Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial

Authors: Dan-Yun Ruan, Wen-Wen Huang, Yongsheng Li, Yanqiu Zhao, Yehui Shi, Yuming Jia, Shundong Cang, Wei Zhang, Jianhua Shi, Jun Chen, Jie Lin, Yunpeng Liu, Jianming Xu, Weiwei Ouyang, Jian Fang, Wu Zhuang, Caigang Liu, Qing Bu, Manxiang Li, Xiangjiao Meng, Meili Sun, Nong Yang, Xiaorong Dong, Yueyin Pan, Xingya Li, Xiujuan Qu, Tongmei Zhang, Xianglin Yuan, Sheng Hu, Wei Guo, Yalun Li, Shengqing Li, Dongying Liu, Feixue Song, Liping Tan, Yan Yu, Xinmin Yu, Aimin Zang, Chang Sun, Qian Zhang, Kai Zou, Mo Dan, Rui-Hua Xu, Hongyun Zhao

Source: Signal Transduction and Targeted Therapy, Vol 10, Iss 1, Pp 1-12 (2025)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/3f2f738d60934328ac41b15893cf9ee4

The first-in-class bispecific antibody IBI318 (LY3434172) targeting PD-1 and PD-L1 in patients with advanced tumors: a phase Ia/Ib study

Authors: Dan-Yun Ruan, Xiao-Li Wei, Fu-Rong Liu, Xi-Chun Hu, Jian Zhang, Dong-Mei Ji, Ding-Zhi Huang, Yan-Qiu Zhao, Hong-Min Pan, Wang-Jun Liao, Kun-Yu Yang, Nong Xu, Xiao-Xiao Lu, Yu-Ling Chen, Wen Zhang, Hui Zhou, Hong-Yun Zhao, Rui-Hua Xu

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-12 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/a9a7ec4c1b9647f89eb73df41a05bd37

Development of antibody‐drug conjugates in cancer: Overview and prospects

Authors: Dan‐Yun Ruan, Hao‐Xiang Wu, Qi Meng, Rui‐Hua Xu

Source: Cancer Communications, Vol 44, Iss 1, Pp 3-22 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2523-3548

Access URL: https://doaj.org/article/8dccdbbcec754aab923da06739da0833

FTO up‐regulation induced by MYC suppresses tumour progression in Epstein‒Barr virus‐associated gastric cancer

Authors: Yun‐Yun Xu, Ting Li, Ao Shen, Xiao‐Qiong Bao, Jin‐Fei Lin, Li‐Zhen Guo, Qi Meng, Dan‐Yun Ruan, Qi‐Hua Zhang, Zhi‐Xiang Zuo, Zhao‐lei Zeng

Source: Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)

Subject Terms: EBV‐associated gastric cancer, FOS, FTO, IGF2BP1, IGF2BP2, m6A, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/3e9a40ea87244b2e9c7df254e98393d9

DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in gastric cancer

Authors: Qi Meng, Yun-Xin Lu, Dan-Yun Ruan, Kai Yu, Yan-Xing Chen, Min Xiao, Yun Wang, Ze-Xian Liu, Rui-Hua Xu, Huai-Qiang Ju, Miao-Zhen Qiu

Source: Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 695-710 (2021)

Subject Terms: DNA methylation, tumor microenvironment, immunotherapy, biomarker, gastric cancer, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253121000950; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/e406e01926b84f209905e5f59f87e2ac

Beclin 1 deficiency correlated with lymph node metastasis, predicts a distinct outcome in intrahepatic and extrahepatic cholangiocarcinoma.

Authors: Tian-Tian Wang, Qing-Hua Cao, Ming-Yuan Chen, Qing Xia, Xin-Juan Fan, Xiao-Kun Ma, Qu Lin, Chang-Chang Jia, Min Dong, Dan-Yun Ruan, Ze-Xiao Lin, Jing-Yun Wen, Li Wei, Xing Li, Zhan-Hong Chen, Lei Wang, Xiang-Yuan Wu, Xiang-Bo Wan

Source: PLoS ONE, Vol 8, Iss 11, p e80317 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3841169?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/adc78059c4f140c09588ea933c85aa77

Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma.

Authors: MIN DONG, ZHAN-HONG CHEN, XING LI, XIAO-YUN LI, JING-YUN WEN, QU LIN, XIAO-KUN MA, LI WEI, JIE CHEN, DAN-YUN RUAN, ZE-XIAO LIN, TIAN-TIAN WANG, DONG-HAO WU, XIANG-YUAN WU

Source: Oncology Letters; Nov2017, Vol. 14 Issue 5, p6277-6284, 8p

Subject Terms: BLOOD proteins, LIVER cancer, BIOMARKERS, CIRRHOSIS of the liver, ALPHA fetoproteins, PROGNOSIS

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma.

Authors: YING-FEN HONG, ZHAN-HONG CHEN, LI WEI, XIAO-KUN MA, XING LI, JING-YUN WEN, TIAN-TIAN WANG, XIU-RONG CAI, DONG-HAO WU, JIE CHEN, DAN-YUN RUAN, ZE-XIAO LIN, QU LIN, MIN DONG, XIANG-YUAN WU

Source: Oncology Letters; Aug2017, Vol. 14 Issue 2, p2089-2096, 8p

Subject Terms: LYMPHOCYTES, MONOCYTES, LIVER cancer, HOMEOSTASIS, INFLAMMATION

Validation and ranking of seven staging systems of hepatocellular carcinoma.

Authors: YING‑FEN HONG, JINXIANG LIN, XING LI, DONG‑HAO WU, JING‑YUN WEN, JIE CHEN, DAN‑YUN RUAN, QU LIN, MIN DONG, LI WEI, TIAN‑TIAN WANG, ZE‑XIAO LIN, XIAO‑KUN MA, XIANG‑YUAN WU, ZHAN‑HONG CHEN, RUIHUA XU

Source: Oncology Letters; Jul2017, Vol. 14 Issue 1, p704-714, 11p, 5 Charts, 9 Graphs

Subject Terms: HEPATITIS B, LIVER cancer, MORTALITY, CARCINOMA, PROGNOSTIC tests, PATIENTS

MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells.

Authors: XIAO-YUN LI, JING-YUN WEN, CHANG-CHANG JIA, TIAN-TIAN WANG, XING LI, MIN DONG, QU LIN, ZHAN-HONG CHEN, XIAO-KUN MA, LI WEI, ZE-XIAO LIN, DAN-YUN RUAN, JIE CHEN, DONG-HAO WU, WEI LIU, YAN TAI, ZHI-YONG XIONG, XIANG-YUAN WU, QI ZHANG

Source: Oncology Letters; Nov2015, Vol. 10 Issue 5, p2691-2698, 8p

Subject Terms: MICRORNA, CYTOPROTECTION, LIVER cancer, CANCER chemotherapy, ANTINEOPLASTIC agents

Aberrant expression of enhancer of zeste homologue 2, correlated with HIF-1α, refines relapse risk and predicts poor outcome for breast cancer.

Authors: MIN DONG, XIN-JUAN FAN, ZHAN-HONG CHEN, TIAN-TIAN WANG, XING LI, JIE CHEN, QU LIN, JING-YUN WEN, XIAO-KUN MA, LI WEI, DAN-YUN RUAN, ZE-XIAO LIN, QUENTIN LIU, XIANG-YUAN WU, XIANG-BO WAN

Source: Oncology Reports; 2014, Vol. 32 Issue 3, p1101-1107, 7p

Deceptive information and the financial burden for Chinese cancer patients.

Authors: Xing Li¹, Yun Deng², Jie Chen¹, Dan-Yun Ruan¹, Zhan-Hong Chen¹, Yan-Fang Xing³, Xiang-Yuan Wu¹ wuxiangy@mail.sysu.edu.cn, Min Dong¹

Source: Lancet Oncology. Jul2014, Vol. 15 Issue 8, pe299-e299. 1p.

Subject Terms: *CANCER patients, *MEDICAL care costs, *CANCER prevention, *PUBLIC health, *CANCER, *ANTINEOPLASTIC agents, *GOVERNMENT policy

Geographic Terms: CHINA