginterferon lambda—the phase 2 LIMT-1 clinical trial

Authors: Etzion, Ohad, Hamid, Saeed, Lurie, Yoav, Gane, Edward J., Yardeni, David, Duehren, Sarah, Bader, Nimrah, Nevo-Shor, Anat, Channa, Saleh Muhammad, Cotler, Scott J., Mawani, Minaz, Parkash, Om, Dahari, Harel, Choong, Ingrid, Glenn, Jeffrey S.

Source: Hepatology. 77(6):2093-2103

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191135680.0x000001&indx=1&recIds=ETOCvdc_100191135680.0x000001

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Machine learning for mathematical models of HCV kinetics during antiviral therapy

Authors: Churkin, Alexander, Kriss, Stephanie, Uziel, Asher, Goyal, Ashish, Zakh, Rami, Cotler, Scott J., Etzion, Ohad, Shlomai, Amir, Rotstein, Horacio G., Dahari, Harel, Barash, Danny

Source: In Mathematical Biosciences January 2022 343

Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies.

Authors: Shi, Zhenzhen, Mhlanga, Adquate, Ishida, Yuji, Josephson, Ari, Collier, Nicholson T., Abe-Chayama, Hiromi, Tateno-Mukaidani, Chise, Cotler, Scott J., Ozik, Jonathan, Major, Marian, Feld, Jordan J., Chayama, Kazuaki, Dahari, Harel

Source: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: HEPATITIS C, MEDICAL sciences, MEDICAL microbiology, HEPATITIS C virus, ORDINARY differential equations

Modeling based response guided therapy in subjects with recent hepatitis C infection

Authors: Gorstein, Evan, Martinello, Marianne, Churkin, Alexander, Dasgupta, Swikriti, Walsh, Kevin, Applegate, Tanya L., Yardeni, David, Etzion, Ohad, Uprichard, Susan L., Barash, Danny, Cotler, Scott J., Matthews, Gail V., Dahari, Harel

Source: In Antiviral Research August 2020 180

Short-course, direct-acting antivirals and ezetimibe to prevent HCV infection in recipients of organs from HCV-infected donors: a phase 3, single-centre, open-label study

Authors: Feld, Jordan J ^*, Cypel, Marcelo, Kumar, Deepali, Dahari, Harel, Pinto Ribeiro, Rafaela Vanin, Marks, Nikki, Kamkar, Nellie, Bahinskaya, Ilona, Onofrio, Fernanda Q, Zahoor, Mohamed A, Cerrochi, Orlando, Tinckam, Kathryn, Kim, S Joseph, Schiff, Jeffrey, Reichman, Trevor W, McDonald, Michael, Alba, Carolina, Waddell, Thomas K, Sapisochin, Gonzalo, Selzner, Markus, Keshavjee, Shaf, Janssen, Harry L A, Hansen, Bettina E, Singer, Lianne G, Humar, Atul

Source: In The Lancet Gastroenterology & Hepatology July 2020 5(7):649-657

Advances in parameter estimation for mathematical models of hepatitis C viral kinetics

Authors: Reinharz, Vladimir, Churkin, Alexander, Dahari, Harel, Barash, Danny

Source: AIP conference proceedings. 2849

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192374053.0x000001&indx=1&recIds=ETOCvdc_100192374053.0x000001

Mathematical modeling suggests that entry-inhibitor bulevirtide may interfere with hepatitis D virus clearance from circulation

Authors: Shekhtman, Louis, Cotler, Scott J., Ploss, Alexander, Dahari, Harel

Source: Journal of hepatology. 76(5):1229-1231

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179671490.0x000001&indx=1&recIds=ETOCvdc_100179671490.0x000001

Modeling challenges of hepatitis D virus kinetics during bulevirtide-based therapy

Authors: Mhlanga, Adquate ¹, Wasserman, Ori ¹, Lampertico, Pietro ^{2, 3}, Cotler, Scott J. ¹, Dahari, Harel ^{1, ⁎}

Source: In JHEP Reports February 2025 7(2)

A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C

Authors: Koh, Christopher, Dubey, Preeti, Han, Ma Ai Thanda, Walter, Peter J., Garraffo, H. Martin, Surana, Pallavi, Southall, Noel T., Borochov, Nathaniel, Uprichard, Susan L., Cotler, Scott J., Etzion, Ohad, Heller, Theo, Dahari, Harel, Liang, T. Jake

Source: In Antiviral Research March 2019 163:149-155

Spatial inequities in access to medications for treatment of opioid use disorder highlight scarcity of methadone providers under counterfactual scenarios.

Authors: Tatara, Eric, Lin, Qinyun, Ozik, Jonathan, Kolak, Marynia, Collier, Nicholson, Halpern, Dylan, Anselin, Luc, Dahari, Harel, Boodram, Basmattee, Schneider, John

Source: PLoS Computational Biology; 7/26/2024, Vol. 20 Issue 7, p1-18, 18p

Subject Terms: OPIOID abuse, DRUG abuse, NEEDLE sharing, HEALTH services accessibility, FENTANYL, METHADONE hydrochloride, HEROIN, NALTREXONE

Geographic Terms: CHICAGO (Ill.)

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice

Authors: Duehren, Sarah, Uchida, Takuro, Tsuge, Masataka, Hiraga, Nobuhiko, Uprichard, Susan L., Etzion, Ohad, Glenn, Jeffrey, Koh, Christopher, Heller, Theo, Cotler, Scott J., Oka, Shiro, Chayama, Kazuaki, Dahari, Harel

Source: In Virus Research November 2024 349

Numerical schemes for solving and optimizing multiscale models with age of hepatitis C virus dynamics

Authors: Reinharz, Vladimir, Dahari, Harel, Barash, Danny

Source: In Mathematical Biosciences June 2018 300:1-13

Rat hepatitis E virus infection in a rat model has multiphasic viral replication kinetics

Authors: Shi, Zhenzhen, Zhang, Xin, Cremers, Niels, Neyts, Johan, Dahari, Harel, Kaptein, Suzanne

Source: Journal of hepatology. 78(S1):S1038-S1039

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195500355.0x000001&indx=1&recIds=ETOCvdc_100195500355.0x000001

Modeling-based response-guided therapy with bulevirtide monotherapy for chronic hepatitis D to identify patients for finite treatment duration

Authors: Duehren, Sarah, Shekhtman, Louis, Cotler, Scott, Aberle, Stephan, Reiberger, Thomas, Ferenci, Peter, Dahari, Harel

Source: Journal of hepatology. 78(S1):S1170-S1171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195499473.0x000001&indx=1&recIds=ETOCvdc_100195499473.0x000001

A Parameter Estimation Method for Multiscale Models of Hepatitis C Virus Dynamics

Authors: Reinharz, Vladimir, Churkin, Alexander, Lewkiewicz, Stephanie, Dahari, Harel, Barash, Danny

Source: Bulletin of mathematical biology. 81(10):3675-3721

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125437777.0x000001&indx=1&recIds=ETOCvdc_100125437777.0x000001