1169 AZD5863: a specific, potent, affinity-optimized claudin 18.2 and CD3 binding T cell-engager that elicits low cytokine release and is capable of bystander killing

Authors: Rakesh Kumar, Yun He, Simon Dovedi, Mark Cobbold, Kristen Pollizzi, Saso Cemerski, Scott Hammond, Marina Natoli, Yiping Rong, Jonathan Fitzgerald, Mary McFarlane, Kathy Mulgrew, Miguel Gaspar, Christopher Lloyd, Douglas C Palmer, Maria AS Broggi, Laure Castan, Sharif Rahmy, Cathryn Kelton, Martin Korade, Oisin Huhn, D Gareth Rees, Anna Sigurdardottir, Benjamin Ridgway, Kathryn Ball, Fred Arce Vargas, Natalia Ceaicovscaia, Gayle Pouliot, Philip Szekeres

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/b829a62d777f404facdf66726405782f

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Authors: Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

Authors: Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart

Source: OncoImmunology, Vol 6, Iss 3 (2017)

Subject Terms: agonist, gitr, gitrl, hexamer, medi1873, t cell, tumor, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/2ce1d1f11ec645bc9ff9055a90e162ac

Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes

Authors: Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg

Source: Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/82c3864e38134c29b42485f93454e6e6

A simeprevir-inducible molecular switch for the control of cell and gene therapies

Authors: Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Gareth Rees, Tim I. M. Malcolm, Samantha J. Spratley, Cecilia Granéli, Jonathan Sumner, Natalie J. Tigue

Source: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1c4fb2f0a98149f7bb083c8fbced398e