TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

Authors: Lascaux, Pauline, Hoslett, Gwendoline, Tribble, Sara, Trugenberger, Camilla, Antičević, Ivan, Otten, Cecile, Torrecilla, Ignacio, Koukouravas, Stelios, Zhao, Yichen, Yang, Hongbin, Aljarbou, Ftoon, Ruggiano, Annamaria, Song, Wei, Peron, Cristiano, Deangeli, Giulio, Domingo, Enric, Bancroft, James, Carrique, Loïc, Johnson, Errin, Vendrell, Iolanda, Fischer, Roman, Ng, Alvin Wei Tian, Ngeow, Joanne, D’Angiolella, Vincenzo, Raimundo, Nuno, Maughan, Tim, Popović, Marta, Milošević, Ira, Ramadan, Kristijan

Source: In Cell 3 October 2024 187(20):5698-5718

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

Authors: Xie, Xiaowen, Zhang, Olivia, Yeo, Megan J. R., Lee, Ceejay, Tao, Ran, Harry, Stefan A., Payne, N. Connor, Nam, Eunju, Paul, Leena, Li, Yiran, Kwok, Hui Si, Jiang, Hanjie, Mao, Haibin, Hadley, Jennifer L., Lin, Hong, Batts, Melissa, Gosavi, Pallavi M., D’Angiolella, Vincenzo, Cole, Philip A., Mazitschek, Ralph, Northcott, Paul A., Zheng, Ning, Liau, Brian B.

Source: Nature; March 2025, Vol. 639 Issue: 8053 p241-249, 9p

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase

Authors: Chen, Zhuoyao, Picaud, Sarah, Filippakopoulos, Panagis, D'Angiolella, Vincenzo, Bullock, Alex N.

Source: In Structure 3 September 2019 27(9):1395-1404

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Authors: Foskolou, Iosifina P., Jorgensen, Christian, Leszczynska, Katarzyna B., Olcina, Monica M., Tarhonskaya, Hanna, Haisma, Bauke, D’Angiolella, Vincenzo, Myers, William K., Domene, Carmen, Flashman, Emily, Hammond, Ester M.

Source: In Molecular Cell 20 April 2017 66(2):206-220

Β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

Authors: Mavrommati, Ioanna, Faedda, Roberta, Galasso, Giovanni, Li, Jie, Burdova, Kamila, Fischer, Roman, Kessler, Benedikt M., Carrero, Zunamys I., Guardavaccaro, Daniele, Pagano, Michele, D'Angiolella, Vincenzo

Source: Cell reports. 24(13):3404-3412

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100073589424.0x000001&indx=1&recIds=ETOCvdc_100073589424.0x000001

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Authors: Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V., Arama, Eli, Baehrecke, Eric H., Barlev, Nickolai A., Bazan, Nicolas G., Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Katiuscia, Blagosklonny, Mikhail V., Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chandel, Navdeep S., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Cohen, Gerald M., Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D'Angiolella, Vincenzo, Dawson, Ted M., Dawson, Valina L., De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J., Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M., Dixon, Scott J., Duckett, Colin S., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J. Marie, Harris, Isaac S., Hengartner, Michael O., Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J., Juin, Philippe P., Kaiser, William J., Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Knight, Richard A., Kumar, Sharad, Lee, Sam W., Lemasters, John J., Levine, Beth, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Lowe, Scott W., Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, Manic, Gwenola, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Sonia, Miao, Edward A., Molkentin, Jeffery D., Moll, Ute M., Muñoz-Pinedo, Cristina, Nagata, Shigekazu, Nuñez, Gabriel, Oberst, Andrew, Oren, Moshe, Overholtzer, Michael, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Piacentini, Mauro, Pinton, Paolo, Prehn, Jochen H.M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rehm, Markus, Rizzuto, Rosario, Rodrigues, Cecilia M.P., Rubinsztein, David C., Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Scorrano, Luca, Shao, Feng, Shi, Yufang, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stockwell, Brent R., Strasser, Andreas, Szabadkai, Gyorgy, Tait, Stephen W.G., Tang, Daolin, Tavernarakis, Nektarios, Thorburn, Andrew, Tsujimoto, Yoshihide, Turk, Boris, Vanden Berghe, Tom, Vandenabeele, Peter, Vander Heiden, Matthew G., Villunger, Andreas, Virgin, Herbert W., Vousden, Karen H., Vucic, Domagoj, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ying, Wells, James A., Wood, Will, Yuan, Junying, Zakeri, Zahra, Zhivotovsky, Boris, Zitvogel, Laurence, Melino, Gerry, Kroemer, Guido

Source: Cell death and differentiation. 25(3):486-541

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111628776.0x000001&indx=1&recIds=ETOCvdc_100111628776.0x000001

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

Authors: Pfister, Sophia X., Markkanen, Enni, Jiang, Yanyan, Sarkar, Sovan, Woodcock, Mick, Orlando, Giulia, Mavrommati, Ioanna, Pai, Chen-Chun, Zalmas, Lykourgos-Panagiotis, Drobnitzky, Neele, Dianov, Grigory L., Verrill, Clare, Macaulay, Valentine M., Ying, Songmin, La Thangue, Nicholas B., D’Angiolella, Vincenzo, Ryan, Anderson J., Humphrey, Timothy C.

Source: In Cancer Cell 9 November 2015 28(5):557-568

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis

Authors: D’Angiolella, Vincenzo, Esencay, Mine, Pagano, Michele

Source: In Trends in Cell Biology March 2013 23(3):135-140

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

Authors: D'Angiolella, Vincenzo, Donato, Valerio, Forrester, Frances M., Jeong, Yeon-Tae, Pellacani, Claudia, Kudo, Yasusei, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Pagano, Michele

Source: In Cell 25 May 2012 149(5):1023-1034

E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

Authors: Burdova, Kamila, Yang, Hongbin, Faedda, Roberta, Hume, Samuel, Chauhan, Jagat, Ebner, Daniel, Kessler, Benedikt M, Vendrell, Iolanda, Drewry, David H, Wells, Carrow I, Hatch, Stephanie B, Dianov, Grigory L, Buffa, Francesca M, D'Angiolella, Vincenzo

Source: EMBO journal. 38(20)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091344829.0x000001&indx=1&recIds=ETOCvdc_100091344829.0x000001

The case of the missing Ks: Base editor screen to assess cellular fitness at single lysines

Authors: Gopala Krishna, Varun, Gautsch, Verena Gudrun, D’Angiolella, Vincenzo

Source: In Molecular Cell 21 December 2023 83(24):4442-4444

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Authors: Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo

Source: Cell Death and Differentiation; 20230101, Issue: Preprints p1-58, 58p

SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation.

Authors: D'Angiolella, Vincenzo, Donato, Valerio, Vijayakumar, Sangeetha

Source: Nature; July 1 2010, Vol. 466, p138-142, 5p

The spindle checkpoint requires cyclin-dependent kinase activity.

Authors: D'Angiolella, Vincenzo, Mari, Cecilia, Nocera, Donatella

Source: Genes & Development; October 15 2003, Vol. 17 Issue 20, p2520-2525, 6p

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Authors: Chen, Zhuoyao, Ioris, Rafael M., Richardson, Stacey, Van Ess, Ava N., Vendrell, Iolanda, Kessler, Benedikt M., Buffa, Francesca M., Busino, Luca, Clifford, Steven C., Bullock, Alex N., D’Angiolella, Vincenzo

Source: Cell Death and Differentiation; October 2022, Vol. 29 Issue: 10 p1955-1969, 15p

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Authors: Zhuoyao Chen, Jinwei Zhang, Murillo-de-Ozores, Adrián R., Castañeda-Bueno, María, D'Amico, Francesca, Heilig, Raphael, Manning, Charlotte E., Sorrell, Fiona J., D'Angiolella, Vincenzo, Fischer, Roman, Mulder, Monique P. C., Gamba, Gerardo, Alessi, Dario R., Bullock, Alex N.

Source: Biochemical Journal; Mar2022, Vol. 479 Issue 5, p661-675, 12p

Subject Terms: UBIQUITIN ligases, PEPTIDES, KINASES, HEMATOCRIT, HYDROGEN bonding interactions

The NUCKS1-SKP2-p21/p27 axis controls S phase entry.

Authors: Hume, Samuel, Grou, Claudia P., Lascaux, Pauline, D'Angiolella, Vincenzo, Legrand, Arnaud J., Ramadan, Kristijan, Dianov, Grigory L.

Source: Nature Communications; 11/29/2021, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: DNA damage, CELL cycle, FETAL tissues, TRANSCRIPTION factors, MITOGENS

SnapShot: F Box Proteins II

Authors: Skaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K., Pagano, Michele

Source: In Cell 26 June 2009 137(7):1358-1358

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

Authors: Li, Ji¹, D'Angiolella, Vincenzo², Seeley, E. Scott³, Kim, Sehyun¹, Kobayashi, Tetsuo¹, Fu, Wenxiang¹, Campos, Eric I.⁴, Pagano, Michele⁵, Dynlacht, Brian David¹

Source: Nature. 3/14/2013, Vol. 495 Issue 7440, p255-259. 5p. 4 Graphs.

Subject Terms: *CENTROSOMES, *UBIQUITINATION, *CELL cycle, *MICROTUBULES, *UBIQUITIN ligases, *T cells

SCF^{Cyclin F} controls centrosome homeostasis and mitotic fidelity through CP110 degradation.

Authors: D'Angiolella, Vincenzo¹, Donato, Valerio¹, Vijayakumar, Sangeetha¹, Saraf, Anita², Florens, Laurence², Washburn, Michael P.^2,3, Dynlacht, Brian¹, Pagano, Michele^1,4 michele.pagano@nyumc.org

Source: Nature. 7/1/2010, Vol. 466 Issue 7302, p138-142. 5p. 4 Graphs.

Subject Terms: *CENTROSOMES, *HOMEOSTASIS, *PROTEINS, *UBIQUITIN, *LIGASES, *PROTEOLYSIS, *EUKARYOTIC cells, *GENOMES, *CELL cycle