Crushing tablets or sprinkling capsules: Implications for clinical strategy and study performance based on BE studies of rivaroxaban and deferasirox.

Authors: Sus, Jan¹ (AUTHOR), Bosak, Jan¹ (AUTHOR) jan.bosak@zentiva.com, Hauser, Tomas¹ (AUTHOR)

Source: CTS: Clinical & Translational Science. Mar2024, Vol. 17 Issue 3, p1-11. 11p.

Subject Terms: *DEFERASIROX, *RIVAROXABAN, *ORAL drug administration, *GENERIC products, *PERFORMANCE theory, *EXCIPIENTS, *GENERIC drugs

Company/Entity: EUROPEAN Medicines Agency

Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs.

Authors: Kontoghiorghes, George J.¹ (AUTHOR) kontoghiorghes.g.j@pri.ac.cy

Source: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 23, p16749. 30p.

Subject Terms: *DEFERASIROX, *CHELATION therapy, *DRUG dosage, *SICKLE cell anemia, *IRON, *STEM cell transplantation, *IRON fertilizers

Development of Drug-Loaded Solid Self-Emulsifying System Based Orally Disintegrating Tablets for the Effectual Oral Delivery of Deferasirox.

Authors: SABLE, PREETI¹ bcoppreeti26sable@gmail.com, LAHOTI, S.¹, GHADALINGE, S.

Source: Indian Journal of Pharmaceutical Sciences. Sep/Oct2023, Vol. 85 Issue 5, p1268-1280. 13p.

Subject Terms: *DEFERASIROX, *DRUG delivery systems, *IRON chelates, *SUNFLOWER seed oil, *IRON overload, *PHASE diagrams, *DRUG solubility

Development and Validation of Robust, Highly Sensitive and Stability-Indicating RP-HPLC Method for Estimation of Deferasirox and its Degradation Products.

Authors: Shishodia, Tarun¹ (AUTHOR), Grover, Parul² (AUTHOR) parul.grvr@gmail.com, Nagarajan, K² (AUTHOR), Bhardwaj, Monika³ (AUTHOR), Chopra, Bhawna⁴ (AUTHOR)

Source: Journal of Chromatographic Science. Sep2024, Vol. 62 Issue 8, p709-718. 10p.

Subject Terms: *ACETONITRILE, *DEFERASIROX, *HIGH performance liquid chromatography, *CONFERENCES & conventions, *DETECTORS

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery.

Authors: Faizi, Hafsa Shahid¹ (AUTHOR), Vora, Lalitkumar K.¹ (AUTHOR), Nasiri, Muhammad Iqbal^1,2 (AUTHOR), Wu, Yu¹ (AUTHOR), Mishra, Deepakkumar¹ (AUTHOR), Anjani, Qonita Kurnia¹ (AUTHOR), Paredes, Alejandro J.¹ (AUTHOR), Thakur, Raghu Raj Singh¹ (AUTHOR), Minhas, Muhammad Usman³ (AUTHOR) usman.minhas@uos.edu.pk, Donnelly, Ryan F.¹ (AUTHOR) usman.minhas@uos.edu.pk

Source: Pharmaceutics. Dec2022, Vol. 14 Issue 12, p2817. 18p.

Subject Terms: *DEFERASIROX, *OPTICAL coherence tomography, *IRON chelates, *IRON overload, *TRANSDERMAL medication

Visual and Auditory Complications during Deferasirox Therapy in Beta-thalassemia.

Authors: Poosheshdoost, Parastoo¹, Faraji, Niloofar², Zeinali, Tahereh², Baghersalimi, Adel¹, Miremarati, Aye¹, Darbandi, Bahram¹ bahram.darbandi.oncology@gmail.com

Source: Iranian Journal of Pediatric Hematology & Oncology. 2022, Vol. 12 Issue 4, p229-239. 11p.

Subject Terms: *DEFERASIROX, *BETA-Thalassemia, *IRON chelates, *HEARING disorders, *SENSORINEURAL hearing loss, *RED blood cell transfusion, *FEMALE condoms

Changes in corticostriatal connectivity and striatal tissue iron associated with efficacy of clozapine for treatment‑resistant schizophrenia.

Authors: Blazer, Annie¹ (AUTHOR), Chengappa, K. N. Roy¹ (AUTHOR), Foran, William¹ (AUTHOR), Parr, Ashley C.¹ (AUTHOR), Kahn, Charles E.¹ (AUTHOR), Luna, Beatriz^1,2 (AUTHOR), Sarpal, Deepak K.¹ (AUTHOR) sarpaldk@upmc.edu

Source: Psychopharmacology. Aug2022, Vol. 239 Issue 8, p2503-2514. 12p. 1 Color Photograph, 1 Diagram, 1 Chart, 1 Graph.

Subject Terms: *DEFERASIROX, *CLOZAPINE, *FRONTOPARIETAL network, *SCHIZOPHRENIA, *FUNCTIONAL connectivity, *ANTIPSYCHOTIC agents

Biofilm Microenvironment Activated Antibiotic Adjuvant for Implant‐Associated Infections by Systematic Iron Metabolism Interference.

Authors: Ding, Jianing¹, Wang, Xin¹, Liu, Wei¹, Ding, Cheng¹, Wu, Jianrong², wujianrong028@shsmu.edu.cn, He, Renke¹, sjtuherenke@shsmu.edu.cn, Zhang, Xianlong¹, dr_zhangxianlong@sjtu.edu.cn

Source: Advanced Science; May2024, Vol. 11 Issue 17, p1-13, 13p

Low‐dose iron chelation as anti‐oxidative therapy in patients with sickle cell disease: A single‐centre pilot study.

Authors: Gaartman, Aafke E., Beuger, Boukje M., de Ligt, Lydian A., Veldthuis, Martijn, Matlung, Hanke L., Meijers, Joost C. M., Schalkwijk, Casper G., de Heer, Koen, Heijmans, Jarom, van Zwieten, Rob, Biemond, Bart J., van Bruggen, Robin, Nur, Erfan

Source: British Journal of Haematology; Mar2025, Vol. 206 Issue 3, p1010-1013, 4p

Subject Terms: SICKLE cell anemia, OXIDATIVE stress, BLOOD viscosity, ANTIOXIDANTS, PILOT projects, HEMOLYSIS & hemolysins, IRON chelates, DEFERASIROX

Comparative Efficacy and Safety Between Deferiprone and Deferasirox with Special Reference to Serum Ferritin Level and Cardiac Function in Bengali β-Thalassemia Major Children.

Authors: Tripathy, Isita¹ (AUTHOR), Panja, Amrita² (AUTHOR), Dolai, Tuphan Kanti³ (AUTHOR), Mallick, Asim Kumar¹ (AUTHOR)

Source: Hemoglobin. Sep2021, Vol. 45 Issue 5, p296-302. 7p.

Subject Terms: *DEFERASIROX, *FERRITIN, *VENTRICULAR ejection fraction, *IRON chelates, *CHILD patients

Pharmacological and clinical evaluation of deferasirox formulations for treatment tailoring.

Authors: Piolatto, Andrea¹ (AUTHOR) andrea.piolatto@unito.it, Berchialla, Paola¹ (AUTHOR), Allegra, Sarah² (AUTHOR), De Francia, Silvia² (AUTHOR), Ferrero, Giovanni Battista¹ (AUTHOR), Piga, Antonio¹ (AUTHOR), Longo, Filomena¹ (AUTHOR)

Source: Scientific Reports. 6/15/2021, Vol. 11 Issue 1, p1-12. 12p.

Subject Terms: *DEFERASIROX, *PHARMACOKINETICS, *PHARMACODYNAMICS, *DRUG bioavailability, *MEDICATION safety

Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation

Authors: Niloofar Honari, Mahtab Sayadi, Seyed Mehdi Sajjadi, Somayeh Solhjoo, Gholamreza Anani Sarab

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-16 (2025)

Subject Terms: Deferasirox, Hematopoiesis, Iron Homeostasis, Menopause, Ovariectomy, Oxidative stress, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/29c77c083e364454a62d87bd2fb8dc18

Assessing the auditory effects of oral chelation therapy drug Deferasirox in individuals with β‐thalassemia major

Authors: Balwinder S. Tiwana, Ankita Aggarwal, Sanjeev Bhagat, Harjinder Singh, Dimple Sahni, Vishav Yadav

Source: World Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 10, Iss 4, Pp 309-314 (2024)

Subject Terms: auditory, deferasirox, distortion product otoacoustic emissions, oral chelating agent, pure tone audiometry, thalassemia, Otorhinolaryngology, RF1-547, Surgery, RD1-811

File Description: electronic resource

Relation: https://doaj.org/toc/2095-8811; https://doaj.org/toc/2589-1081

Access URL: https://doaj.org/article/0610c397942f4f0bbc316ec88b52de63

Long-Term Effectiveness, Safety, and Tolerability of Twice-Daily Dosing with Deferasirox in Children with Transfusion-Dependent Thalassemias Unresponsive to Standard Once-Daily Dosing.

Authors: Jassada Buaboonnam¹, Chayamon Takpradit¹, Vip Viprakasit¹, Nattee Narkbunnam¹, Nassawee Vathana¹, Kamon Phuakpet¹, Kleebsabai Sanpakit¹, Bunchoo Pongtanakul¹ pongtanakul@yahoo.com

Source: Mediterranean Journal of Hematology & Infectious Diseases. 2021, Vol. 13 Issue 1, p1-6. 6p.

Subject Terms: *DEFERASIROX, *CHELATION therapy, *IRON overload, *BLOOD transfusion, *CHELATION

Norepinephrine transporter-derived homing peptides enable rapid endocytosis of drug delivery nanovehicles into neuroblastoma cells.

Authors: Haddad, Yazan^1,2 (AUTHOR), Charousova, Marketa^1,2 (AUTHOR), Zivotska, Hana^1,2 (AUTHOR), Splichal, Zbynek^1,2 (AUTHOR), Merlos Rodrigo, Miguel Angel^1,2 (AUTHOR), Michalkova, Hana^1,2 (AUTHOR), Krizkova, Sona^1,2 (AUTHOR), Tesarova, Barbora^1,2 (AUTHOR), Richtera, Lukas^1,2 (AUTHOR), Vitek, Petr³ (AUTHOR), Stokowa-Soltys, Kamila⁴ (AUTHOR), Hynek, David^1,2 (AUTHOR), Milosavljevic, Vedran^1,2 (AUTHOR), Rex, Simona^1,2 (AUTHOR) simona.rex@mendelu.cz, Heger, Zbynek^1,2 (AUTHOR) zbynek.heger@mendelu.cz

Source: Journal of Nanobiotechnology. 7/13/2020, Vol. 18 Issue 1, p1-20. 20p.

Subject Terms: *REACTIVE oxygen species, *DEFERASIROX, *PEPTIDES, *PEPTIDE antibiotics, *ENDOCYTOSIS, *NORADRENALINE, *TUMORS in children

Effectiveness of Deferasirox in Pediatric Thalassemia Patients: Experience from a Tertiary Care Hospital of Odisha.

Authors: Panigrahi, Mousumee¹ mousumee1989@gmail.com, Swain, Trupti Rekha², Jena, Rabindra Kumar³, Panigrahi, Ashutosh⁴, Debta, Nishant⁵

Source: Indian Journal of Pharmacology. May/Jun2020, Vol. 52 Issue 3, p172-178. 7p.

Subject Terms: *FETAL hemoglobin, *DEFERASIROX, *TERTIARY care, *HOSPITAL care, *THALASSEMIA, *FERRITIN, *ENDOCRINE glands, *PANCREAS

Geographic Terms: INDIA

Clinical Features, Microbiological Characteristics, and Drug Sensitivity Analysis of Rare Human Spinal Pythiosis Strain.

Authors: Li, Mingliang, Zhu, Donglin, Diao, Qiuyue, Liu, Xiaoyun, Bi, Xiaogang, Dong, Jianwen, Sun, Jian, Xi, Yun, Zhang, Kouxing

Source: Journal of Fungi; Dec2024, Vol. 10 Issue 12, p812, 19p

Subject Terms: ANTIFUNGAL agents, IRON chelates, WHOLE genome sequencing, TREATMENT effectiveness, ANTIBACTERIAL agents, DEFERASIROX, ARACHNOID cysts

Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats.

Authors: Alsirhani, Alaa Muqbil, Abu-Almakarem, Amal S., Alwaili, Maha Abdullah, Aljohani, Salwa, Alali, Ibtisam, AlRashidi, Aljazi Abdullah, Abuzinadah, Najlaa Yousef, Alkhodair, Sahar Abdulrahman, Mobasher, Maysa A., Alothaim, Tahiyat, Eid, Thamir M., El-Said, Karim Samy

Source: International Journal of Molecular Sciences; Dec2024, Vol. 25 Issue 23, p12541, 24p

Subject Terms: SPRAGUE Dawley rats, CLOVE tree, IRON overload, WEB 2.0, MOLECULAR docking, DOXORUBICIN, DEFERASIROX

Deferasirox and Ciprofloxacin: Potential Ternary Complex Formation With Ferric Iron, Pharmacodynamic, and Pharmacokinetic Interactions.

Authors: Hamdan, Imad I., Tarawneh, Ruba T., Awwadi, Firas, Al-Qattan, Duaa, Hamdan, Ahmad I., Afifi, Fatma, Cameselle, Claudio

Source: Scientific World Journal; 11/29/2024, Vol. 2024, p1-16, 16p

Subject Terms: PHYSICAL & theoretical chemistry, ERYTHROCYTES, IRON overload, DRUG interactions, DEFERASIROX

COST EFFECTIVENESS ANALYSIS OF ORAL IRON CHELATING DRUGS BETWEEN DEFERIPRONE AND DEFERASIROX IN THALASEMIA MAJOR PATIENTS AT BHAYANGKARA SETUKPA LEMDIKLAT POLRI TK.II HOSPITAL.

Authors: Abidin, Rizal Mustia¹, rizal22005@gmail.com, Suwantika, Auliya A.¹, auliya@unpad.ac.id, Pradipta, Ivan S.¹, Ivanpradipta@unpad.ac.id

Source: Asian Journal of Engineering, Social & Health (AJESH); Jan2024, Vol. 3 Issue 1, p173-184, 12p