Malaria Biomimetic for Tumor Targeted Drug Delivery

Authors: Pihl, Jessica, Clausen, Thomas M., Zhou, Jiarong, Krishnan, Nishta, Ørum-Madsen, Maj S., Gustavsson, Tobias, Dagil, Robert, Daugaard, Mads, Choudhary, Swati, Foged, Camilla

Source: ACS nano. 17(14):13500-13509

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633294858&indx=1&recIds=ETOCRN633294858

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

Authors: Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Riis Paludan, Søren, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G, Dagil, Robert, Goksøyr, Louise, Hulen, Thomas M, Janitzek, Christoph, Jensen, Daniel S, Justesen, Sune, Khalifé, Paul K, Kreidenweiss, Andrea, Lança, Telma, Lie-Andersen, Olivia, Teelen, Karina, Vidal-Calvo, Elena, Paludan, Søren Riis

Source: In The Lancet Microbe March 2023 4(3):e140-e148

Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors.

Authors: Khazamipour, Nastaran, Oo, Htoo Zarni, Al-Nakouzi, Nader, Marzban, Mona, Khazamipour, Nasrin, Roberts, Morgan E, Farivar, Negin, Moskalev, Igor, Lo, Joey, Ghaidi, Fariba, Nelepcu, Irina, Moeen, Alireza, Truong, Sarah, Dagil, Robert, Choudhary, Swati, Gustavsson, Tobias, Zhai, Beibei, Heitzender, Sabine, Salanti, Ali, Sorensen, Poul H

Source: EMBO Molecular Medicine; Nov2024, Vol. 16 Issue 11, p2775-2794, 20p

Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages.

Authors: Walker, Melanie R., Underwood, Alexander, Björnsson, Kasper H., Raghavan, Sai Sundar Rajan, Bassi, Maria R., Binderup, Alekxander, Pham, Long V., Ramirez, Santseharay, Pinholt, Mette, Dagil, Robert, Knudsen, Anne S., Idorn, Manja, Soegaard, Max, Wang, Kaituo, Ward, Andrew B., Salanti, Ali, Bukh, Jens, Barfod, Lea

Source: Communications Biology; 10/2/2024, Vol. 7 Issue 1, p1-14, 14p

Subject Terms: SARS-CoV-2 Omicron variant, SARS-CoV-2, COVID-19 pandemic, IMMUNOGLOBULINS, MONOCLONAL antibodies, HUMAN beings

Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.

Authors: Vidal-Calvo, Elena Ethel, Martin-Salazar, Anne, Choudhary, Swati, Dagil, Robert, Raghavan, Sai Sundar Rajan, Duvnjak, Lara, Nordmaj, Mie Anemone, Clausen, Thomas Mandel, Skafte, Ann, Oberkofler, Jan, Wang, Kaituo, Agerbæk, Mette Ø, Løppke, Caroline, Jørgensen, Amalie Mundt, Ropac, Daria, Mujollari, Joana, Willis, Shona, Garcias López, Agnès, Miller, Rebecca Louise, Karlsson, Richard Torbjörn Gustav

Source: Nature Communications; 8/30/2024, Vol. 15 Issue 1, p1-20, 20p

Subject Terms: CHONDROITIN sulfates, CANCER cells, FETAL tissues, BENIGN tumors, CANCER invasiveness, TARGETED drug delivery, NANOMEDICINE

Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA.

Authors: Raghavan, Sai Sundar Rajan¹ (AUTHOR), Dagil, Robert¹ (AUTHOR), Lopez-Perez, Mary¹ (AUTHOR), Conrad, Julian² (AUTHOR), Bassi, Maria Rosaria¹ (AUTHOR), Quintana, Maria del Pilar¹ (AUTHOR), Choudhary, Swati¹ (AUTHOR), Gustavsson, Tobias¹ (AUTHOR), Wang, Yong³ (AUTHOR), Gourdon, Pontus^4,5 (AUTHOR), Ofori, Michael Fokuo⁶ (AUTHOR), Christensen, Sebastian Boje¹ (AUTHOR), Minja, Daniel Thomas Remias⁷ (AUTHOR), Schmiegelow, Christentze¹ (AUTHOR), Nielsen, Morten Agertoug¹ (AUTHOR), Barfod, Lea¹ (AUTHOR), Hviid, Lars¹ (AUTHOR), Salanti, Ali¹ (AUTHOR), Lavstsen, Thomas¹ (AUTHOR) thomasl@sund.ku.dk, Wang, Kaituo⁴ (AUTHOR) thomasl@sund.ku.dk

Source: PLoS Pathogens. 11/16/2022, Vol. 18 Issue 11, p1-20. 20p.

Subject Terms: *MONOCLONAL antibodies, *ERYTHROCYTE membranes, *ERYTHROCYTES, *MEMBRANE proteins, *CELL-mediated cytotoxicity

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Authors: Salanti, Ali, Clausen, Thomas M., Agerbæk, Mette Ø., Al Nakouzi, Nader, Dahlbäck, Madeleine, Oo, Htoo Z., Lee, Sherry, Gustavsson, Tobias, Rich, Jamie R., Hedberg, Bradley J., Mao, Yang, Barington, Line, Pereira, Marina A., LoBello, Janine, Endo, Makoto, Fazli, Ladan, Soden, Jo, Wang, Chris K., Sander, Adam F., Dagil, Robert, Thrane, Susan, Holst, Peter J., Meng, Le, Favero, Francesco, Weiss, Glen J., Nielsen, Morten A., Freeth, Jim, Nielsen, Torsten O., Zaia, Joseph, Tran, Nhan L., Trent, Jeff, Babcook, John S., Theander, Thor G., Sorensen, Poul H., Daugaard, Mads

Source: In Cancer Cell 12 October 2015 28(4):500-514

Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

Authors: Fougeroux, Cyrielle, Goksøyr, Louise, Idorn, Manja, Soroka, Vladislav, Myeni, Sebenzile K., Dagil, Robert, Janitzek, Christoph M., Søgaard, Max, Aves, Kara-Lee, Horsted, Emma W., Erdoğan, Sayit Mahmut, Gustavsson, Tobias, Dorosz, Jerzy, Clemmensen, Stine, Fredsgaard, Laurits, Thrane, Susan, Vidal-Calvo, Elena E., Khalifé, Paul, Hulen, Thomas M., Choudhary, Swati, Theisen, Michael, Singh, Susheel K., Garcia-Senosiain, Asier, Van Oosten, Linda, Pijlman, Gorben, Hierzberger, Bettina, Domeyer, Tanja, Nalewajek, Blanka W., Strøbæk, Anette, Skrzypczak, Magdalena, Andersson, Laura F., Buus, Søren, Buus, Anette Stryhn, Christensen, Jan Pravsgaard, Dalebout, Tim J., Iversen, Kasper, Harritshøj, Lene H., Mordmüller, Benjamin, Ullum, Henrik, Reinert, Line S., de Jongh, Willem Adriaan, Kikkert, Marjolein, Paludan, Søren R., Theander, Thor G., Nielsen, Morten A., Salanti, Ali, Sander, Adam F.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191414194.0x000001&indx=1&recIds=ETOCvdc_100191414194.0x000001

New horizons for lipoprotein receptors: communication by β-propellers

Authors: Andersen, Olav M. ^*, Dagil, Robert ^†, Kragelund, Birthe B. ^{†, *}

Source: In Journal of Lipid Research October 2013 54(10):2763-2774

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

Authors: Dagil, Robert, O'Shea, Charlotte, Nykjær, Anders, Bonvin, Alexandre M.J.J., Kragelund, Birthe B.

Source: In Journal of Biological Chemistry February 2013 288(6):4424-4435

The WSXWS Motif in Cytokine Receptors Is a Molecular Switch Involved in Receptor Activation: Insight from Structures of the Prolactin Receptor

Authors: Dagil, Robert, Knudsen, Maiken J., Olsen, Johan G., O'Shea, Charlotte, Franzmann, Magnus, Goffin, Vincent, Teilum, Kaare, Breinholt, Jens, Kragelund, Birthe B.

Source: In Structure 8 February 2012 20(2):270-282

Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice.

Authors: Skeltved, Nanna, Nordmaj, Mie A., Berendtsen, Nicolai T., Dagil, Robert, Stormer, Emilie M. R., Al-Nakouzi, Nader, Jiang, Ke, Aicher, Alexandra, Heeschen, Christopher, Gustavsson, Tobias, Choudhary, Swati, Gögenur, Ismail, Christensen, Jan P., Theander, Thor G., Daugaard, Mads, Salanti, Ali, Nielsen, Morten A.

Source: Journal of Experimental & Clinical Cancer Research (17569966); 4/28/2023, Vol. 42 Issue 1, p1-16, 16p

Subject Terms: CHONDROITIN sulfates, IMMUNOLOGIC memory, PSYCHONEUROIMMUNOLOGY, T helper cells, CYTOTOXIC T cells, REGULATORY T cells, FETAL anoxia, PANCREATIC tumors

Structure of the Mature Streptococcal Cysteine Protease Exotoxin mSpeB in Its Active Dimeric Form

Authors: Olsen, Johan G., Dagil, Robert, Niclasen, Louise Meinert, Sørensen, Ole E., Kragelund, Birthe B.

Source: In Journal of Molecular Biology 2009 393(3):693-703

Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer.

Authors: Al-Nakouzi, Nader, Wang, Chris Kedong, Oo, Htoo Zarni, Nelepcu, Irina, Lallous, Nada, Spliid, Charlotte B., Khazamipour, Nastaran, Lo, Joey, Truong, Sarah, Collins, Colin, Hui, Desmond, Esfandnia, Shaghayegh, Adomat, Hans, Clausen, Thomas Mandel, Gustavsson, Tobias, Choudhary, Swati, Dagil, Robert, Corey, Eva, Wang, Yuzhuo, Chauchereau, Anne

Source: Nature Communications; 8/13/2022, Vol. 13 Issue 1, p1-14, 14p

Subject Terms: GLYCOCALYX, CHONDROITIN sulfates, ANDROGEN receptors, PROSTATE cancer, CASTRATION-resistant prostate cancer, PROSTATE cancer patients, CANCER patients, REFORMATION

TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.

Authors: Hertweck, Arnulf, Vila de Mucha, Maria, Barber, Paul R, Dagil, Robert, Porter, Hayley, Ramos, Andres, Lord, Graham M, Jenner, Richard G

Source: Nucleic Acids Research; 5/6/2022, Vol. 50 Issue 8, p4557-4573, 17p

Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells.

Authors: Wang, Chris Kedong, Nelepcu, Irina, Hui, Desmond, Oo, Htoo Zarni, Truong, Sarah, Zhao, Sarah, Tahiry, Zakir, Esfandnia, Shaghayegh, Ghaidi, Fariba, Adomat, Hans, Dagil, Robert, Gustavsson, Tobias, Choudhary, Swati, Salanti, Ali, Sorensen, Poul H., Al Nakouzi, Nader, Daugaard, Mads

Source: Scientific Reports; 2/23/2022, Vol. 12 Issue 1, p1-13, 13p

Subject Terms: CHONDROITIN sulfates, LECTINS, TUMOR proteins, PROTEOGLYCANS, CHONDROITIN

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding.

Authors: Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, Sandeep K., Spliid, Charlotte B., Wang, Yong, Gustavsson, Tobias, Sandoval, Daniel R., Vidal-Calvo, Elena Ethel, Choudhary, Swati, Agerbaek, Mette Ø, Lindorff-Larsen, Kresten, Nielsen, Morten A., Theander, Thor G., Sharp, Joshua S., Clausen, Thomas Mandel, Gourdon, Pontus, Salanti, Ali

Source: Nature Communications; 5/19/2021, Vol. 12 Issue 1, p1-10, 10p

Subject Terms: MOLECULAR dynamics, MALARIA, ERYTHROCYTES, CHONDROITIN sulfates, MOLECULAR interactions, GLYCOSAMINOGLYCANS, CHONDROITIN sulfate proteoglycan, VACCINE effectiveness

Development of a bispecific immune engager using a recombinant malaria protein.

Authors: Nordmaj, Mie A., Roberts, Morgan E., Sachse, Emilie S., Dagil, Robert, Andersen, Anne Poder, Skeltved, Nanna, Grunddal, Kaare V., Erdoğan, Sayit Mahmut, Choudhary, Swati, Gustsavsson, Tobias, Ørum-Madsen, Maj Sofie, Moskalev, Igor, Tian, Weihua, Yang, Zhang, Clausen, Thomas M., Theander, Thor G., Daugaard, Mads, Nielsen, Morten A., Salanti, Ali

Source: Cell Death & Disease; Apr2021, Vol. 12 Issue 4, p1-11, 11p

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Authors: Dagil, Robert, Ball, Neil J, Ogrodowicz, Roksana W, Hobor, Fruzsina, Purkiss, Andrew G, Kelly, Geoff, Martin, Stephen R, Taylor, Ian A, Ramos, Andres

Source: Nucleic Acids Research; 5/7/2019, Vol. 47 Issue 8, p4334-4348, 15p

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