Antitumor Activity of Radiation Therapy Combined with Checkpoint Kinase Inhibition in SHH/ p53 -Mutated Human Medulloblastoma.

Authors: Kuchařová, Zuzana¹ (AUTHOR), Glasow, Annegret^1,2 (AUTHOR), Kortmann, Rolf-Dieter¹ (AUTHOR), Patties, Ina^1,2 (AUTHOR) ina.patties@medizin.uni-leipzig.de

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2577. 17p.

Subject Terms: *CHECKPOINT kinase 1, *DNA damage, *TUMOR growth, *CELL cycle, *BRAIN tumors

HPF1 Regulates Pol β Efficiency in Nucleosomes via the Modulation of Total Poly(ADP-Ribose) Synthesis.

Authors: Kutuzov, Mikhail¹ (AUTHOR), Sayfullina, Dinara¹ (AUTHOR), Belousova, Ekaterina¹ (AUTHOR), Lavrik, Olga (AUTHOR) lavrik@niboch.nsc.ru

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p1794. 18p.

Subject Terms: *DNA repair, *DNA damage, *DNA polymerases, *GENOMES, *CHROMATIN

Capsicum chinense Jacq. fruit plays an immunomodulatory role in cytokine attenuation and DNA damage protection.

Authors: Saha, Srabonti¹ (AUTHOR), Hossain, Md. Altaf¹ (AUTHOR), Ferdousi, Humayra¹ (AUTHOR), Deen, Jobaier Ibne¹ (AUTHOR), Chowdhury, Akhlak¹ (AUTHOR), Mannan, Md.¹ (AUTHOR), Khan, Md. Asif Nadim¹ (AUTHOR), Rahman, Md. Atiar¹ (AUTHOR) atiar@cu.ac.bd

Source: PLoS ONE. 2/25/2025, Vol. 20 Issue 2, p1-24. 24p.

Subject Terms: *HELA cells, *DNA damage, *CYTOTOXINS, *NATURAL immunity, *BIOACTIVE compounds

N-benzyl-N-methyldecane-1-amine derived from garlic ameliorates UVB-induced photoaging in HaCaT cells and SKH-1 hairless mice.

Authors: Budluang, Phatcharaporn¹ (AUTHOR), Kim, Ji Eun² (AUTHOR), Park, Eun Seo² (AUTHOR), Seol, Ayun² (AUTHOR), Jang, Hee Jeong¹ (AUTHOR), Kang, Moon Sung¹ (AUTHOR), Kim, Yeon Ha³ (AUTHOR), Choi, Jongdoo⁴ (AUTHOR), Kim, Seonghye⁴ (AUTHOR), Kim, Suhkmann⁴ (AUTHOR), Koh, Minseob⁴ (AUTHOR), Kang, Ho Young³ (AUTHOR), Kim, Bae-Hwan⁵ (AUTHOR), Han, Dong-Wook¹ (AUTHOR), Hwang, Dae Youn² (AUTHOR) dyhwang@pusan.ac.kr, Chung, Young-Hwa¹ (AUTHOR) younghc@pusan.ac.kr

Source: Scientific Reports. 2/26/2025, Vol. 15 Issue 1, p1-14. 14p.

Subject Terms: *TOPICAL drug administration, *DNA damage, *GENETIC markers, *CELL cycle, *PHENOL oxidase, *MELANOGENESIS, *WRINKLES (Skin)

Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice.

Authors: Scheijen, Elle EM¹ (AUTHOR), Veeningen, Naomi² (AUTHOR), Duwé, Sam³ (AUTHOR), Ivanova, Anna⁴ (AUTHOR), Van Broeckhoven, Jana² (AUTHOR), Hendrix, Sven⁵ (AUTHOR), Wilson III, David M¹ (AUTHOR) david.wilson@uhasselt.be

Source: Journal of Biomedical Science. 1/23/2025, Vol. 32 Issue 1, p1-16. 16p.

Subject Terms: *DNA repair, *DNA damage, *SPINAL cord injuries, *MEDICAL sciences, *BIOLOGICAL networks

Investigating the Lethal Effects of Carvone on the Protoscoleces of Hydatid Cyst, In Vitro and Ex Vivo.

Authors: Mahmoudvand, Hossein¹, Khalaf, Amal Khudair², Moghadam, Ezatollah Fazeli³, Yadegari, Javad Ghasemian⁴, Adineh, Ahmad⁵ ahmadadineh48@gmail.com, Jalili, Amir⁶

Source: Iranian Journal of Parasitology. Jan-Mar2025, Vol. 20 Issue 1, p91-99. 9p.

Subject Terms: *ECHINOCOCCOSIS, *DNA damage, *OPERATIVE surgery, *MEDICINAL plants, *CASPASES

Oxygen Effect on 0–30 eV Electron Damage to DNA Under Different Hydration Levels: Base and Clustered Lesions, Strand Breaks and Crosslinks.

Authors: Gao, Yingxia¹ (AUTHOR) gyxmyr3719@163.com, Wang, Xuran¹ (AUTHOR) xr_wang1215@163.com, Cloutier, Pierre² (AUTHOR) pierre.cloutier@usherbrooke.ca, Zheng, Yi^1,2 (AUTHOR) yi.zheng@usherbrooke.ca, Sanche, Léon² (AUTHOR) leon.sanche@usherbrooke.ca

Source: Molecules. Dec2024, Vol. 29 Issue 24, p6033. 23p.

Subject Terms: *REACTIVE oxygen species, *DNA damage, *ATMOSPHERIC pressure, *RADIOBIOLOGY, *ATMOSPHERIC oxygen

Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex—Lessons from Transcription-Coupled DNA Damages.

Authors: Rezano, Andri¹ (AUTHOR) andri.rezano@unpad.ac.id, Gondo, Naomi² (AUTHOR) ngondo@sagara.or.jp, Sakai, Yasuhiro³ (AUTHOR) ya-sakai@hama-med.ac.jp, Nakamura, Yuko⁴ (AUTHOR) y.nakamura@med.kindai.ac.jp, Phimsen, Suchada⁵ (AUTHOR) suchadaph@nu.ac.th, Tani, Tokio⁶ (AUTHOR) ttani@kumamoto-u.ac.jp, Ito, Akihiko⁷ (AUTHOR) aito@med.kindai.ac.jp, Okada, Seiji⁸ (AUTHOR) okadas@kumamoto-u.ac.jp, Kuwahara, Kazuhiko⁹ (AUTHOR) kazukuwa@med.kindai.ac.jp

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13612. 16p.

Subject Terms: *DNA damage, *REACTIVE oxygen species, *IONIZING radiation, *NUCLEAR proteins, *GENETIC transcription

VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma.

Authors: Wu, Zuqian¹ (AUTHOR), Omura, Issei^1,2 (AUTHOR), Saito, Atsushi^1,2 (AUTHOR), Imaizumi, Kazunori¹ (AUTHOR), Kamikawa, Yasunao¹ (AUTHOR) kamikawa@hiroshima-u.ac.jp

Source: Nucleus (1949-1034). Dec2024, Vol. 15 Issue 1, p1-18. 18p.

Subject Terms: *NUCLEAR shapes, *DNA damage, *FUNCTIONAL analysis, *GLIOBLASTOMA multiforme, *CELL lines

Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action.

Authors: Chernyshova, Irina¹ (AUTHOR) chernyshova0305@gmail.com, Vasil'eva, Inna¹ (AUTHOR) iva@niboch.nsc.ru, Moor, Nina¹ (AUTHOR) moor@niboch.nsc.ru, Ivanisenko, Nikita^2,3 (AUTHOR) ivanisenko@bionet.nsc.ru, Kutuzov, Mikhail¹ (AUTHOR) kutuzov.mm@mail.ru, Abramova, Tatyana¹ (AUTHOR) abramova@niboch.nsc.ru, Zakharenko, Alexandra¹ (AUTHOR) sashaz@niboch.nsc.ru, Lavrik, Olga¹ (AUTHOR) lavrik@niboch.nsc.ru

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12526. 18p.

Subject Terms: *DNA repair, *DNA damage, *MOLECULAR docking, *NUCLEOSIDES, *CYTOTOXINS, *POLY ADP ribose

Effects of Short-Term Treatment with α-Lipoic Acid on Neuropathic Pain and Biomarkers of DNA Damage in Patients with Diabetes Mellitus.

Authors: Lazutka, Juozas R.¹ (AUTHOR) juozas.lazutka@gf.vu.lt, Daniūnaitė, Kristina¹ (AUTHOR) veronika.dedonyte@gmc.vu.lt, Dedonytė, Veronika¹ (AUTHOR) aiste.popandopula@gmc.stud.vu.lt, Popandopula, Aistė¹ (AUTHOR) karolina.zukaite@mf.stud.vu.lt, Žukaitė, Karolina¹ (AUTHOR), Visockienė, Žydrūnė^2,3 (AUTHOR) zydrune.visockiene@santa.lt, Šiaulienė, Laura^1,3 (AUTHOR) juozas.lazutka@gf.vu.lt

Source: Pharmaceuticals (14248247). Nov2024, Vol. 17 Issue 11, p1538. 12p.

Subject Terms: *DNA damage, *BLOOD plasma, *NEURALGIA, *INTRAVENOUS therapy, *METABOLIC disorders

Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro.

Authors: Lihua Yang¹, Yindan Zhang^1,2, Jianghuan Hua^1,3,4 huajianghuan@163.com, Guili Song¹, Fan Li^1,2, Na Zheng^1,2, Taotao Zhang³, Zhixiang Xu^1,5, Xinxin Ren^1,2, Biran Zhu^1,3, Yanna Han⁶, Yongyong Guo¹, Jian Han¹, Bingsheng Zhou¹ bszhou@ihb.ac.cn

Source: Environmental Health Perspectives. Nov2024, Vol. 132 Issue 11, p117005-1-117005-20. 20p.

Subject Terms: *Biphenyl compounds, *Apoptosis, *Fishes, *Environmental exposure, Spermatozoa, Glycolysis, Phosphorylation, Germ cells, In vivo studies, Behavior, Reverse transcriptase polymerase chain reaction, Cellular signal transduction, Conception, Energy metabolism, Reactive oxygen species, Cell culture, DNA damage, Proteomics, Western immunoblotting, One-way analysis of variance, Sperm motility, Data analysis software, Reproduction

Minocycline prevents early age-related cognitive decline in a mouse model of intellectual disability caused by ZBTB18/RP58 haploinsufficiency.

Authors: Tanaka, Tomoko^1,2 (AUTHOR) tanaka-tm@igakuken.or.jp, Hirai, Shinobu¹ (AUTHOR), Manabe, Hiroyuki³ (AUTHOR), Endo, Kentaro⁴ (AUTHOR), Shimbo, Hiroko¹ (AUTHOR), Nishito, Yasumasa⁴ (AUTHOR), Horiuchi, Junjiro⁴ (AUTHOR), Yoshitane, Hikari² (AUTHOR), Okado, Haruo¹ (AUTHOR) okado-hr@igakuken.or.jp

Source: Journal of Neuroinflammation. 10/12/2024, Vol. 21 Issue 1, p1-13. 13p.

Subject Terms: *DNA repair, *DNA damage, *DENTATE gyrus, *MITOCHONDRIAL DNA, *COGNITION disorders

Present Scenario and Future Landscape of Payloads for ADCs: Focus on DNA-Interacting Agents.

Authors: Valsasina, Barbara¹ (AUTHOR) barbara.valsasina@nervianoms.com, Orsini, Paolo¹ (AUTHOR), Terenghi, Chiara² (AUTHOR), Ocana, Alberto^3,4,5 (AUTHOR)

Source: Pharmaceuticals (14248247). Oct2024, Vol. 17 Issue 10, p1338. 22p.

Subject Terms: *PLASMA stability, *DNA damage, *CELL death, *CHEMICAL structure, *ANTHRACYCLINES, *DNA topoisomerase I, *MONOCLONAL antibodies

Elucidating the genotoxicity of Fusobacterium nucleatum-secreted mutagens in colorectal cancer carcinogenesis.

Authors: Xu, Wenye^1,2 (AUTHOR), Zhang, Yuchen³ (AUTHOR), Chen, Dongjiao² (AUTHOR), Huang, Dan² (AUTHOR), Zhao, Yang⁴ (AUTHOR), Hu, Wei⁵ (AUTHOR), Lin, Ling^1,2 (AUTHOR), Liu, Yingzhi^1,2 (AUTHOR), Wang, Shilan^1,6 (AUTHOR), Zeng, Judeng^2,7 (AUTHOR), Xie, Chuan^2,8 (AUTHOR), Chan, Hung² (AUTHOR), Li, Qing^2,7,9 (AUTHOR), Chen, Huarong^2,7,9 (AUTHOR), Liu, Xiaodong^2,7 (AUTHOR), Wong, Sunny H.¹⁰ (AUTHOR), Yu, Jun^6,7,9 (AUTHOR), Chan, Francis K. L.^1,11 (AUTHOR), Chan, Matthew T. V.² (AUTHOR) mtvchan@cuhk.edu.hk, Ng, Siew C.^1,6,9 (AUTHOR) siewchienng@cuhk.edu.hk

Source: Gut Pathogens. 9/27/2024, Vol. 16 Issue 1, p1-13. 13p.

Subject Terms: *DNA damage, *COLORECTAL cancer, *COLON tumors, *GENETIC toxicology, *MUTAGENS

The Interstitial Gland as a Source of Pro- or Anti-Senescent Cells during Chinchilla Rabbit Ovarian Aging.

Authors: Díaz-Hernández, Verónica¹ (AUTHOR) roveazdih@yahoo.com.mx, Marmolejo-Valencia, Alejandro² (AUTHOR) alemarmol@biomedicas.unam.mx, Montiel-De la Cruz, César³ (AUTHOR) cmdlc@ciencias.unam.mx, Piñón-Zárate, Gabriela⁴ (AUTHOR) gabrielapinon@unam.mx, Montaño, Luis M.⁵ (AUTHOR) lmmr@unam.mx, Mora-Herrera, Silvia Ivonne⁶ (AUTHOR) sivonnemor@iibiomedicas.unam.mx, Caldelas, Ivette² (AUTHOR) caldelas@unam.mx

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9906. 16p.

Subject Terms: *INTERSTITIAL cells, *DNA damage, *SEX hormones, *OVARIES, *LIPOFUSCINS

Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Authors: Ouararhni, Khalid¹ (AUTHOR), Mietton, Flore² (AUTHOR), Sabir, Jamal S. M.^3,4 (AUTHOR), Ibrahim, Abdulkhaleg^1,5 (AUTHOR), Molla, Annie² (AUTHOR), Albheyri, Raed S.^3,4 (AUTHOR), Zari, Ali T.^3,4 (AUTHOR), Bahieldin, Ahmed^3,4 (AUTHOR), Menoni, Hervé² (AUTHOR), Bronner, Christian¹ (AUTHOR), Dimitrov, Stefan^2,6 (AUTHOR) stefan.dimitrov@univ-grenoble-alpes.fr, Hamiche, Ali¹ (AUTHOR) hamiche@igbmc.fr

Source: BMC Biology. 9/2/2024, Vol. 22 Issue 1, p1-14. 14p.

Subject Terms: *POLY(ADP-ribose) polymerase, *DNA damage, *ALKYLATING agents, *GENETIC transcription regulation, *CELL survival, *DNA repair, *CHROMATIN

Neuroprotective Activity of Strawberry Tree (Arbutus unedo L.) Against Formaldehyde-Induced Oxidative Stress in The Rat Hippocampus.

Alternate Title: Actividad Neuroprotectora del Madroño (Arbutus Unedo L.) contra el Estrés Oxidativo Inducido por Formaldehído en el Hipocampo de Rata.

Authors: Erdogan, Mehtap¹ mehtaperdogan@sakarya.edu.tr, Colak, Tuncay², Ceylan, Fatma Sureyya³, Kir, Hale Maral⁴, Kurnaz, Sema³, Ozsoy, Ozgur Doga⁴, Sahin, Zuhal⁵

Source: International Journal of Morphology. 2024, Vol. 42 Issue 5, p1338-1346. 9p.

Subject Terms: *BRAIN-derived neurotrophic factor, *DNA damage, *CELL death, *FRUIT extracts, *REDUCTION potential, *OXIDATIVE stress

Types of DNA damage and research progress.

Authors: Nian, Liu^1,2 (AUTHOR), Xiaohua, Li³ (AUTHOR), Rongcheng, Li^1,2 (AUTHOR), Song-Bai, Liu^1,2 (AUTHOR) liusongbai@126.com

Source: Nucleosides, Nucleotides & Nucleic Acids. 2024, Vol. 43 Issue 9, p881-901. 21p.

Subject Terms: *DNA damage, *GENETIC mutation, *DNA structure, *NUCLEOTIDES, *AGING

Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells.

Authors: Barszczewska-Pietraszek, Gabriela¹ (AUTHOR) gabriela.barszczewska.pietraszek@edu.uni.lodz.pl, Czarny, Piotr² (AUTHOR), Drzewiecka, Małgorzata¹ (AUTHOR), Błaszczyk, Maciej³ (AUTHOR), Radek, Maciej³ (AUTHOR), Synowiec, Ewelina¹ (AUTHOR), Wigner-Jeziorska, Paulina¹ (AUTHOR), Sitarek, Przemysław⁴ (AUTHOR), Szemraj, Janusz² (AUTHOR), Skorski, Tomasz⁵ (AUTHOR), Śliwiński, Tomasz¹ (AUTHOR) tomasz.sliwinski@biol.uni.lodz.pl

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9134. 17p.

Subject Terms: *DNA damage, *DNA polymerases, *CELL cycle, *GENE expression, *CELL analysis, *POLY ADP ribose